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Cited by 65Genomics, phytochemicals, and oxidative stressSkin Protection and AgingToxic Organic Pollutants Impact

Perillaldehyde inhibits AHR signaling and activates NRF2 antioxidant pathway in human keratinocytes

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Fuyuno, Yoko, Uchi, Hiroshi, Yasumatsu, Mao, Morino-Koga, Saori, Tanaka, Yuka, Mitoma, Chikage, Furue, Masutaka·2018·Oxidative Medicine and Cellular Longevity
DOI 10.1155/2018/9524657PMC PMC5832143
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Abstract

The skin covers the outer surface of the body, so the epidermal keratinocytes within it are susceptible to reactive oxygen species (ROS) generated by environmental pollutants such as benzo(a)pyrene (BaP), a potent activator of aryl hydrocarbon receptor (AHR). Antioxidant activity is generally mediated by the nuclear factor‐erythroid 2‐related factor‐2 (NRF2) and heme oxygenase‐1 (HO1) axis in human keratinocytes. Perillaldehyde is the main component of Perilla frutescens, which is a medicinal antioxidant herb traditionally consumed in East Asia. However, the effect of perillaldehyde on the AHR/ROS and/or NRF2/HO1 pathways remains unknown. In human keratinocytes, we found that perillaldehyde (1) inhibited BaP‐induced AHR activation and ROS production, (2) inhibited BaP/AHR‐mediated release of the CCL2 chemokine, and (3) activated the NRF2/HO1 antioxidant pathway. Perillaldehyde is thus potentially useful for managing inflammatory skin diseases or disorders related to oxidative stress.

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  • GFF induces nuclear translocation of NRF2 in keratinocytes.

    “In addition to its AHR-stimulating properties, GFF induces nuclear translocation of NRF2 in the cytoplasm (Figure 3) and upregulates the expression of GPX2, NQO1, and HMOX1 [10,56,74,76,77].”

    From Galactomyces Ferment Filtrate Potentiates an Anti-Inflammaging System in Keratinocytes (2022) · cites this paper as [74]

    Results §3.4 reports NRF2 translocation from the cytoplasm into the nucleus in keratinocytes stimulated with PAH (perillaldehyde). It does not report this effect for GFF, the agent named in the claim. No page number is available in our copy. (LLM, conf=0.86)

    Experimental — accuracy not yet measured

  • GFF upregulates the expression of GPX2, NQO1, and HMOX1.

    “In addition to its AHR-stimulating properties, GFF induces nuclear translocation of NRF2 in the cytoplasm (Figure 3) and upregulates the expression of GPX2, NQO1, and HMOX1 [10,56,74,76,77].”

    From Galactomyces Ferment Filtrate Potentiates an Anti-Inflammaging System in Keratinocytes (2022) · cites this paper as [74]

    The Results (section 3.4; page not provided) report that perillaldehyde (PAH) upregulated HO1 expression in human keratinocytes. Our copy does not report an effect of GFF on GPX2, NQO1, or HMOX1; searches for GFF and those genes found no passage addressing the attributed claim. (LLM, conf=0.76)

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Cited by

Sorted by citations

Authors
Fuyuno, Y., Uchi, H., Yasumatsu, M., Morino-Koga, S., Tanaka, Y., Mitoma, C., & Furue, M.
Affiliations
  • Kyushu University (JP)
  • Kyushu University Hospital (JP)
Corresponding author
Fuyuno, Yoko
ORCID
Venue
Oxidative Medicine and Cellular Longevity
Publisher
Wiley
Published
2018-01
Volume
2018
Issue
1
Pages
9524657-9524657
ISSN
  • 1942-0994 (ISSN-L)
  • 1942-0900
DOI
10.1155/2018/9524657
PMC
PMC5832143
OpenAlex
W2792638548
Cited by
65
References
4
Citations by year
2026: 3 · 2025: 9 · 2024: 8 · 2023: 10 · 2022: 7 · 2021: 11 · 2020: 10 · 2019: 4 · 2018: 3
FWCI
2.49
Type
journal article
Language
en
Update notices
correction (2018-05-22)
Open access
Licence
Locations
  • Oxidative Medicine and Cellular Longevity (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Kyushu University Institutional Repository (QIR) (Kyushu University) (submittedVersion, other-oa)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders
Ministry of Health, Labour and Welfare (H27-Shokuhin-Shitei-017)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics, phytochemicals, and oxidative stress
  • Health Sciences › Medicine › Dermatology › Skin Protection and Aging
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Toxic Organic Pollutants Impact
Keywords
perillaldehyde, aryl hydrocarbon receptor, benzo[a]pyrene, Nrf2, heme oxygenase-1, keratinocytes, reactive oxygen species, oxidative stress, CCL2 chemokine, Perilla frutescens, skin inflammation, antioxidant pathways
MeSH terms
Antioxidants, Benzo(a)pyrene, Cell Line, Cell Nucleus, Cell Survival, Humans, Signal Transduction, Keratinocytes, Reactive Oxygen Species, Receptors, Aryl Hydrocarbon, Chemokine CCL2, Cytochrome P-450 CYP1A1, Monoterpenes, NF-E2-Related Factor 2, Heme Oxygenase-1, Basic Helix-Loop-Helix Transcription Factors, Basic Helix-Loop-Helix Proteins

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