Ketogenic Diet‐Induced Diabetic Ketoacidosis in a Young Adult with Unrecognized Type 1 Diabetes
Open accessAbstract
Ketogenic diet, a very low‐carbohydrate diet and high‐fat diet, has emerged as a popular approach for weight reduction, particularly in young adults. However, a serious but rare complication of the ketogenic diet is ketoacidosis associated with low carbohydrate intake, which should be cautiously monitored in people with a predisposition to the condition. We report a 22‐year‐old Thai woman with an unremarkable past medical history who presented with an acute onset of dyspnea of 2 days’ duration. Diabetic ketoacidosis was diagnosed by elevated capillary blood glucose, significant metabolic acidosis, and a high serum beta‐hydroxybutyrate level. Low C‐peptide level and positive islet autoantibodies confirmed the new diagnosis of type 1 diabetes in this patient. After her conditions were stabilized, the patient revealed that she began a ketogenic diet for weight reduction 4 days before her illness. Other precipitating factors were not identified. This highlights that ketogenic diet may increase diabetic ketoacidosis risk at the presentation of previously unrecognized type 1 diabetes.
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Metabolic ketoacidosis with ketogenic diets is a hazard, particularly with sodium−glucose cotransporter 2 (SGLT2) inhibitors.
“Metabolic ketoacidosis with ketogenic diets is a hazard, particularly with sodium−glucose cotransporter 2 (SGLT2) inhibitors [82–87].”
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- Authors
- Charoensri, S., Sothornwit, J., Trirattanapikul, A., & Pongchaiyakul, C.
- Affiliations
- Khon Kaen University (TH)
- Corresponding author
- Charoensri, Suranut
- Venue
- Case Reports in Endocrinology
- Publisher
- Wiley
- Published
- 2021-01
- Volume
- 2021
- Issue
- 1
- Pages
- 6620832-6620832
- ISSN
- 2090-6501 (ISSN-L)
- 2090-651X
- PMC
- PMC7884107
- OpenAlex
- W3128177795
- Cited by
- 14
- References
- 25
- Citations by year
- 2025: 2 · 2024: 3 · 2023: 3 · 2022: 4 · 2021: 2
- FWCI
- 1.89
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Case Reports in Endocrinology (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Greater South Information System
- Topics
- Health Sciences › Medicine › Physiology › Diet and metabolism studies
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
- Keywords
- ketogenic diet, diabetic ketoacidosis, type 1 diabetes, undiagnosed diabetes, weight loss, metabolic acidosis, beta-hydroxybutyrate, C-peptide, islet autoantibodies, young adults
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