The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
Oxidative Stress in Alzheimer’s Disease: Why Did Antioxidant Therapy Fail?
Open accessAbstract
Alzheimer’s disease (AD) is the most common form of dementia in the elderly, with increasing prevalence and no disease-modifying treatment available yet. A remarkable amount of data supports the hypothesis that oxidative stress is an early and important pathogenic operator in AD. However, all clinical studies conducted to date did not prove a clear beneficial effect of antioxidant treatment in AD patients. In the current work, we review the current knowledge about oxidative stress in AD pathogeny and we suggest future paths that are worth to be explored in animal models and clinical studies, in order to get a better approach of oxidative imbalance in this inexorable neurodegenerative disease.
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Cites
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Oxidative Damage Is the Earliest Event in Alzheimer Disease
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Oxidative stress in the progression of Alzheimer disease in the frontal cortex
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Cited by
Targeting Free Radicals in Oxidative Stress-Related Human Diseases
Poprac, P., Jomova, K., Simunkova, M., Kollar, V., Rhodes, C. J., & Valko, M. (2017) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2017.04.005 · Cited by 1,107
Oxidative stress: The core pathogenesis and mechanism of Alzheimer’s disease
Bai, R., Guo, J., Ye, X.-Y., Xie, Y., & Xie, T. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101619 · Cited by 813
Selenium-Dependent Antioxidant Enzymes: Actions and Properties of Selenoproteins
Zoidis, E., Seremelis, I., Kontopoulos, N., & Danezis, G. (2018) · Antioxidants · doi:10.3390/antiox7050066 · Cited by 473
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Perluigi, M., Di Domenico, F., & Butterfield, D. A. (2024) · Physiological Reviews · doi:10.1152/physrev.00030.2022 · Cited by 282
Metadata
- Authors
- Persson, T., Popescu, B. O., & Cedazo-Minguez, A.
- Venue
- Oxidative Medicine and Cellular Longevity
- Publisher
- Wiley
- Published
- 2014
- Volume
- 2014
- Pages
- 1-11
- ISSN
- 1942-0994 (ISSN-L)
- 1942-0900
- OpenAlex
- W1997288864
- Cited by
- 312
- References
- 19
- FWCI
- 13.80
- Type
- journal article
- Language
- en
- Open access
- hybrid
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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