The DOI matches its Crossref record; 139 of the 140 references it cites were found in a registry or an index.
The Reactive Oxygen Species in Macrophage Polarization: Reflecting Its Dual Role in Progression and Treatment of Human Diseases
Open accessAbstract
High heterogeneity of macrophage is associated with its functions in polarization to different functional phenotypes depending on environmental cues. Macrophages remain in balanced state in healthy subject and thus macrophage polarization may be crucial in determining the tissue fate. The two distinct populations, classically M1 and alternatively M2 activated, representing the opposing ends of the full activation spectrum, have been extensively studied for their associations with several disease progressions. Accumulating evidences have postulated that the redox signalling has implication in macrophage polarization and the key roles of M1 and M2 macrophages in tissue environment have provided the clue for the reasons of ROS abundance in certain phenotype. M1 macrophages majorly clearing the pathogens and ROS may be crucial for the regulation of M1 phenotype, whereas M2 macrophages resolve inflammation which favours oxidative metabolism. Therefore how ROS play its role in maintaining the homeostatic functions of macrophage and in particular macrophage polarization will be reviewed here. We also review the biology of macrophage polarization and the disturbance of M1/M2 balance in human diseases. The potential therapeutic opportunities targeting ROS will also be discussed, hoping to provide insights for development of target-specific delivery system or immunomodulatory antioxidant for the treatment of ROS-related diseases.
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“In macrophages, ROS regulates cell death, proliferation, motility and phagocytic ability, and it is linked to an M1-like polarisation, which help to defend the body against bacteria and other pathogens [117, 118].”
From Iron oxide nanoparticles: Diagnostic, therapeutic and theranostic applications (2019) · cites this paper as [118]
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Orecchioni, M., Ghosheh, Y., Pramod, A. B., & Ley, K. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01084 · Cited by 2,063
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Metadata
- Authors
- Tan, H.-Y., Wang, N., Li, S., Hong, M., Wang, X., & Feng, Y.
- Affiliations
- University of Hong Kong (HK)
- Hubei University of Medicine (CN)
- Corresponding author
- Feng, Yibin
- Venue
- Oxidative Medicine and Cellular Longevity
- Publisher
- Wiley
- Published
- 2016-01
- Volume
- 2016
- Issue
- 1
- Pages
- 2795090-2795090
- ISSN
- 1942-0994 (ISSN-L)
- 1942-0900
- PMC
- PMC4837277
- OpenAlex
- W2319967189
- Cited by
- 657
- References
- 140
- Citations by year
- 2026: 66 · 2025: 75 · 2024: 78 · 2023: 77 · 2022: 73 · 2021: 82 · 2020: 83 · 2019: 54 · 2018: 38 · 2017: 30 · 2016: 1
- FWCI
- 3.98
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Oxidative Medicine and Cellular Longevity (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- The HKU Scholars Hub (University of Hong Kong) (submittedVersion, cc-by-nc-nd)
- Funders
- Research Council of the University of Hong Kong (104002889, 104003422, 200006276, 200007008, WDCM001, 200007477)
- Wong’s donation (104002889, 104003422, 200006276, 200007008, WDCM001, 200007477)
- Gaia Family Trust, New Zealand (104002889, 104003422, 200006276, 200007008, WDCM001, 200007477)
- Hubei University of Medicine (104002889, 104003422, 200006276, 200007008, WDCM001, 200007477)
- Vita Green Health Products Co., Ltd. (104002889, 104003422, 200006276, 200007008, WDCM001, 200007477)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Keywords
- reactive oxygen species, macrophage polarization, M1 macrophages, M2 macrophages, redox signaling, oxidative metabolism, inflammation resolution, antioxidant therapy, immunomodulation, disease progression
- MeSH terms
- Cells, Cultured, Humans, Macrophages, Reactive Oxygen Species, Disease Progression
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