The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Mesenchymal Stem Cell-Based Immunomodulation: Properties and Clinical Application
Open accessAbstract
Mesenchymal stem cells (MSCs) are multipotent stem cells characterized by self-renewal, production of clonal cell populations, and multilineage differentiation. They exist in nearly all tissues and play a significant role in tissue repair and regeneration. Additionally, MSCs possess wide immunoregulatory properties via interaction with immune cells in both innate and adaptive immune systems, leading to immunosuppression of various effector functions. Numerous bioactive molecules secreted by MSCs, particularly cytokines, growth factors, and chemokines, exert autocrine/paracrine effects that modulate the physiological processes of MSCs. These invaluable virtues of MSCs provide new insight into potential treatments for tissue damage and inflammation. In particular, their extensive immunosuppressive properties are being explored for promising therapeutic application in immune disorders. Recently, clinical trials for MSC-mediated therapies have rapidly developed for immune-related diseases following reports from preclinical studies declaring their therapeutic safety and efficacy. Though immunotherapy of MSCs remains controversial, these clinical trials pave the way for their widespread therapeutic application in immune-based diseases. In this review, we will summarize and update the latest research findings and clinical trials on MSC-based immunomodulation.
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Cites
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Recent Updates of Diagnosis, Pathophysiology, and Treatment on Osteoarthritis of the Knee
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Aspects of the Tumor Microenvironment Involved in Immune Resistance and Drug Resistance
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Mesenchymal stromal cell therapies: immunomodulatory properties and clinical progress
Wu, X., Jiang, J., Gu, Z., Zhang, J., Chen, Y., & Liu, X. (2020) · Stem Cell Research & Therapy · doi:10.1186/s13287-020-01855-9 · Cited by 343
Xiang, E., Han, B., Zhang, Q., Rao, W., Wang, Z., Chang, C., Zhang, Y., Tu, C., Li, C., & Wu, D. (2020) · Stem Cell Research & Therapy · doi:10.1186/s13287-020-01852-y · Cited by 331
Dental Pulp Stem Cell-Derived Secretome and Its Regenerative Potential
Bar, J. K., Lis-Nawara, A., & Grelewski, P. G. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222112018 · Cited by 142
Metadata
- Authors
- Wang, M., Yuan, Q., & Xie, L.
- Venue
- Stem Cells International
- Publisher
- Wiley
- Published
- 2018-06-14
- Volume
- 2018
- Pages
- 1-12
- ISSN
- 1687-966X (ISSN-L)
- 1687-9678
- OpenAlex
- W2808355836
- Cited by
- 505
- References
- 12
- FWCI
- 31.41
- Type
- journal article
- Language
- en
- Open access
- gold
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