Identification and Characterization of a Novel and Specific Inhibitor of the Ataxia-Telangiectasia Mutated Kinase ATM

DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation

Bakkenist, C. J., & Kastan, M. B. (2003) · Nature · doi:10.1038/nature01368 · Cited by 3,466

A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002).

Vlahos, C. J., Matter, W. F., Hui, K. Y., & Brown, R. F. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)37680-9 · Cited by 3,248

ATM and related protein kinases: safeguarding genome integrity

Shiloh, Y. (2003) · Nature Reviews Cancer · doi:10.1038/nrc1011 · Cited by 2,577

Activation of the ATM Kinase by Ionizing Radiation and Phosphorylation of p53

Canman, C. E., Lim, D.-S., Cimprich, K. A., Taya, Y., Tamai, K., Sakaguchi, K., Appella, E., Kastan, M. B., & Siliciano, J. D. (1998) · Science · doi:10.1126/science.281.5383.1677 · Cited by 2,042

Cell cycle checkpoint signaling through the ATM and ATR kinases

Abraham, R. T. (2001) · Genes & Development · doi:10.1101/gad.914401 · Cited by 1,966

ATM Phosphorylates Histone H2AX in Response to DNA Double-strand Breaks

Burma, S., Chen, B. P., Murphy, M., Kurimasa, A., & Chen, D. J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.c100466200 · Cited by 1,954

Enhanced Phosphorylation of p53 by ATM in Response to DNA Damage

Banin, S., Moyal, L., Shieh, S.-Y., Taya, Y., Anderson, C. W., Chessa, L., Smorodinsky, N. I., Prives, C., Reiss, Y., Shiloh, Y., et al. (1998) · Science · doi:10.1126/science.281.5383.1674 · Cited by 1,797

Chk1 is an essential kinase that is regulated by Atr and required for the G 2 /M DNA damage checkpoint

Liu, Q., Guntuku, S., Cui, X.-S., Matsuoka, S., Cortez, D., Tamai, K., Luo, G., Carattini-Rivera, S., DeMayo, F., Bradley, A., et al. (2000) · Genes & Development · doi:10.1101/gad.14.12.1448 · Cited by 1,625

Structural Determinants of Phosphoinositide 3-Kinase Inhibition by Wortmannin, LY294002, Quercetin, Myricetin, and Staurosporine

Walker, E. H., Pacold, M. E., Perišić, O., Stephens, L., Hawkins, P. T., Wymann, M. P., & Williams, R. L. (2000) · Molecular Cell · doi:10.1016/s1097-2765(05)00089-4 · Cited by 1,211

ATM and DNA-PK Function Redundantly to Phosphorylate H2AX after Exposure to Ionizing Radiation

Stiff, T., O’Driscoll, M., Rief, N., Iwabuchi, K., Löbrich, M., & Jeggo, P. A. (2004) · Cancer Research · doi:10.1158/0008-5472.can-03-3207 · Cited by 1,050

ATM phosphorylation of the actin-binding protein drebrin controls oxidation stress-resistance in mammalian neurons and C. elegans

Kreis, P., Gallrein, C., Puente, E. R., Mack, T. G. A., Kroon, C., Dinkel, V., Willmes, C. G., Murk, K., Dieck, S. T., Schuman, E. M., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-08420-w · Cited by 35

Overcoming Radioresistance: Small Molecule Radiosensitisers and Hypoxia-activated Prodrugs

Jackson, R. K., Liew, L. P., & Hay, M. P. (2019) · Clinical Oncology · doi:10.1016/j.clon.2019.02.004 · Cited by 36

DNA Damage Repair Inhibitors—Combination Therapies

Smith, G., Alholm, Z., Coleman, R. L., & Monk, B. J. (2021) · The Cancer Journal · doi:10.1097/ppo.0000000000000561 · Cited by 35

Characterization of Glioma Stem Cells Through Multiple Stem Cell Markers and Their Specific Sensitization to Double‐Strand Break‐Inducing Agents by Pharmacological Inhibition of Ataxia Telangiectasia Mutated Protein

Raso, A., Vecchio, D., Cappelli, E., Ropolo, M., Poggi, A. D., Nozza, P., Biassoni, R., Mascelli, S., Capra, V., Kalfas, F., et al. (2012) · Brain Pathology · doi:10.1111/j.1750-3639.2012.00566.x · Cited by 35

Alterations in Cellular Energy Metabolism Associated with the Antiproliferative Effects of the ATM Inhibitor KU-55933 and with Metformin

Zakikhani, M., Bazile, M., Hashemi, S., Javeshghani, S., Avizonis, D. Z., St‐Pierre, J., & Pollak, M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0049513 · Cited by 36

Biomarkers for DNA DSB inhibitors and radiotherapy clinical trials

Liu, S. K., Olive, P. L., & Bristow, R. G. (2008) · Cancer and Metastasis Reviews · doi:10.1007/s10555-008-9137-8 · Cited by 35

DNA Damage-Sensing Kinases Mediate the Mouse 2-Cell Embryo's Response to Genotoxic Stress

Mu, X., Jin, X., Farnham, M. M. J., Li, Y., & O’Neill, C. (2011) · Biology of Reproduction · doi:10.1095/biolreprod.110.089334 · Cited by 34

Baculoviruses Modulate a Proapoptotic DNA Damage Response To Promote Virus Multiplication

Mitchell, J. K., & Friesen, P. D. (2012) · Journal of Virology · doi:10.1128/jvi.02246-12 · Cited by 35

A Novel Dual ATM/DNA-PK Inhibitor, XRD-0394, Potently Radiosensitizes and Potentiates PARP and Topoisomerase I Inhibitors

Gilmer, T. M., Lai, C.-H., Guo, K., Deland, K., Ashcraft, K. A., Stewart, A. E., Wang, Y., Fu, J., Wood, K. C., Kirsch, D. G., et al. (2024) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-23-0890 · Cited by 35

Pemetrexed induces both intrinsic and extrinsic apoptosis through ataxia telangiectasia mutated/p53‐dependent and ‐independent signaling pathways

Yang, T., Chang, G., Chen, K., Hung, H., Hsu, K.-H., Wu, C., Sheu, G., & Hsu, S. (2011) · Molecular Carcinogenesis · doi:10.1002/mc.21842 · Cited by 34

ATMIN Is Required for Maintenance of Genomic Stability and Suppression of B Cell Lymphoma

Loizou, J. I., Sancho, R., Kanu, N., Bolland, D. J., Yang, F., Rada, C. A., Corcoran, A. E., & Behrens, A. (2011) · Cancer Cell · doi:10.1016/j.ccr.2011.03.022 · Cited by 34

Targeted Radiosensitization of Cells Expressing Truncated DNA Polymerase β

Neijenhuis, S., Verwijs-Janssen, M., van den Broek, L. J., Begg, A. C., & Vens, C. (2010) · Cancer Research · doi:10.1158/0008-5472.can-09-3901 · Cited by 34

p53 and p73 Regulate Apoptosis but Not Cell-Cycle Progression in Mouse Embryonic Stem Cells upon DNA Damage and Differentiation

He, H., Wang, C., Dai, Q., Li, F., Bergholz, J. S., Li, Z., Li, Q., & Xiao, Z. J. (2016) · Stem Cell Reports · doi:10.1016/j.stemcr.2016.10.008 · Cited by 34

Trovafloxacin Enhances Lipopolysaccharide-Stimulated Production of Tumor Necrosis Factor-α by Macrophages: Role of the DNA Damage Response

Poulsen, K. L., Olivero‐Verbel, J., Beggs, K. M., Ganey, P. E., & Roth, R. A. (2014) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.114.214189 · Cited by 34

Curcumin enhances the response of non-Hodgkin’s lymphoma cells to ionizing radiation through further induction of cell cycle arrest at the G2/M phase and inhibition of mTOR phosphorylation

Qiao, Q., Jiang, Y., & Li, G. (2012) · Oncology Reports · doi:10.3892/or.2012.2091 · Cited by 33

ATM kinase activity modulates Fas sensitivity through the regulation of FLIP in lymphoid cells

Stagni, V., di Bari, M. G., Cursi, S., Condò, I., Cencioni, M. T., Testi, R., Lerenthal, Y., Cundari, E., & Barilà, D. (2007) · Blood · doi:10.1182/blood-2007-04-085399 · Cited by 32

Ataxia telangiectasia mutated influences cytochrome c oxidase activity

Patel, A., McDonald, T. M., Spears, L. D., Ching, J. K., & Fisher, J. S. (2011) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2011.01.075 · Cited by 33

Three independent mechanisms for arrest in G2after ionizing radiation

Landsverk, K. S., Patzke, S., Rein, I. D., Stokke, C., Lyng, H., Angelis, P. M. D., & Stokke, T. (2011) · Cell Cycle · doi:10.4161/cc.10.5.14968 · Cited by 35

Simian Virus 40 Activates ATR-Δp53 Signaling To Override Cell Cycle and DNA Replication Control

Rohaly, G., Korf, K., Dehde, S., & Dornreiter, I. (2010) · Journal of Virology · doi:10.1128/jvi.00122-10 · Cited by 33

Effect of ATM and HDAC Inhibition on Etoposide-Induced DNA Damage in Porcine Early Preimplantation Embryos

Wang, H., Luo, Y., Lin, Z., Lee, I., Kwon, J., Cui, X., & Kim, N. (2015) · PLoS ONE · doi:10.1371/journal.pone.0142561 · Cited by 33

ATM mutation and radiosensitivity: An opportunity in the therapy of mantle cell lymphoma

Ahmed, M., Li, L., Pinnix, C. C., Dabaja, B. S., Nomie, K. J., Lam, L. T., & Wang, M. L. (2016) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2016.08.008 · Cited by 32

Improving 131I Radioiodine Therapy By Hybrid Polymer-Grafted Gold Nanoparticles

Goas, M. L., Paquet, M., Paquirissamy, A., Guglielmi, J., Compin, C., Thariat, J., Vassaux, G., Geertsen, V., Humbert, O., Renault, J., et al. (2019) · International Journal of Nanomedicine · doi:10.2147/ijn.s211496 · Cited by 33

Phospho-Ser784-VCP Is Required for DNA Damage Response and Is Associated with Poor Prognosis of Chemotherapy-Treated Breast Cancer

Zhu, C., Rogers, A. M., Asleh, K., Won, J., Gao, D., Leung, S. C. Y., Li, S., Vij, K. R., Zhu, J., Held, J. M., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.107745 · Cited by 32

Regulation of the activity and expression of ERK8 by DNA damage

Klevernic, I. V., Martin, N. M. B., & Cohen, P. (2009) · FEBS Letters · doi:10.1016/j.febslet.2009.01.011 · Cited by 33

Deoxycytidine Kinase Augments ATM-Mediated DNA Repair and Contributes to Radiation Resistance

Bunimovich, Y. L., Nair‐Gill, E., Riedinger, M., McCracken, M. N., Cheng, D., McLaughlin, J., Radu, C. G., & Witte, O. N. (2014) · PLoS ONE · doi:10.1371/journal.pone.0104125 · Cited by 32

Mitochondria are required for ATM activation by extranuclear oxidative stress in cultured human hepatoblastoma cell line Hep G2 cells

Morita, A., Tanimoto, K., Murakami, T., Morinaga, T., & Hosoi, Y. (2014) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2013.12.139 · Cited by 32

Non‐thermal DNA damage of cancer cells using near‐infrared irradiation

Tanaka, Y., Tatewaki, N., Nishida, H., Eitsuka, T., Ikekawa, N., & Nakayama, J. (2012) · Cancer Science · doi:10.1111/j.1349-7006.2012.02310.x · Cited by 33

ATM protects against oxidative stress induced by oxidized low-density lipoprotein

Semlitsch, M., Shackelford, R. E., Zirkl, S., Sattler, W., & Malle, E. (2011) · DNA repair · doi:10.1016/j.dnarep.2011.05.004 · Cited by 33

Intestinal exposure to PCB 153 induces inflammation via the ATM/NEMO pathway

Phillips, M. C., Dheer, R., Santaolalla, R., Davies, J. M., Burgueño, J. F., Lang, J. K., Toborek, M. J., & Abreu, M. T. (2017) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2017.11.027 · Cited by 34

Dual targeting of higher-order DNA structures by azacryptands induces DNA junction-mediated DNA damage in cancer cells

Zell, J., Duskova, K., Chouh, L., Bossaert, M., Chéron, N., Granzhan, A., Britton, S., & Monchaud, D. (2021) · Nucleic Acids Research · doi:10.1093/nar/gkab796 · Cited by 31

Identification of ATR–Chk1 Pathway Inhibitors That Selectively Target p53-Deficient Cells without Directly Suppressing ATR Catalytic Activity

Kawasumi, M., Bradner, J. E., Tolliday, N. J., Thibodeau, R. M., Sloan, H., Brummond, K. M., & Nghiem, P. (2014) · Cancer Research · doi:10.1158/0008-5472.can-14-2650 · Cited by 30

Blockade of ataxia telangiectasia mutated sensitizes hepatoma cell lines to sorafenib by interfering with Akt signaling

Fujimaki, S., Matsuda, Y., Wakai, T., Sanpei, A., Kubota, M., Takamura, M., Yamagiwa, S., Yano, M., Ohkoshi, S., & Aoyagi, Y. (2012) · Cancer Letters · doi:10.1016/j.canlet.2011.12.043 · Cited by 32

ATM- and ATR-mediated response to DNA damage induced by a novel camptothecin, ST1968

Zuco, V., Benedetti, V., & Zunino, F. (2009) · Cancer Letters · doi:10.1016/j.canlet.2009.12.001 · Cited by 32

Activation of ataxia telangiectasia muted under experimental models and human Parkinson’s disease

Camins, A., Pizarro, J. G., Alvira, D., Cuesta, J., de la Torre, A. V., Folch, J., Sureda, F. X., Verdaguer, E., Junyent, F., Jordán, J., et al. (2010) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-010-0408-5 · Cited by 32

Determination of Cell Colony Formation in a High-Content Screening Assay

Wylie, P. G., & Bowen, W. P. (2007) · Clinics in Laboratory Medicine · doi:10.1016/j.cll.2006.12.008 · Cited by 32

Phosphatidylinositol 3 kinase (PI3K) modulates manganese homeostasis and manganese-induced cell signaling in a murine striatal cell line

Bryan, M. R., Uhouse, M. A., Nordham, K. D., Joshi, P. K., Rose, D. I. R., O’Brien, M. T., Aschner, M., & Bowman, A. B. (2017) · NeuroToxicology · doi:10.1016/j.neuro.2017.07.026 · Cited by 32

Evaluation of ATM Kinase Inhibitor KU-55933 as Potential Anti-Toxoplasma gondii Agent

Lopez, J. M., Ganuza, A., Bogado, S. S., Muñoz, D., Ruiz, D. M., Sullivan, W. J., Vanagas, L., & Angel, S. O. (2019) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2019.00026 · Cited by 32

Perspectives on the combination of radiotherapy and targeted therapy with DNA repair inhibitors in the treatment of pancreatic cancer

Yang, S., Kuo, T., Wu, H., Guo, J., Hsu, C., Hsu, C., Tien, Y., Yeh, K., Cheng, A., & Kuo, S. (2016) · World Journal of Gastroenterology · doi:10.3748/wjg.v22.i32.7275 · Cited by 33

Folate deficiency induced H2A ubiquitination to lead to downregulated expression of genes involved in neural tube defects

Pei, P., Cheng, X., Yu, J., Shen, J., Li, X., Wu, J., Wang, S., & Zhang, T. (2019) · Epigenetics & Chromatin · doi:10.1186/s13072-019-0312-7 · Cited by 33

Phosphorylation of seryl-tRNA synthetase by ATM/ATR is essential for hypoxia-induced angiogenesis

Shi, Y., Liu, Z., Zhang, Q., Vallee, I., Mo, Z., Kishi, S., & Yang, X. (2020) · PLoS Biology · doi:10.1371/journal.pbio.3000991 · Cited by 31

Structural insights into the activation of ataxia-telangiectasia mutated by oxidative stress

Howes, A. C., Perišić, O., & Williams, R. L. (2023) · Science Advances · doi:10.1126/sciadv.adi8291 · Cited by 32

The Role of ATM in the Deficiency in Nonhomologous End-Joining near Telomeres in a Human Cancer Cell Line

Muraki, K., Han, L., Miller, D., & Murnane, J. P. (2013) · PLoS Genetics · doi:10.1371/journal.pgen.1003386 · Cited by 30

Tug of War between Survival and Death: Exploring ATM Function in Cancer

Stagni, V., Oropallo, V., Fianco, G., Antonelli, M., Cinà, I., & Barilà, D. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms15045388 · Cited by 32

Synergistic Antitumor Effect of Sorafenib in Combination with ATM Inhibitor in Hepatocellular Carcinoma Cells

Liu, J., Liu, Y., Meng, L., Ji, B., & Yang, D. (2017) · International Journal of Medical Sciences · doi:10.7150/ijms.19033 · Cited by 31

Phosphorylation of Ewing's sarcoma protein (EWS) and EWS-Fli1 in response to DNA damage

Klevernic, I. V., Morton, S., Davis, R. J., & Cohen, P. (2008) · Biochemical Journal · doi:10.1042/bj20082097 · Cited by 33

WRN participates in translesion synthesis pathway through interaction with NBS1

Kobayashi, J., Okui, M., Asaithamby, A., Burma, S., Chen, B. P. C., Tanimoto, K., Matsuura, S., Komatsu, K., & Chen, D. J. (2010) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2010.06.005 · Cited by 33

SV40 Utilizes ATM Kinase Activity to Prevent Non-homologous End Joining of Broken Viral DNA Replication Products

Sowd, G. A., Mody, D., Eggold, J. T., Cortez, D., Friedman, K. L., & Fanning, E. (2014) · PLoS Pathogens · doi:10.1371/journal.ppat.1004536 · Cited by 29

Nitric Oxide Induces Ataxia Telangiectasia Mutated (ATM) Protein-dependent γH2AX Protein Formation in Pancreatic β Cells

Oleson, B. J., Broniowska, K. A., Schreiber, K. H., Tarakanova, V. L., & Corbett, J. A. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.531228 · Cited by 29

Genetic variants of DNA repair-related genes predict efficacy of TAS-102 in patients with refractory metastatic colorectal cancer

Suenaga, M., Schirripa, M., Cao, S., Zhang, W., Yang, D., Murgioni, S., Rossini, D., Marmorino, F., Mennitto, A., Ning, Y., et al. (2017) · Annals of Oncology · doi:10.1093/annonc/mdx035 · Cited by 30

Exploiting DNA Damage Repair in Precision Cancer Therapy: BRCA1 as a Prime Therapeutic Target

Raimundo, L., Calheiros, J., & Saraiva, L. (2021) · Cancers · doi:10.3390/cancers13143438 · Cited by 33

A DNA/HDAC dual‐targeting drug CY190602 with significantly enhanced anticancer potency

Liu, C., Ding, H., Li, X., Pallasch, C. P., Hong, L., Guo, D., Chen, Y., Wang, D., Wang, W., Wang, Y., et al. (2015) · EMBO Molecular Medicine · doi:10.15252/emmm.201404580 · Cited by 30

Controlling the Mdm2-Mdmx-p53 Circuit

Waning, D. L., Lehman, J. A., Batuello, C. N., & Mayo, L. D. (2010) · Pharmaceuticals · doi:10.3390/ph3051576 · Cited by 30

Development of a High-Content Screening Method for Chemicals Modulating DNA Damage Response

Kim, S., Jun, D. W., Kim, H. J., Jeong, K., & Lee, C. H. (2011) · SLAS DISCOVERY · doi:10.1177/1087057110392993 · Cited by 31

ATM-ROS-iNOS axis regulates nitric oxide mediated cellular senescence

Bagheri, M., Nair, R. R., Singh, K. K., & Saini, D. K. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2016.11.008 · Cited by 31

The ATM kinase inhibitor KU-55933 provides neuroprotection against hydrogen peroxide-induced cell damage via a γH2AX/p-p53/caspase-3-independent mechanism: Inhibition of calpain and cathepsin D

Chwastek, J., Jantas, D., & Lasoń, W. (2017) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2017.03.015 · Cited by 31

DNA Damage Signaling Is Induced in the Absence of Epstein—Barr Virus (EBV) Lytic DNA Replication and in Response to Expression of ZEBRA

Wang’ondu, R. W., Teal, S., Park, R., Heston, L., Delecluse, H., & Miller, G. (2015) · PLoS ONE · doi:10.1371/journal.pone.0126088 · Cited by 32

A designer bow-tie combination therapeutic platform: An approach to resistant cancer treatment by simultaneous delivery of cytotoxic and anti-inflammatory agents and radiation

Pathak, R., Basu, U., Ahmad, A., Sarkar, S., Kumar, A., Surnar, B., Ansari, S., Wilczek, K., Ivan, M. E., Marples, B., et al. (2018) · Biomaterials · doi:10.1016/j.biomaterials.2018.08.062 · Cited by 32

S phase entry causes homocysteine-induced death while ataxia telangiectasia and Rad3 related protein functions anti-apoptotically to protect neurons

Ye, W., & Blain, S. W. (2010) · Brain · doi:10.1093/brain/awq139 · Cited by 30

IKKβ Regulates the Repair of DNA Double-Strand Breaks Induced by Ionizing Radiation in MCF-7 Breast Cancer Cells

Wu, L., Shao, L., An, N., Wang, J., Pazhanisamy, S. K., Feng, W., Hauer‐Jensen, M., Miyamoto, S., & Zhou, D. (2011) · PLoS ONE · doi:10.1371/journal.pone.0018447 · Cited by 29

Targeting ATM pathway for therapeutic intervention in cancer

Khalil, H. S., Tummala, H., Chakarov, S., Zhelev, N., & Lane, D. P. (2012) · Biodiscovery · doi:10.7750/biodiscovery.2012.1.3 · Cited by 31

TRAF6 mediates human DNA2 polyubiquitination and nuclear localization to maintain nuclear genome integrity

Meng, Y., Liu, C., Shen, L., Zhou, M., Liu, W., Kowolik, C. M., Campbell, J. L., Zheng, L., & Shen, B. (2019) · Nucleic Acids Research · doi:10.1093/nar/gkz537 · Cited by 29

Impaired ATM activation in B cells is associated with bone resorption in rheumatoid arthritis

Mensah, K. A., Chen, J. W., Schickel, J., Isnardi, I., Yamakawa, N., Vega-Loza, A., Anolik, J. H., Gatti, R. A., Gelfand, E. W., Montgomery, R. R., et al. (2019) · Science Translational Medicine · doi:10.1126/scitranslmed.aaw4626 · Cited by 30

Silibinin protects murine fibroblast L 929 cells from UVB ‐induced apoptosis through the simultaneous inhibition of ATM ‐p53 pathway and autophagy

Liu, W., Otkur, W., Zhang, Y., Li, Q., Ye, Y., Zang, L., He, H., Hayashi, T., Tashiro, S., Onodera, S., et al. (2013) · FEBS Journal · doi:10.1111/febs.12426 · Cited by 29

The DNA Damage Response Kinases DNA-dependent Protein Kinase (DNA-PK) and Ataxia Telangiectasia Mutated (ATM) Are Stimulated by Bulky Adduct-containing DNA

Kemp, M. G., Lindsey‐Boltz, L. A., & Sancar, A. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.235036 · Cited by 30

The Antibiotic Monensin Causes Cell Cycle Disruption ofToxoplasma gondiiMediated through the DNA Repair Enzyme TgMSH-1

Lavine, M. D., & Arrizabalaga, G. (2010) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01092-10 · Cited by 29

Ran Binding Protein 9 (RanBP9) is a novel mediator of cellular DNA damage response in lung cancer cells

Palmieri, D., Scarpa, M., Tessari, A., Uka, R., Amari, F., Lee, C., Richmond, T. K., Foray, C., Sheetz, T. J., Braddom, A. E., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.7813 · Cited by 29

And-1 is required for homologous recombination repair by regulating DNA end resection

Li, Y., Li, Z., Wu, R., Han, Z., & Zhu, W. (2016) · Nucleic Acids Research · doi:10.1093/nar/gkw1241 · Cited by 29

TGFβ Promotes Genomic Instability after Loss of RUNX3

Krishnan, V., Chong, Y. L., Tan, T. Z., Kulkarni, M., Rahmat, M. B. B., Tay, L. S., Sankar, H., Jokhun, D. S., Ganesan, A., Chuang, L. S. H., et al. (2017) · Cancer Research · doi:10.1158/0008-5472.can-17-1178 · Cited by 30

Ionizing radiation induces ATM-independent degradation of p21Cip1 in transformed cells

Stuart, S. A., & Wang, J. Y. J. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m808810200 · Cited by 28

DNA damage response in brain tumors: A Society for Neuro-Oncology consensus review on mechanisms and translational efforts in neuro-oncology

Rahman, R. M., Shi, D. D., Reitman, Z. J., Hamerlik, P., de Groot, J., Haas-Kogan, D. A., D’Andrea, A. D., Sulman, E. P., Tanner, K. G., Agar, N. Y. R., et al. (2024) · Neuro-Oncology · doi:10.1093/neuonc/noae072 · Cited by 34

Replication stress induced site-specific phosphorylation targets WRN to the ubiquitin-proteasome pathway

Su, F., Bhattacharya, S., Abdisalaam, S., Mukherjee, S., Yajima, H., Yang, Y., Mishra, R., Kalayarasan, S., Ghose, S., Chen, D. J., et al. (2015) · Oncotarget · doi:10.18632/oncotarget.6659 · Cited by 28

p27Kip1 Is Required to Mediate a G1 Cell Cycle Arrest Downstream of ATM following Genotoxic Stress

Cassimere, E. K., Mauvais, C., & Denicourt, C. (2016) · PLoS ONE · doi:10.1371/journal.pone.0162806 · Cited by 29

Contribution of canonical nonhomologous end joining to chromosomal rearrangements is enhanced by ATM kinase deficiency

Bhargava, R., Carson, C. R., Lee, G., & Stark, J. M. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1612204114 · Cited by 31

Anti-Tumor Effect of Inhibition of DNA Damage Response Proteins, ATM and ATR, in Endometrial Cancer Cells

Takeuchi, M., Tanikawa, M., Nagasaka, K., Oda, K., Kawata, Y., Oki, S., Chuwa, A. H., Sone, K., Miyagawa, Y., Hiraike, H., et al. (2019) · Cancers · doi:10.3390/cancers11121913 · Cited by 30

The transcriptional regulation of normal and malignant blood cell development

Edginton‐White, B., & Bonifer, C. (2021) · FEBS Journal · doi:10.1111/febs.15735 · Cited by 27

ATM inhibitor KU‐55933 induces apoptosis and inhibits motility by blocking GLUT1‐mediated glucose uptake in aggressive cancer cells with sustained activation of Akt

Harris, B., Zhang, Y., Tao, J., Shen, R., Zhao, X., Cleary, M. P., Wang, T., & Yang, D. (2021) · The FASEB Journal · doi:10.1096/fj.202001415rr · Cited by 28

Distinct transcriptional responses elicited by unfolded nuclear or cytoplasmic protein in mammalian cells

Miyazaki, Y., Chen, L., Chu, B. W., Swigut, T., & Wandless, T. J. (2015) · eLife · doi:10.7554/elife.07687 · Cited by 28

A pathway from leukemogenic oncogenes and stem cell chemokines to RNA processing via THOC5

Griaud, F., Pierce, A., Gonzalez-Sanchez, M.-B., Scott, M. T., Abraham, S. A., Holyoake, T. L., Tran, D. D. H., Tamura, T., & Whetton, A. D. (2012) · Leukemia · doi:10.1038/leu.2012.283 · Cited by 28

Harmonic analysis of vibrations of morpholine-4-ylmethylthiourea: A DFT, midinfrared and Raman spectral study

Ramalingam, S., Jaccob, M., Swaminathan, J., Venuvanalingam, P., & Sundaraganesan, N. (2008) · Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy · doi:10.1016/j.saa.2008.02.034 · Cited by 28

Chk1 inhibition activates p53 through p38 MAPK in tetraploid cancer cells

Vitale, I., Senovilla, L., Galluzzi, L., Criollo, A., Vivet, S., Castedo, M., & Kroemer, G. (2008) · Cell Cycle · doi:10.4161/cc.7.13.6073 · Cited by 34

UV-induced RPA phosphorylation is increased in the absence of DNA polymerase η and requires DNA-PK

Cruet-Hennequart, S., Coyne, S., Glynn, M. T., Oakley, G. G., & Carty, M. P. (2006) · DNA repair · doi:10.1016/j.dnarep.2006.01.008 · Cited by 30

Optimization of Potent and Selective Ataxia Telangiectasia-Mutated Inhibitors Suitable for a Proof-of-Concept Study in Huntington’s Disease Models

Toledo, L. M., Breccia, P., Cachope, R., Bate, J. R., Angulo-Herrera, I., Wishart, G., Matthews, K. L., Martin, S. L., Cox, H. C., McAllister, G., et al. (2019) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.8b01819 · Cited by 27

Fibroblast Growth Factor 2 lethally sensitizes cancer cells to stress‐targeted therapeutic inhibitors

Dias, M. H., Fonseca, C. S., Zeidler, J. D., Albuquerque, L. L., da Silva, M. S., Lopes, E. C., Reis, M. S., Noël, V., dos Santos, E. O., Prior, I. A., et al. (2018) · Molecular Oncology · doi:10.1002/1878-0261.12402 · Cited by 26

Synthetic lethality on drug discovery: an update on cancer therapy

Yar, M. S., Haider, K., Gohel, V., Siddiqui, N. A., & Kamal, Ä. (2020) · Expert Opinion on Drug Discovery · doi:10.1080/17460441.2020.1744560 · Cited by 27

Phosphorylation of SAF-A/hnRNP-U Serine 59 by Polo-Like Kinase 1 Is Required for Mitosis

Douglas, P., Ye, R., Morrice, N. A., Britton, S., Trinkle‐Mulcahy, L., & Lees‐Miller, S. P. (2015) · Molecular and Cellular Biology · doi:10.1128/mcb.01312-14 · Cited by 26

Reduction of phosphorylated histone H3 serine 10 and serine 28 cell cycle marker intensities after DNA damage

Ozawa, K. (2008) · Cytometry Part A · doi:10.1002/cyto.a.20559 · Cited by 27

Conserved and Distinct Modes of CREB/ATF Transcription Factor Regulation by PP2A/B56γ and Genotoxic Stress

Shanware, N. P., Zhan, L., Hutchinson, J. A., Kim, S. H., Williams, L. M., & Tibbetts, R. S. (2010) · PLoS ONE · doi:10.1371/journal.pone.0012173 · Cited by 27

Quantitative Proteomics Reveal ATM Kinase-dependent Exchange in DNA Damage Response Complexes

Choi, S., Srivas, R., Fu, K. Y., Hood, B. L., Dost, B., Gibson, G. A., Watkins, S. C., Houten, B. V., Bandeira, N., Conrads, T. P., et al. (2012) · Journal of Proteome Research · doi:10.1021/pr3005524 · Cited by 27

The CEACAM1 tumor suppressor is an ATM and p53-regulated gene required for the induction of cellular senescence by DNA damage

Sappino, A.-P., Buser, R., Seguin, Q., Fernet, M., Lesne, L., Gumy‐Pause, F., Reith, W., Favaudon, V., & Mandriota, S. J. (2012) · Oncogenesis · doi:10.1038/oncsis.2012.7 · Cited by 27

CX-5461 Preferentially Induces Top2α-Dependent DNA Breaks at Ribosomal DNA Loci

Cameron, D. P., Sornkom, J., Alsahafi, S., Drygin, D., Poortinga, G., McArthur, G. A., Hein, N., Hannan, R. D., & Panov, K. I. (2024) · Biomedicines · doi:10.3390/biomedicines12071514 · Cited by 28

ATM-Dependent Phosphorylation of MEF2D Promotes Neuronal Survival after DNA Damage

Chan, S. F., Sances, S., Brill, L. M., Okamoto, S., Zaidi, R., McKercher, S. R., Akhtar, M. W., Nakanishi, N., & Lipton, S. A. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.2510-12.2014 · Cited by 26

Investigation of the Functional Link between ATM and NBS1 in the DNA Damage Response in the Mouse Cerebellum

Dar, I., Yosha, G., Elfassy, R., Galron, R., Wang, Z., Shiloh, Y., & Barzilai, A. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.204172 · Cited by 26

mTOR kinase-dependent, but raptor-independent regulation of downstream signaling is important for cell cycle exit and myogenic differentiation

Pollard, H. J., Willett, M., & Morley, S. (2014) · Cell Cycle · doi:10.4161/15384101.2014.941747 · Cited by 26

Ionizing radiation response of primary normal human lens epithelial cells

Hamada, N. (2017) · PLoS ONE · doi:10.1371/journal.pone.0181530 · Cited by 26

Nuclear poly(A)-binding protein 1 is an ATM target and essential for DNA double-strand break repair

Gavish-Izakson, M., Velpula, B. B., Elkon, R., Prados‐Carvajal, R., Barnabas, G. D., Ugalde, A. P., Agami, R., Geiger, T., Huertas, P., Ziv, Y., et al. (2017) · Nucleic Acids Research · doi:10.1093/nar/gkx1240 · Cited by 26

Long-Term In vivo Effects of Cisplatin on γ-H2AX Foci Signaling in Peripheral Lymphocytes of Tumor Patients After Irradiation

Sak, A., Grehl, S., Engelhard, M., Wierlemann, A., Kaelberlah, H.-P., Erichsen, P., Pöttgen, C., Groneberg, M., & Stuschke, M. (2009) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-08-0650 · Cited by 27

HSATII RNA is induced via a noncanonical ATM-regulated DNA damage response pathway and promotes tumor cell proliferation and movement

Nogalski, M. T., & Shenk, T. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2017734117 · Cited by 25

Bimodal regulation of p21waf1protein as function of DNA damage levels

Buscemi, G., Ricci, C., Zannini, L., Fontanella, E., Plevani, P., & Delia, D. (2014) · Cell Cycle · doi:10.4161/15384101.2014.946852 · Cited by 25

Cells and Stripes: A novel quantitative photo-manipulation technique

Mistrík, M., Veselá, E., Fürst, T., Hanzlíková, H., Frydrych, I., Gurský, J., Majera, D., & Bártek, J. (2016) · Scientific Reports · doi:10.1038/srep19567 · Cited by 23

The sirtuin 1/2 inhibitor tenovin-1 induces a nonlinear apoptosis-inducing factor-dependent cell death in a p53 null Ewing’s sarcoma cell line

Marx, C., Marx-Blümel, L., Lindig, N., Thierbach, R., Hoelzer, D., Becker, S., Wittig, S., Lehmann, R., Slevogt, H., Heinzel, T., et al. (2017) · Investigational New Drugs · doi:10.1007/s10637-017-0541-1 · Cited by 25

Abstract 3928: KU-0060019, a novel small molecule inhibitor of ATM

Shea, K. F., Albertella, M. R., Bárdos, J. I., Batey, M. A., Cranston, A. N., Curtin, N. J., Griffin, R. J., Lau, A., Menear, K. A., Newell, D. R., et al. (2010) · Cancer Research · doi:10.1158/1538-7445.am10-3928

PRECLINICAL STUDIES ON ATM KINASE INHIBITORS AS ANTI-CANCER AGENTS

Choi, S. (2011) · D-Scholarship@Pitt (University of Pittsburgh)

Transient Inhibition of ATM Kinase Is Sufficient to Enhance Cellular Sensitivity to Ionizing Radiation

Rainey, M. D., Charlton, M. E., Stanton, R. V., & Kastan, M. B. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-0763 · Cited by 273

Pharmacological inhibition of ATM by KU55933 stimulates ATM transcription

Khalil, H. S., Tummala, H., Hupp, T. R., & Zhelev, N. (2012) · Experimental Biology and Medicine · doi:10.1258/ebm.2012.011378 · Cited by 24

Irreversible chromosome damage accumulates rapidly in the absence of ATM kinase activity

White, J. S., Choi, S., & Bakkenist, C. J. (2008) · Cell Cycle · doi:10.4161/cc.7.9.5961 · Cited by 51