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Cited by 33MicroRNA in disease regulationPlant Molecular Biology ResearchChromosomal and Genetic Variations

Evolutionary and Expression Analysis of miR-#-5p and miR-#-3p at the miRNAs/isomiRs Levels

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Guo, Li, Yu, Jiafeng, Yu, Hao, Zhao, Yang, Chen, Shujie, Xu, Changqing, Chen, Feng·2015·BioMed Research International
DOI 10.1155/2015/168358PMC PMC4436453
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Abstract

We mainly discussed miR-#-5p and miR-#-3p under three aspects: (1) primary evolutionary analysis of human miRNAs; (2) evolutionary analysis of miRNAs from different arms across the typical 10 vertebrates; (3) expression pattern analysis of miRNAs at the miRNA/isomiR levels using public small RNA sequencing datasets. We found that no bias can be detected between the numbers of 5p-miRNA and 3p-miRNA, while miRNAs from miR-#-5p and miR-#-3p show variable nucleotide compositions. IsomiR expression profiles from the two arms are always stable, but isomiR expressions in diseased samples are prone to show larger degree of dispersion. miR-#-5p and miR-#-3p have relative independent evolution/expression patterns and datasets of target mRNAs, which might also contribute to the phenomena of arm selection and/or arm switching. Simultaneously, miRNA/isomiR expression profiles may be regulated via arm selection and/or arm switching, and the dynamic miRNAome and isomiRome will adapt to functional and/or evolutionary pressures. A comprehensive analysis and further experimental study at the miRNA/isomiR levels are quite necessary for miRNA study.

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Cited by

Sorted by citations

Authors
Guo, L., Yu, J., Yu, H., Zhao, Y., Chen, S., Xu, C., & Chen, F.
Affiliations
  • Nanjing Medical University (CN)
  • Dezhou University (CN)
Corresponding author
Guo, Li
ORCID
Venue
BioMed Research International
Publisher
Wiley
Published
2015
Volume
2015
Pages
1-14
ISSN
  • 1110-7243 (ISSN-L)
  • 2314-6133
  • 2314-6141
DOI
10.1155/2015/168358
PMC
PMC4436453
OpenAlex
W1543931293
Cited by
33
References
2
Citations by year
2026: 1 · 2025: 2 · 2024: 3 · 2023: 3 · 2022: 2 · 2021: 7 · 2020: 2 · 2019: 3 · 2018: 2 · 2017: 3 · 2016: 4 · 2015: 1
FWCI
1.21
Type
journal article
Language
en
Open access
Licence
Locations
  • BioMed Research International (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders
  • National Natural Science Foundation of China (61301251, 81473070, 81373102, 20133234120009, BK20130885, 12KJB310003, 13KJB330003)
  • Research Fund for the Doctoral Program of Higher Education of China (61301251, 81473070, 81373102, 20133234120009, BK20130885, 12KJB310003, 13KJB330003)
  • Natural Science Foundation of Jiangsu Province (61301251, 81473070, 81373102, 20133234120009, BK20130885, 12KJB310003, 13KJB330003)
  • Natural Science Foundation of the Jiangsu Higher Education Institutions (61301251, 81473070, 81373102, 20133234120009, BK20130885, 12KJB310003, 13KJB330003)
  • Shandong Provincial Key Laboratory of Functional Macromolecular Biophysics (61301251, 81473070, 81373102, 20133234120009, BK20130885, 12KJB310003, 13KJB330003)
  • Priority Academic Program Development of Jiangsu Higher Education Institutions (61301251, 81473070, 81373102, 20133234120009, BK20130885, 12KJB310003, 13KJB330003)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Molecular Biology Research
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Chromosomal and Genetic Variations
Keywords
miRNA evolution, isomiRs, miRNA expression profiling, nucleotide composition, miRNAome
MeSH terms
Animals, Female, Humans, Phylogeny, Genetic Variation, Vertebrates, Evolution, Molecular, Gene Expression Profiling, Databases, Nucleic Acid, MicroRNAs

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