Cited by 54Ovarian function and disordersReproductive Biology and FertilityEndometriosis Research and Treatment

N-Acetylcysteine for Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis of Randomized Controlled Clinical Trials

Open access
Thakker, Divyesh, Raval, Amit, Patel, Isha, Walia, Rama·2015·Obstetrics and Gynecology International

Abstract

Objective . To review the benefits and harms of N-acetylcysteine (NAC) in women with polycystic ovary syndrome (PCOS). Method . Literature search was conducted using the bibliographic databases, MEDLINE (Ovid), CINAHL, EMBASE, Scopus, PsyInfo, and PROQUEST (from inception to September 2013) for the studies on women with PCOS receiving NAC. Results . Eight studies with a total of 910 women with PCOS were randomized to NAC or other treatments/placebo. There were high risk of selection, performance, and attrition bias in two studies and high risk of reporting bias in four studies. Women with NAC had higher odds of having a live birth, getting pregnant, and ovulation as compared to placebo. However, women with NAC were less likely to have pregnancy or ovulation as compared to metformin. There was no significant difference in rates of the miscarriage, menstrual regulation, acne, hirsutism, and adverse events, or change in body mass index, testosterone, and insulin levels with NAC as compared to placebo. Conclusions . NAC showed significant improvement in pregnancy and ovulation rate as compared to placebo. The findings need further confirmation in well-designed randomized controlled trials to examine clinical outcomes such as live birth rate in longer follow-up periods. Systematic review registration number is CRD42012001902 .

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1155/2015/817849

Cites

31 of 31 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

1 retracted

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Thakker, D., Raval, A., Patel, I., & Walia, R.
Affiliations
  • Department of Pharmacology, SAL Institute of Pharmacy, Ahmadabad, Gujarat 380060, India
  • West Virginia University (US)
  • Shenandoah University (US)
  • Post Graduate Institute of Medical Education and Research (IN)
Corresponding author
Raval, Amit
Venue
Obstetrics and Gynecology International
Publisher
Wiley
Published
2015
Volume
2015
Pages
1-13
ISSN
  • 1687-9589 (ISSN-L)
  • 1687-9597
OpenAlex
W1993780026
Cited by
54
References
31
Citations by year
2026: 5 · 2025: 3 · 2024: 7 · 2023: 7 · 2022: 3 · 2021: 9 · 2020: 7 · 2019: 5 · 2018: 5 · 2017: 1 · 2015: 1 · 2013: 1
FWCI
0.35
Type
journal article
Language
en
Open access
Locations
  • Obstetrics and Gynecology International (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
  • Greater South Information System
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Biology and Fertility
  • Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
Keywords
N-acetylcysteine, polycystic ovary syndrome, ovulation induction, pregnancy rate, live birth, metformin, hirsutism, acne, menstrual regulation, insulin, testosterone, body mass index, adverse events

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review