Cited by 22Circadian rhythm and melatoninRegulation of Appetite and ObesityPharmacology and Obesity Treatment

Melatonin Supplementation and Anthropometric Indices: A Randomized Double‐Blind Controlled Clinical Trial

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Mohammadi, Salman, Rastmanesh, Reza, Jahangir, Farzaneh, Amiri, Zohreh, Djafarian, Kurosh, Mohsenpour, Mohammad Ali, Hassanipour, Soheil, Ghaffarian-Bahraman, Ali·2021·BioMed Research International

Abstract

Obesity, as the most common metabolic disorder in the world, is characterized by excess body fat. This study is aimed at determining the effects of melatonin supplementation on body weight, nody mass index (BMI), waist circumference (WC), and body fat mass percentage (BFMP) in people with overweight or obesity. Thirty eight overweight or class‐I obese adult individuals were recruited in the study (8 men and 30 women). Participants prescribed a weight‐loss diet and then randomly were allocated to melatonin or placebo groups. Participants received either a 3‐milligram melatonin or placebo tablet per day for 12 weeks. In order to assess differences at the significance level of 0.05, repeated measure ANOVA and paired t‐test were used. According to the results, a significant reduction was found in participants’ body weight, WC, and BMI in both groups (p = 0.001). However, for the last six weeks, significant reductions of these parameters were observed only in the melatonin group (p = 0.01). The BFMP of participants in the melatonin group showed a significant reduction at the end of the study compared to the initial measurements (p = 0.008). Nevertheless, the results of the present study alone are not sufficient to conclude on the effects of melatonin consumption on anthropometric indices, and it seems that further studies are required in this regard.

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Authors
Mohammadi, S., Rastmanesh, R., Jahangir, F., Amiri, Z., Djafarian, K., Mohsenpour, M. A., Hassanipour, S., & Ghaffarian-Bahraman, A.
Affiliations
  • National Nutrition and Food Technology Research Institute (IR)
  • Tehran University of Medical Sciences (IR)
  • Shiraz University of Medical Sciences (IR)
  • Guilan University of Medical Sciences (IR)
Venue
BioMed Research International
Publisher
Wiley
Published
2021-01
Volume
2021
Issue
1
Pages
3502325-3502325
ISSN
  • 1110-7243 (ISSN-L)
  • 2314-6133
  • 2314-6141
OpenAlex
W3189771718
Cited by
22
References
52
Citations by year
2026: 3 · 2025: 3 · 2024: 6 · 2023: 5 · 2022: 4 · 2021: 1
FWCI
2.10
Type
journal article
Language
en
Open access
Locations
  • BioMed Research International (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders
Shahid Beheshti University of Medical Sciences
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
  • Health Sciences › Medicine › Pharmacology › Pharmacology and Obesity Treatment
Keywords
melatonin supplementation, obesity, overweight, anthropometric indices, body weight, body mass index, waist circumference, fat mass, weight loss diet, weight loss
MeSH terms
Adult, Anthropometry, Body Composition, Body Weight, Diet, Reducing, Double-Blind Method, Female, Humans, Iran, Male, Melatonin, Middle Aged, Obesity, Body Mass Index, Treatment Outcome, Overweight, Waist Circumference

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