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The Reactive Oxygen Species in Macrophage Polarization: Reflecting Its Dual Role in Progression and Treatment of Human Diseases
Open accessAbstract
High heterogeneity of macrophage is associated with its functions in polarization to different functional phenotypes depending on environmental cues. Macrophages remain in balanced state in healthy subject and thus macrophage polarization may be crucial in determining the tissue fate. The two distinct populations, classically M1 and alternatively M2 activated, representing the opposing ends of the full activation spectrum, have been extensively studied for their associations with several disease progressions. Accumulating evidences have postulated that the redox signalling has implication in macrophage polarization and the key roles of M1 and M2 macrophages in tissue environment have provided the clue for the reasons of ROS abundance in certain phenotype. M1 macrophages majorly clearing the pathogens and ROS may be crucial for the regulation of M1 phenotype, whereas M2 macrophages resolve inflammation which favours oxidative metabolism. Therefore how ROS play its role in maintaining the homeostatic functions of macrophage and in particular macrophage polarization will be reviewed here. We also review the biology of macrophage polarization and the disturbance of M1/M2 balance in human diseases. The potential therapeutic opportunities targeting ROS will also be discussed, hoping to provide insights for development of target-specific delivery system or immunomodulatory antioxidant for the treatment of ROS-related diseases.
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“In macrophages, ROS regulates cell death, proliferation, motility and phagocytic ability, and it is linked to an M1-like polarisation, which help to defend the body against bacteria and other pathogens [117, 118].”
From Iron oxide nanoparticles: Diagnostic, therapeutic and theranostic applications (2019) · cites this paper as [118]
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Cites
The metabolic phenotype in obesity: Fat mass, body fat distribution, and adipose tissue function
Goossens, G. H. (2017) · Obesity Facts · doi:10.1159/000471488 · Cited by 8,481
The chemokine system in diverse forms of macrophage activation and polarization
MANTOVANI, A., SICA, A., SOZZANI, S., ALLAVENA, P., VECCHI, A., & LOCATI, M. (2004) · Trends in Immunology · doi:10.1016/j.it.2004.09.015 · Cited by 6,534
Macrophage plasticity and polarization: in vivo veritas
Sica, A., & Mantovani, A. (2012) · Journal of Clinical Investigation · doi:10.1172/jci59643 · Cited by 6,335
Takeda, K., Kaisho, T., & Akira, S. (2003) · Annual Review of Immunology · doi:10.1146/annurev.immunol.21.120601.141126 · Cited by 6,143
A role for mitochondria in nlrp3 inflammasome activation
Zhou, R., Yazdi, A. S., Menu, P., & Tschopp, J. (2011) · Nature · doi:10.1038/nature09663 · Cited by 5,602
Macrophage Diversity Enhances Tumor Progression and Metastasis
Qian, B., & Pollard, J. W. (2010) · Cell · doi:10.1016/j.cell.2010.03.014 · Cited by 5,338
Obesity induces a phenotypic switch in adipose tissue macrophage polarization
Lumeng, C. N., Bodzin, J. L., & Saltiel, A. R. (2007) · Journal of Clinical Investigation · doi:10.1172/jci29881 · Cited by 4,664
Release of chromatin protein HMGB1 by necrotic cells triggers inflammation
Scaffidi, P., Misteli, T., & Bianchi, M. E. (2002) · Nature · doi:10.1038/nature00858 · Cited by 4,221
Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm
Biswas, S. K., & Mantovani, A. (2010) · Nature Immunology · doi:10.1038/ni.1937 · Cited by 3,840
Role of Adaptor TRIF in the MyD88-Independent Toll-Like Receptor Signaling Pathway
Yamamoto, M., Sato, S., Hemmi, H., Hoshino, K., Kaisho, T., Sanjo, H., Takeuchi, O., Sugiyama, M., Okabe, M., Takeda, K., et al. (2003) · Science · doi:10.1126/science.1087262 · Cited by 3,286
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Orecchioni, M., Ghosheh, Y., Pramod, A. B., & Ley, K. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01084 · Cited by 2,063
Mitochondrial metabolism and cancer
Porporato, P. E., Filigheddu, N., Pedro, J. M. B., Kroemer, G., & Galluzzi, L. (2017) · Cell Research · doi:10.1038/cr.2017.155 · Cited by 1,315
Iron oxide nanoparticles: Diagnostic, therapeutic and theranostic applications
Dadfar, S. M., Roemhild, K., Drude, N. I., von Stillfried, S., Knüchel, R., Kiessling, F., & Lammers, T. (2019) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2019.01.005 · Cited by 1,181
Reactive Oxygen Species: Drivers of Physiological and Pathological Processes
Checa, J., & Aran, J. M. (2020) · Journal of Inflammation Research · doi:10.2147/jir.s275595 · Cited by 1,060
Engineering Macrophages for Cancer Immunotherapy and Drug Delivery
Xia, Y., Rao, L., Yao, H., Wang, Z., Ning, P., & Chen, X. (2020) · Advanced Materials · doi:10.1002/adma.202002054 · Cited by 949
PGC-1 α , Inflammation, and Oxidative Stress: An Integrative View in Metabolism
Rius‐Pérez, S., Torres-Cuevas, I., Millán, I., Ortega, Á., & Pérez, S. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/1452696 · Cited by 671
Tanase, D. M., Gosav, E. M., Costea, C. F., Ciocoiu, M., Lacatusu, C. M., Maranduca, M. A., Ouatu, A., & Floria, M. (2020) · Journal of Diabetes Research · doi:10.1155/2020/3920196 · Cited by 627
Metabolic Regulation of Macrophage Polarization in Cancer
Mehla, K., & Singh, P. K. (2019) · Trends in cancer · doi:10.1016/j.trecan.2019.10.007 · Cited by 621
Mitochondrial oxidative stress in the tumor microenvironment and cancer immunoescape: foe or friend?
Kuo, C., Babuharisankar, A. P., Lin, Y., Lien, H., Lo, Y. K., Chou, H.-Y., Tangeda, V., Cheng, L.-C., Cheng, A. N., & Lee, A. Y. (2022) · Journal of Biomedical Science · doi:10.1186/s12929-022-00859-2 · Cited by 367
Tumour treating fields therapy for glioblastoma: current advances and future directions
Rominiyi, O., Vanderlinden, A., Clenton, S. J., Bridgewater, C. H., Al-Tamimi, Y., & Collis, S. J. (2020) · British Journal of Cancer · doi:10.1038/s41416-020-01136-5 · Cited by 336
Macrophage Metabolism As Therapeutic Target for Cancer, Atherosclerosis, and Obesity
Geeraerts, X., Bolli, E., Fendt, S., & Ginderachter, J. A. V. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00289 · Cited by 326
Regulatory Effects of Quercetin on M1/M2 Macrophage Polarization and Oxidative/Antioxidative Balance
Tsai, C., Chen, G., Chen, Y.-C., Shen, C., Lu, D., Yang, L., Chen, J.-H., & Yeh, W. (2021) · Nutrients · doi:10.3390/nu14010067 · Cited by 319
Devanney, N. A., Stewart, A. N., & Gensel, J. C. (2020) · Experimental Neurology · doi:10.1016/j.expneurol.2020.113310 · Cited by 315
Macrophage Polarization and Reprogramming in Acute Inflammation: A Redox Perspective
Pérez, S., & Rius-Pérez, S. (2022) · Antioxidants · doi:10.3390/antiox11071394 · Cited by 312
Macrophage Related Chronic Inflammation in Non-Healing Wounds
Li, M., Hou, Q., Zhong, L., Zhao, Y., & Fu, X. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.681710 · Cited by 307
Han, J., Kim, Y. S., Lim, M.-Y., Kim, H. Y., Kong, S., Kang, M., Choo, Y. W., Jun, J. H., Ryu, S., Jeong, H.-Y., et al. (2018) · ACS Nano · doi:10.1021/acsnano.7b09107 · Cited by 261
Zhang, B., Yang, Y., Yi, J., Zhao, Z., & Ye, R. (2021) · Journal of Periodontal Research · doi:10.1111/jre.12912 · Cited by 260
Ashok, A., Andrabi, S. S., Mansoor, S., Kuang, Y., Kwon, B. K., & Labhasetwar, V. D. (2022) · Antioxidants · doi:10.3390/antiox11020408 · Cited by 270
Sun, Y. L., Sun, X., Li, X., Li, W., Li, C., Zhou, Y., Wang, L., & Dong, B. (2020) · Biomaterials · doi:10.1016/j.biomaterials.2020.120614 · Cited by 247
Santoni, M., Romagnoli, E., Saladino, T., Foghini, L., Guarino, S., Capponi, M., Giannini, M., Cognigni, P. D., Ferrara, G., & Battelli, N. (2017) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2017.10.007 · Cited by 241
Macrophage-Osteoclast Associations: Origin, Polarization, and Subgroups
Sun, Y., Li, J., Xie, X., Gu, F., Sui, Z., Zhang, K., & Yu, T. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.778078 · Cited by 241
Metabolic aspects in NAFLD, NASH and hepatocellular carcinoma: the role of PGC1 coactivators
Piccinin, E., Villani, G., & Moschetta, A. (2018) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-018-0089-3 · Cited by 232
Duan, H., Wang, L., Huangfu, M., & Li, H. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115276 · Cited by 252
Wang, Y., Li, C., Wan, Y., Qi, M., Chen, Q., Sun, Y. L., Sun, X., Fang, J., Fu, L., Xu, L. H., et al. (2021) · Small · doi:10.1002/smll.202101505 · Cited by 228
Macrophages and bone inflammation
Gu, Q., Yang, H., & Shi, Q. (2017) · Journal of Orthopaedic Translation · doi:10.1016/j.jot.2017.05.002 · Cited by 221
The hormetic dose-response mechanism: Nrf2 activation
Calabrese, E. J., & Kozumbo, W. J. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2021.105526 · Cited by 216
New Perspectives in Biofilm Eradication
Wolfmeier, H., Pletzer, D., Mansour, S., & Hancock, R. E. W. (2017) · ACS Infectious Diseases · doi:10.1021/acsinfecdis.7b00170 · Cited by 200
Yang, Y. M., Cho, Y. E., & Hwang, S. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23020774 · Cited by 207
Griess, B., Mir, S. U. R., Datta, K., & Teoh-Fitzgerald, M. L. T. (2019) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2019.12.018 · Cited by 200
Wan, Y., Fang, J., Wang, Y., Sun, J., Sun, Y. L., Sun, X., Qi, M., Li, W., Li, C., Zhou, Y., et al. (2021) · Advanced Healthcare Materials · doi:10.1002/adhm.202101515 · Cited by 176
Iron induces anti-tumor activity in tumor-associated macrophages
Costa da Silva, M., Breckwoldt, M. O., Vinchi, F., Correia, M. P., Stojanovic, A., Thielmann, C. M., Meister, M., Muley, T., Warth, A., Platten, M., et al. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01479 · Cited by 164
Roles of reactive oxygen species in inflammation and cancer
Yu, Y., Liu, S., Yang, L., Song, P., Liu, Z., Liu, X., Yan, X., & Dong, Q. (2024) · MedComm · doi:10.1002/mco2.519 · Cited by 180
Marrocco, A., & Ortiz, L. A. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.936167 · Cited by 173
Yuan, Y., Chen, Y., Peng, T., Li, L., Zhu, W., Liu, F., Liu, S., An, X., Luo, R., Cheng, J., et al. (2019) · Clinical Science · doi:10.1042/cs20190672 · Cited by 163
Role of Reactive Oxygen Species in Inflammation: A Minireview
Chelombitko, M. A. (2018) · Moscow University Biological Sciences Bulletin · doi:10.3103/s009639251804003x · Cited by 161
The Role of Reactive Oxygen Species in the Rheumatoid Arthritis-Associated Synovial Microenvironment
Wang, X., Fan, D., Cao, X., Ye, Q., Wang, Q., Zhang, M., & Xiao, C. (2022) · Antioxidants · doi:10.3390/antiox11061153 · Cited by 176
Lee, W. H., Ong, S., Zhou, Y., Tian, L., Bae, H. R., Baker, N., Whitlatch, A., Mohammadi, L., Guo, H., Nadeau, K. C., et al. (2019) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2019.03.476 · Cited by 157
Dietary Fat and Cancer—Which Is Good, Which Is Bad, and the Body of Evidence
Bojková, B., Winklewski, P. J., & Wszędybył-Winklewska, M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21114114 · Cited by 166
Reactive Oxygen Species and Antitumor Immunity—From Surveillance to Evasion
Kotsafti, A., Scarpa, M., Castagliuolo, I., & Scarpa, M. (2020) · Cancers · doi:10.3390/cancers12071748 · Cited by 161
Santa, F. D., Vitiello, L., Torcinaro, A., & Ferraro, E. (2018) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7420 · Cited by 157
Adipose oxidative stress and protein carbonylation
Hauck, A. K., Huang, Y., Hertzel, A. V., & Bernlohr, D. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.r118.003214 · Cited by 152
Li, F., Qiu, Y., Xia, F., Sun, H., Liao, H., Xie, A., Lee, J., Lin, P., Wei, M., Shao, Y., et al. (2020) · Nano Today · doi:10.1016/j.nantod.2020.100925 · Cited by 148
Signaling pathways in macrophages: molecular mechanisms and therapeutic targets
Li, M., Wang, M., Wen, Y., Zhang, H., Zhao, G., & Gao, Q. (2023) · MedComm · doi:10.1002/mco2.349 · Cited by 157
Zhou, F., Li, M., Chen, M., Chen, M., Chen, X., Luo, Z. Y., Cai, K., & Hu, Y. (2023) · ACS Nano · doi:10.1021/acsnano.2c09127 · Cited by 145
Precise modulation and use of reactive oxygen species for immunotherapy
Li, X., Gao, J., Wu, C., Wang, C., Zhang, R., He, J., Xia, Z. J., Joshi, N., Karp, J. M., & Kuai, R. (2024) · Science Advances · doi:10.1126/sciadv.adl0479 · Cited by 140
Tian, M., Chen, G., Xu, J., Lin, Y., Zeng, Y., Chen, X., Li, X., & Chen, S. (2021) · Chemical Engineering Journal · doi:10.1016/j.cej.2021.132197 · Cited by 138
Figueiredo, P., Lepland, A., Scodeller, P., Fontana, F., Torrieri, G., Tiboni, M., Shahbazi, M., Casettari, L., Kostiainen, M. A., Hirvonen, J. J., et al. (2020) · Acta Biomaterialia · doi:10.1016/j.actbio.2020.09.038 · Cited by 137
Mendoza, M. S., & Morales‐Montor, J. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00348 · Cited by 133
Ren, Y., Wang, R., Weng, S., Xu, H., Zhang, Y., Chen, S., Liu, S., Ba, Y., Zhou, Z., Luo, P., et al. (2023) · Molecular Cancer · doi:10.1186/s12943-023-01831-w · Cited by 149
Ceria-based nanotheranostic agent for rheumatoid arthritis
Kalashnikova, I. V., Chung, S., Nafiujjaman, M., Hill, M. L., Siziba, M. E., Contag, C. H., & Kim, T. (2020) · Theranostics · doi:10.7150/thno.49069 · Cited by 131
Functional polarization of tumor-associated macrophages dictated by metabolic reprogramming
Zeng, W., Li, F., Jin, S., Ho, P., Liu, P.-S., & Xie, X. (2023) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-023-02832-9 · Cited by 139
Macrophages in osteoarthritis: pathophysiology and therapeutics.
Chen, Y., Jiang, W. H., Yong, H., He, M., Yang, Y., Deng, Z., & Li, Y. (2020) · PubMed Central · Cited by 130
Transcriptional, Epigenetic and Metabolic Programming of Tumor-Associated Macrophages
Larionova, I., Kazakova, E., Patysheva, M. R., & Kzhyshkowska, J. G. (2020) · Cancers · doi:10.3390/cancers12061411 · Cited by 126
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Jeong, J., Cha, H., Han, M. H., Hwang, S. J., Lee, D.-S., Yoo, J. S., Choi, I., Kim, S., Kim, H., Kim, G., et al. (2017) · Biomolecules & Therapeutics · doi:10.4062/biomolther.2016.272 · Cited by 125
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Wissing, T. B., Bonito, V., van Haaften, E. E., van Doeselaar, M., Brugmans, M. C. P., Janssen, H. M., Bouten, C. V. C., & Smits, A. I. P. M. (2019) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2019.00087 · Cited by 127
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Orillion, A. R., Damayanti, N. P., Shen, L., Adelaiye-Ogala, R. M., Affronti, H. C., Elbanna, M., Chintala, S., Ciesielski, M. J., Fontana, L., Kao, C. H., et al. (2018) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-18-0980 · Cited by 121
Radiotherapy treatment of human inflammatory diseases and conditions: Optimal dose
Calabrese, E. J., Dhawan, G., Kapoor, R., & Kozumbo, W. J. (2019) · Human & Experimental Toxicology · doi:10.1177/0960327119846925 · Cited by 113
Shan, M., Qin, J., Jin, F., Han, X., Guan, H., Li, X., Zhang, J., Zhang, H., & Wang, Y. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2017.05.021 · Cited by 112
Labonte, A. C., Kegerreis, B. J., Geraci, N., Bachali, P., Madamanchi, S., Robl, R. D., Catalina, M. D., Lipsky, P. E., & Grammer, A. C. (2018) · PLoS ONE · doi:10.1371/journal.pone.0208132 · Cited by 111
Ni, K., Xu, Z., Culbert, A. A., Luo, T., Guo, N., Yang, K., Pearson, E. A., Preusser, B., Wu, T., Rivière, P. J. L., et al. (2022) · Nature Biomedical Engineering · doi:10.1038/s41551-022-00846-w · Cited by 113
Azzini, E., Peña‐Corona, S. I., Hernández‐Parra, H., Chandran, D., Saleena, L. A. K., Sawikr, Y., Peluso, I., Dhumal, S., Kumar, M., Leyva‐Gómez, G., et al. (2024) · Phytotherapy Research · doi:10.1002/ptr.8200 · Cited by 127
ISG15 governs mitochondrial function in macrophages following vaccinia virus infection
Baldanta, S., Fernández‐Escobar, M., Acín‐Pérez, R., Albert, M., Camafeita, E., Jorge, I., Vázquez, J., Enrı́quez, J. A., & Guerra, S. (2017) · PLoS Pathogens · doi:10.1371/journal.ppat.1006651 · Cited by 109
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Kriško, A., & Radman, M. (2019) · Open Biology · doi:10.1098/rsob.180249 · Cited by 114
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Wang, T., Zhang, H., Han, Y., Liu, H., Ren, F. Z., Zeng, J., Sun, Q., Li, Z., & Gao, M. (2019) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.9b03541 · Cited by 107
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Sohrab, S. S., Raj, R., Nagar, A., Hawthorne, S. J., Paiva‐Santos, A. C., Kamal, M. A., El-Daly, M. M., Azhar, E. I., & Sharma, A. (2023) · Molecules · doi:10.3390/molecules28114413 · Cited by 116
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Gerrick, K. Y., Gerrick, E. R., Gupta, A. K., Wheelan, S. J., Yegnasubramanian, S., & Jaffee, E. M. (2018) · PLoS ONE · doi:10.1371/journal.pone.0208602 · Cited by 105
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Jankowska-Kieltyka, M., Roman, A., & Nalepa, I. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.647643 · Cited by 99
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Jafarzadeh, N., Safari, Z., Pornour, M., Amirizadeh, N., Moghadam, M. F., & Sadeghizadeh, M. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.27142 · Cited by 95
Nanomaterial-enabled metabolic reprogramming strategies for boosting antitumor immunity
Ma, M., Zhang, Y., Pu, K., & Tang, W. (2024) · Chemical Society Reviews · doi:10.1039/d4cs00679h · Cited by 100
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Gupta, V. G., Yull, F. E., & Khabele, D. (2018) · Cancers · doi:10.3390/cancers10100366 · Cited by 94
Oxidative stress modulating nanomaterials and their biochemical roles in nanomedicine
Patel, K. D., Keskin‐Erdogan, Z., Sawadkar, P., Sharifulden, N. S. A. N., Shannon, M. R., Patel, M., Silva, L. V. B., Patel, R., Chau, D. Y. S., Knowles, J. C., et al. (2024) · Nanoscale Horizons · doi:10.1039/d4nh00171k · Cited by 91
He, J., Zhang, W., Zhou, X., Xu, F., Zou, J., Zhang, Q., Zhao, Y., He, H., Yang, H., & Liu, J. (2022) · Bioactive Materials · doi:10.1016/j.bioactmat.2022.03.041 · Cited by 88
Islam, S. U., Lee, J., Shehzad, A., Ahn, E., Lee, Y. J., & Lee, Y. K. (2018) · Molecules · doi:10.3390/molecules23081880 · Cited by 84
Kwon, D. H., Lee, H., Park, C., Hong, S. H., Hong, S. H., Kim, G., Cha, H., Kim, S., Kim, H., Hwang, H., et al. (2019) · Antioxidants · doi:10.3390/antiox8090413 · Cited by 87
Liu, L., He, H., Liang, R., Yi, H., Meng, X., Chen, Z., Pan, H., Ma, Y., & Cai, L. (2018) · Biomacromolecules · doi:10.1021/acs.biomac.8b00239 · Cited by 83
Lai, W., Zhang, J., Sun, J., Min, T., Bai, Y., He, J., Cao, H., Che, Q., Guo, J., & Su, Z. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.134809 · Cited by 89
Tkaczenko, H., & Kurhaluk, N. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26031098 · Cited by 80
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Luque-Campos, N., Bustamante-Barrientos, F. A., Pradenas, C., García, C., Araya, M. J., Bohaud, C., Contreras-López, R., Elizondo-Vega, R., Djouad, F., Luz-Crawford, P., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.624746 · Cited by 82
ROS homeostasis, a key determinant in liver ischemic-preconditioning
Priéto, I., & Monsalve, M. (2017) · Redox Biology · doi:10.1016/j.redox.2017.04.036 · Cited by 81
Shi, J., Zhang, Y., Zhang, X., Chen, R., Wei, J., Hou, J., Wang, B., Lai, H., & Huang, Y. (2021) · Journal of Nanobiotechnology · doi:10.1186/s12951-021-01175-x · Cited by 81
Yang, K., Deng, X., Jian, S., Zhang, M., Wen, C., Xin, Z., Zhang, L., Tong, A., Ye, S., Liao, P., et al. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2021.813890 · Cited by 82
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Jeong, J.-W., Hwang, S. J., Han, M. H., Lee, D.-S., Yoo, J. S., Choi, I., Cha, H., Kim, S., Kim, H., Kim, G., et al. (2017) · Molecular & Cellular Toxicology · doi:10.1007/s13273-017-0045-2 · Cited by 76
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Lin, Z., Chen, Z., Chen, Y., Yang, N., Shi, J., Tang, Z., Zhang, C., Lin, H., & Yin, J. (2023) · Exploration · doi:10.1002/exp.20220149 · Cited by 81
Clough, E., Inigo, J., Chandra, D., Chaves, L., Reynolds, J. L., Aalinkeel, R., Schwartz, S. A., Khmaladze, A., & Mahajan, S. D. (2021) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-021-10015-6 · Cited by 75
Banerjee, S., Ghosh, S., Mandal, A., Ghosh, N., & Sil, P. C. (2020) · Archives of Toxicology · doi:10.1007/s00204-020-02801-7 · Cited by 73
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Kimura, T., Tajiri, K., Sato, A., Sakai, S., Wang, Z., Yoshida, T., Uede, T., Hiroe, M., Aonuma, K., Ieda, M., et al. (2018) · Cardiovascular Research · doi:10.1093/cvr/cvy244 · Cited by 71
Metadata
- Authors
- Tan, H.-Y., Wang, N., Li, S., Hong, M., Wang, X., & Feng, Y.
- Affiliations
- University of Hong Kong (HK)
- Hubei University of Medicine (CN)
- Corresponding author
- Feng, Yibin
- Venue
- Oxidative Medicine and Cellular Longevity
- Publisher
- Wiley
- Published
- 2016-01
- Volume
- 2016
- Issue
- 1
- Pages
- 2795090-2795090
- ISSN
- 1942-0994 (ISSN-L)
- 1942-0900
- PMC
- PMC4837277
- OpenAlex
- W2319967189
- Cited by
- 657
- References
- 140
- Citations by year
- 2026: 66 · 2025: 75 · 2024: 78 · 2023: 77 · 2022: 73 · 2021: 82 · 2020: 83 · 2019: 54 · 2018: 38 · 2017: 30 · 2016: 1
- FWCI
- 3.98
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Oxidative Medicine and Cellular Longevity (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- The HKU Scholars Hub (University of Hong Kong) (submittedVersion, cc-by-nc-nd)
- Funders
- Research Council of the University of Hong Kong (104002889, 104003422, 200006276, 200007008, WDCM001, 200007477)
- Wong’s donation (104002889, 104003422, 200006276, 200007008, WDCM001, 200007477)
- Gaia Family Trust, New Zealand (104002889, 104003422, 200006276, 200007008, WDCM001, 200007477)
- Hubei University of Medicine (104002889, 104003422, 200006276, 200007008, WDCM001, 200007477)
- Vita Green Health Products Co., Ltd. (104002889, 104003422, 200006276, 200007008, WDCM001, 200007477)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Keywords
- reactive oxygen species, macrophage polarization, M1 macrophages, M2 macrophages, redox signaling, oxidative metabolism, inflammation resolution, antioxidant therapy, immunomodulation, disease progression
- MeSH terms
- Cells, Cultured, Humans, Macrophages, Reactive Oxygen Species, Disease Progression
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