Tumors face NO problems?
Abstract
The effect of nitric oxide (NO) synthase (NOS) II expression on cancer biology is unclear and difficult to define, with multiple reports of pro- and anti-cancer actions. Here we address the major factors that seem likely to account for these paradoxical behaviors, which include variability in NO production, heterogeneity in NO chemistry (and thus its cellular actions), and differential cellular responses. In addition, we suggest that a major determinant of the outcome of NO actions in the tumor environment is cellular adaptation/selection to the cytotoxic actions of NO.
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Depending on the sites and amounts of NO generation, NO might represent a double-edged sword in that it confers both protective and deleterious effects on cancer development.
“Depending on the sites and amounts of NO generation, NO might represent a double-edged sword in the sense that it confers both protective and deleterious effects on cancer development [150,151].”
From NO-Rich Diet for Lifestyle-Related Diseases (2015) · cites this paper as [151]
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Chromium Complex of Macrocyclic Ligands as Precursor for Nitric Oxide Release: A Theoretical Study
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- Authors
- Lancaster, J. R., & Xie, K.
- Affiliations
- University of Alabama at Birmingham (US)
- The University of Texas MD Anderson Cancer Center (US)
- ORCID
- Xie, Keping
- Venue
- Cancer Research
- Published
- 2006-07-01
- Volume
- 66
- Issue
- 13
- Pages
- 6459-6462
- ISSN
- 0008-5472 (ISSN-L)
- 1538-7445
- OpenAlex
- W1989170288
- Cited by
- 98
- References
- 25
- Citations by year
- 2025: 1 · 2024: 4 · 2023: 1 · 2022: 1 · 2021: 3 · 2020: 2 · 2017: 5 · 2016: 2 · 2015: 4 · 2014: 5 · 2013: 8 · 2012: 8
- FWCI
- 7.95
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cancer Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5p20ca101936-05)
- National Heart, Lung, and Blood Institute (R01 HL 71189-01, R01HL071189, R01HL074391)
- National Cancer Institute (R01CA093829, P20-CA101936)
- Topics
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Keywords
- nitric oxide, nitric oxide synthase II, tumor biology, cancer cell adaptation, cellular heterogeneity, tumor microenvironment
- MeSH terms
- Animals, Humans, Neoplasms, Nitric Oxide, Cell Death, Nitric Oxide Synthase Type II
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