The Involvement of Mg2+ in Regulation of Cellular and Mitochondrial Functions
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Mg2+ is an essential mineral with pleotropic impacts on cellular physiology and functions. It acts as a cofactor of several important enzymes, as a regulator of ion channels such as voltage‐dependent Ca2+ channels and K+ channels and on Ca2+‐binding proteins. In general, Mg2+ is considered as the main intracellular antagonist of Ca2+, which is an essential secondary messenger initiating or regulating a great number of cellular functions. This review examines the effects of Mg2+ on mitochondrial functions with a particular focus on energy metabolism, mitochondrial Ca2+ handling, and apoptosis.
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Magnesium has a predominant role in the production and utilization of ATP.
“Magnesium has a predominant role in the production and utilization of ATP.”
From Vitamins and Minerals for Energy, Fatigue and Cognition: A Narrative Review of the Biochemical and Clinical Evidence (2020) · cites this paper as [55]
Each molecule of ATP binds to a magnesium ion to compose its biologically functional form; in the cell, most of the ATP is present as Mg-ATP complexes.
“Indeed, each molecule of ATP binds to a magnesium ion (Mg2 +) to compose its biologically functional form: in the cell, most of the ATP is present as Mg-ATP complexes.”
From Vitamins and Minerals for Energy, Fatigue and Cognition: A Narrative Review of the Biochemical and Clinical Evidence (2020) · cites this paper as [55]
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- Authors
- Pilchova, I., Klacanova, K., Tatarkova, Z., Kaplan, P., & Racay, P.
- Affiliations
- Comenius University Bratislava (SK)
- ORCID
- Racay, Peter
- Venue
- Oxidative Medicine and Cellular Longevity
- Publisher
- Wiley
- Published
- 2017-01
- Volume
- 2017
- Issue
- 1
- Pages
- 6797460-6797460
- ISSN
- 1942-0994 (ISSN-L)
- 1942-0900
- PMC
- PMC5516748
- OpenAlex
- W2732080466
- Cited by
- 198
- References
- 103
- Citations by year
- 2026: 29 · 2025: 35 · 2024: 28 · 2023: 24 · 2022: 26 · 2021: 17 · 2020: 21 · 2019: 15 · 2018: 3
- FWCI
- 1.10
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Oxidative Medicine and Cellular Longevity (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- European Regional Development Fund
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Magnesium in Health and Disease
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Physical Sciences › Materials Science › Biomaterials › Magnesium Alloys: Properties and Applications
- Keywords
- magnesium, mitochondrial function, mitochondrial bioenergetics, mitochondrial calcium handling, apoptosis, enzyme cofactors, ion channels, calcium signaling, intracellular calcium
- MeSH terms
- Animals, Energy Metabolism, Humans, Magnesium, Mitochondria, Calcium Channels, Potassium Channels, Apoptosis, Mitochondrial Proteins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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