Effects of Oleacein on High-Fat Diet-Dependent Steatosis, Weight Gain, and Insulin Resistance in Mice
Open accessAbstract
Many reports indicate that the protective action of nutraceuticals in the Mediterranean diet, against metabolic and cardiovascular diseases, can be attributed to the action of polyphenolic components of extra-virgin olive oil (EVOO). Here, we evaluated the protective effects of oleacein, one of the most abundant secoiridoids in EVOO, on the damages/metabolic alterations caused by high-fat diet (HFD) in male C57BL/6JolaHsd mice. After 5 weeks of treatment with 20 mg/kg of oleacein, body weight, glycemia, insulinemia, serum lipids, and histologic examination of liver tissue indicated a protective action of oleacein against abdominal fat accumulation, weight gain, and liver steatosis, with improvement of insulin-dependent glucose and lipid metabolism. Both serum parameters and hepatic histologic examination were altered in mice fed with HFD. By contrast, in the animals that received oleacein, plasma glucose, cholesterol and triglyceride serum levels, and liver histology were similar to controls fed with normocaloric diet. In addition, protein levels of FAS, SREBP-1, and phospho-ERK in liver were positively modulated by oleacein, indicating an improvement in liver insulin sensitivity. In a group of obese mice, treatment with oleacein determined a light, but still significant reduction of the increase in body weight, mainly due to lesser liver steatosis enlargement, associated with reduced levels of SREBP-1 and phospho-ERK and lower levels of total serum cholesterol; in these animals, altered plasma glucose and triglyceride serum levels were not reverted by oleacein. These results indicate that HFD-related hepatic insulin resistance may be partially prevented by oral administration of oleacein, suggesting a protective role of this nutraceutical against diet-dependent metabolic alterations. Additional studies are necessary to check whether oleacein can be used as an adjuvant to improve insulin sensitivity in humans.
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SREBP-1 and its target FAS protein levels were significantly reduced following oleacein treatment in liver and fat.
“Some of the molecular constituents, that appear to be involved in oleacein action, include some known nutrient-responsive regulators of lipid metabolism: the transcriptional activator sterol regulatory element-binding transcription factor-1 (SREBP-1), and its target fatty acid synthase (FAS), whose protein levels were significantly reduced following oleacein treatment in liver and fat [85,87].”
From Mediterranean diet nutrients to turn the tide against insulin resistance and related diseases (2020) · cites this paper as [85]
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- Authors
- Lombardo, G. E., Lepore, S. M., Morittu, V. M., Arcidiacono, B., Colica, C., Procopio, A., Maggisano, V., Bulotta, S., Costa, N., Mignogna, C., Britti, D., Brunetti, A., Russo, D., & Celano, M.
- Affiliations
- Magna Graecia University (IT)
- Corresponding author
- Brunetti, Antonio
- Russo, Diego
- ORCID
- Venue
- Frontiers in Endocrinology
- Publisher
- Frontiers Media SA
- Published
- 2018-03-19
- Volume
- 9
- Pages
- 116-116
- ISSN
- 1664-2392 (ISSN-L)
- PMC
- PMC5868215
- OpenAlex
- W2789596223
- Cited by
- 55
- References
- 45
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 9 · 2023: 11 · 2022: 6 · 2021: 6 · 2020: 9 · 2019: 8 · 2018: 1
- FWCI
- 2.45
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Frontiers in Endocrinology (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Topics
- Physical Sciences › Chemistry › Organic Chemistry › Edible Oils Quality and Analysis
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
- Health Sciences › Medicine › Epidemiology › Liver Disease Diagnosis and Treatment
- Keywords
- oleacein, secoiridoids, extra virgin olive oil, high-fat diet, hepatic steatosis, insulin resistance, weight gain, obesity, glucose metabolism, lipid metabolism, SREBP1, Fas, ERK1/2 phosphorylation, nutraceuticals, Mediterranean diet, serum cholesterol, triglycerides
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