Tannase-Converted Green Tea Extract with High (−)-Epicatechin Inhibits Skeletal Muscle Mass in Aged Mice
Open accessAbstract
The objective of this study was to investigate the effects of tannase‐converted green tea extract on body composition, muscle oxidative stress‐related factors, and differentiation‐related factors. The mean bone‐related parameters and body composition were determined by the live dual‐energy X‐ray absorptiometry (DEXA). Quantitative real‐time polymerase chain reaction (qRT‐PCR) and western blotting were used to determine mRNA expression and protein levels, respectively. The results of total mass testing in the epicatechin control (EC) and middle concentration tannase‐converted green tea extract (T1) intake groups were not significantly different compared with those in the control group; however, the high‐concentration tannase‐converted green tea extract (T2) group showed a significantly higher effect to the lean than that of all other groups (p < 0.05). The results of the assay of muscle differentiation‐related genes indicated that the expression levels in the EC and T1 groups (p < 0.05) and the expression levels in the T2 group (p < 0.01) were significantly different in the bicep femoris compared with that in the control group. The results of the SOD gene assay indicate that the expression levels in the EC and T1 groups (p < 0.05) and the expression level in the T2 group (p < 0.01) were significantly different in the bicep femoris compared with that in the control group. Additionally, SOD gene expression in the T2 group was significantly increased (p < 0.05) in the soleus compared with that in the control, EC and T1 groups. Our results suggest that tannase‐converted green tea extract prevents muscle loss and regulates the quantity and quality of muscle by the levels of antioxidant stress‐related enzymes and muscle differentiation factors to a greater extent than the administration of epicatechin and middle dose green tea extract.
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Dietary supplementation of epicatechin prevents muscle loss and regulates quantity and quality of muscle by increasing MyoD, superoxide dismutase, and catalase in biceps femoris and decreasing FoxO3a, myostatin, and MuRF1 in soleus of ICR mice.
“Dietary supplementation of epicatechin prevents muscle loss and regulates the quantity and quality of muscle by increasing the expression of MyoD, superoxide dismutase, and catalase in the biceps femoris muscle and decreasing the expression of FoxO3a, myostatin, and MuRF1 in the soleus muscle of ICR mice [91].”
From Nutraceuticals in the Prevention and Treatment of the Muscle Atrophy (2021) · cites this paper as [91]
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Cites
Regulation of skeletal muscle mass in mice by a new TGF-p superfamily member
McPherron, A. C., Lawler, A. M., & Lee, S.-J. (1997) · Nature · doi:10.1038/387083a0 · Cited by 4,013 · see citing works
Oxidative stress, aging, and diseases
Liguori, I., Russo, G., Curcio, F., Bulli, G., Aran, L., Della-Morte, D., Gargiulo, G., Testa, G., Cacciatore, F., Bonaduce, D., et al. (2018) · Clinical Interventions in Aging · doi:10.2147/cia.s158513 · Cited by 3,979 · see citing works
Beneficial Effects of Green Tea—A Review
Cabrera, C., Artacho, R., & Giménez, R. (2006) · Journal of the American College of Nutrition · doi:10.1080/07315724.2006.10719518 · Cited by 1,904 · see citing works
Beneficial effects of green tea: A literature review
Sabu, M. C., Thambi, P. T., Kuttan, R., & Nishigaki, I. (2010) · Chinese Medicine · doi:10.1186/1749-8546-5-13 · Cited by 992 · see citing works
Eccentric exercise-induced injury to rat skeletal muscle
Armstrong, R. B., Ogilvie, R. W., & SCHWANE, J. A. (1983) · Journal of Applied Physiology · doi:10.1152/jappl.1983.54.1.80 · Cited by 774 · see citing works
Palafox-Carlos, H., Ayala-Zavala, J. F., & González-Aguilar, G. A. (2011) · Journal of Food Science · doi:10.1111/j.1750-3841.2010.01957.x · Cited by 686 · see citing works
Anticancer Efficacy of Polyphenols and Their Combinations
Niedzwiecki, A., Roomi, M. W., Kalinovsky, T., & Rath, M. (2016) · Nutrients · doi:10.3390/nu8090552 · Cited by 541 · see citing works
Latres, E., Amini, A. R., Amini, A. A., Griffiths, J. S., Martin, F. J., Wei, Y., Lin, H. C., Yancopouloš, G., & Glass, D. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m407517200 · Cited by 514 · see citing works
Reactive Oxygen Species: Impact on Skeletal Muscle
Powers, S. K., Ji, L. L., Kavazis, A. N., & Jackson, M. J. (2011) · Comprehensive physiology · doi:10.1002/cphy.c100054 · Cited by 509 · see citing works
Nagao, T., Komine, Y., Soga, S., Meguro, S., Hase, T., Tanaka, Y., & Tokimitsu, I. (2005) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/81.1.122 · Cited by 467 · see citing works
Reactive Oxygen Species in Skeletal Muscle Signaling
Barbieri, E., & Sestili, P. (2011) · Journal of Signal Transduction · doi:10.1155/2012/982794 · Cited by 414 · see citing works
Araghizadeh, A., Kohanteb, J., & Fani, M. M. (2013) · Medical Principles and Practice · doi:10.1159/000348299 · Cited by 348 · see citing works
Quadrupling Muscle Mass in Mice by Targeting TGF-ß Signaling Pathways
Lee, S.-J. (2007) · PLoS ONE · doi:10.1371/journal.pone.0000789 · Cited by 316 · see citing works
Skeletal muscle aging: influence of oxidative stress and physical exercise
Gomes, M. J., Martinez, P. F., Pagan, L. U., Damatto, R. L., Mariano Cezar, M. D., Ruiz Lima, A. R., Okoshi, K., & Okoshi, M. P. (2017) · Oncotarget · doi:10.18632/oncotarget.14670 · Cited by 285 · see citing works
Relating the mechanics of the primary plant cell wall to morphogenesis
Bidhendi, A. J., & Geitmann, A. (2015) · Journal of Experimental Botany · doi:10.1093/jxb/erv535 · Cited by 265 · see citing works
Enzymatic Preparation of Kaempferol from Green Tea Seed and Its Antioxidant Activity
Park, J. S., Rho, H. S., Kim, D. H., et al. (2006) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf052900a · Cited by 158 · see citing works
Self-citationAntioxidants of the Beverage Tea in Promotion of Human Health
Siddiqui, I. A., Afaq, F., Adhami, V. M., Ahmad, N., & Mukhtar, H. (2004) · Antioxidants and Redox Signaling · doi:10.1089/152308604773934323 · Cited by 126 · see citing works
Effects of the Extent of Enzymatic Hydrolysis on Functional Properties of Shark Protein Hydrolysate
Diniz, F. M., & Martin, A. M. (1997) · LWT · doi:10.1006/fstl.1996.0184 · Cited by 118 · see citing works
Relationship between Human Aging Muscle and Oxidative System Pathway
Doria, E., Buonocore, D., Focarelli, A., & Marzatico, F. (2012) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2012/830257 · Cited by 117 · see citing works
Effects of (−)-epicatechin on molecular modulators of skeletal muscle growth and differentiation
Gutiérrez-Salmeán, G., Ciaraldi, T. P., Nogueira, L., Barboza, J., Taub, P. R., Hogan, M. C., Henry, R. R., Meaney, E., Villarreal, F. J., Ceballos, G. M., et al. (2013) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2013.09.007 · Cited by 113 · see citing works
Tea Polysaccharides and Their Bioactivities
Du, L.-L., Fu, Q.-Y., Xiang, L., et al. (2016) · Molecules · doi:10.3390/molecules21111449 · Cited by 108 · see citing works
Malaguti, M., Angeloni, C., Garatachea, N., Baldini, M., Leoncini, E., Collado, P. S., Teti, G., Falconi, M., Gonzalez-Gallego, J., & Hrelia, S. (2009) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00293.2009 · Cited by 103 · see citing works
Characterization of tannase activity in cell-free extracts of Lactobacillus plantarum CECT 748T
Rodrı́guez, H., Rivas, B. D. L., Gómez‐Cordovés, C., & Múñoz, R. (2007) · International Journal of Food Microbiology · doi:10.1016/j.ijfoodmicro.2007.11.002 · Cited by 102 · see citing works
Quaglia, G. B., & Orban, E. (1990) · Journal of Food Science · doi:10.1111/j.1365-2621.1990.tb03571.x · Cited by 101 · see citing works
Wagner, A. E., Piegholdt, S., Rabe, D., Baenas, N., Schloesser, A., Eggersdorfer, M. L., Stocker, A., & Rimbach, G. H. (2015) · Oncotarget · doi:10.18632/oncotarget.5215 · Cited by 85 · see citing works
Hong, Y.-H., Jung, E. Y., Park, Y., Shin, K., Kim, T. Y., Yu, K., Chang, U. J., & Suh, H. J. (2013) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.120373 · Cited by 68 · see citing works
Self-citationGreen Tea Extract Induces the Resistance of Caenorhabditis elegans against Oxidative Stress
Abbas, S., & Wink, M. (2014) · Antioxidants · doi:10.3390/antiox3010129 · Cited by 66 · see citing works
Polyphenols prevent clinorotation-induced expression of atrogenes in mouse C2C12 skeletal myotubes
Hemdan, D. I. I., Hirasaka, K., Nakao, R., Kohno, S., Kagawa, S., Abe, T., Harada‐Sukeno, A., Okumura, Y., Nakaya, Y., Terao, J., et al. (2009) · The Journal of Medical Investigation · doi:10.2152/jmi.56.26 · Cited by 56 · see citing works
Lu, M.-J., & Chen, C. (2007) · Process Biochemistry · doi:10.1016/j.procbio.2007.06.003 · Cited by 52 · see citing works
Lopez, T. E., Schriner, S. E., Okoro, M. C., Lu, D., Chiang, B. T., Huey, J., & Jafari, M. (2014) · Journal of Medicinal Food · doi:10.1089/jmf.2013.0190 · Cited by 49 · see citing works
Catechins Activate Muscle Stem Cells by Myf5 Induction and Stimulate Muscle Regeneration
Kim, A. R., Kim, K. M., Byun, M. R., Hwang, J.-H., Park, J. I., Oh, H. T., Kim, H. K., Jeong, M. G., Hwang, E. S., & Hong, J.-H. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2017.05.114 · Cited by 49 · see citing works
Machado, Á. S., da Silva, W., Souza, M. A., & Carpes, F. P. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.01137 · Cited by 47 · see citing works
Epicatechin elicits MyoD-dependent myoblast differentiation and myogenic conversion of fibroblasts
Lee, S.-J., Leem, Y.-E., Go, G.-Y., Choi, Y., Song, Y. J., Kim, I., Kim, D. Y., Kim, Y. K., Seo, D. W., Kang, J., et al. (2017) · PLoS ONE · doi:10.1371/journal.pone.0175271 · Cited by 35 · see citing works
Self-citationThe Effect of Green Tea Extract and EGCG on the Signaling Network in Squamous Cell Carcinoma
Liu, X., Zhang, D., Zhang, W., et al. (2011) · Nutrition and Cancer · doi:10.1080/01635581.2011.532901 · Cited by 33 · see citing works
Popović, L., Mitić, N. R., Radić, I., Miric, D. J., Kisić, B., Krdžić, B., & Djokic, T. (2012) · PubMed · Cited by 27 · see citing works
Enzymatic Hydrolysis of Green Tea Seed Extract and Its Activity on 5α-Reductase Inhibition
Park, J., Yeom, M. H., Park, W.-S., et al. (2006) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.70.387 · Cited by 27 · see citing works
Catechin-rich oil palm leaf extract enhances bone calcium content of estrogen-deficient rats
Ahdab, B., Mustapha, N. M., & Mohamed, S. (2013) · Nutrition · doi:10.1016/j.nut.2012.09.005 · Cited by 23 · see citing works
Hydrolysis of green tea residue protein using proteolytic enzyme derived from Aspergillus oryzae
Xu, Y.-Q., Zhong, X.-Y., Chen, S.-Q., & Yin, J.-F. (2011) · Journal of Food Science and Technology · doi:10.1007/s13197-011-0239-x · Cited by 21 · see citing works
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Nutraceuticals in the Prevention and Treatment of the Muscle Atrophy
Wang, Y., Liu, Q., Quan, H., Kang, S.-G., Huang, K., & Tong, T. (2021) · Nutrients · doi:10.3390/nu13061914 · Cited by 61 · see citing works
Flavonoids: Nutraceutical Potential for Counteracting Muscle Atrophy
Kim, C., & Hwang, J.-K. (2020) · Food Science and Biotechnology · doi:10.1007/s10068-020-00816-5 · Cited by 45 · see citing works
- Authors
- Hong, K.-B., Lee, H.-S., Kim, D. H., Moon, J. M., & Park, Y.
- Affiliations
- Korea University (KR)
- Chung-Ang University (KR)
- Dongguk University (KR)
- Corresponding author
- Park, Yooheon
- Venue
- Evidence-based Complementary and Alternative Medicine
- Publisher
- Wiley
- Published
- 2020-01
- Volume
- 2020
- Issue
- 1
- Pages
- 4319398-4319398
- ISSN
- 1741-427X (ISSN-L)
- 1741-4288
- PMC
- PMC7008272
- OpenAlex
- W3004097891
- Cited by
- 10
- References
- 38
- Citations by year
- 2024: 2 · 2023: 3 · 2022: 1 · 2021: 2 · 2020: 2
- FWCI
- 1.31
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Evidence-based Complementary and Alternative Medicine (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- Ministry of SMEs and Startups (S2449634)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Tea Polyphenols and Effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Keywords
- tannase, green tea extract, epicatechin, skeletal muscle mass, muscle atrophy, aging, body composition, lean body mass, superoxide dismutase, myogenesis, biceps femoris, soleus muscle, antioxidant enzymes
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