Diosgenin: An Updated Pharmacological Review and Therapeutic Perspectives

Natural Products as Sources of New Drugs over the Nearly Four Decades from 01/1981 to 09/2019

Newman, D. J., & Cragg, G. M. L. (2020) · Journal of Natural Products · doi:10.1021/acs.jnatprod.9b01285 · Cited by 7,153 · see citing works

Artemisinin—A Gift from Traditional Chinese Medicine to the World (Nobel Lecture)

Tu, Y. (2016) · Angewandte Chemie International Edition · doi:10.1002/anie.201601967 · Cited by 815 · see citing works

Global, regional, and national burden of colorectal cancer and its risk factors, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019

Sharma, R., Abbasi‐Kangevari, M., Abd-Rabu, R., Abidi, H., Abu-Gharbieh, E., Acuna, J. M., Adhikari, S., Advani, S. M., Afzal, M. S., Meybodi, M. A., et al. (2022) · The Lancet. Gastroenterology & hepatology · doi:10.1016/s2468-1253(22)00044-9 · Cited by 665 · see citing works

Best practice in research – Overcoming common challenges in phytopharmacological research

Heinrich, M., Appendino, G., Efferth, T., Fürst, R., Izzo, A. A., Kayser, O., Pezzuto, J. M., & Viljoen, A. M. (2019) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2019.112230 · Cited by 619 · see citing works

The multifaceted role of reactive oxygen species in tumorigenesis

Kirtonia, A., Sethi, G., & Garg, M. (2020) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-020-03536-5 · Cited by 452 · cited 1× · see citing works

Chemical study and medical application of saponins as anti-cancer agents

Man, S., Gao, W., Zhang, Y., Huang, L., & Liu, C. (2010) · Fitoterapia · doi:10.1016/j.fitote.2010.06.004 · Cited by 437 · see citing works

Paclitaxel: Application in Modern Oncology and Nanomedicine‐Based Cancer Therapy

Sharifi‐Rad, J., Quispe, C., Patra, J. K., Singh, Y. D., Panda, M. K., Das, G., Adetunji, C. O., Michael, O. S., Sytar, O., Polito, L., et al. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/3687700 · Cited by 316 · see citing works

Chitosan nanoparticles as a promising tool in nanomedicine with particular emphasis on oncological treatment

Sharifi-Rad, J., Quispe, C., Butnariu, M., Rotariu, L. S., Sytar, O., Sestito, S., Rapposelli, S., Akram, M., Iqbal, M., Krishna, A., et al. (2021) · Cancer Cell International · doi:10.1186/s12935-021-02025-4 · Cited by 290 · see citing works

Diosgenin: Recent Highlights on Pharmacology and Analytical Methodology

Jesus, M., Martins, A. P. J., Gallardo, E., & Silvestre, S. (2016) · Journal of Analytical Methods in Chemistry · doi:10.1155/2016/4156293 · Cited by 273 · see citing works

Role of Microglia in Neurological Disorders and Their Potentials as a Therapeutic Target

Du, L., Zhang, Y., Chen, Y., Zhu, J., Yang, Y., & Zhang, H.-L. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-0245-0 · Cited by 266 · see citing works

Pro-Apoptotic and Anti-Cancer Properties of Diosgenin: A Comprehensive and Critical Review

Sethi, G., Shanmugam, M. K., Warrier, S. R., Mérarchi, M., Arfuso, F., Kumar, A. P., & Bishayee, A. (2018) · Nutrients · doi:10.3390/nu10050645 · Cited by 254 · see citing works

Diosgenin, a Steroidal Saponin, Inhibits Migration and Invasion of Human Prostate Cancer PC-3 Cells by Reducing Matrix Metalloproteinases Expression

Chen, P.-S., Shih, Y., Huang, H.-C., & Cheng, H.-W. (2011) · PLoS ONE · doi:10.1371/journal.pone.0020164 · Cited by 225 · see citing works

Cancer Chemopreventive and Therapeutic Effects of Diosgenin, a Food Saponin

Raju, J., & Mehta, R. (2009) · Nutrition and Cancer · doi:10.1080/01635580802357352 · Cited by 210 · see citing works

Evidence for the Involvement of the Master Transcription Factor NF-κB in Cancer Initiation and Progression

Puar, Y., Shanmugam, M. K., Fan, L., Arfuso, F., Sethi, G., & Tergaonkar, V. (2018) · Biomedicines · doi:10.3390/biomedicines6030082 · Cited by 199 · see citing works

Advances in the pharmacological activities and mechanisms of diosgenin

Chen, Y., Tang, Y., Yu, S., Han, Y., Kou, J., Liu, B., & Yu, B. (2015) · Chinese Journal of Natural Medicines · doi:10.1016/s1875-5364(15)30053-4 · Cited by 192 · see citing works

Effects of wild yam extract on menopausal symptoms, lipids and sex hormones in healthy menopausal women

Komesaroff, P. A., Black, C. V. S., Cable, V., & Sudhir, K. (2001) · Climacteric · doi:10.1080/cmt.4.2.144.150 · Cited by 172 · see citing works

The Involvement of the Oxidative Stress Status in Cancer Pathology: A Double View on the Role of the Antioxidants

Kamal, F. Z., Lefter, R. M., Ali, A., Ech‐Chahad, A., Truş, C., Ciobica, A. S., & Timofte, D. V. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/9965916 · Cited by 170 · see citing works

Diosgenin is an exogenous activator of 1,25D3-MARRS/Pdia3/ERp57 and improves Alzheimer's disease pathologies in 5XFAD mice

Tohda, C., Urano, T., Umezaki, M., Nemere, I., & Kuboyama, T. (2012) · Scientific Reports · doi:10.1038/srep00535 · Cited by 167 · see citing works

Diosgenin targets Akt‐mediated prosurvival signaling in human breast cancer cells

Srinivasan, S., Koduru, S. V., Kumar, R., Venguswamy, G., Kyprianou, N., & Damodaran, C. (2009) · International Journal of Cancer · doi:10.1002/ijc.24419 · Cited by 159 · see citing works

Diosgenin, a steroidal saponin, and its analogs: Effective therapies against different chronic diseases

Parama, D., Boruah, M., Yachna, K., Rana, V., Banik, K., Harsha, C., Thakur, K. K., Dutta, U., Arya, A., Mao, X., et al. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.118182 · Cited by 155 · see citing works

Diosgenin from Dioscorea bulbifera: Novel Hit for Treatment of Type II Diabetes Mellitus with Inhibitory Activity against α-Amylase and α-Glucosidase

Ghosh, S., More, P. A., Derle, A., Patil, A. B., Markad, P. R., Asok, A., Kumbhar, N., Shaikh, M. L., Boppana, R., Shinde, V., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0106039 · Cited by 145 · see citing works

Quercetin in Food: Possible Mechanisms of Its Effect on Memory

Babaei, F., Mirzababaei, M., & Nassiri‐Asl, M. (2018) · Journal of Food Science · doi:10.1111/1750-3841.14317 · Cited by 137 · see citing works

Urtica dioica-Derived Phytochemicals for Pharmacological and Therapeutic Applications

Taheri, Y., Quispe, C., Herrera‐Bravo, J., Sharifi‐Rad, J., Ezzat, S. M., Merghany, R. M., Shaheen, S., Azmi, L., Mishra, A. P., Şener, B., et al. (2022) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2022/4024331 · Cited by 133 · see citing works

Ficusplants: State of the art from a phytochemical, pharmacological, and toxicological perspective

Salehi, B., Mishra, A. P., Nigam, M., Karazhan, N., Shukla, I., Kiełtyka‐Dadasiewicz, A., SAWICKA, B. H., Głowacka, A., Abu-Darwish, M. S., Tarawneh, A. H., et al. (2020) · Phytotherapy Research · doi:10.1002/ptr.6884 · Cited by 128 · see citing works

Therapeutic Potential of Diosgenin and Its Major Derivatives against Neurological Diseases: Recent Advances

Cai, B., Zhang, Y., Wang, Z., Xu, D., Jia, Y., Guan, Y., Liao, A., Liu, G., Chun, C., & Li, J. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/3153082 · Cited by 124 · see citing works

Dioscin, a natural steroid saponin, induces apoptosis and DNA damage through reactive oxygen species: A potential new drug for treatment of glioblastoma multiforme

Lv, L., Zheng, L., Dong, D., Xu, L., Yin, L., Xu, Y., Qi, Y., Han, X., & Peng, J. (2013) · Food and Chemical Toxicology · doi:10.1016/j.fct.2013.07.012 · Cited by 119 · see citing works

The role of diosgenin in diabetes and diabetic complications

Gan, Q., Wang, J., Hu, J., Lou, G., Xiong, H., Peng, C., Zheng, S., & Huang, Q. (2019) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2019.105575 · Cited by 119 · see citing works

Acute toxicity and sub-chronic toxicity of steroidal saponins from Dioscorea zingiberensis C.H.Wright in rodents

Yuan, Q., Wu, X., Huang, W. Q., Gong, G., Li, D., He, Y., & Zhao, Y. (2009) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2009.08.047 · Cited by 118 · see citing works

Dioscin alleviates alcoholic liver fibrosis by attenuating hepatic stellate cell activation via the TLR4/MyD88/NF-κB signaling pathway

Liu, M., Xu, Y., Han, X., Yin, L., Xu, L., Qi, Y., Zhao, Y., Liu, K., & Peng, J. (2015) · Scientific Reports · doi:10.1038/srep18038 · Cited by 118 · see citing works

A stable yeast strain efficiently producing cholesterol instead of ergosterol is functional for tryptophan uptake, but not weak organic acid resistance

Souza, C. M., Schwabe, T. M. E., Pichler, H., Ploier, B., Leitner, E., Guan, X. L., Wenk, M. R., Riezman, I., & Riezman, H. (2011) · Metabolic Engineering · doi:10.1016/j.ymben.2011.06.006 · Cited by 117 · see citing works

Diosgenin ameliorates testicular damage in streptozotocin-diabetic rats through attenuation of apoptosis, oxidative stress, and inflammation

Khosravi, Z., Sedaghat, R., Baluchnejadmojarad, T., & Roghani, M. (2019) · International Immunopharmacology · doi:10.1016/j.intimp.2019.01.047 · Cited by 116 · see citing works

Apoptosis Induced by Dioscin in Hela Cells.

Cai, J., Liu, M., Wang, Z., & Ju, Y. (2002) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.25.193 · Cited by 114 · see citing works

Efficacy of natural diosgenin on cardiovascular risk, insulin secretion, and beta cells in streptozotocin (STZ)-induced diabetic rats

Kalailingam, P., Kannaian, B., Eevera, T., & Kaliaperumal, R. (2014) · Phytomedicine · doi:10.1016/j.phymed.2014.04.005 · Cited by 112 · see citing works

Cucurbita Plants: From Farm to Industry

Salehi, B., Sharifi‐Rad, J., Çapanoğlu, E., Adrar, N., Çatalkaya, G., Shaheen, S., Jaffer, M., Giri, L., Suyal, R., Jugran, A. K., et al. (2019) · Applied Sciences · doi:10.3390/app9163387 · Cited by 110 · see citing works

Diosgenin inhibits the migration of human breast cancer MDA-MB-231 cells by suppressing Vav2 activity

He, Z., Chen, H., Li, G., Zhu, H., Gao, Y., Zhang, L., & Sun, J. (2014) · Phytomedicine · doi:10.1016/j.phymed.2014.02.002 · Cited by 106 · see citing works

Effects of processing adjuvants on traditional Chinese herbs

Chen, L., Verpoorte, R., Yen, H., Peng, W., Cheng, Y., Chao, J., & Pao, L. (2018) · Journal of Food and Drug Analysis · doi:10.1016/j.jfda.2018.02.004 · Cited by 105 · see citing works

Diosgenin induces ROS-dependent autophagy and cytotoxicity via mTOR signaling pathway in chronic myeloid leukemia cells

Jiang, S., Fan, J., Wang, Q., Ju, D., Feng, M., Li, J., Guan, Z.-B., An, D., Wang, X., & Li, Y. (2016) · Phytomedicine · doi:10.1016/j.phymed.2016.01.010 · Cited by 101 · see citing works

Targeted Metabolomic Analysis of Serum Fatty Acids for the Prediction of Autoimmune Diseases

Tsoukalas, D., Fragoulakis, V., Sarandi, E., Docea, A. O., Papakonstaninou, E., Τσιλιμιδός, Γ., Anamaterou, C., Fragkiadaki, P., Aschner, M., Tsatsakis, A. M., et al. (2019) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2019.00120 · Cited by 96 · see citing works

Tobacco Smoking and Liver Cancer Risk: Potential Avenues for Carcinogenesis

Jain, D., Chaudhary, P., Varshney, N., Razzak, K. S. B., Verma, D., Zahra, T. R. K., Janmeda, P., Sharifi‐Rad, J., Daştan, S. D., Mahmud, S., et al. (2021) · Journal of Oncology · doi:10.1155/2021/5905357 · Cited by 96 · see citing works

Epibatidine: A Promising Natural Alkaloid in Health

Salehi, B., Sestito, S., Rapposelli, S., Peron, G., Calina, D., Sharifi-Rad, M., Sharopov, F., Martins, N., & Sharifi-Rad, J. (2018) · Biomolecules · doi:10.3390/biom9010006 · Cited by 91 · see citing works

The origin and evolution of the diosgenin biosynthetic pathway in yam

Cheng, J. G., Chen, J., Liu, X., Li, X., Zhang, W., Dai, Z., Lu, L., Zhou, X., Cai, J., Zhang, X., et al. (2020) · Plant Communications · doi:10.1016/j.xplc.2020.100079 · Cited by 89 · see citing works

Diosgenin Induces Apoptosis in HepG2 Cells through Generation of Reactive Oxygen Species and Mitochondrial Pathway

Kim, D. S., Jeon, B. K., Lee, Y. E., Woo, W.-H., & Mun, Y. J. (2012) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2012/981675 · Cited by 87 · see citing works

Methyl protodioscin from Polygonatum sibiricum inhibits cervical cancer through cell cycle arrest and apoptosis induction

Ma, Y., Zhang, Y.-S., Zhang, F., Zhang, Y., Thakur, K., Zhang, J., & Wei, Z. (2019) · Food and Chemical Toxicology · doi:10.1016/j.fct.2019.110655 · Cited by 87 · see citing works

Diosgenin inhibits atherosclerosis via suppressing the MiR-19b-induced downregulation of ATP-binding cassette transporter A1

Lv, Y.-C., Yang, J., Yao, F., Xie, W., Tang, Y., Ouyang, X.-P., He, P., Tan, Y.-L., Li, L., Zhang, M., et al. (2015) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2015.02.044 · Cited by 86 · see citing works

Dioscin Induces Gallbladder Cancer Apoptosis by Inhibiting ROS-Mediated PI3K/AKT Signalling

Song, X., Wang, Z., Liang, H., Zhang, W., Ye, Y., Li, H., Hu, Y., Zhang, Y., Weng, H., Lu, J., et al. (2017) · International Journal of Biological Sciences · doi:10.7150/ijbs.18732 · Cited by 86 · see citing works

A Review of Recent Studies on the Antioxidant and Anti‐Infectious Properties of Senna Plants

Alshehri, M. M., Quispe, C., Herrera‐Bravo, J., Sharifi‐Rad, J., Tütüncü, S., Aydar, E. F., Topkaya, C., Mertdinç, Z., Özçelik, B., Aital, M., et al. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/6025900 · Cited by 86 · see citing works

Diosgenin ameliorates development of neuropathic pain in diabetic rats: Involvement of oxidative stress and inflammation

Kiasalari, Z., Rahmani, T., Mahmoudi, N., Baluchnejadmojarad, T., & Roghani, M. (2016) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2016.12.068 · Cited by 83 · see citing works

Diosgenin-Rich Yam Extract Enhances Cognitive Function: A Placebo-Controlled, Randomized, Double-Blind, Crossover Study of Healthy Adults

Tohda, C., Yang, X., Matsui, M., Inada, Y., Kadomoto, E., Nakada, S., Watari, H., & Shibahara, N. (2017) · Nutrients · doi:10.3390/nu9101160 · Cited by 83 · see citing works

Methyl protodioscin induces G2/M cell cycle arrest and apoptosis in HepG2 liver cancer cells

Wang, G., Chen, H., Huang, M., Wang, N., Zhang, J., Zhang, Y., Bai, G., Fong, W. F., Yang, M., & Yao, X. (2006) · Cancer Letters · doi:10.1016/j.canlet.2005.10.050 · Cited by 82 · see citing works

Sterols. CLVII. Sapogenins. LXIX.1 Isolation and Structures of Thirteen New Steroidal Sapogenins. New Sources for Known Sapogenins

Marker, R. E., Wagner, R. B., Ulshafer, P. R., Wittbecker, E. L., Goldsmith, D. P. J., & Ruof, C. H. (1943) · Journal of the American Chemical Society · doi:10.1021/ja01246a051 · Cited by 82 · see citing works

Increased vulnerability of ApoE4 neurons to HIV proteins and opiates: Protection by diosgenin and l-deprenyl

Turchan-Cholewo, J. T., Liu, Y., Gartner, S., Reid, R., Jie, C., Peng, X., Chen, K. C., Chauhan, A., Haughey, N. J., Cutler, R. G., et al. (2006) · Neurobiology of Disease · doi:10.1016/j.nbd.2006.02.005 · Cited by 81 · see citing works

In Vivo Protective Effects of Diosgenin against Doxorubicin-Induced Cardiotoxicity

Chen, C.-T., Wang, Z.-H., Hsu, C., Lin, H., & Chen, J. (2015) · Nutrients · doi:10.3390/nu7064938 · Cited by 81 · see citing works

Resveratrol’ biotechnological applications: Enlightening its antimicrobial and antioxidant properties

Sharifi-Rad, J., Quispe, C., Durazzo, A., Lucarini, M., Souto, E. B., Santini, A., Imran, M., Moussa, A. Y., Mostafa, N. M., El-Shazly, M., et al. (2022) · Journal of Herbal Medicine · doi:10.1016/j.hermed.2022.100550 · Cited by 81 · see citing works

Nutraceutical Profiling, Bioactive Composition, and Biological Applications of Lepidium sativum L.

Painuli, S., Quispe, C., Herrera‐Bravo, J., Semwal, P., Martorell, M., Almarhoon, Z. M., Seilkhan, A., Ydyrys, A., Sharifi‐Rad, J., Alshehri, M. M., et al. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/2910411 · Cited by 77 · see citing works

Structural analogues of diosgenyl saponins: Synthesis and anticancer activity

Kaskiw, M. J., Tassotto, M. L., Mok, M., Tokar, S. L., Pycko, R., Th'ng, J. P. H., & Jiang, Z. (2009) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2009.09.046 · Cited by 76 · see citing works

Dioscin suppresses hepatocellular carcinoma tumor growth by inducing apoptosis and regulation of TP53, BAX, BCL2 and cleaved CASP3

Zhang, G., Zeng, X., Zhang, R., Liu, J., Zhang, W., Zhao, Y., Zhang, X., Wu, Z., Tan, Y., Wu, Y., et al. (2016) · Phytomedicine · doi:10.1016/j.phymed.2016.07.003 · Cited by 76 · see citing works

Association of nutraceutical supplements with longer telomere length

Tsoukalas, D., Fragkiadaki, P., Docea, A. O., Alegakis, A. K., Sarandi, E., Vakonaki, E., Salataj, E., Kouvidi, E., Nikitovic, D., Kovatsi, L., et al. (2019) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2019.4191 · Cited by 76 · see citing works

Induction of G2/M Phase Arrest by Diosgenin via Activation of Chk1 Kinase and Cdc25C Regulatory Pathways to Promote Apoptosis in Human Breast Cancer Cells

Liao, W., Lin, J.-Y., Shieh, J., Yeh, H.-F., Hsieh, Y., Cheng, Y.-C., Lee, H., Shen, C., & Cheng, C. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms21010172 · Cited by 76 · see citing works

Diosgenin promotes oligodendrocyte progenitor cell differentiation through estrogen receptor‐mediated ERK1/2 activation to accelerate remyelination

Xiao, L., Guo, D., Hu, C., Shen, W., Shan, L., Li, C., Liu, X., Yang, W., Zhang, W., & He, C. (2012) · Glia · doi:10.1002/glia.22333 · Cited by 75 · see citing works

Dioscin and diosgenin: Insights into their potential protective effects in cardiac diseases

Li, X., Liu, S., Qu, L., Chen, Y., Yuan, C., Qin, A., Liang, J., Huang, Q., Jiang, M., & Zou, W. (2021) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2021.114018 · Cited by 73 · see citing works

Natural products and synthetic analogues against HIV: A perspective to develop new potential anti-HIV drugs

Popović‐Djordjević, J. B., Quispe, C., Giordo, R., Kostić, A. Ž., Stanković, J. S. K., Fokou, P. V. T., Carbone, K., Martorell, M., Kumar, M., Pintus, G., et al. (2022) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2022.114217 · Cited by 72 · see citing works

Disocin prevents postmenopausal atherosclerosis in ovariectomized LDLR-/- mice through a PGC-1α/ERα pathway leading to promotion of autophagy and inhibition of oxidative stress, inflammation and apoptosis

Yang, Q., Wang, C., Jin, Y., Ma, X., Xie, T., Wang, J., Liu, K., & Sun, H. (2019) · Pharmacological Research · doi:10.1016/j.phrs.2019.104414 · Cited by 71 · see citing works

Diosgenin from Dioscorea nipponica Ameliorates Diabetic Neuropathy by Inducing Nerve Growth Factor

Kang, T. H., Moon, E., Hong, B. N., Choi, S. Z., Son, M., Park, J. H., & Kim, S. Y. (2011) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.34.1493 · Cited by 69 · see citing works

The anticancer potential of steroidal saponin, dioscin, isolated from wild yam (Dioscorea villosa) root extract in invasive human breast cancer cell line MDA-MB-231 in vitro

Aumsuwan, P., Khan, S. I., Khan, I. A., Ali, Z., Avula, B., Walker, L., Shariat‐Madar, Z., Helferich, W. G., Katzenellenbogen, B. S., & Dasmahapatra, A. K. (2015) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2015.12.001 · Cited by 68 · see citing works

Identification of a novel cytochrome P450 enzyme that catalyzes the C-2α hydroxylation of pentacyclic triterpenoids and its application in yeast cell factories

Dai, Z., Liu, Y., Sun, Z., Wang, D., Qu, G., Ma, X., Fan, F., Zhang, L., Li, S.-L., & Zhang, X. (2018) · Metabolic Engineering · doi:10.1016/j.ymben.2018.10.001 · Cited by 68 · see citing works

Natural Bioactives and Phytochemicals Serve in Cancer Treatment and Prevention

Yang, S., Weng, C., Sethi, G., & Hu, D. (2013) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2013/698190 · Cited by 66 · see citing works

Diosgenin Ameliorates Cognition Deficit and Attenuates Oxidative Damage in Senescent Mice Induced by D-Galactose

Chiu, C., Chiu, Y., Wu, L., Lu, T.-C., Huang, T.-H., Hsieh, M., Lu, C., & Peng, W. (2011) · The American Journal of Chinese Medicine · doi:10.1142/s0192415x11009020 · Cited by 66 · see citing works

Histochemical and immunohistochemical evidence of tumor heterogeneity in colorectal cancer.

Zlatian, O. M., Comanescu, M. V., Roşu, A. F., Roşu, L., Cruce, M., Găman, A. E., Călina, C. D., & Sfredel, V. (2015) · PubMed · Cited by 65 · see citing works

The Treatment of Cognitive, Behavioural and Motor Impairments from Brain Injury and Neurodegenerative Diseases through Cannabinoid System Modulation—Evidence from In Vivo Studies

Calina, D., Buga, A. M., Mitroi, M., Buha, A., Caruntu, C., Scheau, C., Bouyahya, A., El Omari, N., El Menyiy, N., & Docea, A. O. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9082395 · Cited by 65 · see citing works

Cytotoxicity of dioscin in human gastric carcinoma cells through death receptor and mitochondrial pathways

Hu, M., Xu, L., Yin, L., Qi, Y., Li, H., Xu, Y., Han, X., Peng, J., & Wan, X. (2012) · Journal of Applied Toxicology · doi:10.1002/jat.2715 · Cited by 64 · see citing works

Acute administration of diosgenin or dioscorea improves hyperglycemia with increases muscular steroidogenesis in STZ-induced type 1 diabetic rats

Sato, K., Fujita, S., & Iemitsu, M. (2014) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2014.02.020 · Cited by 64 · see citing works

Evaluation of antioxidant, anti-inflammatory and anticancer activities of diosgenin enriched Paris polyphylla rhizome extract of Indian Himalayan landraces

Gupta, D. D., Mishra, S., Verma, S. S., Shekher, A., Rai, V., Awasthee, N., Das, T. J., Paul, D., Das, S. K., Tag, H., et al. (2021) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2021.113842 · Cited by 64 · see citing works

Dioscin induces caspase-independent apoptosis through activation of apoptosis-inducing factor in breast cancer cells

Kim, E., Jang, J., Lee, Y., Sung, E., Song, I., Kim, J., Kim, S., Sohn, H.-Y., & Lee, T. J. (2014) · APOPTOSIS · doi:10.1007/s10495-014-0994-z · Cited by 63 · see citing works

Diosgenin down-regulates NF- κB p65/p50 and p38MAPK pathways and attenuates acute lung injury induced by lipopolysaccharide in mice

Gao, M., Chen, L., Yu, H., Sun, Q., Kou, J., & Yu, B. (2013) · International Immunopharmacology · doi:10.1016/j.intimp.2012.11.019 · Cited by 63 · see citing works

Comparison of ultrasound and microwave assisted extraction of diosgenin from Trigonella foenum graceum seed

Arya, P., & Kumar, P. (2021) · Ultrasonics Sonochemistry · doi:10.1016/j.ultsonch.2021.105572 · Cited by 62 · see citing works

Post-Concussion Syndrome and Chronic Traumatic Encephalopathy: Narrative Review on the Neuropathology, Neuroimaging and Fluid Biomarkers

Mavroudis, I. A., Kazis, D. A., Chowdhury, R., Petridis, F., Costa, V., Balmuș, I.-M., Ciobica, A. S., Luca, A.-C., Radu, I., Dobrin, R., et al. (2022) · Diagnostics · doi:10.3390/diagnostics12030740 · Cited by 62 · see citing works

Atherogenic diet induced lipid accumulation induced NFκB level in heart, liver and brain of Wistar rat and diosgenin as an anti-inflammatory agent

Binesh, A., Devaraj, S. N., & Devaraj, H. (2018) · Life Sciences · doi:10.1016/j.lfs.2018.01.012 · Cited by 61 · see citing works

Diosgenin-induced cognitive enhancement in normal mice is mediated by 1,25D3-MARRS

Tohda, C., Lee, Y., Goto, Y., & Nemere, I. (2013) · Scientific Reports · doi:10.1038/srep03395 · Cited by 60 · see citing works

Potent effects of dioscin against gastric cancer in vitro and in vivo

Zhao, X., Xu, L., Zheng, L., Yin, L., Qi, Y., Han, X., Xu, Y., & Peng, J. (2016) · Phytomedicine · doi:10.1016/j.phymed.2016.01.012 · Cited by 60 · see citing works

Dioscin Induces Apoptosis in Human Cervical Carcinoma HeLa and SiHa Cells through ROS-Mediated DNA Damage and the Mitochondrial Signaling Pathway

Zhao, X., Tao, X., Xu, L., Yin, L., Qi, Y., Xu, Y., Han, X., & Peng, J. (2016) · Molecules · doi:10.3390/molecules21060730 · Cited by 60 · see citing works

Neuroprotective effect of diosgenin in a mouse model of diabetic peripheral neuropathy involves the Nrf2/HO-1 pathway

Leng, J., Li, X., Tian, H., Liu, C., Guo, Y., Zhang, S., Chu, Y., Li, J., Wang, Y., & Zhang, L. (2020) · BMC Complementary Medicine and Therapies · doi:10.1186/s12906-020-02930-7 · Cited by 60 · see citing works

Characterization of in Vitro ADME Properties of Diosgenin and Dioscin from Dioscorea villosa

Manda, V. K., Avula, B., Ali, Z., Wong, Y.-H., Smillie, T. J., Khan, I. A., & Khan, S. I. (2013) · Planta Medica · doi:10.1055/s-0033-1350699 · Cited by 59 · see citing works

Diosgenin Attenuates Lipopolysaccharide-Induced Parkinson’s Disease by Inhibiting the TLR/NF-κB Pathway

Li, B., Xu, P., Wu, S., Jiang, Z., Huang, Z., Li, Q., & Chen, D. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-180330 · Cited by 59 · see citing works

Synthesis and Characterization of Diosgenin Encapsulated Poly-ε-Caprolactone-Pluronic Nanoparticles and Its Effect on Brain Cancer Cells

Rabha, B., Bharadwaj, K. K., Baishya, D., Sarkar, T., Edinur, H. A., & Pati, S. (2021) · Polymers · doi:10.3390/polym13081322 · Cited by 58 · see citing works

Modulatory Effects of Diosgenin on Attenuating the Key Enzymes Activities of Carbohydrate Metabolism and Glycogen Content in Streptozotocin-Induced Diabetic Rats

Saravanan, G., Ponmurugan, P., Deepa, M. A., & Senthilkumar, B. (2014) · Canadian Journal of Diabetes · doi:10.1016/j.jcjd.2014.02.004 · Cited by 57 · see citing works

Diosgenin-induced autophagy and apoptosis in a human prostate cancer cell line

Nie, C., Zhou, J., Qin, X., Shi, X., Zeng, Q., Liu, J., Yan, S., & Zhang, L. (2016) · Molecular Medicine Reports · doi:10.3892/mmr.2016.5750 · Cited by 56 · see citing works

Molecular and cellular stratagem of brain metastases associated with melanoma (Review)

Bugă, A. M., Docea, A. O., Albu, C. V., Mălin, R. D., Branisteanu, D. E., Ianoși, G., Ianoși, S. L., Iordache, A. M., & Călina, D. C. (2019) · Oncology Letters · doi:10.3892/ol.2019.9933 · Cited by 55 · see citing works

Dioscin induces cancer cell apoptosis through elevated oxidative stress mediated by downregulation of peroxiredoxins

Zhiyu, W., Cheng, Y., Wang, N., Mei, W. D., Li, W., Feng, H., Gang, S. J., Po, Y. D., Yuan, G. X., & Chen, J. (2012) · Cancer Biology & Therapy · doi:10.4161/cbt.13.3.18693 · Cited by 54 · see citing works

Apoptotic, necrotic, and antiproliferative activity of diosgenin and diosgenin glycosides on cervical cancer cells

Hernández-Vázquez, J. M. V., López‐Muñoz, H., Escobar-Sánchez, M. L., Flores-Guzmán, F., Weiss‐Steider, B., Hilario-Martínez, J. C., Sandoval-Ramı́rez, J., Fernández‐Herrera, M. A., & Sánchez, L. S. (2020) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2020.172942 · Cited by 54 · see citing works

Cannabinoids and Inflammations of the Gut-Lung-Skin Barrier

Scheau, C., Căruntu, C., Bădărău, I. A., Scheau, A.-E., Docea, A. O., Călina, D. C., & Căruntu, A. (2021) · Journal of Personalized Medicine · doi:10.3390/jpm11060494 · Cited by 54 · see citing works

High-Dose Diosgenin Reduces Bone Loss in Ovariectomized Rats via Attenuation of the RANKL/OPG Ratio

Zhang, Z., Song, C., Fu, X., Liu, M., Li, Y., Pan, J., Liu, H., Wang, S., Xiang, L., Xiao, G. G., et al. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms150917130 · Cited by 53 · see citing works

Renoprotective effect of diosgenin in streptozotocin induced diabetic rats

Kanchan, D. M., Somani, G. S., Peshattiwar, V., Kaikini, A., & Sathaye, S. (2016) · Pharmacological Reports · doi:10.1016/j.pharep.2015.10.011 · Cited by 53 · see citing works

Diosgenin ameliorates gestational diabetes through inhibition of sterol regulatory element-binding protein-1

Hua, S., Li, Y., Su, L., & Liu, X. (2016) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2016.10.049 · Cited by 52 · see citing works

Dioscin inhibits ischemic stroke‑induced inflammation through inhibition of the TLR4/MyD88/NF‑κB signaling pathway in a rat model

Zhu, S., Tang, S., & Su, F. (2017) · Molecular Medicine Reports · doi:10.3892/mmr.2017.7900 · Cited by 52 · see citing works

Design, synthesis and evaluation of diosgenin carbamate derivatives as multitarget anti-Alzheimer’s disease agents

Yang, G., Huang, Y., Zheng, L., Zhang, L., Su, L., Wu, Y., Li, J., Zhou, L., Huang, J. Y., Tang, Y., et al. (2019) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2019.111913 · Cited by 52 · see citing works

Diosgenin glucoside provides neuroprotection by regulating microglial M1 polarization

Wang, S., Wang, F., Yang, H., Li, R., Guo, H., & Hu, L. (2017) · International Immunopharmacology · doi:10.1016/j.intimp.2017.06.008 · Cited by 50 · see citing works

A more ecological and efficient approach for producing diosgenin from Dioscorea zingiberensis tubers via pressurized biphase acid hydrolysis

Yang, H., Yin, H., Shen, Y., Xia, G., Zhang, B., Wu, X., Cai, B., & Tam, J. P. (2016) · Journal of Cleaner Production · doi:10.1016/j.jclepro.2016.05.030 · Cited by 49 · see citing works

Cyclooxygenase-2 and 5-lipoxygenase pathways in diosgenin-induced apoptosis in HT-29 and HCT-116 colon cancer cells

Liagre (2010) · International Journal of Oncology · doi:10.3892/ijo_00000601 · Cited by 48 · see citing works

Anti-inflammatory, antioxidant and antiangiogenic activities of diosgenin isolated from traditional medicinal plant, Costus speciosus (Koen ex.Retz.) Sm

Selim, S., & Jaouni, S. A. (2015) · Natural Product Research · doi:10.1080/14786419.2015.1065493 · Cited by 47 · see citing works

Anti- trachea inflammatory effects of diosgenin from Dioscorea nipponica through interactions with glucocorticoid receptor α

Junchao, Y., Zhen, W., Wang, Y., Xu, L., Jiang, L., Yuanhong, Z., Zhao, W. L., Ruilin, C., & Lu, Z. (2016) · Journal of International Medical Research · doi:10.1177/0300060516676724 · Cited by 47 · see citing works

i TRAQ ‐based proteomic analysis of dioscin on human HCT ‐116 colon cancer cells

Chen, H., Xu, L., Yin, L., Xu, Y., Han, X., Qi, Y., Zhao, Y., Liu, K., & Peng, J. (2013) · PROTEOMICS · doi:10.1002/pmic.201300101 · Cited by 46 · see citing works

Diosgenin Glucoside Protects against Spinal Cord Injury by Regulating Autophagy and Alleviating Apoptosis

Chen, X.-B., Wang, Z., Yang, Q., Zhao, F., Qin, X., Tang, X., Du, J.-L., Chen, Z.-H., Zhang, K., & Huang, F. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19082274 · Cited by 46 · see citing works

Diosgenin Suppresses Hepatocyte Growth Factor (HGF)-Induced Epithelial–Mesenchymal Transition by Down-regulation of Mdm2 and Vimentin

Chang, H., Kao, M., Way, T., Ho, C., & Fu, E. (2011) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf200598w · Cited by 45 · see citing works

Targeting NFE2L2, a transcription factor upstream of MMP-2: A potential therapeutic strategy for temozolomide resistant glioblastoma

Rajesh, Y., Biswas, A., Kumar, U., Das, S., Banerjee, I., Banik, P., Bharti, R., Nayak, S., Ghosh, S. K., & Mandal, M. (2019) · Biochemical Pharmacology · doi:10.1016/j.bcp.2019.03.025 · Cited by 45 · see citing works

Chemical fingerprint analysis and quantitative determination of steroidal compounds from Dioscorea villosa, Dioscorea species and dietary supplements using UHPLC‐ELSD

Avula, B., Wang, Y., Ali, Z., Smillie, T. J., & Khan, I. A. (2013) · Biomedical Chromatography · doi:10.1002/bmc.3019 · Cited by 44 · see citing works

Diosgenin Mitigates Streptozotocin Diabetes-induced Vascular Dysfunction of the Rat Aorta

Roghani, F., Roghani, M., & Baluchnejadmojarad, T. (2015) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0000000000000308 · Cited by 43 · see citing works

Diosgenin inhibited the expression of TAZ in hepatocellular carcinoma

Chen, Z., Xu, J., Wu, Y., Lei, S., Liu, H., Meng, Q., & Xia, Z. (2018) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2018.07.022 · Cited by 43 · see citing works

Modification of cellulase and its application to extraction of diosgenin from Dioscorea zingiberensis C.H. Wright

Zhang, Y., Tang, L., An, X., Fu, E. H., & Ma, C. (2009) · Biochemical Engineering Journal · doi:10.1016/j.bej.2009.07.006 · Cited by 41 · see citing works

Pharmacological management of non-alcoholic fatty liver disease: Atorvastatin versus pentoxifylline

Cioboată, R., Găman, A. E., Trașcă, D.-M., Ungureanu, A. M., Docea, A. O., Tomescu, P. I., Gherghina, F. L., Arsene, A. L., Badiu, C., Tsatsakis, A. M., et al. (2017) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2017.4256 · Cited by 41 · see citing works

Trillium tschonoskii maxim saponin mitigates D-galactose-induced brain aging of rats through rescuing dysfunctional autophagy mediated by Rheb-mTOR signal pathway

Wang, L., Du, J.-L., Zhao, F., Chen, Z., Chang, J., Qin, F., Wang, Z., Wang, F., Chen, X., & Chen, N. (2017) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2017.12.046 · Cited by 41 · see citing works

Osteoprotective Effect of Monascus-fermented Dioscorea in Ovariectomized Rat Model of Postmenopausal Osteoporosis

Chiang, S., Chang, S.-P., & Pan, T. (2011) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf201640j · Cited by 40 · see citing works

Diosgenin Exerts Antitumor Activity via Downregulation of Skp2 in Breast Cancer Cells

Liu, Y., Zhou, Z., Yan, J., Wu, X., & Xu, G. (2020) · BioMed Research International · doi:10.1155/2020/8072639 · Cited by 40 · see citing works

Diosgenin Derivatives as Potential Antitumor Agents: Synthesis, Cytotoxicity, and Mechanism of Action

Yin, H., Zhang, M., An, R.-F., Zhou, J., Liu, W. Y., Morris-Natschke, S. L., Cheng, Y., Lee, K., & Huang, X. (2020) · Journal of Natural Products · doi:10.1021/acs.jnatprod.0c00698 · Cited by 40 · see citing works

Design and synthesis of diosgenin derivatives as apoptosis inducers through mitochondria-related pathways

Ma, L., Zhang, J., Wang, X., Yang, J., Guo, L., Wang, X., Song, B., Dong, W., & Wang, W. (2021) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2021.113361 · Cited by 40 · see citing works

Dioscin relieves endotoxemia induced acute neuro-inflammation and protect neurogenesis via improving 5-HT metabolism

Yang, R., Chen, W., Lu, Y. F., Li, Y., Du, H., Gao, S., Dong, X. W., & Yuan, H. (2017) · Scientific Reports · doi:10.1038/srep40035 · Cited by 39 · see citing works

Immunohistochemical expression of TGF beta (TGF-β), TGF beta receptor 1 (TGFBR1), and Ki67 in intestinal variant of gastric adenocarcinomas.

Docea, A. O., Mitruț, P., Grigore, D., Pirici, D., Călina, D. C., & Gofiţă, E. (2012) · PubMed · Cited by 38 · see citing works

Ethnobotany, Phytochemistry, Biological Activities, and Health-Promoting Effects of the Genus Bulbophyllum

Sharifi‐Rad, J., Quispe, C., Bouyahya, A., Menyiy, N. E., Omari, N. E., Shahinozzaman, M., Ovey, M. A. H., Koirala, N., Panthi, M., Ertani, A., et al. (2022) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2022/6727609 · Cited by 38 · see citing works

Dioscin inhibits gastric tumor growth through regulating the expression level of lncRNA HOTAIR

Ma, T., Wang, R., & Zou, X. (2016) · BMC Complementary and Alternative Medicine · doi:10.1186/s12906-016-1360-1 · Cited by 37 · see citing works

Bivalent ligands incorporating curcumin and diosgenin as multifunctional compounds against Alzheimer’s disease

Chojnacki, J. E., Liu, K., Saathoff, J. M., & Zhang, S. (2015) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2015.10.032 · Cited by 36 · see citing works

Exploration in the cascade working mechanisms of liver injury induced by total saponins extracted from Rhizoma Dioscorea bulbifera

Yang, F., Liang, Y., Xu, L., Ji, L., Yao, N., Liu, R., Shi, L., & Liang, T. (2016) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2016.08.017 · Cited by 36 · see citing works

The Impact of a Standardized Oral Multinutrient Supplementation on Embryo Quality in in vitro Fertilization/Intracytoplasmic Sperm Injection: A Prospective Randomized Trial

Nouri, K., Walch, K., Weghofer, A., Imhof, M., Egarter, C., & Ott, J. (2016) · Gynecologic and Obstetric Investigation · doi:10.1159/000452662 · Cited by 36 · see citing works

Diosgenin relieves goiter via the inhibition of thyrocyte proliferation in a mouse model of Graves' disease

Cai, H., Wang, Z., Zhang, H., Wang, F., Yu, C., Zhang, F., Gao, L., Zhang, J., & Zhao, J. (2013) · Acta Pharmacologica Sinica · doi:10.1038/aps.2013.133 · Cited by 36 · see citing works

A Novel Nutraceutical Formulation Can Improve Motor Activity and Decrease the Stress Level in a Murine Model of Middle-Age Animals

Tsoukalas, D., Zlatian, O. M., Mitroi, M. R., Renieri, E. A., Tsatsakis, A. M., Izotov, B. N., Burada, F., Sosoi, S. S., Burada, E., Bugă, A. M., et al. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10040624 · Cited by 36 · see citing works

Synthesis, characterization and biological studies of diosgenyl analogues

Huang, B., Du, D., Zhang, R., Wu, X., Xing, Z., He, Y., & Huang, W. Q. (2012) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2012.10.086 · Cited by 35 · see citing works

Inhibitory effects of Dioscin on atherosclerosis and foam cell formation in hyperlipidemia rats

Wang, P., He, L., Shen, G., Li, R., & Yang, J. (2017) · Inflammopharmacology · doi:10.1007/s10787-017-0341-4 · Cited by 35 · see citing works

Water-Soluble Arginyl–Diosgenin Analog Attenuates Hippocampal Neurogenesis Impairment Through Blocking Microglial Activation Underlying NF-κB and JNK MAPK Signaling in Adult Mice Challenged by LPS

Cai, B., Seong, K.-J., Bae, S., Kook, M. S., Chun, C., Lee, J. H., Choi, W., Jung, J., & Kim, W.-J. (2019) · Molecular Neurobiology · doi:10.1007/s12035-019-1496-3 · Cited by 35 · see citing works

Anti-Apoptotic Effects of Diosgenin in D-Galactose-Induced Aging Brain

Cheng, S., Ho, Y., Yu, S.-H., Liu, Y.-F., Lin, Y.-Y., Huang, C., Ou, H., Huang, H., & Lee, S. (2020) · The American Journal of Chinese Medicine · doi:10.1142/s0192415x20500202 · Cited by 34 · see citing works

Diosgenin attenuates the brain injury induced by transient focal cerebral ischemia-reperfusion in rats

Zhang, X., Xue, X., Zhao, J., Qian, C., Guo, Z., Ito, Y., & Sun, W.-J. (2016) · Steroids · doi:10.1016/j.steroids.2016.07.006 · Cited by 33 · see citing works

Saponins: the phytochemical with an emerging potential for curing clinical depression

Abbas, G., Rauf, K., & Mahmood, W. (2014) · Natural Product Research · doi:10.1080/14786419.2014.942661 · Cited by 31 · see citing works

Expression of chemokines in macrophage polarization and downregulation of NFκB in aorta allow macrophage polarization by diosgenin in atherosclerosis

Binesh, A., Devaraj, S. N., & Devaraj, H. (2019) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.22422 · Cited by 31 · see citing works

Identification of Polyphenols, Glycoalkaloids, and Saponins in Solanum scabrum Berries Using HPLC‐UV/Vis‐MS

Yuan, B., Byrnes, D., Dinssa, F. F., Simon, J. E., & Wu, Q. (2019) · Journal of Food Science · doi:10.1111/1750-3841.14424 · Cited by 30 · see citing works

Dioscorea deltoidea wall. Ex Griseb: A review of traditional uses, bioactive compounds and biological activities

Semwal, P., Painuli, S., & Martins, N. A. (2021) · Food Bioscience · doi:10.1016/j.fbio.2021.100969 · Cited by 30 · see citing works

Diosgenin attenuates neuropathic pain in a rat model of chronic constriction injury

Zhao, W.-X., Wang, P., Song, H.-G., & Sun, N. C. (2017) · Molecular Medicine Reports · doi:10.3892/mmr.2017.6723 · Cited by 29 · see citing works

Diosgenin Suppresses Cholangiocarcinoma Cells Via Inducing Cell Cycle Arrest And Mitochondria-Mediated Apoptosis

Mao, X., Zhou, P., Li, S., Zhang, X., Shen, J.-X., Qing-xi, C., Zhuang, J.-X., & Shen, D. (2019) · OncoTargets and Therapy · doi:10.2147/ott.s226261 · Cited by 29 · see citing works

Diosgenin inhibits the expression of NEDD4 in prostate cancer cells.

Zhang, J., Xie, J., Zhou, S., Chen, J., Hu, Q., Pu, J., & Lu, J. (2019) · PubMed Central · Cited by 29 · see citing works

ADORA2A rs5760423 and CYP1A2 rs762551 Polymorphisms as Risk Factors for Parkinson’s Disease

Siokas, V., Aloizou, A.-M., Tsouris, Z., Liampas, I., Liakos, P., Calina, D., Docea, A. O., Tsatsakis, A., Bogdanos, D. P., Hadjigeorgiou, G. M., et al. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10030381 · Cited by 29 · see citing works

Neurobiological Promises of the Bitter Diterpene Lactone Andrographolide

Hossain, R., Quispe, C., Herrera‐Bravo, J., Beltrán, J. F., Islam, M. T., Shaheen, S., Martins, N. A., Martorell, M., Kumar, M., Sharifi‐Rad, J., et al. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/3079577 · Cited by 29 · see citing works

Isolation and characterization of diosgenin from in vitro cultured tissues of Helicteres isora L

Deshpande, H. A., & Bhalsing, S. R. (2013) · Physiology and Molecular Biology of Plants · doi:10.1007/s12298-013-0205-3 · Cited by 28 · see citing works

Yam (Dioscorea pseudojaponicaYamamoto) Ameliorates Cognition Deficit and Attenuates Oxidative Damage in Senescent Mice Induced by D-Galactose

Chiu, C., Deng, J., Hsieh, M., Fan, M., Lee, M., Chueh, F., Han, C., Lin, Y.-C., & Peng, W. (2009) · The American Journal of Chinese Medicine · doi:10.1142/s0192415x09007296 · Cited by 28 · see citing works

Spectrophotometric determination of diosgenin in Dioscorea composita following thin-layer chromatography

Sánchez, G. L., Acevedo, J. C. M., & Soto, R. R. (1972) · The Analyst · doi:10.1039/an9729700973 · Cited by 28 · see citing works

Preventive effect of a novel diosgenin derivative on arterial and venous thrombosis in vivo

Zheng, H., Wei, Z., Xin, G., Ji, C., Wen, L., Xia, Q., Niu, H., & Huang, W. Q. (2016) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2016.05.032 · Cited by 28 · see citing works

Characterization of ADME Properties of Diosgenin and Dioscin: Bioactive Constituents of Dioscorea villosa (Wild yam)

Manda, V., Avula, B., Ali, Z., Smillie, T., Khan, I., & Khan, S. I. (2013) · Planta Medica · doi:10.1055/s-0033-1336521 · Cited by 27 · see citing works

An Antivirulence Approach for Preventing Cryptococcus neoformans from Crossing the Blood-Brain Barrier via Novel Natural Product Inhibitors of a Fungal Metalloprotease

Aaron, P. A., Vu, K., & Gelli, A. (2020) · mBio · doi:10.1128/mbio.01249-20 · Cited by 27 · see citing works

Diosgenin increased DDX3 expression in hepatocellular carcinoma.

Yu, H., Liu, Y., Niu, C., & Cheng, Y. (2018) · Europe PMC (PubMed Central) · Cited by 26 · see citing works

Design, Synthesis and Biological Evaluation of Diosgenin-Amino Acid Derivatives with Dual Functions of Neuroprotection and Angiogenesis

Cai, D., Qi, J., Yang, Y., Zhang, W., Zhou, F., Jia, X., Guo, W., Huang, X., Gao, F., Chen, H., et al. (2019) · Molecules · doi:10.3390/molecules24224025 · Cited by 26 · see citing works

Protective role of diosgenin against hyperglycaemia-mediated cerebral ischemic brain injury in zebrafish model of type II diabetes mellitus

Akinsipo, O. B., Dare, E. O., & Katare, D. P. (2020) · Heliyon · doi:10.1016/j.heliyon.2020.e03296 · Cited by 25 · see citing works

Cytotoxic activity of standardized extracts, a fraction, and individual secondary metabolites from fenugreek seeds against SKOV-3, HeLa and MOLT-4 cell lines

Stefanowicz‐Hajduk, J., Król-Kogus, B., Sparzak-Stefanowska, B., Kimel, K., Ochocka, J. R., & Krauze‐Baranowska, M. (2021) · Pharmaceutical Biology · doi:10.1080/13880209.2021.1903047 · Cited by 25 · see citing works

Diosgenin effectively suppresses skin inflammation induced by phthalic anhydride in IL-4/Luc/CNS-1 transgenic mice

Kim, J. E., Go, J., Koh, E. K., Song, S. H., Sung, J. E., Lee, H. A., Kim, D. S., Son, H. J., Lee, H. S., Lee, C. Y., et al. (2016) · Bioscience Biotechnology and Biochemistry · doi:10.1080/09168451.2015.1135040 · Cited by 24 · see citing works

Prevention properties on cerebral ischemia reperfusion of medicine food homologous Dioscorea yam-derived diosgenin based on mediation of potential targets

Zhang, X., Wang, X., Xue, Z., Zhan, G., Ito, Y., & Guo, Z. (2020) · Food Chemistry · doi:10.1016/j.foodchem.2020.128672 · Cited by 24 · see citing works

HPTLC quantification of diosgenin in Dioscorea deltoidea: Evaluation of extraction efficacy, organ selection, drying method and seasonal variation

Nazir, R., Kumar, V., Dey, A., & Pandey, D. K. (2021) · South African Journal of Botany · doi:10.1016/j.sajb.2020.12.027 · Cited by 24 · see citing works

Diosgenin attenuates hepatic stellate cell activation through transforming growth factor-β/Smad signaling pathway.

Xie, W., Jiang, R., Shen, X., Chen, Z., & Deng, X. (2015) · PubMed Central · Cited by 22 · see citing works

Colorectal Cancer and Inflammatory Bowel Disease

Mitruț, P., Docea, A. O., Kamal, A. M., Mitruţ, R., Călina, D. C., Gofiţă, E., Pădureanu, V., Gruia, C. L., & Streba, L. (2016) · InTech eBooks · doi:10.5772/63408 · Cited by 22 · see citing works

Diosgenin improves functional recovery from sciatic crushed nerve injury in rats

Lee, B.-K., Kim, C., Shin, M., & Cho, Y. S. (2018) · Journal of Exercise Rehabilitation · doi:10.12965/jer.1836340.170 · Cited by 22 · see citing works

Investigation on the mechanisms for biotransformation of saponins to diosgenin

Zhu, Y., Zhu, H., Qiu, M., Zhu, T., & Ni, J. (2013) · World Journal of Microbiology and Biotechnology · doi:10.1007/s11274-013-1429-7 · Cited by 21 · see citing works

Azasteroids from diosgenin: Synthesis and evaluation of their antiproliferative activity

Martínez-Gallegos, A. A., Guerrero‐Luna, G., Ortiz-González, A., Cárdenas-García, M., Bernès, S., & Hernández-Linares, M. G. (2020) · Steroids · doi:10.1016/j.steroids.2020.108777 · Cited by 21 · see citing works

Diosgenin inhibits angiotensin II-induced extracellular matrix remodeling in cardiac fibroblasts through regulating the TGF-β1/Smad3 signaling pathway

Zhou, H.-T., Yu, X., & Zhou, G. (2017) · Molecular Medicine Reports · doi:10.3892/mmr.2017.6280 · Cited by 20 · see citing works

Therapeutic effects of diosgenin in experimental autoimmune encephalomyelitis.

Liu, W., Zhu, M., Yu, Z., Yin, D., Lu, F., Pu, Y.-Y., Zhao, C., He, C., & Cao, L. (2017) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2017.10.018 · Cited by 18 · see citing works

Exploring the impact of a naturally occurring sapogenin diosgenin on underlying mechanisms of Ca2+ movement and cytotoxicity in human prostate cancer cells

Sun, G., Jan, C., & Liang, W. (2019) · Environmental Toxicology · doi:10.1002/tox.22876 · Cited by 17 · see citing works

Beneficial effect of diosgenin as a stimulator of NGF on the brain with neuronal damage induced by Aβ-42 accumulation and neurotoxicant injection

Koh, E.-K., Yun, W.-B., Kim, J.-E., Song, S., Sung, J.-E., Lee, H. A., Seo, E.-J., Jee, S. W., Bae, C.-J., & Hwang, D. Y. (2016) · Laboratory Animal Research · doi:10.5625/lar.2016.32.2.105 · Cited by 16 · see citing works

The role of diallyl thiosulfinate associated with nuciferine and diosgenin in the treatment of premature ejaculation: A pilot study

Cai, T., Cocci, A., Cito, G., Giammusso, B., Zucchi, A., Chianchone, F., Carrino, M., Mastroeni, F., Comerci, F., Franco, G., et al. (2018) · Archivio Italiano di Urologia e Andrologia · doi:10.4081/aiua.2018.1.59 · Cited by 15 · see citing works

The induction of apoptosis by a newly synthesized diosgenyl saponin through the suppression of estrogen receptor-α in MCF-7 human breast cancer cells

Chun, J., Han, L., Xu, M. Y., Wang, B., Cheng, M. S., & Kim, Y. S. (2013) · Archives of Pharmacal Research · doi:10.1007/s12272-013-0279-z · Cited by 14 · see citing works

Minireview on the Connections between the Neuropsychiatric and Dental Disorders: Current Perspectives and the Possible Relevance of Oxidative Stress and Other Factors

Ciobica, A. S., Pădurariu, M., Curpăn, A.-Ș., Antioch, I., Chiriță, R., Ștefănescu, C., Luca, A.-C., & Tomida, M. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/6702314 · Cited by 11 · see citing works

Effect of extract of Trillium tschonoskii Maxim on ciliary neurotropic factor and its receptor α in rats suffering from spinal cord injury

Chen, X., Zhu, M.-Y., Qin, F.-R., Tang, S.-Q., Wang, F., Long, B.-L., & Yuan, D.-P. (2015) · Jiefangjun yixue zazhi · Cited by 6 · see citing works

[Protective effect of diosgenin on chondrocytes mediated by JAK2/STAT3 signaling pathway in mice with osteoarthritis].

Liu, J., He, X., Zhen, P., Zhou, S., & Li, X. (2016) · PubMed Central · doi:10.3785/j.issn.1008-9292.2016.09.02 · Cited by 6 · see citing works

Designing and optimizing a parallel neural network model for predicting the solubility of diosgenin in n-alkanols

Lv, H., & Tian, D. (2020) · Chinese Journal of Chemical Engineering · doi:10.1016/j.cjche.2020.09.009 · Cited by 3 · see citing works

Quantitative Analysis of (+)-Catechin and Diosgenin from Smilax china L. Rhizome

Yin, J., Yoon, K. H., Hwang, Y. J., Lee, J. Y., Shin, H., & Lee, M. W. (2015) · 생약학회지 · Cited by 1 · see citing works

Recent advances and limitations of mTOR inhibitors in the treatment of cancer

Ali, E. S., Mitra, K., Akter, S., Ramproshad, S., Mondal, B., Khan, I. N., Islam, M. T., Sharifi‐Rad, J., Călina, D. C., & Cho, W. C. S. (2022) · Cancer Cell International · doi:10.1186/s12935-022-02706-8 · Cited by 213 · see citing works

Multi-Target Mechanisms of Phytochemicals in Alzheimer’s Disease: Effects on Oxidative Stress, Neuroinflammation and Protein Aggregation

Sharifi-Rad, J., Rapposelli, S., Sestito, S., Herrera-Bravo, J., Arancibia-Diaz, A., Salazar, L. A., Yeskaliyeva, B., Beyatli, A., Leyva-Gómez, G., González-Contreras, C., et al. (2022) · Journal of Personalized Medicine · doi:10.3390/jpm12091515 · Cited by 125 · see citing works

Phenolic compounds as Nrf2 inhibitors: potential applications in cancer therapy

Sharifi‐Rad, J., Seidel, V., Izabela, M., Monserrat-Mesquida, M., Sureda, A., Ormazábal, V., Zuñiga, F. A., Shetty, M. S., Pezzani, R., Ydyrys, A., et al. (2023) · Cell Communication and Signaling · doi:10.1186/s12964-023-01109-0 · Cited by 105 · see citing works

Artemisia spp.: An Update on Its Chemical Composition, Pharmacological and Toxicological Profiles

Sharifi‐Rad, J., Herrera‐Bravo, J., Semwal, P., Painuli, S., Badoni, H., Ezzat, S. M., Farid, M. M., Merghany, R. M., Aborehab, N. M., Salem, M. A., et al. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/5628601 · Cited by 101 · see citing works

Recent advances in the therapeutic potential of emodin for human health

Sharifi‐Rad, J., Herrera‐Bravo, J., Kamiloğlu, S., Petroni, K., Mishra, A. P., Monserrat-Mesquida, M., Sureda, A., Martorell, M., Dossymbetova, S., Yessimsiitova, Z. B., et al. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113555 · Cited by 100 · see citing works

Anticancer Potential and Other Pharmacological Properties of Prunus armeniaca L.: An Updated Overview

Kitic, D., Miladinovic, B., Randjelovic, M., Szopa, A., Sharifi-Rad, J., Calina, D., & Seidel, V. (2022) · Plants · doi:10.3390/plants11141885 · Cited by 96 · see citing works

Recent updates on anticancer mechanisms of polyphenols

Sharma, E., Attri, D. C., Sati, P., Dhyani, P., Szopa, A., Sharifi‐Rad, J., Hano, C., Călina, D. C., & Cho, W. C. S. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.1005910 · Cited by 96 · see citing works

Myricetin: Targeting signaling networks in cancer and its implication in chemotherapy

Javed, Z., Khan, K., Herrera-Bravo, J., Naeem, S., Iqbal, M. J., Raza, Q., Sadia, H., Raza, S., Bhinder, M., Calina, D., et al. (2022) · Cancer Cell International · doi:10.1186/s12935-022-02663-2 · Cited by 93 · see citing works

Sesquiterpenoid lactones as potential anti-cancer agents: an update on molecular mechanisms and recent studies

Dhyani, P., Sati, P., Sharma, E., Attri, D. C., Bahukhandi, A., Tynybekov, B., Szopa, A., Sharifi‐Rad, J., Călina, D. C., Suleria, H. A. R., et al. (2022) · Cancer Cell International · doi:10.1186/s12935-022-02721-9 · Cited by 76 · see citing works

Camellia sinensis: Insights on its molecular mechanisms of action towards nutraceutical, anticancer potential and other therapeutic applications

Chaudhary, P., Mitra, D., MOHAPATRA, P. K. D., Docea, A. O., Myo, E. M., Janmeda, P., Martorell, M., Iriti, M., Ibrayeva, M., Sharifi‐Rad, J., et al. (2023) · Arabian Journal of Chemistry · doi:10.1016/j.arabjc.2023.104680 · Cited by 60 · see citing works

Targeting Ras-ERK cascade by bioactive natural products for potential treatment of cancer: an updated overview

Ali, E. S., Akter, S., Ramproshad, S., Mondal, B., Riaz, T. A., Islam, M. T., Khan, I. N., Docea, A. O., Călina, D. C., Sharifi‐Rad, J., et al. (2022) · Cancer Cell International · doi:10.1186/s12935-022-02666-z · Cited by 48 · see citing works

<i>Santalum</i> Genus: phytochemical constituents, biological activities and health promoting-effects

Sharifi-Rad, J., Quispe, C., Turgumbayeva, A., Mertdinç, Z., Tütüncü, S., Aydar, E. F., Özçelik, B., Anna, S.-W., Mariola, S., Koziróg, A., et al. (2023) · Zeitschrift für Naturforschung C · doi:10.1515/znc-2022-0076 · Cited by 39 · see citing works

Diosgenin alleviates alcohol-mediated escalation of social defeat stress and the neurobiological sequalae

Ben‐Azu, B., Moke, E. G., Chris-Ozoko, L. E., Jaiyeoba-Ojigho, E. J., Adebayo, O. G., Ajayi, A. M., Oyovwi, M. O., Odjugo, G., Omozojie, V. I., Ejomafuwe, G., et al. (2024) · Psychopharmacology · doi:10.1007/s00213-023-06509-1 · Cited by 38 · see citing works

Natural essential oils as a new therapeutic tool in colorectal cancer

Garzoli, S., Alarcón, P., Seitimova, G. A., Alarcón-Zapata, B., Martorell, M., Sharopov, F. S., Fokou, P. V. T., Dize, D., Yamthé, L. R. T., Les, F., et al. (2022) · Cancer Cell International · doi:10.1186/s12935-022-02806-5 · Cited by 38 · see citing works

Anti-Neuroinflammatory Potential of Natural Products in the Treatment of Alzheimer’s Disease

Deng, M., Yan, W., Gu, Z., Li, Y., Chen, L., & He, B. (2023) · Molecules · doi:10.3390/molecules28031486 · Cited by 34 · see citing works

Epigallocatechin gallate and curcumin inhibit Bcl-2: a pharmacophore and docking based approach against cancer

Bahadar, N., Bahadar, S., Sajid, A., Wahid, M., Ali, G., Alghamdi, A., Zada, H., Khan, T., Ullah, S., & Sun, Q. (2024) · Breast Cancer Research · doi:10.1186/s13058-024-01868-9 · Cited by 31 · see citing works

Nanomaterials for delivery of medicinal plant extracts and phytochemicals: Potential applications and future perspectives

Ghosh, S., Solanki, R., Bhatia, D. D., & Sankaranarayanan, S. (2025) · Plant Nano Biology · doi:10.1016/j.plana.2025.100161 · Cited by 33 · see citing works

Cytotoxic and Antioxidant Properties of Natural Bioactive Monoterpenes Nerol, Estragole, and 3,7-Dimethyl-1-Octanol

Coêlho, M. L., Islam, M. T., Oliveira, G. L. D. S., de Alencar, M. V. O. B., Santos, J. V. D. O., dos Reis, A. C., da Mata, A. M. O. F., Paz, M. F. C. J., Docea, A. O., Călina, D. C., et al. (2022) · Advances in Pharmacological and Pharmaceutical Sciences · doi:10.1155/2022/8002766 · Cited by 30 · see citing works

Bioactivities of morroniside: A comprehensive review of pharmacological properties and molecular mechanisms

Bhuia, M. S., Chowdhury, R., Ara, I., Mamun, M. M. A., Rouf, R., Khan, M. A., Uddin, S. J., Shakil, M. A. K., Habtemariam, S., Ferdous, J., et al. (2024) · Fitoterapia · doi:10.1016/j.fitote.2024.105896 · Cited by 29 · see citing works

Phytochemicals in regulating PD‐1/PD‐L1 and immune checkpoint blockade therapy

Zhang, Q., Yang, C., Gao, X.-S., Dong, J., & Zhong, C.-Y. (2023) · Phytotherapy Research · doi:10.1002/ptr.8082 · Cited by 26 · see citing works

Assessing Therapeutic Value and Side Effects of Key Botanical Compounds for Optimized Medical Treatments

Al‐Shuhaib, M. B. S., & Al‐Shuhaib, J. M. B. (2024) · Chemistry & Biodiversity · doi:10.1002/cbdv.202401754 · Cited by 29 · see citing works

Exploring the potential of diosgenin as a promising antitumor agent through comprehensive spectroscopic characterization, solvent–solute interactions, topological properties, Hirshfeld surface, and molecular docking interactions with 2NZT and 2I1V proteins

Kumar, A. R., Selvaraj, S., Vickram, A. S., Mol, G. P. S., Awasthi, S., Thirunavukkarasu, M., Selvaraj, M., & Basumatary, S. (2024) · Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy · doi:10.1016/j.saa.2024.125349 · Cited by 27 · see citing works

Anti-angiogenic potential of bioactive phytochemicals from Helicteres isora targeting VEGFR-2 to fight cancer through molecular docking and molecular dynamics simulation

Rahman, M. O., & Ahmed, S. S. (2022) · Journal of Biomolecular Structure and Dynamics · doi:10.1080/07391102.2022.2122568 · Cited by 27 · see citing works

A comprehensive review on traditional uses, phytochemistry and pharmacological properties of Paeonia emodi Wall. ex Royle: current landscape and future perspectives

Zahra, N., Iqbal, J., Arif, M., Abbasi, B. A., Sher, H., Nawaz, A. F., Yaseen, T., Ydyrys, A., Sharifi‐Rad, J., & Călina, D. C. (2023) · Chinese Medicine · doi:10.1186/s13020-023-00727-7 · Cited by 26 · see citing works

Therapeutic Approaches in Pancreatic Cancer: Recent Updates

Kumar, L., Kumar, S., Sandeep, K., & Patel, S. K. S. (2023) · Biomedicines · doi:10.3390/biomedicines11061611 · Cited by 25 · see citing works

Fenugreek derived diosgenin as an emerging source for diabetic therapy

Tak, Y., Kaur, M., Chitranashi, A., Samota, M. K., Verma, P., Bali, M., & Kumawat, C. (2024) · Frontiers in Nutrition · doi:10.3389/fnut.2024.1280100 · Cited by 25 · see citing works

Key oncologic pathways inhibited by Erinacine A: A perspective for its development as an anticancer molecule

Prasher, P., Sharma, M., Sharma, A. K., Sharifi‐Rad, J., Călina, D. C., Hano, C., & Cho, W. C. S. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.114332 · Cited by 23 · see citing works

Diosgenin alters LPS-induced macrophage polarization by activating PPARγ/NF-κB signaling pathway

Xiang, X., Xin, X., Hou, Y., Deng, Y. L., Liu, X., & Yu, W. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.111270 · Cited by 23 · see citing works

Containment of neuroimmune challenge by diosgenin confers amelioration of neurochemical and neurotrophic dysfunctions in ketamine-induced schizophrenia in mice

Ben‐Azu, B., Adebayo, O. G., Fokoua, A. R., Onuelu, J. E., Asiwe, J. N., Moke, E. G., Omogbiya, I. A., Okpara, O. L., Okoro, J. E., Oghenevwerutevwe, O. M., et al. (2024) · Brain Disorders · doi:10.1016/j.dscb.2024.100122 · Cited by 23 · see citing works

Anti-Aging Potential of Bioactive Phytoconstituents Found in Edible Medicinal Plants: A Review

Iweala, E., Adurosakin, O. E., Ugochukwu, I., Omonhinmin, C. A., Dania, O. E., & Ugbogu, E. A. (2024) · Sci · doi:10.3390/sci6020036 · Cited by 21 · see citing works

Dietary Supplements for Erectile Dysfunction: Analysis of Marketed Products, Systematic Review, Meta-Analysis and Rational Use

Petre, G. C., Francini‐Pesenti, F., Vitagliano, A., Grande, G., Ferlin, A., & Garolla, A. (2023) · Nutrients · doi:10.3390/nu15173677 · Cited by 21 · see citing works

Evaluation of chitosan/diosgenin-infused manganese dioxide nanocomposite for highly effective photocatalytic and antibacterial activity

Raj, C. K., Siranjeevi, R., Susmitha, R., Shabnum, S. S., Nivetha, P., Benazir, K., Saravanan, A., & Vickram, A. S. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.139380 · Cited by 21 · see citing works

Adaptogenic action of diosgenin againsts chronic unpredictable mild stress-induced neuroimmune dysfunction of HPA axis reverses psychiatric behavior in mice

Ben‐Azu, B., Chidebe, E. O., Toloyai, P.-E. Y., Annafi, O. S., Oritsemuelebi, B., Asiwe, J. N., Moke, E. G., Ajayi, A. M., Chukwuebuka, N. B., Onuelu, J. E., et al. (2024) · Clinical Traditional Medicine and Pharmacology · doi:10.1016/j.ctmp.2024.200148 · Cited by 20 · see citing works

Plant based steroidal and triterpenoid sapogenins: Chemistry on diosgenin and biological aspects

Pathak, N., & Negi, A. S. (2024) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2024.116915 · Cited by 20 · see citing works

Diosgenin Exerts Analgesic Effects by Antagonizing the Selective Inhibition of Transient Receptor Potential Vanilloid 1 in a Mouse Model of Neuropathic Pain

Rahman, M. M., Jo, H. J., Park, C., & Kim, Y. H. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232415854 · Cited by 20 · see citing works

Diosgenin normalization of disrupted behavioral and central neurochemical activity after single prolonged stress

Malik, H., Usman, M., Arif, M., Ahmed, Z. S., Ali, G., Rauf, K., & Sewell, R. D. E. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1232088 · Cited by 20 · see citing works

Antioxidants from different citrus peels provide protection against cancer

ALaqeel, N. K. (2023) · Brazilian Journal of Biology · doi:10.1590/1519-6984.271619 · Cited by 19 · see citing works

Gut microbiota modification by diosgenin mediates antiepileptic effects in a mouse model of epilepsy

Li, X., Li, J., Ji, J., Li, S., Yao, X., Fan, H., & Yao, R. (2023) · Journal of Neurochemistry · doi:10.1111/jnc.16033 · Cited by 19 · see citing works

Diosgenin as a substitute for cholesterol alleviates NAFLD by affecting CYP7A1 and NPC1L1-related pathway

Yan, M., Zhao, Y., Man, S., Dai, Y., Ma, L., & Gao, W. (2024) · Phytomedicine · doi:10.1016/j.phymed.2023.155299 · Cited by 19 · see citing works

Recent advances in phytosomes for the safe management of cancer

Singh, A., Srivastav, S., Singh, M. P., Singh, R., Kumar, P., & Kush, P. (2024) · Phytomedicine Plus · doi:10.1016/j.phyplu.2024.100540 · Cited by 19 · see citing works

Diosgenin-Conjugated Zinc Oxide Nanoparticles: A Sustainable Approach to Counter Antibiotic-Induced Oxidative Stress in the Aquatic Environment Using the in vivo Zebrafish Larvae Model (Danio rerio)

Issac, P. K., Santhi, J. J., Janarthanam, V. A., & Velumani, K. (2024) · BioNanoScience · doi:10.1007/s12668-024-01383-3 · Cited by 19 · see citing works

Multidimensional Chromatography and Its Applications in Food Products, Biological Samples and Toxin Products: A Comprehensive Review

Amin, R., Alam, F., Dey, B. K., Mandhadi, J. R., Emran, T. B., Khandaker, M. U., & Safi, S. Z. (2022) · Separations · doi:10.3390/separations9110326 · Cited by 16 · see citing works

Dietary phytoestrogen diosgenin interrupts metabolism, physiology, and reproduction of Swiss albino mice: Possible mode of action as an emerging environmental contaminant, endocrine disruptor and reproductive toxicant

Khushboo, M., Sanjeev, S., Murthy, M. K., Sunitadevi, M., Dinata, R., Bhanushree, B., Bidanchi, R. M., Nisa, N., Lalrinzuali, S., Manikandan, B., et al. (2023) · Food and Chemical Toxicology · doi:10.1016/j.fct.2023.113798 · Cited by 14 · see citing works

Advances in Alzheimer’s disease therapeutics: biochemistry, exploring bioactive compounds and novel approaches

Atoki, A. V., Aja, P. M., Ondari, E. N., & Shinkafi, T. S. (2023) · International Journal of Food Properties · doi:10.1080/10942912.2023.2243050 · Cited by 19 · see citing works

Role of diosgenin extracted from Helicteres isora L in suppression of HIV-1 replication: An in vitro preclinical study

Rakshit, S., More, A. N., Gaikwad, S., Seniya, C., Gade, A., Muley, V. Y., Mukherjee, A., & Kamble, K. D. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e24350 · Cited by 14 · see citing works

Correlation between Molecular Docking and the Stabilizing Interaction of HOMO-LUMO: Spirostans in CHK1 and CHK2, an In Silico Cancer Approach

Rosales-López, A., López-Castillo, G. N., Sandoval-Ramı́rez, J., Terán, J. L., & Carrasco‐Carballo, A. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25168588 · Cited by 14 · see citing works

The microbiota-gut-brain axis: a potential target in the small-molecule compounds and gene therapeutic strategies for Parkinson’s disease

Jiao, F., Zhou, L., & Wu, Z. (2024) · Neurological Sciences · doi:10.1007/s10072-024-07878-x · Cited by 13 · see citing works

Rapid and sensitive electrochemical detection of oxidized form of glutathione in whole blood samples using Bi-metallic nanocomposites

Nagabooshanam, S., Kumar, A., Ramamoorthy, S., Saravanan, N., & Sundaramurthy, A. (2023) · Chemosphere · doi:10.1016/j.chemosphere.2023.140517 · Cited by 14 · see citing works

Literature review on hepatoprotective effects of diosgenin: possible mechanisms of action

Moghaddam, P. M., Khanmohammadi, M., & Roghani, M. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1226548 · Cited by 12 · see citing works

The polypharmacology of natural products in drug discovery and development

Choo, M. Z. Y., & Chai, C. L. L. (2023) · Annual reports in medicinal chemistry · doi:10.1016/bs.armc.2023.10.002 · Cited by 12 · see citing works

Historical and ethnopharmacological perspectives on African medicinal plants: From traditional remedies to computational drug discovery

Agu, P. C., Nduneseokwu, N. C., Nwiziogo, F. C., Okafor, M. U., Alum, E. U., Egwu, C. O., Anidu, I. C., Ezinwa, C. A., Ibiam, A. U., & Aja, P. M. (2025) · Scientific African · doi:10.1016/j.sciaf.2025.e02941 · Cited by 15 · see citing works

Solanum nigrum Toxicity and Its Neuroprotective Effect Against Retinal Ganglion Cell Death Through Modulation of Extracellular Matrix in a Glaucoma Rat Model

Yadav, K. S., Bisen, A. C., Ishteyaque, S., Sharma, I., Verma, S., Sanap, S. N., Verma, S., Washimkar, K. R., Kumar, A., Tripathi, V., et al. (2024) · Journal of Ocular Pharmacology and Therapeutics · doi:10.1089/jop.2023.0089 · Cited by 11 · see citing works

Identification of genetic variants controlling diosgenin content in Dioscorea zingiberensis tuber by genome-wide association study

Shi, S. U. N., Li, Y., Jia, L., Ye, S., & Luan, Y. (2024) · BMC Plant Biology · doi:10.1186/s12870-024-05133-1 · Cited by 11 · see citing works

Diosgenin alleviates lipid accumulation in NAFLD through the pathways of ferroptosis defensive and executive system

Wang, L., Yu, H., Wang, D., Yin, G., Chen, S., Zhang, X., Yu, W., Meng, D., Liu, H., Jiang, W., et al. (2025) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2025.109886 · Cited by 11 · see citing works

An overview of the nutritional composition, bioactivities and applications of Chinese yam (Dioscoreas Oppositae)

Edo, G. I., Nwachukwu, S. C., Akpoghelie, P. O., Mafe, A. N., Isoje, E. F., Igbuku, U. A., Yousif, E., Zainulabdeen, K., Jikah, A. N., Owheruo, J. O., et al. (2025) · Ecological Frontiers · doi:10.1016/j.ecofro.2025.02.010 · Cited by 11 · see citing works

Effect of Chitosan-Diosgenin Combination on Wound Healing

Petrov, L., Stoilova, O., Pramatarov, G., Kanzova, H., Tsvetanova, E. R., Andreeva, M., Georgieva, A. P., Atanasova, D., Philipov, S., & Alexandrova, A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24055049 · Cited by 11 · see citing works

Theranostic Nanoparticles in Prostate Cancer: Disrupting Hypoxia‐Induced Glycolysis by Targeting Hypoxia‐Inducible Factor‐1 Alpha and Downstream Metabolites

Uti, D. E., Omang, W. A., Alum, E. U., Bawa, I., Ugwu, O. P.-C., Idowu, A. O., Atangwho, I. J., & Egbung, G. E. (2026) · Cancer Medicine · doi:10.1002/cam4.71519 · Cited by 10 · see citing works

Construction of an Innovative Nanogel and Its Applications for Achieving Chemo-Immunotherapy of Tumors

Wang, S., Nie, F., Lin, Z. Y., Cao, R., Xu, J., & Guo, Y. (2024) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.4c13445 · Cited by 10 · see citing works

Diosgenin prevents dexamethasone-induced myotube atrophy in C2C12 cells

Yoshioka, Y., Oishi, S., Onoda, K., Shibata, K., & Miyoshi, N. (2023) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2023.109759 · Cited by 10 · see citing works

Diosgenin attenuates metabolic-associated fatty liver disease through the hepatic NLRP3 inflammasome-dependent signaling pathway

Yu, W., Yin, G., Chen, S., Zhang, X., Meng, D., Wang, L., Liu, H., Jiang, W., Sun, Y., & Zhang, F. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.112581 · Cited by 10 · see citing works

Comparative transcriptomic and metabolomic analyses reveal key regulatory gene for methyl jasmonate-induced steroidal saponins synthesis in Dioscorea composita

Yu, S., Zhang, J., Cao, Y., Zhong, C., & Xie, J. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.135788 · Cited by 9 · see citing works

Protective Effects of Dioscin and Diosgenin on Plateau Hyperuricemia by Attenuating Renal Inflammation via EPHX2

Dang, W., Li, F., Gao, R., Zhang, C., Cheng, H., Wu, Z., Yang, T., Pan, J.-C., Tang, X., & Gao, Y. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252413399 · Cited by 8 · see citing works

Steroidal saponins: a treasure trove of natural resources that require urgent development

Sun, Z., Zhong, C., Zhang, H., Liu, Y., Wang, Y., Zhang, C., Cai, C., & Xie, J. (2025) · Phytochemistry Reviews · doi:10.1007/s11101-025-10107-8 · Cited by 8 · see citing works

AI-Driven Multiscale Study on the Mechanism of Polygonati Rhizoma in Regulating Immune Function in STAD

Yang, P., Wang, X., Yang, J., Yan, B., Sheng, H., Li, Y., Yang, Y., & Wang, J. (2025) · ACS Omega · doi:10.1021/acsomega.5c00981 · Cited by 8 · see citing works

Preparation, stability, and in vitro transport of soybean protein-based diosgenin nanoemulsions

Li, G., Liu, Q., Gao, A., Ren, L., Ying-han, Z., Guo, W., He, S., Fengyi, G., & Peng, X. (2023) · Food Chemistry X · doi:10.1016/j.fochx.2023.100982 · Cited by 8 · see citing works

Potential targets of diosgenin for the treatment of oral squamous cell carcinoma and their bioinformatics and transcriptional profiling analyses

Xiao, Y., Xu, B., Li, X., Ding, T., Zhao, W., Nie, X., Mu, J. L., Xiao, Z., Wang, Q., Ren, Q., et al. (2024) · Steroids · doi:10.1016/j.steroids.2024.109393 · Cited by 7 · see citing works

Diosgenin mitigates oxidative stress and inflammation within the hepatorenal system associated with epilepsy and alcohol use disorders in murine models

Chidebe, E. O., Ben‐Azu, B., Oritsemuelebi, B., Moke, E. G., Omogbiya, I. A., & Ezedom, T. (2025) · Phytomedicine Plus · doi:10.1016/j.phyplu.2025.100833 · Cited by 7 · see citing works

The Functional Characterization of DzCYP72A12-4 Related to Diosgenin Biosynthesis and Drought Adaptability in Dioscorea zingiberensis

Wang, W., Hou, L., Li, S., & Li, J. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24098430 · Cited by 7 · see citing works

Telomerase Inhibition in the Treatment of Leukemia: A Comprehensive Review

Bartoszewska, E., Molik, K., Choromańska, A., & Woźniak, M. (2024) · Antioxidants · doi:10.3390/antiox13040427 · Cited by 8 · see citing works

Spectroscopic, DFT and molecular docking studies of novel diosgenin NSAID conjugates and their in vitro evaluation as potential anti-cancer agents against SiHa cells

Verma, A., Rawat, P., Yadav, A., Parveen, S., Singh, A., Singh, R. P., Banerjee, M., Sethi, A., & Singh, S. K. (2024) · Journal of Molecular Structure · doi:10.1016/j.molstruc.2024.140086 · Cited by 7 · see citing works

Herbal Remedies for Hepatic Inflammation: Unravelling Pathways and Mechanisms for Therapeutic Intervention

Saraswat, I., & Goel, A. (2024) · Current Pharmaceutical Design · doi:10.2174/0113816128348771240925100639 · Cited by 7 · see citing works

Diosgenin loaded-chitosan biodegradable nanoparticles ameliorate adjuvant-induced arthritis, pain, and peripheral neuropathy through moderation of inflammatory and oxidative stress biomarkers

Tahir, M., Saleem, A., & Akhtar, M. F. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.138926 · Cited by 7 · see citing works

Neuroprotective effect of curcumin and curcumin-integrated nanocarriers in stroke: from mechanisms to therapeutic opportunities

Sharifi‐Rad, J., Almarhoon, Z. M., Adetunji, C. O., Michael, O. S., Chandran, D., Radha, R., Sharma, N., Kumar, M., & Călina, D. C. (2022) · Minerva Biotechnology and Biomolecular Research · doi:10.23736/s2724-542x.22.02946-7 · Cited by 7 · see citing works

Regulation of cytokinesis and necroptosis pathways by diosgenin inhibits the proliferation of NCI-H460 lung cancer cells

da Silva, M. F., de Lima, L. V. A., de Oliveira, L. M., Semprebon, S. C., Silva, N. D. O., de Aguiar, A. P., & Mantovani, M. S. (2023) · Life Sciences · doi:10.1016/j.lfs.2023.122033 · Cited by 6 · see citing works

Paris polyphylla Sm. extract enriched with diosgenin as an antidiabetic agent: In vitro and in vivo study

Kshetrimayum, V., Chanu, K. D., Ghosh, S., Haldar, P. K., Mukherjee, P. K., & Sharma, N. (2023) · Phytomedicine Plus · doi:10.1016/j.phyplu.2023.100497 · Cited by 6 · see citing works

Safety of Innovative Nanotechnology Oral Formulations Loaded with Bioactive Menopause Molecules: Influence of Genotoxicity and Biochemical Parameters on a Menopausal Rat Model

Crișan, S., Pop, A. L., Lăcătuşu, I., Badea, N. M., Mustăciosu, C. C., Radu, M., Varlas, V. N., Peneş, O. N., Ciobanu, A. M., Ghica, M., et al. (2023) · Nutrients · doi:10.3390/nu15234951 · Cited by 6 · see citing works

Exploring the therapeutic potential of dioscin and diosgenin in neurological disorders

Biswas, S., Patil, P., Ranjan, S., & Gautam, A. (2024) · Brain Behavior and Immunity Integrative · doi:10.1016/j.bbii.2024.100069 · Cited by 6 · see citing works

Insight into the Course of the Ferrier Rearrangement Used to Obtain Untypical Diosgenyl Saponins

Detlaff, G., Zdrowowicz, M., Paduszynska, M. A., Datta, M., Grzywacz, D., Kamysz, W., Rak, J., Nowacki, A., Myszka, H., & Liberek, B. (2024) · The Journal of Organic Chemistry · doi:10.1021/acs.joc.4c01756 · Cited by 6 · see citing works

Characterization and Biological Activities of Four Biotransformation Products of Diosgenin from Rhodococcus erythropolis

Li, Y., Zhang, C., Kong, K., & Yan, X. (2023) · Molecules · doi:10.3390/molecules28073093 · Cited by 6 · see citing works

Integrative Approach to Identifying System-Level Mechanisms of Chung-Sang-Bo-Ha-Hwan’s Influence on Respiratory Tract Diseases: A Network Pharmacological Analysis with Experimental Validation

Park, S.-Y., Kim, K.-S., Lee, W.-Y., Kim, C.-E., & Lee, S. (2023) · Plants · doi:10.3390/plants12173024 · Cited by 6 · see citing works

Phytofabricated ZnO-NPs mediated by Hibiscus tiliaceus leaf extract and its potential as a diosgenin delivery vehicle

Putri, O. K., Rahayu, L. O., Kusumawati, Y., Fadlan, A., Subagyo, R., & Santoso, M. (2024) · RSC Advances · doi:10.1039/d4ra03249g · Cited by 5 · see citing works

Polygonum cuspidatum Loaded Nanostructured Lipid Carriers for Dual Inhibition of TNF-α- and IL-6 Cytokines and Free Radical Species

Iordache, T.-A., Badea, N. M., Mihaila, M. A., Crișan, S., Pop, A. L., & Lăcătuşu, I. (2023) · Materials · doi:10.3390/ma16093492 · Cited by 5 · see citing works

NMR Studies on the Structure and Functions of Small Biomolecules with Highly Flexible Conformation

Murata, M., Umegawa, Y., & Hanashima, S. (2023) · Bulletin of the Chemical Society of Japan · doi:10.1246/bcsj.20230166 · Cited by 5 · see citing works

In vitro Evaluation of Fungal Susceptibility and Inhibition of Virulence by Diosgenin

Costa, M. D. S., Silva, A. R., Araújo, J. S., Santos, A., Fonseca, V. J. A., Alencar, G. G., Moura, T. F., Gonçalves, S. A., Barbosa‐Filho, J. M., Morais‐Braga, M. F. B., et al. (2024) · Chemistry & Biodiversity · doi:10.1002/cbdv.202400444 · Cited by 5 · see citing works

The neuroprotective effect of Diosgenin in the rat Valproic acid model of autism

naghdi, M. R., Ahadi, R., Nezhad, A. M., Tabatabaei, F. S. A., Soleimani, M., & Hajisoltani, R. (2024) · Brain Research · doi:10.1016/j.brainres.2024.148963 · Cited by 5 · see citing works

A review of natural products and small‐molecule therapeutics acting on central nervous system malignancies: Approaches for drug development, targeting pathways, clinical trials, and challenges

Pasdaran, A., Grice, I. D., & Hamedi, A. (2024) · Drug development research (Print) · doi:10.1002/ddr.22180 · Cited by 5 · see citing works

Exploring the Pharmacodynamic and Molecular Interactions of Diosgenin as a Multitarget Therapeutic Agent in Breast and Ovarian Cancer Pathways

Ullah, T. N., Tag, H., & Hui, P. K. (2025) · Peptide Science · doi:10.1002/pep2.70009 · Cited by 4 · see citing works

Diosgenin-based nanomedicine: Advances in formulation strategies, biomedical applications, and translational challenges

Amini, S. M. (2025) · Nano-Structures & Nano-Objects · doi:10.1016/j.nanoso.2025.101556 · Cited by 4 · see citing works

Shatavari (Asparagus racemosus): A Promising Ally for Fertility

Oyovwi, M. O., Agbonifo‐Chijiokwu, E., Ben‐Azu, B., Ugwuishi, E. W., & Jeroh, E. (2025) · Current Nutrition Reports · doi:10.1007/s13668-025-00694-5 · Cited by 4 · see citing works

Diosgenin ameliorates colitis by inhibiting mitochondrial DNA synthesis in macrophages via STAT2-CMPK2 pathway

Qiao, X., Zhang, L., Wang, T., Liang, X., Yao, S., Wang, L., Ma, G., Yang, J., & Wen, X. (2025) · Phytomedicine · doi:10.1016/j.phymed.2025.157605 · Cited by 4 · see citing works

Harnessing Endophytic Fungi as a Sustainable Source of Novel Anticancer Agents: Opportunities, Challenges, and Future Directions

Lowen, E., Moulton, S. E., Palombo, E. A., Kwa, F. A. A., & Zaferanloo, B. (2026) · Molecules · doi:10.3390/molecules31040693 · Cited by 4 · see citing works

Solanum incanum L.: an updated review of botany, traditional uses, phytochemistry, and pharmacology

Rani, A., Singh, J., Pawar, S., Jangra, A., & Kumar, D. (2025) · Discover Applied Sciences · doi:10.1007/s42452-025-06646-6 · Cited by 3 · see citing works

Functional characterization of a novel β-glucosidase converting trillin to diosgenin from Enterococcus faecalis

Zhou, C., Zhu, M., Li, Q., Deng, W., Sun, N., Liu, W., Li, Y., Wang, X., Zhang, F., Li, L., et al. (2026) · Microbial Cell Factories · doi:10.1186/s12934-025-02910-x · Cited by 3 · see citing works

Ethnomedicinal and traditional application of Allium wallichii Kunth (Himalayan Onion): An unexplored and underutilized nutraceutical plant foods from Himalayan regions.

Rana, V. S., Sethiya, N. K., Duseja, M., Gupta, R., Bisht, D., & Gangal, A. (2022) · Ethnobotany Research and Applications · doi:10.32859/era.24.15.1-16 · Cited by 3 · see citing works

Diosgenin intervention: targeting lipophagy to counter high glucose diet-induced lipid accumulation and lifespan reduction

Thiruppathi, G., Mohankumar, A., Shanmugam, G., Duraisamy, K., Cho, J. H., Tawata, S., Bhavan, P. S., & Sundararaj, P. (2024) · 3 Biotech · doi:10.1007/s13205-024-04017-3 · Cited by 3 · see citing works

Modulating the gut microbiota and inflammation is involved in the effect of diosgenin against diabetic nephropathy in rat

Shanshan, J., Shu, P., Xiao, H., Kuerban, K., Zhu, H., Yujie, W., Wang, R., Yuhuan, S., & Yong-fang, Y. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1555849 · Cited by 3 · see citing works

Hormonal contraception, past, present, and future part 1: the early path – facts, stories, and controversies

Farris, M., Bastianelli, C., Habiba, M. A., & Benagiano, G. (2025) · Expert Review of Clinical Pharmacology · doi:10.1080/17512433.2025.2517748 · Cited by 3 · see citing works

Inhibition of (p)ppGpp Synthesis and Membrane Fluidity Modulation by Diosgenin: A Strategy to Suppress Staphylococcus aureus Persister Cells

Seo, Y., Kim, M., & Kim, T. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26136335 · Cited by 3 · see citing works

Antihypertensive potential of diosgenin: A comparative pharmacoinformatics study

Chahal, S., Debnath, A., Kumari, R., Ridhal, P., Sahoo, R. K., Biswal, B. K., Mishra, A., & Siwach, P. (2025) · Computers in Biology and Medicine · doi:10.1016/j.compbiomed.2025.110911 · Cited by 3 · see citing works

A review on pharmacological and analytical aspects of diosgenin: a concise report

Patel, K., Gadewar, M. M., Tahilyani, V., & Patel, D. K. (2012) · Natural Products and Bioprospecting · doi:10.1007/s13659-012-0014-3 · Cited by 144 · see citing works

Recent advances of diosgenin in its pharmacologic activities and mechanism

Bo-yang, Y. (2010) · Zhongguo linchuang yaolixue yu zhiliaoxue · Cited by 5 · see citing works

Review Nat. Prod. Bioprospect. 2012, 2, 46–52 DOI 10.1007/s13659-012-0014-3

(2016)

Pharmacological and Therapeutic Aspects of Diosgenin: A Prospects for Its Pharmaceutical Development

Vengaimaran, M., Dhamodharan, K., & Mirunalini, S. (2022) · Book Publisher International (a part of SCIENCEDOMAIN International) · doi:10.9734/bpi/nvbs/v9/1734b

Diosgenin: Therapeutic Action, Pharmacology and Applications

Sanjeev, S., Devi, M. S., Khushboo, M., Roy, V. K., & Gurusubramanian, G. (2017) · Science & Technology Journal · doi:10.22232/stj.2017.05.01.01