Melatonin Supplementation and Anthropometric Indices: A Randomized Double‐Blind Controlled Clinical Trial
Open accessAbstract
Obesity, as the most common metabolic disorder in the world, is characterized by excess body fat. This study is aimed at determining the effects of melatonin supplementation on body weight, nody mass index (BMI), waist circumference (WC), and body fat mass percentage (BFMP) in people with overweight or obesity. Thirty eight overweight or class‐I obese adult individuals were recruited in the study (8 men and 30 women). Participants prescribed a weight‐loss diet and then randomly were allocated to melatonin or placebo groups. Participants received either a 3‐milligram melatonin or placebo tablet per day for 12 weeks. In order to assess differences at the significance level of 0.05, repeated measure ANOVA and paired t‐test were used. According to the results, a significant reduction was found in participants’ body weight, WC, and BMI in both groups (p = 0.001). However, for the last six weeks, significant reductions of these parameters were observed only in the melatonin group (p = 0.01). The BFMP of participants in the melatonin group showed a significant reduction at the end of the study compared to the initial measurements (p = 0.008). Nevertheless, the results of the present study alone are not sufficient to conclude on the effects of melatonin consumption on anthropometric indices, and it seems that further studies are required in this regard.
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Clinical evidence reveals melatonin supplements did not have striking effects on weight and the results of various doses and times on weight are inconsistent.
“However, the clinical evidence reveals melatonin supplements did not have striking effects on weight and the results of various doses and times on weight are inconsistent. 39-42”
From Melatonin supplementation improves glycemic hemostasis, lipid profile, and adipokine concentrations of obese women: A double-blind randomized clinical trial (2024) · cites this paper as [42]
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- Authors
- Mohammadi, S., Rastmanesh, R., Jahangir, F., Amiri, Z., Djafarian, K., Mohsenpour, M. A., Hassanipour, S., & Ghaffarian-Bahraman, A.
- Affiliations
- National Nutrition and Food Technology Research Institute (IR)
- Tehran University of Medical Sciences (IR)
- Shiraz University of Medical Sciences (IR)
- Guilan University of Medical Sciences (IR)
- ORCID
- Venue
- BioMed Research International
- Publisher
- Wiley
- Published
- 2021-01
- Volume
- 2021
- Issue
- 1
- Pages
- 3502325-3502325
- ISSN
- 1110-7243 (ISSN-L)
- 2314-6133
- 2314-6141
- PMC
- PMC8373505
- OpenAlex
- W3189771718
- Cited by
- 22
- References
- 52
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 6 · 2023: 5 · 2022: 4 · 2021: 1
- FWCI
- 2.10
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- BioMed Research International (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- Shahid Beheshti University of Medical Sciences
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Pharmacology › Pharmacology and Obesity Treatment
- Keywords
- melatonin supplementation, obesity, overweight, anthropometric indices, body weight, body mass index, waist circumference, fat mass, weight loss diet, weight loss
- MeSH terms
- Adult, Anthropometry, Body Composition, Body Weight, Diet, Reducing, Double-Blind Method, Female, Humans, Iran, Male, Melatonin, Middle Aged, Obesity, Body Mass Index, Treatment Outcome, Overweight, Waist Circumference
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