New Trends in Extraction, Identification and Quantification of Artemisinin and its Derivatives
Abstract
Artemisinin, a sesquiterpene lactone endoperoxide, and a number of its precursors, metabolites and semisynthetic derivatives have shown to possess antimalarial properties. Several methods have been reported for the measurement of artemisinin and its main derivatives in plant material and biological fluids. However, most of them are either not sufficiently sensitive and do not offer reliable results, or are difficult to apply in routine analyses. Therefore, new m ethods for the determination of these compounds, such as supercritical fluid extraction and chromatography, pressurized solvent extraction, microwave-assisted extraction, high-performance liquid chromatography coupled to mass spectrometry or evaporative light scattering detection, will be presented. Applications to plant material, pharmaceutical formulations and biological fluids will also be reviewed. Keywords: Artemisinin, Artemisia annua, A. annua, artemisitene, artemisinic acid, arteannuin B, Pressurized solvent extraction (PSE), Microwave-assisted Extraction, Thermolysis, dihydroartemisinin, TANDEM MASS SPECTROMETRY, HPLC-UV, HPLC-MS, ENZYME-LINKED IMMUNOSORBENT ASSAY, CAPILLARY ELECTROPHORESIS, EVAPORATIVE LIGHT SCATTERING DETECTOR
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Many investigators use the HPLC Q260 method of analysis, but it can result in false positives regarding artemisinin mainly because it cannot distinguish between artemisinin and deoxyartemisinin.
“Many investigators use the HPLC Q260 method of analysis, but it can result in false positives regarding artemisinin mainly because it cannot distinguish between artemisinin and deoxyartemisinin (Lapkin et al. 2009; Christen and Veuthey 2001; Smith et al. 2010).”
From Enhancing artemisinin content in and delivery from Artemisia annua: a review of alternative, classical, and transgenic approaches (2021) · cites this paper as Christen and Veuthey 2001
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Sesquiterpene Lactones from<i>Artemisia</i>Genus: Biological Activities and Methods of Analysis
Ivanescu, B., Miron, A., & Corciova, A. (2015) · Journal of Analytical Methods in Chemistry · doi:10.1155/2015/247685 · Cited by 201 · see citing works
“Pressure had no noticeable influence on the recovery of artemisinin, whatever the solvent used, but a higher temperature significantly favoured artemisinin extraction, particularly in water [114].”
BackgroundDevelopment of HPLC analytical protocols for quantification of artemisinin in biomass and extracts
Lapkin, A. A., Walker, A., Sullivan, N., Khambay, B., Mlambo, B., & Chemat, S. (2009) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2009.01.025 · Cited by 78 · see citing works
Wani, K. I., Choudhary, S., Zehra, A., Naeem, M., Weathers, P., & Aftab, T. (2021) · Planta · doi:10.1007/s00425-021-03676-3 · Cited by 74 · see citing works
Sixt, M., Schmidt, A., Mestmäcker, F., Huter, M. J., Uhlenbrock, L., & Strube, J. (2018) · Processes · doi:10.3390/pr6090161 · Cited by 25 · see citing works
Khan, S., Ali, A., Ahmad, S., & Abdin, M. Z. (2015) · Biomedical Chromatography · doi:10.1002/bmc.3465 · Cited by 21 · see citing works
Chemistry, biosynthesis and biological activity of artemisinin and related natural peroxides
Rydén, A.-M., & Kayser, O. (2007) · Topics in Heterocyclic Chemistry · doi:10.1007/7081_2007_085 · Cited by 16 · see citing works
- Authors
- Christen, P., & Veuthey, J.
- Affiliations
- University of Geneva (CH)
- Corresponding author
- Veuthey, J.
- Venue
- Current Medicinal Chemistry
- Publisher
- Bentham Science Publishers Ltd.
- Published
- 2001-12-01
- Volume
- 8
- Issue
- 15
- Pages
- 1827-1839
- ISSN
- 0929-8673 (ISSN-L)
- OpenAlex
- W2004079629
- Cited by
- 114
- References
- 0
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 4 · 2023: 5 · 2022: 3 · 2021: 3 · 2020: 3 · 2019: 3 · 2018: 4 · 2017: 5 · 2016: 1 · 2015: 5 · 2014: 5 · 2013: 12 · 2012: 7
- FWCI
- 0.38
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Medicinal Chemistry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Sesquiterpenes and Asteraceae Studies
- Physical Sciences › Chemistry › Analytical Chemistry › Analytical Methods in Pharmaceuticals
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Phytochemical compounds biological activities
- Keywords
- artemisinin, artemisinin derivatives, antimalarial drugs, Artemisia annua, artemisinic acid, arteannuin B, dihydroartemisinin, supercritical fluid extraction, accelerated solvent extraction, microwave-assisted extraction, HPLC-MS, tandem mass spectrometry, enzyme-linked immunosorbent assay, capillary electrophoresis, evaporative light scattering detection, extraction methods, biological fluids, drug formulation
- MeSH terms
- Antimalarials, Chromatography, High Pressure Liquid, Desiccation, Electrochemistry, Enzyme-Linked Immunosorbent Assay, Light, Scattering, Radiation, Sesquiterpenes, Solvents, Mass Spectrometry, Electrophoresis, Capillary, Artemisia, Artemisinins
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