Cited by 55Gestational Diabetes Research and ManagementOvarian function and disordersDiabetes, Cardiovascular Risks, and Lipoproteins

Effect of Metformin Intervention during Pregnancy on the Gestational Diabetes Mellitus in Women with Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis

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Zhuo, Zhihong, Wang, Aiming, Yu, Huimin·2014·Journal of Diabetes Research

Abstract

Metformin is an effective insulin sensitizer treating type 2 diabetes mellitus. However, the functional consequences of metformin administration throughout pregnancy on gestational diabetes mellitus (GDM) with polycystic ovary syndrome (PCOS) have not been assessed. We therefore performed a meta-analysis and system review to determine the effect of metformin on GDM in PCOS. A meta-analysis was performed on the published studies before December, 2013. Meta-analysis examined whether metformin could reduce GDM occurrence in PCOS with a fixed effect model. The odds ratio (OR) with 95% confidence interval (95% CI) was calculated to estimate the strength of association. A total of 13 studies including 5 RCTs and 8 non-RCTs were enrolled. Ultimately, effectiveness analysis demonstrated that, in total, there was no significant availability of metformin on GDM in PCOS in contrast to placebo (OR = 1.07, 95% CI 0.60–1.92) in RCTs and significant availability of metformin on GDM (OR = 0.19, 95% CI 0.13–0.27) was indicated in non-RCTs. In summary, according to the results of our meta-analysis, strictly, metformin did not significantly effect on GDM with PCOS, though more multicenters RCTs still need to be investigated.

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  1. [18]David E Poly cystic ovarian syndrome The New England Journal of Medicine 2005 352 1223 1236
  2. [24]Cochrane Menstrual Disorders and Subfertility Group Resources for review authors. Available at, http://mdsg.cochrane.org/resources-review-authors/.

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Authors
Zhuo, Z., Wang, A., & Yu, H.
Affiliations
  • Ningbo No. 2 Hospital (CN)
  • PLA Navy General Hospital (CN)
Corresponding author
Wang, Aiming
Venue
Journal of Diabetes Research
Published
2014
Volume
2014
Pages
1-13
ISSN
  • 2314-6745 (ISSN-L)
  • 2314-6753
OpenAlex
W2018022686
Cited by
55
References
48
Citations by year
2026: 1 · 2025: 5 · 2023: 2 · 2022: 3 · 2021: 4 · 2020: 7 · 2019: 6 · 2018: 6 · 2017: 4 · 2016: 6 · 2015: 10 · 2014: 1
FWCI
1.12
Type
journal article
Language
en
Open access
Locations
  • Journal of Diabetes Research (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics
  • Health Sciences › Medicine › Obstetrics and Gynecology › Gestational Diabetes Research and Management
  • Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Keywords
metformin, gestational diabetes mellitus, polycystic ovary syndrome, pregnancy, insulin sensitizers, type 2 diabetes prevention, drug efficacy
MeSH terms
Female, Humans, Hypoglycemic Agents, Metformin, Polycystic Ovary Syndrome, Pregnancy, Multicenter Studies as Topic, Odds Ratio, Randomized Controlled Trials as Topic, Diabetes, Gestational, Treatment Outcome

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