Identification and Characterization of a Novel and Specific Inhibitor of the Ataxia-Telangiectasia Mutated Kinase ATM

DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation

Bakkenist, C. J., & Kastan, M. B. (2003) · Nature · doi:10.1038/nature01368 · Cited by 3,466

A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002).

Vlahos, C. J., Matter, W. F., Hui, K. Y., & Brown, R. F. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)37680-9 · Cited by 3,248

ATM and related protein kinases: safeguarding genome integrity

Shiloh, Y. (2003) · Nature Reviews Cancer · doi:10.1038/nrc1011 · Cited by 2,577

Activation of the ATM Kinase by Ionizing Radiation and Phosphorylation of p53

Canman, C. E., Lim, D.-S., Cimprich, K. A., Taya, Y., Tamai, K., Sakaguchi, K., Appella, E., Kastan, M. B., & Siliciano, J. D. (1998) · Science · doi:10.1126/science.281.5383.1677 · Cited by 2,042

Cell cycle checkpoint signaling through the ATM and ATR kinases

Abraham, R. T. (2001) · Genes & Development · doi:10.1101/gad.914401 · Cited by 1,966

ATM Phosphorylates Histone H2AX in Response to DNA Double-strand Breaks

Burma, S., Chen, B. P., Murphy, M., Kurimasa, A., & Chen, D. J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.c100466200 · Cited by 1,954

Enhanced Phosphorylation of p53 by ATM in Response to DNA Damage

Banin, S., Moyal, L., Shieh, S.-Y., Taya, Y., Anderson, C. W., Chessa, L., Smorodinsky, N. I., Prives, C., Reiss, Y., Shiloh, Y., et al. (1998) · Science · doi:10.1126/science.281.5383.1674 · Cited by 1,797

Chk1 is an essential kinase that is regulated by Atr and required for the G 2 /M DNA damage checkpoint

Liu, Q., Guntuku, S., Cui, X.-S., Matsuoka, S., Cortez, D., Tamai, K., Luo, G., Carattini-Rivera, S., DeMayo, F., Bradley, A., et al. (2000) · Genes & Development · doi:10.1101/gad.14.12.1448 · Cited by 1,625

Structural Determinants of Phosphoinositide 3-Kinase Inhibition by Wortmannin, LY294002, Quercetin, Myricetin, and Staurosporine

Walker, E. H., Pacold, M. E., Perišić, O., Stephens, L., Hawkins, P. T., Wymann, M. P., & Williams, R. L. (2000) · Molecular Cell · doi:10.1016/s1097-2765(05)00089-4 · Cited by 1,211

ATM and DNA-PK Function Redundantly to Phosphorylate H2AX after Exposure to Ionizing Radiation

Stiff, T., O’Driscoll, M., Rief, N., Iwabuchi, K., Löbrich, M., & Jeggo, P. A. (2004) · Cancer Research · doi:10.1158/0008-5472.can-03-3207 · Cited by 1,050

Double‐strand DNA breaks are mainly repaired by the homologous recombination pathway in early developing swine embryos

Bohrer, R. C., Dicks, N., Gutierrez, K., Duggavathi, R., & Bordignon, V. (2017) · The FASEB Journal · doi:10.1096/fj.201700800r · Cited by 25

DNA Repair Mechanisms and Therapeutic Targets in Glioma

Elmore, K. B., & Schaff, L. R. (2021) · Current Oncology Reports · doi:10.1007/s11912-021-01077-z · Cited by 24

MLK4 regulates DNA damage response and promotes triple-negative breast cancer chemoresistance

Mehlich, D., Łomiak, M., Sobiborowicz, A., Mazan, A., Dymerska, D., Szewczyk, Ł. M., Mehlich, A., Borowiec, A., Prełowska, M. K., Gorczyński, A., et al. (2021) · Cell Death and Disease · doi:10.1038/s41419-021-04405-0 · Cited by 26

Radiation affects glutathione redox reaction by reduced glutathione peroxidase activity in human fibroblasts

Shimura, T., Nakashiro, C., Fujiwara, K., Shiga, R., Sasatani, M., Kamiya, K., & Ushiyama, A. (2021) · Journal of Radiation Research · doi:10.1093/jrr/rrab122 · Cited by 25

The role of DNA damage response pathways in chromosome fragility in Fragile X syndrome

Kumari, D., Somma, V., Nakamura, A., Bonner, W. M., D’Ambrosio, E., & Usdin, K. (2009) · Nucleic Acids Research · doi:10.1093/nar/gkp391 · Cited by 25

Pharmacological inhibition of ATM by KU55933 stimulates ATM transcription

Khalil, H. S., Tummala, H., Hupp, T. R., & Zhelev, N. (2012) · Experimental Biology and Medicine · doi:10.1258/ebm.2012.011378 · Cited by 25

Inhibition of Ataxia Telangiectasia Mutated (ATM) Kinase Suppresses Herpes Simplex Virus Type 1 (HSV-1) Keratitis

Alekseev, O., Donovan, K., & Azizkhan‐Clifford, J. (2013) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.13-13461 · Cited by 25

Characterization of mre11 loss following HSV-1 infection

Gregory, D. A., & Bachenheimer, S. L. (2008) · Virology · doi:10.1016/j.virol.2007.12.005 · Cited by 27

Imatinib Mesylate Induces Cisplatin Hypersensitivity in Bcr-Abl+ Cells by Differential Modulation of p53 Transcriptional and Proapoptotic Activity

Skorta, I., Oren, M., Markwardt, C., Gutekunst, M., Aulitzky, W. E., & van der Kuip, H. (2009) · Cancer Research · doi:10.1158/0008-5472.can-09-0548 · Cited by 24

Replication stress by Py–Im polyamides induces a non-canonical ATR-dependent checkpoint response

Martinez, T. F., Phillips, J. W., Karanja, K. K., Polaczek, P., Wang, C.-M., Li, B. C., Campbell, J. L., & Dervan, P. B. (2014) · Nucleic Acids Research · doi:10.1093/nar/gku866 · Cited by 27

Inhibition of Repair of Radiation-Induced DNA Damage Enhances Gene Expression from Replication-Defective Adenoviral Vectors

Hingorani, M., White, C. L., Merron, A., Peerlinck, I., Gore, M. E., Slade, A., Scott, S. D., Nutting, C. M., Pandha, H., Melcher, A. A., et al. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-1911 · Cited by 25

DNA Damage Response Is Involved in the Developmental Toxicity of Mebendazole in Zebrafish Retina

Sasagawa, S., Nishimura, Y., Kon, T., Yamanaka, Y., Murakami, S., Ashikawa, Y., Yuge, M., Okabe, S., Kawaguchi, K., Kawase, R., et al. (2016) · Frontiers in Pharmacology · doi:10.3389/fphar.2016.00057 · Cited by 25

Exposure to chronic hyperglycemic conditions results in Ras-related C3 botulinum toxin substrate 1 (Rac1)-mediated activation of p53 and ATM kinase in pancreatic β-cells

Sidarala, V., & Kowluru, A. (2017) · APOPTOSIS · doi:10.1007/s10495-017-1354-6 · Cited by 24

Clinically Applicable Inhibitors Impacting Genome Stability

Prakash, A., García-Moreno, J. F., Brown, J. A. L., & Bourke, E. (2018) · Molecules · doi:10.3390/molecules23051166 · Cited by 24

Valproic acid enhances fludarabine-induced apoptosis mediated by ROS and involving decreased AKT and ATM activation in B-cell-lymphoid neoplastic cells

Yoon, J., Ishdorj, G., Graham, B. A., Johnston, J. B., & Gibson, S. B. (2013) · APOPTOSIS · doi:10.1007/s10495-013-0906-7 · Cited by 24

The Ataxia Telangiectasia Mutated Kinase Pathway Regulates IL-23 Expression by Human Dendritic Cells

Wang, Q., Franks, H., Lax, S. J., Refaee, M. E., Malecka, A. A., Shah, S., Spendlove, I., Gough, M. J., Seedhouse, C., Madhusudan, S., et al. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1201484 · Cited by 27

Exploring metabolism in scleroderma reveals opportunities for pharmacological intervention for therapy in fibrosis

Cantanhede, I. G., Liu, H., Liu, H., Rodriguez, V. B., Shiwen, X., Ong, V. H., Denton, C. P., Ponticos, M., Xiong, G., de Lima-Filho, J. L., et al. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1004949 · Cited by 26

DNA repair in tumor radioresistance: insights from fruit flies genetics

Porrazzo, A., Cassandri, M., D’Alessandro, A., Morciano, P., Rota, R., Marampon, F., & Cenci, G. (2023) · Cellular Oncology · doi:10.1007/s13402-023-00906-6 · Cited by 26

Autophagy and reactive oxygen species modulate cytotoxicity induced by suppression of ATM kinase activity in head and neck cancer cells

Lin, C., Wang, Y.-C., Huang, J.-L., Hung, C.-C., & Chen, J. Y. (2012) · Oral Oncology · doi:10.1016/j.oraloncology.2012.05.020 · Cited by 24

Radiosensitising agents for the radiotherapy of cancer: novel molecularly targeted approaches

Dumont, F. J., Altmeyer, A., & Bischoff, P. L. (2009) · Expert Opinion on Therapeutic Patents · doi:10.1517/13543770902967666 · Cited by 25

Trovafloxacin-induced replication stress sensitizes HepG2 cells to tumor necrosis factor-alpha-induced cytotoxicity mediated by extracellular signal-regulated kinase and ataxia telangiectasia and Rad3-related

Beggs, K. M., Maiuri, A. R., Fullerton, A. M., Poulsen, K. L., Breier, A. B., Ganey, P. E., & Roth, R. A. (2015) · Toxicology · doi:10.1016/j.tox.2015.03.002 · Cited by 24

CHEK2 genomic and proteomic analyses reveal genetic inactivation or endogenous activation across the 60 cell lines of the US National Cancer Institute

Zoppoli, G. M., Solier, S., Reinhold, W. C., Liu, H., Connelly, J. W., Monks, A. P., Shoemaker, R. H., Abaan, O. D., Davis, S. R., Meltzer, P. S., et al. (2011) · Oncogene · doi:10.1038/onc.2011.283 · Cited by 23

Canine Adenovirus Type 2 Vector Generation via I-Sce1-Mediated Intracellular Genome Release

Ibanes, S., & Kremer, E. J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0071032 · Cited by 23

An ataxia-telangiectasia-mutated (ATM) kinase mediated response to DNA damage down-regulates the mRNA-binding potential of THOC5

Ramachandran, S., Tran, D. D. H., Klebba-Färber, S., Kardinal, C., Whetton, A. D., & Tamura, T. (2011) · RNA · doi:10.1261/rna.2820911 · Cited by 24

A nucleoside anticancer drug, 1-(3-C-ethynyl-β-D-ribo-pentofuranosyl)cytosine (TAS106), sensitizes cells to radiation by suppressing BRCA2 expression

Meike, S., Yamamori, T., Yasui, H., Eitaki, M., Matsuda, A., Morimatsu, M., Fukushima, M., Yamasaki, Y., & Inanami, O. (2011) · Molecular Cancer · doi:10.1186/1476-4598-10-92 · Cited by 25

Regulation of Oxidative Stress Responses by Ataxia-Telangiectasia Mutated Is Required for T Cell Proliferation

Bagley, J., Singh, G., & Iacomini, J. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.8.4757 · Cited by 24

A balanced pyrimidine pool is required for optimal Chk1 activation to prevent ultrafine anaphase bridge formation

Gemble, S., Buhagiar‐Labarchède, G., Onclercq, R., Biard, D. S. F., Lambert, S., & Amor-Guéret, M. (2016) · Journal of Cell Science · doi:10.1242/jcs.187781 · Cited by 24

Hypoxia-Directed Drug Strategies to Target the Tumor Microenvironment

Hay, M. P., Hicks, K. O., & Wang, J. (2013) · Advances in experimental medicine and biology · doi:10.1007/978-1-4614-5915-6_6 · Cited by 24

Protection of DNA Ends by Telomeric 3′ G-Tail Sequences

Tsai, Y.-C., Qi, H., & Liu, L. F. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m702171200 · Cited by 24

SAHA and cisplatin sensitize gastric cancer cells to doxorubicin by induction of DNA damage, apoptosis and perturbation of AMPK-mTOR signalling

Seah, K. S., Loh, J. Y., Nguyen, T. T. T., Tan, H. L., Hutchinson, P. E., Lim, K. K., Dymock, B. W., Long, Y. C., Lee, E. J. D., Shen, H., et al. (2018) · Experimental Cell Research · doi:10.1016/j.yexcr.2018.06.029 · Cited by 23

Precision Targeting of BFL-1/A1 and an ATM Co-dependency in Human Cancer

Guerra, R. M., Bird, G. H., Harvey, E. P., Dharia, N. V., Korshavn, K. J., Prew, M. S., Stegmaier, K., & Walensky, L. D. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.08.089 · Cited by 23

PP2Cδ inhibits p300-mediated p53 acetylation via ATM/BRCA1 pathway to impede DNA damage response in breast cancer

Li, Q., Hao, Q., Cao, W., Li, J., Wu, K., Elshimali, Y., Zhu, D., Chen, Q., Chen, G., Pollack, J. R., et al. (2019) · Science Advances · doi:10.1126/sciadv.aaw8417 · Cited by 23

Rewiring glucose metabolism improves 5-FU efficacy in p53-deficient/KRASG12D glycolytic colorectal tumors

Ludikhuize, M. C., Gevers, S., Nguyen, N. B., Meerlo, M., Roudbari, S. K. S., Gülersönmez, M. C., Stigter, E. C. A., Drost, J., Clevers, H. C., Burgering, B. M. T., et al. (2022) · Communications Biology · doi:10.1038/s42003-022-04055-8 · Cited by 23

Mild replication stress causes premature centriole disengagement via a sub-critical Plk1 activity under the control of ATR-Chk1

Dwivedi, D., Harry, D., & Meraldi, P. (2023) · Nature Communications · doi:10.1038/s41467-023-41753-1 · Cited by 23

Wild-type p53-induced phosphatase 1 (Wip1) forestalls cellular premature senescence at physiological oxygen levels by regulating DNA damage response signaling during DNA replication

Sakai, H., Fujigaki, H., Mazur, S. J., & Appella, E. (2014) · Cell Cycle · doi:10.4161/cc.27920 · Cited by 24

ATM-dependent phosphorylation of SNEVhPrp19/hPso4 is involved in extending cellular life span and suppression of apoptosis

Dellago, H., Khan, A., Nussbacher, M., Gstraunthaler, A., Lämmermann, I., Schosserer, M., Mück, C., Anrather, D., Scheffold, A., Ammerer, G., et al. (2012) · Aging · doi:10.18632/aging.100452 · Cited by 23

Tetraploidization or autophagy: The ultimate fate of senescent human endometrial stem cells under ATM or p53 inhibition

Borodkina, A. V., Shatrova, A. N., Deryabin, P. I., Grukova, A. A., Nikolsky, N. N., & Burova, E. (2015) · Cell Cycle · doi:10.1080/15384101.2015.1121326 · Cited by 23

Kinase inhibitors as potential agents in the treatment of multiple myeloma

Abramson, H. N. (2016) · Oncotarget · doi:10.18632/oncotarget.10745 · Cited by 23

A CRISPR/Cas9–Based Screening for Non-Homologous End Joining Inhibitors Reveals Ouabain and Penfluridol as Radiosensitizers

Du, J., Shang, J., Chen, F., Zhang, Y., Yin, N., Xie, T., Zhang, H., Yu, J., & Liu, F. (2017) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-17-0090 · Cited by 23

ATR addiction in multiple myeloma: synthetic lethal approaches exploiting established therapies

Botrugno, O. A., Bianchessi, S., Zambroni, D., Frenquelli, M., Belloni, D., Bongiovanni, L., Girlanda, S., Terlizzi, S. D., Ferrarini, M., Ferrero, E., et al. (2019) · Haematologica · doi:10.3324/haematol.2018.215210 · Cited by 24

PARP inhibition during alkylation-induced genotoxic stress signals a cell cycle checkpoint response mediated by ATM

Carrozza, M. J., Stefanick, D. F., Horton, J. K., Kedar, P. S., & Wilson, S. H. (2009) · DNA repair · doi:10.1016/j.dnarep.2009.07.010 · Cited by 24

Characterization of an NBS1 C-Terminal Peptide That Can Inhibit Ataxia Telangiectasia Mutated (ATM)-Mediated DNA Damage Responses and Enhance Radiosensitivity

Cariveau, M. J., Tang, X., Cui, X.-L., & Xu, B. (2007) · Molecular Pharmacology · doi:10.1124/mol.107.036681 · Cited by 22

Imatinib inhibits inactivation of the ATM/ATR signaling pathway and recovery from adriamycin/doxorubicin‐induced DNA damage checkpoint arrest

Morii, M., Fukumoto, Y., Kubota, S., Yamaguchi, N., Nakayama, Y., & Yamaguchi, N. (2015) · Cell Biology International · doi:10.1002/cbin.10460 · Cited by 22

TP53 mutant MDM2-amplified cell lines selected for resistance to MDM2-p53 binding antagonists retain sensitivity to ionizing radiation

Drummond, C. J., Esfandiari, A., Liu, J., Lü, X., Hutton, C., Jackson, J., Bennaceur, K., Xu, Q., Makimanejavali, A. R., Bello, F. D., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.10073 · Cited by 22

Pharmacological inhibition of ataxia-telangiectasia mutated exacerbates acute kidney injury by activating p53 signaling in mice

Uehara, M., Kusaba, T., Ida, T., Nakai, K., Nakata, T., Tomita, A., Uehara-Watanabe, N., Ikeda, K., Kitani, T., YAMASHITA, N., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-61456-7 · Cited by 21

Repair-independent functions of DNA-PKcs protect irradiated cells from mitotic slippage and accelerated senescence

Liu, Y., Efimova, E. V., Ramamurthy, A., & Kron, S. J. (2019) · Journal of Cell Science · doi:10.1242/jcs.229385 · Cited by 22

Discovery and Evaluation of 3-Quinoxalin Urea Derivatives as Potent, Selective, and Orally Available ATM Inhibitors Combined with Chemotherapy for the Treatment of Cancer via Goal-Oriented Molecule Generation and Virtual Screening

Deng, D., Yang, Y., Zou, Y., Liu, K., Zhang, C., Tang, M., Yang, T., Chen, Y. X., Xue, Y., Guo, Y. C., et al. (2023) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.3c00082 · Cited by 22

Identification of Novel, Selective Ataxia-Telangiectasia Mutated Kinase Inhibitors with the Ability to Penetrate the Blood–Brain Barrier: The Discovery of AZD1390

Pike, K. G., Hunt, T. A., Barlaam, B. C., Benstead, D., Cadogan, E. B., Chen, K., Cook, C., Colclough, N., Deng, C., Durant, S. T., et al. (2024) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.3c02277 · Cited by 21

Adenovirus E4-ORF3 Targets PIAS3 and Together with E1B-55K Remodels SUMO Interactions in the Nucleus and at Virus Genome Replication Domains

Higginbotham, J. M., & O’Shea, C. C. (2015) · Journal of Virology · doi:10.1128/jvi.01091-15 · Cited by 21

Differential epithelium DNA damage response to ATM and DNA-PK pathway inhibition in human prostate tissue culture

Zhang, Z., Yang, Z., Jäämaa, S., Liu, H., Pellakuru, L. G., Iwata, T., af Hällström, T. M., Marzo, A. M. D., & Laiho, M. (2011) · Cell Cycle · doi:10.4161/cc.10.20.17841 · Cited by 21

The activation of the p53 pathway by the AMP mimetic AICAR is reduced by inhibitors of the ATM or mTOR kinases

Zajkowicz, A., & Rusin, M. (2011) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2011.09.002 · Cited by 21

Frontiers in targeting glioma stem cells

Fròsina, G. (2010) · European Journal of Cancer · doi:10.1016/j.ejca.2010.11.017 · Cited by 21

p38MAPK and MK2 Pathways Are Important for the Differentiation-Dependent Human Papillomavirus Life Cycle

Satsuka, A., Mehta, K. P. M., & Laimins, L. A. (2014) · Journal of Virology · doi:10.1128/jvi.02712-14 · Cited by 21

ATM in focus: A damage sensor and cancer target

Khalil, H. S., Tummala, H., & Zhelev, N. (2012) · Biodiscovery · doi:10.7750/biodiscovery.2012.5.1 · Cited by 23

Ataxia telangiectasia mutated impacts insulin‐like growth factor 1 signalling in skeletal muscle

Ching, J. K., Luebbert, S. H., Collins, R. L., Zhang, Z., Marupudi, N., Banerjee, S., Hurd, R. D., Ralston, L., & Fisher, J. S. (2012) · Experimental Physiology · doi:10.1113/expphysiol.2012.066357 · Cited by 21

Inactivation of the ATMIN/ATM pathway protects against glioblastoma formation

Blake, S. M., Stricker, S. H., Halavach, H., Poetsch, A. R., Cresswell, G. D., Kelly, G. P., Kanu, N., Marino, S., Luscombe, N. M., Pollard, S. M., et al. (2016) · eLife · doi:10.7554/elife.08711 · Cited by 21

Autophagic Organelles in DNA Damage Response

Kim, J., Lee, S.-M., Kim, H., Lee, H., Seong, K. M., Youn, H., & Youn, B. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.668735 · Cited by 21

Regulation of Rad17 Protein Turnover Unveils an Impact of Rad17-APC Cascade in Breast Carcinogenesis and Treatment*

Zhou, Z., Jing, C., Zhang, L., Fujita, T., Kim, H., Huang, Y., Liu, Z., & Wan, Y. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.456962 · Cited by 21

Udu Deficiency Activates DNA Damage Checkpoint

Lim, C.-H., Chong, S., & Jiang, Y. (2009) · Molecular Biology of the Cell · doi:10.1091/mbc.e09-02-0109 · Cited by 21

Targeting the CINful genome: Strategies to overcome tumor heterogeneity

Cunningham, C. E., MacAuley, M. J., Yadav, G., Vizeacoumar, F. S., Freywald, A., & Vizeacoumar, F. J. (2019) · Progress in Biophysics and Molecular Biology · doi:10.1016/j.pbiomolbio.2019.02.006 · Cited by 19

The methyl methanesulfonate induced S-phase delay in XRCC1-deficient cells requires ATM and ATR

Brem, R., Fernet, M., Chapot, B., & Hall, J. (2008) · DNA Repair · doi:10.1016/j.dnarep.2008.02.002 · Cited by 20

Medicinal chemistry breakthroughs on ATM, ATR, and DNA-PK inhibitors as prospective cancer therapeutics

Sharma, R. L., Mishra, A., Bhardwaj, M., Singh, G., Harahap, L. V. I., Vanjani, S., Pan, C., & Nepali, K. (2025) · Journal of Enzyme Inhibition and Medicinal Chemistry · doi:10.1080/14756366.2025.2489720 · Cited by 20

Distinct regulation of ATM signaling by DNA single-strand breaks and APE1

Zhao, H., Li, J., You, Z., Lindsay, H. D., & Yan, S. (2024) · Nature Communications · doi:10.1038/s41467-024-50836-6 · Cited by 22

Dynamic Coregulatory Complex Containing BRCA1, E2F1 and CtIP Controls ATM Transcription

Moiola, C. P., Luca, P. D., Cotignola, J., Gardner, K. L., Vazquez, E. S., & Siervi, A. D. (2012) · Cellular Physiology and Biochemistry · doi:10.1159/000341441 · Cited by 20

Ataxia Telangiectasia Mutated (ATM) Inhibition Transforms Human Mammary Gland Epithelial Cells

Mandriota, S. J., Buser, R., Lesne, L., Stouder, C., Favaudon, V., Maechler, P., Bena, F. S., Clément, V., Rüegg, C., Montesano, R., et al. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.078360 · Cited by 20

Ionizing radiation enhances dl922–947-mediated cell death of anaplastic thyroid carcinoma cells

Passaro, C., Abagnale, A., Libertini, S., Volpe, M., Botta, G., Cella, L., Pacelli, R., Halldén, G., Gillespie, D. A., & Portella, G. (2013) · Endocrine Related Cancer · doi:10.1530/erc-13-0001 · Cited by 20

DNA-Dependent Protein Kinase and Ataxia Telangiectasia Mutated (ATM) Promote Cell Survival in Response to NK314, a Topoisomerase IIα Inhibitor

Guo, L., Liu, X., Jiang, Y., Nishikawa, K., & Plunkett, W. K. (2011) · Molecular Pharmacology · doi:10.1124/mol.109.057125 · Cited by 20

Human MLH1 suppresses the insertion of telomeric sequences at intra-chromosomal sites in telomerase-expressing cells

Jia, P., Chastain, M., Zou, Y. S., Her, C., & Chai, W. (2016) · Nucleic Acids Research · doi:10.1093/nar/gkw1170 · Cited by 19

Pharmacologic ATM but not ATR kinase inhibition abrogates p21-dependent G1 arrest and promotes gastrointestinal syndrome after total body irradiation

Vendetti, F. P., Leibowitz, B. J., Barnes, J., Schamus, S., Kiesel, B. F., Abberbock, S. R., Conrads, T. P., Clump, D. A., Cadogan, E. B., O’Connor, M. J., et al. (2017) · Scientific Reports · doi:10.1038/srep41892 · Cited by 21

Potential Telomere-Related Pharmacological Targets

Berei, J., Eckburg, A., Miliavski, E., Anderson, A. D., Miller, R. J., Dein, J., Giuffre, A. M., Tang, D., Deb, S., Racherla, K. S., et al. (2020) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026620666200109114339 · Cited by 21

Mycobacterium tuberculosis exploits host ATM kinase for survival advantage through SecA2 secretome

Lochab, S., Singh, Y. P., Sengupta, S., & Nandicoori, V. K. (2020) · eLife · doi:10.7554/elife.51466 · Cited by 21

A robust CRISPR–Cas9-based fluorescent reporter assay for the detection and quantification of DNA double-strand break repair

Eki, R., She, J., Parlak, M., Benamar, M., Du, K., Kumar, P., & Abbas, T. (2020) · Nucleic Acids Research · doi:10.1093/nar/gkaa897 · Cited by 20

Telomerase inhibition induces acute ATM-dependent growth arrest in human astrocytomas

Wong, V. C. H., Ma, J., & Hawkins, C. E. (2008) · Cancer Letters · doi:10.1016/j.canlet.2008.09.012 · Cited by 20

Increased Artemis levels confer radioresistance to both high and low LET radiation exposures

Sridharan, D., Whalen, M. B., Almendrala, D. K., Cucinotta, F. A., Kawahara, M., Yannone, S. M., & Pluth, J. M. (2012) · Radiation Oncology · doi:10.1186/1748-717x-7-96 · Cited by 20

Squalene Inhibits ATM-Dependent Signaling in γIR-Induced DNA Damage Response through Induction of Wip1 Phosphatase

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Ku70 Serine 155 mediates Aurora B inhibition and activation of the DNA damage response

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Mechanism of Action Studies of Lomaiviticin A and the Monomeric Lomaiviticin Aglycon. Selective and Potent Activity Toward DNA Double-Strand Break Repair-Deficient Cell Lines

Colis, L. C., Hegan, D. C., Kaneko, M., Glazer, P. M., & Herzon, S. B. (2015) · Journal of the American Chemical Society · doi:10.1021/ja513117p · Cited by 19

Synthesis of 1,4-dithiins and 1,4-diselenins from alkynes and elemental sulfur/selenium under transition metal-free conditions with high regioselectivity

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Chromatin modifying protein 1A (Chmp1A) of the endosomal sorting complex required for transport (ESCRT)-III family activates ataxia telangiectasia mutated (ATM) for PanC-1 cell growth inhibition

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Involvement of ATM‐mediated Chk1/2 and JNK kinase signaling activation in HKH40A‐induced cell growth inhibition

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Essential Factors for Incompatible DNA End Joining at Chromosomal DNA Double Strand Breaks In Vivo

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YU238259 Is a Novel Inhibitor of Homology-Dependent DNA Repair That Exhibits Synthetic Lethality and Radiosensitization in Repair-Deficient Tumors

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Part III: Novel checkpoint kinase 2 (Chk2) inhibitors; design, synthesis and biological evaluation of pyrimidine-benzimidazole conjugates

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The efficacy and toxicity of ATM inhibition in glioblastoma initiating cells-driven tumor models

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It takes two

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Radiation and ATM inhibition: the heart of the matter

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The ATM protein: The importance of being active

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Causative mechanisms and clinical impact of immunoglobulin deficiencies in ataxia telangiectasia

Takada, S., Weitering, T. J., van Os, N. J. H., Du, L., Pico‐Knijnenburg, I., Kuipers, T. B., Mei, H., Salzer, E., Willemsen, M. A. A. P., Weemaes, C. M. R., et al. (2024) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2023.12.029 · Cited by 17

Excessive MYC-topoisome activity triggers acute DNA damage, MYC degradation, and replacement by a p53-topoisome

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Priming and potentiation of DNA damage response by fibronectin in human colon cancer cells and tumor-derived myofibroblasts

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Therapeutic Effect of Sodium Iodide Symporter Gene Therapy Combined With External Beam Radiotherapy and Targeted Drugs That Inhibit DNA Repair

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Gene expression profiling of archival tongue squamous cell carcinomas provides sub-classification based on DNA repair genes

Rentoft (2009) · International Journal of Oncology · doi:10.3892/ijo_00000450 · Cited by 18

DNA repair inhibitors sensitize cells differently to high and low LET radiation

Bannik, K., Madas, B. G., Jarke, S., Sutter, A. P., Siemeister, G., Schatz, C. A., Mumberg, D., & Zitzmann-Kolbe, S. (2021) · Scientific Reports · doi:10.1038/s41598-021-02719-9 · Cited by 20

Functional switching of ATM: sensor of DNA damage in proliferating cells and mediator of Akt survival signal in post-mitotic human neuron-like cells

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DNA damage response and development of targeted cancer treatments

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ATM controls DNA repair and mitochondria transfer between neighboring cells

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Telomere erosion in human pluripotent stem cells leads to ATR-mediated mitotic catastrophe

Vessoni, A. T., Zhang, T., Quinet, A., Jeong, H., Munroe, M., Wood, M. D., Tedone, E., Vindigni, A., Shay, J. W., Greenberg, R. A., et al. (2021) · The Journal of Cell Biology · doi:10.1083/jcb.202011014 · Cited by 17

Non-homologous End Joining Inhibitor SCR-7 to Exacerbate Low-dose Doxorubicin Cytotoxicity in HeLa Cells

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Identification of the main barriers to Ku accumulation in chromatin

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Abstract 3928: KU-0060019, a novel small molecule inhibitor of ATM

Shea, K. F., Albertella, M. R., Bárdos, J. I., Batey, M. A., Cranston, A. N., Curtin, N. J., Griffin, R. J., Lau, A., Menear, K. A., Newell, D. R., et al. (2010) · Cancer Research · doi:10.1158/1538-7445.am10-3928

PRECLINICAL STUDIES ON ATM KINASE INHIBITORS AS ANTI-CANCER AGENTS

Choi, S. (2011) · D-Scholarship@Pitt (University of Pittsburgh)

Transient Inhibition of ATM Kinase Is Sufficient to Enhance Cellular Sensitivity to Ionizing Radiation

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Pharmacological inhibition of ATM by KU55933 stimulates ATM transcription

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Irreversible chromosome damage accumulates rapidly in the absence of ATM kinase activity

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