The DOI matches its Crossref record.
A 3D-Printed PLCL Scaffold Coated with Collagen Type I and Its Biocompatibility
Open accessAbstract
Scaffolds play an important role in tissue engineering and their structure and biocompatibility have great influence on cell behaviors. In this study, poly(l-lactide-co- ε -caprolactone) (PLCL) scaffolds were printed by a 3D printing technology, low-temperature deposition manufacturing (LDM), and then PLCL scaffolds were treated by alkali and coated with collagen type I (COLI). The scaffolds were characterized by scanning electron microscopy (SEM), porosity test, mechanical test, and infrared spectroscopy. The prepared PLCL and PLCL-COLI scaffolds had three-dimensional (3D) porous structure and they not only have macropores but also have micropores in the deposited lines. Although the mechanical property of PLCL-COLI was slightly lower than that of PLCL scaffold, the hydrophilicity of PLCL-COLI was significantly enhanced. Rabbit articular chondrocytes were extracted and were identified as chondrocytes by toluidine blue staining. To study the biocompatibility, the chondrocytes were seeded on scaffolds for 1, 3, 5, 7, and 10 days. MTT assay showed that the proliferation of chondrocytes on PLCL-COLI scaffold was better than that on PLCL scaffold. And the morphology of cells on PLCL-COLI after 1-day culture was much better than that on PLCL. This 3D-printed PLCL scaffold coated with COLI shows a great potential application in tissue engineering.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
PLCL porous scaffolds prepared via LTD printing have surfaces containing a microporous structure with a size range of 6.9-12.1 μm.
“The SEM images of the scaffolds show that their surfaces contain a microporous structure with a size range of 6.9–12.1 μm [108].”
From Application of PLCL as a biodegradable polymer in biomedical engineering (2026) · cites this paper as [108]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
No references could be resolved yet.
Research works printed but not linked: 39
- 10.1002/mabi.201500014 · DOI
- 2010, Journal of Bone and Joint Surgery American Volume, 92, 2220, 10.2106/JBJS.J.00049 · DOI
- 10.1177/1602400214 · DOI
- 10.1097/JSA.0000000000000115 · DOI
- 10.1016/j.addr.2007.08.027 · DOI · Paper page
- 10.1177/0885328216638587 · DOI
- 10.1089/ten.teb.2012.0437 · DOI · Paper page
- 2008, Manufacturing Technology and Machine Tool, 71
- 10.1002/term.2038 · DOI
- 10.1002/bip.21701 · DOI
- 10.1155/2013/412745 · DOI
- 10.1155/2012/579141 · DOI
- 10.1177/0883911508095517 · DOI
- 10.4028/www.scientific.net/KEM.522.97 · DOI
- 2012, Journal of Xinjiang Medical University, 35, 755
- 10.3724/SP.J.1077.2011.00012 · DOI
- 2006, Journal of Tsinghua University, 46, 1357
- 10.1016/S1359-6462(02)00071-4 · DOI
- 10.1016/S0928-4931(01)00313-7 · DOI
- 10.1016/S0142-9612(02)00067-4 · DOI
- 10.1007/s10856-007-3281-5 · DOI
- 10.1016/j.actbio.2013.10.022 · DOI
- 2017, Journal of Cellular Biochemistry
- 10.2217/rme.13.29 · DOI
- 10.1007/s40883-015-0002-3 · DOI
- 10.1002/(SICI)1097-4636(19981215)42:4<540::AID-JBM9>3.0.CO;2-2 · DOI
- 10.1016/j.jamcollsurg.2015.08.212 · DOI
- 10.1007/s10856-013-5129-5 · DOI
- 10.1089/ten.tec.2009.0422 · DOI
- 10.1016/j.actbio.2006.12.009 · DOI
- 10.1016/j.actbio.2010.11.003 · DOI
- 10.1007/s10616-015-9895-4 · DOI
- 10.1021/la202255w · DOI
- 10.1016/j.colsurfb.2013.08.031 · DOI
- 10.5301/ijao.5000516 · DOI
- 10.1088/1758-5090/8/2/025020 · DOI
- 10.1089/ten.tec.2010.0200 · DOI
- 10.1039/C6BM00068A · DOI
- 10.1080/09205063.2016.1217607 · DOI
Cited by
Sorted by citations
Ebrahimi, Z., Irani, S., Ardeshirylajimi, A., & Seyedjafari, E. (2022) · Scientific Reports · doi:10.1038/s41598-022-15602-y · Cited by 141
de Souza, J. R., Cardoso, L. M., de Toledo, P. T. A., Rahimnejad, M., Kito, L. T., Thim, G. P., Campos, T. M. B., Borges, A. L. S., & Bottino, M. C. (2024) · Journal of Biomedical Materials Research Part B: Applied Biomaterials · doi:10.1002/jbm.b.35406 · Cited by 30
Structure-property relationships in 3D-printed poly(l-lactide-co-ε-caprolactone) degradable polymer
Bachtiar, E. O., Ritter, V. C., & Gall, K. (2021) · Journal of the Mechanical Behavior of Biomedical Materials · doi:10.1016/j.jmbbm.2021.104650 · Cited by 27
Cai, G., Yuan, Z., Wang, X., Wu, S., Zhou, S., Lei, Z., Li, P., EL-Newehy, M., Moydeen Abdulhameed, M., Shafiq, M., et al. (2024) · Chemical Engineering Journal · doi:10.1016/j.cej.2024.156555 · Cited by 13
Teng, Y., Wang, X., Song, L., Yang, J., Hou, S., Lv, Q., Jiang, L., Guan, Y., & Shi, J. (2025) · Biomedical Materials · doi:10.1088/1748-605x/adb2ce · Cited by 8
Han, Y., Wang, H., Guan, Y., Li, S., Yuan, Z., Lu, L., & Zheng, X. (2024) · Biomedical Materials · doi:10.1088/1748-605x/ad407c · Cited by 7
Application of PLCL as a biodegradable polymer in biomedical engineering
Zhao, Y., & Liu, H. (2026) · Journal of Materials Science Materials in Medicine · doi:10.1007/s10856-026-07016-3 · Cited by 7
Metadata
- Authors
- He, Y., Liu, W., Guan, L., Chen, J., Duan, L., Jia, Z., Huang, J., Li, W., Liu, J., Xiong, J., Liu, L., & Wang, D.
- Affiliations
- Shenzhen University (CN)
- Department of Orthopedics, People’s Hospital of Yangjiang, Yangjiang, Guangdong 529500, China
- Department of Orthopedics, The First Hospital Affiliated to Shenzhen University, Shenzhen, Guangdong 518035, China
- Corresponding author
- Wang, Daping
- ORCID
- Venue
- BioMed Research International
- Publisher
- Wiley
- Published
- 2018
- Volume
- 2018
- Pages
- 1-10
- ISSN
- 1110-7243 (ISSN-L)
- 2314-6133
- 2314-6141
- PMC
- PMC5911326
- OpenAlex
- W2789408749
- Cited by
- 63
- References
- 0
- Citations by year
- 2026: 5 · 2025: 4 · 2024: 12 · 2023: 13 · 2022: 12 · 2021: 10 · 2020: 4 · 2019: 3
- FWCI
- 1.51
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- BioMed Research International (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (81572198, JCYJ20160425104858256, 201605006)
- Shenzhen Science and Technology Innovation Committee (81572198, JCYJ20160425104858256, 201605006)
- Shenzhen Municipal Health and Family Planning Commission (81572198, JCYJ20160425104858256, 201605006)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Keywords
- 3D printing, porous scaffolds, hydrophilicity, chondrocyte proliferation, biocompatibility, articular cartilage tissue engineering, porosity, mechanical properties
- MeSH terms
- Animals, Female, Polyesters, Rabbits, Porosity, Spectroscopy, Fourier Transform Infrared, Chondrocytes, Coated Materials, Biocompatible, Collagen Type I, Sus scrofa, Cell Shape, Tissue Scaffolds, Elastic Modulus, Hydrophobic and Hydrophilic Interactions, Optical Imaging, Printing, Three-Dimensional
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
