Early effects of a hypocaloric, Mediterranean diet on laboratory parameters in obese individuals
Open accessAbstract
Calorie restriction is a common strategy for weight loss in obese individuals. However, little is known about the impact of moderate hypocaloric diets on obesity-related laboratory parameters in a short-term period. Aim of this study was to evaluate the variation of laboratory biomarkers in obese individuals following a Mediterranean, hypocaloric (1400-1600 Kcal/die) diet. 23 obese, pharmacologically untreated patients were enrolled and subjected to the determination of anthropometric variables and blood collection at baseline, 1 and 4 months after diet initiation. After 4 months of calorie restriction, we observed a significant decrease in body weight and BMI (both P < 0.0001), insulin (P = 0.037), HOMA-IR (P = 0.026), leptin (P = 0.008), and LDH (P = 0.023) and an increase in EGF (P = 0.013). All these parameters, except LDH, varied significantly already at 1 month after diet initiation. Also, lower levels of insulin (P = 0.025), leptin (P = 0.023), and EGF (P = 0.035) were associated with a greater (>5%) weight loss. Collectively, our data support a precocious improvement of insulin and leptin sensitivity after a modest calorie restriction and weight reduction. Moreover, EGF and LDH may represent novel markers of obesity, which deserve further investigations.
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The Mediterranean diet is associated with greater improvement of insulin resistance in obese individuals compared with other nutritional interventions.
“The Mediterranean diet (MedDiet), characterized by high consumption of extra-virgin olive oil (EVOO), nuts, red wine, vegetables and other polyphenol-rich elements, has proved to be associated with greater improvement of IR in obese individuals, when compared to other nutritional interventions.”
From Mediterranean diet nutrients to turn the tide against insulin resistance and related diseases (2020) · cites this paper as [18]
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- Authors
- Greco, M., Chiefari, E., Montalcini, T., Accattato, F., Costanzo, F. S., Pujia, A., Foti, D., Brunetti, A., & Gulletta, E.
- Affiliations
- Magna Graecia University (IT)
- Corresponding author
- Foti, Daniela
- ORCID
- Venue
- Mediators of Inflammation
- Publisher
- Wiley
- Published
- 2014
- Volume
- 2014
- Pages
- 1-8
- ISSN
- 0962-9351 (ISSN-L)
- 1466-1861
- PMC
- PMC3960747
- OpenAlex
- W1966884669
- Cited by
- 98
- References
- 72
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 8 · 2023: 5 · 2022: 8 · 2021: 10 · 2020: 10 · 2019: 7 · 2018: 36 · 2017: 4 · 2016: 1 · 2015: 1 · 2013: 1
- FWCI
- 1.52
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Mediators of Inflammation (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Physiology › Dietary Effects on Health
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Keywords
- obesity, caloric restriction, hypocaloric diet, Mediterranean diet, weight loss, insulin resistance, HOMA-IR, leptin, insulin sensitivity, epidermal growth factor, lactate dehydrogenase, obesity biomarkers, body mass index
- MeSH terms
- Anthropometry, Diet, Epidermal Growth Factor, Female, Humans, Insulin, Insulin Resistance, L-Lactate Dehydrogenase, Male, Middle Aged, Obesity, Prospective Studies, Biomarkers, Weight Loss, Body Mass Index, Leptin, Caloric Restriction, Diet, Mediterranean, Adipokines
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