Cited by 98Adipokines, Inflammation, and Metabolic DiseasesDietary Effects on HealthNutritional Studies and Diet

Early effects of a hypocaloric, Mediterranean diet on laboratory parameters in obese individuals

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Greco, Marta, Chiefari, Eusebio, Montalcini, Tiziana, Accattato, Francesca, Costanzo, Francesco S., Pujia, Arturo, Foti, Daniela, Brunetti, Antonio +1 more·2014·Mediators of Inflammation

Abstract

Calorie restriction is a common strategy for weight loss in obese individuals. However, little is known about the impact of moderate hypocaloric diets on obesity-related laboratory parameters in a short-term period. Aim of this study was to evaluate the variation of laboratory biomarkers in obese individuals following a Mediterranean, hypocaloric (1400-1600 Kcal/die) diet. 23 obese, pharmacologically untreated patients were enrolled and subjected to the determination of anthropometric variables and blood collection at baseline, 1 and 4 months after diet initiation. After 4 months of calorie restriction, we observed a significant decrease in body weight and BMI (both P < 0.0001), insulin (P = 0.037), HOMA-IR (P = 0.026), leptin (P = 0.008), and LDH (P = 0.023) and an increase in EGF (P = 0.013). All these parameters, except LDH, varied significantly already at 1 month after diet initiation. Also, lower levels of insulin (P = 0.025), leptin (P = 0.023), and EGF (P = 0.035) were associated with a greater (>5%) weight loss. Collectively, our data support a precocious improvement of insulin and leptin sensitivity after a modest calorie restriction and weight reduction. Moreover, EGF and LDH may represent novel markers of obesity, which deserve further investigations.

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  • The Mediterranean diet is associated with greater improvement of insulin resistance in obese individuals compared with other nutritional interventions.

    “The Mediterranean diet (MedDiet), characterized by high consumption of extra-virgin olive oil (EVOO), nuts, red wine, vegetables and other polyphenol-rich elements, has proved to be associated with greater improvement of IR in obese individuals, when compared to other nutritional interventions.”

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  1. [14]Berenbaum F Eymard F Houard X Osteoarthritis, inflammation an obesity Current Opinion in Rheumatology 2013 25 114 118 23090672
  2. [16]Haslam DW James WPT Obesity The Lancet 2005 366 9492 1197 1209 2-s2.0-25844457693 16198769

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Authors
Greco, M., Chiefari, E., Montalcini, T., Accattato, F., Costanzo, F. S., Pujia, A., Foti, D., Brunetti, A., & Gulletta, E.
Affiliations
Magna Graecia University (IT)
Corresponding author
Foti, Daniela
Venue
Mediators of Inflammation
Publisher
Wiley
Published
2014
Volume
2014
Pages
1-8
ISSN
  • 0962-9351 (ISSN-L)
  • 1466-1861
OpenAlex
W1966884669
Cited by
98
References
72
Citations by year
2026: 2 · 2025: 5 · 2024: 8 · 2023: 5 · 2022: 8 · 2021: 10 · 2020: 10 · 2019: 7 · 2018: 36 · 2017: 4 · 2016: 1 · 2015: 1 · 2013: 1
FWCI
1.52
Type
journal article
Language
en
Open access
Locations
  • Mediators of Inflammation (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
  • Health Sciences › Medicine › Physiology › Dietary Effects on Health
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
Keywords
obesity, caloric restriction, hypocaloric diet, Mediterranean diet, weight loss, insulin resistance, HOMA-IR, leptin, insulin sensitivity, epidermal growth factor, lactate dehydrogenase, obesity biomarkers, body mass index
MeSH terms
Anthropometry, Diet, Epidermal Growth Factor, Female, Humans, Insulin, Insulin Resistance, L-Lactate Dehydrogenase, Male, Middle Aged, Obesity, Prospective Studies, Biomarkers, Weight Loss, Body Mass Index, Leptin, Caloric Restriction, Diet, Mediterranean, Adipokines

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