Isolation of Artemisinin (Qinghaosu) from Artemisia annua Growing in the United States
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ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTIsolation of Artemisinin (Qinghaosu) from Artemisia annua Growing in the United StatesDaniel L. Klayman, Ai J. Lin, Nancy Acton, John P. Scovill, James M. Hoch, Wilbur K. Milhous, Anthony D. Theoharides, and Arthur S. DobekCite this: J. Nat. Prod. 1984, 47, 4, 715–717Publication Date (Print):July 1, 1984Publication History Published online1 July 2004Published inissue 1 July 1984https://pubs.acs.org/doi/10.1021/np50034a027https://doi.org/10.1021/np50034a027research-articleACS PublicationsRequest reuse permissionsArticle Views1683Altmetric-Citations181LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
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Artemisia annua L. is the only known source of the sesquiterpene artemisinin (Qinghaosu).
“The Chinese medicinal plant Artemisia annua L. (Qinghao) is the only known source of the sesquiterpene artemisinin (Qinghaosu), which is used in the treatment of malaria.”
From The Biosynthesis of Artemisinin (Qinghaosu) and the Phytochemistry of Artemisia annua L. (Qinghao) (2010) · cites this paper as [10]
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“…treatment of Alzheimer's disease and was initially discovered in Galanthus nivalis L. (Mashkovsky and Kruglikova-Lvova, 1951), and the important antimalarial and potential anti-cancer agent artemisinin originally derived from the traditional Chinese herb Artemisia annua L. (Klayman et al., 1984).”
BackgroundQinghaosu (Artemisinin): an Antimalarial Drug from China
Klayman, D. L. (1985) · Science · doi:10.1126/science.3887571 · Cited by 2,186 · see citing works
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The Biosynthesis of Artemisinin (Qinghaosu) and the Phytochemistry of Artemisia annua L. (Qinghao)
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“They are extracted from a herb called quinghao (Artemisia annua—sweet Annie, sweet wormwood), which has been used in the Chinese medicine as an antimalarial herb [148].”
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“Some herb extracts have been also found effective against parasites, e.g. Plasmodium spp. (Klayman et al., 1984; Klayman, 1985; Dutta et al., 1989; Lin et al., 1987), Schistosoma mansoni (Shuhua and Catto, 1989), Toxoplasma gondii (Qu-Yang et al., 1990), and helminths (Matsuda et al., 1989).”
BackgroundArtemisinin, a Novel Antimalarial Drug: Biochemical and Molecular Approaches for Enhanced Production
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“Artemisinin is still obtained by extraction from qinghao (Artemisia annua—sweet Annie, sweet wormwood ), a genus of plant that also gives us absinthe (Klayman et al., 1984).”
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“annua leaves with petroleum ether followed by column chromatography of the extract over silica gel and elution with a chloroform-ethyl acetate mixture [109].”
MethodArtemisinin, a Constituent of Annual Wormwood (Artemisia annua), is a Selective Phytotoxin
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“Acknowledgments Some compounds mentioned in this review article that were isolated in our laboratory, were obtained as a result of grant P01 CA125066, funded by the National Cancer Institute, NIH, Bethesda, MD, USA.”
MethodInfluentialSurvey of artemisinin production by diverse Artemisia species in northern Pakistan
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“The first published laboratory procedure for isolation of artemisinin was described by the late Dr Daniel Klayman (Klayman et al., 1984).”
MethodQuinolines and Artemisinin: Chemistry, Biology and History
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“In the past few years, various detection methods have been developed to detect ART, such as thin layer chromatography (TLC) [32], high performance liquid chromatography (HPLC), HPLC-mass spectrometry [12].”
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“Although artemisinins also show cytotoxic activity against cancer cells by various mechanisms of action (Efferth, 2006), the antimalarial activity is the prominent medicinal use (Klayman et al., 1984; Sriram et al., 2004).”
BackgroundState of the art of the production of the antimalarial compound artemisinin in plants
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“extracted dried leaves with petroleum ether and fractionated the extract on a silica column [40].”
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“In 1984 they finally succeeded and published their findings, including its extraction with petroleum ether, chromatographic separation, and potent antimalarial activity against chloroquine sensitive and resistant strains of P. falciparum in vitro [Klayman et al., 1984].”
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HPLC−Electrospray Ionization Mass Spectrometric Analysis of Antimalarial Drug Artemisinin
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“Hindawi Publishing Corporation Malaria Research and Treatment Volume 2012, Article ID 727032, 8 pages doi:10.1155/2012/727032 Research Article”
BackgroundInfluentialA novel purification method of artemisinin from Artemisia annua
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“To solve this problem, since the 1970s, substantial effort has been directed toward understanding the genetic characteristics of this plant and discovering or developing new varieties with improved artemisinin production ( Klayman et al. 1984; Liersch et al. 1986; Tu et al. 1982; WHO 1998, 2010).”
BackgroundGenotoxicity and Teratogenicity of African Medicinal Plants
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“The classical drugs quinine and artemisinin are both plant derivatives obtained from Cinchona specie [3] and Artemisia annua [4] respectively, suggesting that other effective drugs might be plant-derived.”
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“…annua (sweet wormwood), the antiviral drug podophyllotoxin, isolated from Podophyllum peltatum (American mayapple) and the decongestant pseudoephedrine, isolated from Ephedra sinica (ma huang) (Klayman et al., 1984; Wall and Wani, 1996; White et al., 1997; Eyberger et al., 2006; Lee et al., 2013).”
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Antimalarial Activity of Some Kenyan Medicinal Plants
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“1B), including the antimalarial artemisinin, found in Artemisia annua (Klayman et al., 1984); and anticancer agent paclitaxel, marketed as Taxol, discovered in Taxus brevifolia (Rowinsky and Donehower, 1995).”
BackgroundComparison of antimalarial activity of Artemisia turanica extract with current drugs in vivo
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- Authors
- Klayman, D. L., Lin, A. J., Acton, N., Scovill, J. P., Hoch, J. M., Milhous, W. K., Theoharides, A. D., & Dobek, A. S.
- Venue
- Journal of Natural Products
- Publisher
- American Chemical Society (ACS)
- Published
- 1984-07
- Volume
- 47
- Issue
- 4
- Pages
- 715-717
- ISSN
- 0163-3864 (ISSN-L)
- 1520-6025
- OpenAlex
- W2008246758
- Cited by
- 251
- References
- 0
- Citations by year
- 2026: 4 · 2024: 4 · 2023: 10 · 2022: 8 · 2021: 9 · 2020: 2 · 2019: 10 · 2018: 16 · 2017: 11 · 2016: 6 · 2015: 7 · 2014: 9 · 2013: 10 · 2012: 18
- FWCI
- 1.99
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Natural Products (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Sesquiterpenes and Asteraceae Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Phytochemical compounds biological activities
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bioactive Natural Diterpenoids Research
- Keywords
- artemisinin, Artemisia annua, natural product isolation, plant extracts, medicinal plants, United States
- MeSH terms
- Animals, Antimalarials, Bacteria, Chromatography, Plants, Medicinal, Plasmodium falciparum, Sesquiterpenes, United States, Artemisinins
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