Cited by 238Dupuytren's Contracture and TreatmentsUrological Disorders and TreatmentsSexual function and dysfunction studies

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The Role of Intrinsic Pathway in Apoptosis Activation and Progression in Peyronie’s Disease

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Loreto, Carla, La Rocca, Giampiero, Anzalone, Rita, Caltabiano, Rosario, Vespasiani, Giuseppe, Castorina, Sergio, Ralph, David J., Cellek, Selim, Musumeci, Giuseppe, Giunta, Salvatore, Djinovic, Rados, Basic, Dragoslav, Sansalone, Salvatore·2014·BioMed Research International

DOI 10.1155/2014/616149PMC PMC4147380

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Abstract

Peyronie’s disease (PD) is characterized with formation of fibrous plaques which result in penile deformity, pain, and erectile dysfunction. The aim of this study was to investigate the activation of the intrinsic apoptotic pathway in plaques from PD patients. Tunica albuginea from either PD or control patients was assessed for the expression of bax, bcl-2 and caspases 9 and 3 using immunohistochemistry and by measurement of apoptotic cells using TUNEL assay. Bax overexpression was observed in metaplastic bone tissue, in fibroblasts, and in myofibroblast of plaques from PD patients. Little or no bcl-2 immunostaining was detected in samples from either patients or controls. Caspase 3 immunostaining was very strong in fibrous tissue, in metaplasic bone osteocytes, and in primary ossification center osteoblasts. Moderate caspase 9 immunostaining was seen in fibrous cells plaques and in osteocytes and osteoblasts of primary ossification centers from PD patients. Control samples were negative for caspase 9 immunostaining. In PD patients the TUNEL immunoassay showed intense immunostaining of fibroblasts and myofibroblasts, the absence of apoptotic cells in metaplasic bone tissue and on the border between fibrous and metaplastic bone tissue. Apoptosis occurs in stabilized PD plaques and is partly induced by the intrinsic pathway.

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Authors: Loreto, C., La Rocca, G., Anzalone, R., Caltabiano, R., Vespasiani, G., Castorina, S., Ralph, D. J., Cellek, S., Musumeci, G., Giunta, S., Djinovic, R., Basic, D., & Sansalone, S.
Affiliations: University of Catania (IT)
Department of Experimental Biomedicine and Clinical Neuroscience, University of Palermo, 90100 Palermo, Italy
University of Palermo (IT)
University of Rome Tor Vergata (IT)
University College Hospital (GB)
Cranfield University (GB)
Sava Perovic Foundation, Center for Genito-Urinary Reconstructive Surgery, 11000 Belgrade, Serbia
Clinic of Urology, Clinical Center Nis, 18000 Nis, Serbia
Corresponding author: Loreto, Carla
ORCID: Loreto, Carla
La Rocca, Giampiero
Anzalone, Rita
Caltabiano, Rosario
Castorina, Sergio
Ralph, David J.
Cellek, Selim
Musumeci, Giuseppe
Giunta, Salvatore
Basic, Dragoslav
Sansalone, Salvatore
Venue: BioMed Research International
Publisher: Wiley
Published: 2014
Volume: 2014
Pages: 1-10
ISSN: 1110-7243 (ISSN-L)
2314-6133
2314-6141
DOI: 10.1155/2014/616149
PMC: PMC4147380
OpenAlex: W1973666710
Cited by: 108
References: 48
Citations by year: 2026: 1 · 2025: 6 · 2024: 4 · 2023: 14 · 2022: 20 · 2021: 22 · 2020: 15 · 2019: 12 · 2018: 4 · 2017: 3 · 2016: 5 · 2015: 2
FWCI: 2.77
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
creativecommons.org/licenses/by/3.0/ (unspecified)
Locations: BioMed Research International (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
Cineca Institutional Research Information System (Tor Vergata University) (submittedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Nova Science Publishers (Nova Science Publishers, Inc.) (submittedVersion, other-oa)
Topics: Health Sciences › Medicine › Rheumatology › Dupuytren's Contracture and Treatments
Health Sciences › Medicine › Urology › Urological Disorders and Treatments
Health Sciences › Medicine › Psychiatry and Mental health › Sexual function and dysfunction studies
Keywords: Peyronie's disease, mitochondrial apoptosis, apoptosis, tunica albuginea, fibrous plaque, Bax, Bcl-2, caspase-3, caspase-9, myofibroblasts, fibroblasts, ossification centers, penile deformity
MeSH terms: Adult, Aged, Humans, Male, Middle Aged, Penile Induration, Staining and Labeling, Signal Transduction, Apoptosis, Disease Progression, In Situ Nick-End Labeling, bcl-2-Associated X Protein, Caspase 3, Caspase 9, Young Adult

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The Role of Intrinsic Pathway in Apoptosis Activation and Progression in Peyronie’s Disease

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