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MicroRNAs: New Regulators of Toll-Like Receptor Signalling Pathways
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Toll-like receptors (TLRs), a critical family of pattern recognition receptors (PRRs), are responsible for the innate immune responses via signalling pathways to provide effective host defence against pathogen infections. However, TLR-signalling pathways are also likely to stringently regulate tissue maintenance and homeostasis by elaborate modulatory mechanisms. MicroRNAs (miRNAs) have emerged as key regulators and as an essential part of the networks involved in regulating TLR-signalling pathways. In this review, we highlight our understanding of the regulation of miRNA expression profiles by TLR-signalling pathways and the regulation of TLR-signalling pathways by miRNAs. We focus on the roles of miRNAs in regulating TLR-signalling pathways by targeting multiple molecules, including TLRs themselves, their associated signalling proteins and regulatory molecules, and transcription factors and functional cytokines induced by them, at multiple levels.
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“TLR signalling has also been shown to be regulated by microRNAs at multiple levels, such as by targeting TLRs, downstream signalling proteins, related regulatory molecules, transcription factors as well as genes induced by TLR signalling (e.g., cytokines), which was reviewed elsewhere [128].”
From Transition from inflammation to proliferation: a critical step during wound healing (2016) · cites this paper as [128]
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Metadata
- Authors
- He, X., Jing, Z., & Cheng, G.
- Affiliations
- Lanzhou Veterinary Research Institute (CN)
- Shanghai Veterinary Research Institute (CN)
- Corresponding author
- Jing, Zhizhong
- Cheng, Guofeng
- Venue
- BioMed Research International
- Publisher
- Wiley
- Published
- 2014
- Volume
- 2014
- Pages
- 1-14
- ISSN
- 1110-7243 (ISSN-L)
- 2314-6133
- 2314-6141
- PMC
- PMC3977468
- OpenAlex
- W2066588601
- Cited by
- 238
- References
- 150
- Citations by year
- 2026: 5 · 2025: 7 · 2024: 17 · 2023: 12 · 2022: 14 · 2021: 43 · 2020: 28 · 2019: 21 · 2018: 19 · 2017: 28 · 2016: 21 · 2015: 15 · 2014: 8
- FWCI
- 2.34
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- BioMed Research International (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (31302072, 31372423, 30871884)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
- Keywords
- microRNA, Toll-like receptors, innate immunity, pattern recognition receptors, miRNA expression regulation, microRNA target regulation, transcription factors, cytokines, tissue homeostasis
- MeSH terms
- Animals, Humans, Signal Transduction, MicroRNAs, Toll-Like Receptors
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