Cited by 98Nitric Oxide and Endothelin EffectsRedox biology and oxidative stressAngiogenesis and VEGF in Cancer

Tumors face NO problems?

Lancaster, Jack R., Xie, Keping·2006·Cancer Research

Abstract

The effect of nitric oxide (NO) synthase (NOS) II expression on cancer biology is unclear and difficult to define, with multiple reports of pro- and anti-cancer actions. Here we address the major factors that seem likely to account for these paradoxical behaviors, which include variability in NO production, heterogeneity in NO chemistry (and thus its cellular actions), and differential cellular responses. In addition, we suggest that a major determinant of the outcome of NO actions in the tumor environment is cellular adaptation/selection to the cytotoxic actions of NO.

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Crossref · 10.1158/0008-5472.can-05-2900

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25 of 25 references verified0 citation errors · 0 not checkable

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  • Depending on the sites and amounts of NO generation, NO might represent a double-edged sword in that it confers both protective and deleterious effects on cancer development.

    “Depending on the sites and amounts of NO generation, NO might represent a double-edged sword in the sense that it confers both protective and deleterious effects on cancer development [150,151].”

    From NO-Rich Diet for Lifestyle-Related Diseases (2015) · cites this paper as [151]

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Authors
Lancaster, J. R., & Xie, K.
Affiliations
  • University of Alabama at Birmingham (US)
  • The University of Texas MD Anderson Cancer Center (US)
Venue
Cancer Research
Published
2006-07-01
Volume
66
Issue
13
Pages
6459-6462
ISSN
  • 0008-5472 (ISSN-L)
  • 1538-7445
OpenAlex
W1989170288
Cited by
98
References
25
Citations by year
2025: 1 · 2024: 4 · 2023: 1 · 2022: 1 · 2021: 3 · 2020: 2 · 2017: 5 · 2016: 2 · 2015: 4 · 2014: 5 · 2013: 8 · 2012: 8
FWCI
7.95
Type
journal article
Language
en
Open access
closed
Locations
  • Cancer Research (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5p20ca101936-05)
  • National Heart, Lung, and Blood Institute (R01 HL 71189-01, R01HL071189, R01HL074391)
  • National Cancer Institute (R01CA093829, P20-CA101936)
Topics
  • Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
Keywords
nitric oxide, nitric oxide synthase II, tumor biology, cancer cell adaptation, cellular heterogeneity, tumor microenvironment
MeSH terms
Animals, Humans, Neoplasms, Nitric Oxide, Cell Death, Nitric Oxide Synthase Type II

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