Effect of Metformin Intervention during Pregnancy on the Gestational Diabetes Mellitus in Women with Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis
Open accessAbstract
Metformin is an effective insulin sensitizer treating type 2 diabetes mellitus. However, the functional consequences of metformin administration throughout pregnancy on gestational diabetes mellitus (GDM) with polycystic ovary syndrome (PCOS) have not been assessed. We therefore performed a meta-analysis and system review to determine the effect of metformin on GDM in PCOS. A meta-analysis was performed on the published studies before December, 2013. Meta-analysis examined whether metformin could reduce GDM occurrence in PCOS with a fixed effect model. The odds ratio (OR) with 95% confidence interval (95% CI) was calculated to estimate the strength of association. A total of 13 studies including 5 RCTs and 8 non-RCTs were enrolled. Ultimately, effectiveness analysis demonstrated that, in total, there was no significant availability of metformin on GDM in PCOS in contrast to placebo (OR = 1.07, 95% CI 0.60–1.92) in RCTs and significant availability of metformin on GDM (OR = 0.19, 95% CI 0.13–0.27) was indicated in non-RCTs. In summary, according to the results of our meta-analysis, strictly, metformin did not significantly effect on GDM with PCOS, though more multicenters RCTs still need to be investigated.
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Evidence regarding the impact of metformin on the incidence of gestational diabetes mellitus is controversial.
“Evidence regarding the impact of metformin on the incidence of GDM is controversial [58–61].”
From From Prediabetes to Type 2 Diabetes Mellitus in Women with Polycystic Ovary Syndrome: Lifestyle and Pharmacological Management (2020) · cites this paper as [61]
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- Authors
- Zhuo, Z., Wang, A., & Yu, H.
- Affiliations
- Ningbo No. 2 Hospital (CN)
- PLA Navy General Hospital (CN)
- Corresponding author
- Wang, Aiming
- Venue
- Journal of Diabetes Research
- Publisher
- Hindawi Limited
- Published
- 2014
- Volume
- 2014
- Pages
- 1-13
- ISSN
- 2314-6745 (ISSN-L)
- 2314-6753
- PMC
- PMC4055053
- OpenAlex
- W2018022686
- Cited by
- 55
- References
- 48
- Citations by year
- 2026: 1 · 2025: 5 · 2023: 2 · 2022: 3 · 2021: 4 · 2020: 7 · 2019: 6 · 2018: 6 · 2017: 4 · 2016: 6 · 2015: 10 · 2014: 1
- FWCI
- 1.12
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Journal of Diabetes Research (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Obstetrics and Gynecology › Gestational Diabetes Research and Management
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- metformin, gestational diabetes mellitus, polycystic ovary syndrome, pregnancy, insulin sensitizers, type 2 diabetes prevention, drug efficacy
- MeSH terms
- Female, Humans, Hypoglycemic Agents, Metformin, Polycystic Ovary Syndrome, Pregnancy, Multicenter Studies as Topic, Odds Ratio, Randomized Controlled Trials as Topic, Diabetes, Gestational, Treatment Outcome
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