Heparanase, Hyaluronan, and CD44 in Cancers: A Breast Carcinoma Perspective

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Prevalence of CD44+/CD24−/low Cells in Breast Cancer May Not Be Associated with Clinical Outcome but May Favor Distant Metastasis

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Hyaluronan in Peritumoral Stroma and Malignant Cells Associates with Breast Cancer Spreading and Predicts Survival

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Recent advances in tumor-targeting anticancer drug conjugates

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Identification of sulfated oligosaccharide-based inhibitors of tumor growth and metastasis using novel in vitro assays for angiogenesis and heparanase activity.

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Physiological degradation converts the soluble syndecan-1 ectodomain from an inhibitor to a potent activator of FGF-2

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Heparanases and tumor metastasis

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Regulation of MDR1 Expression and Drug Resistance by a Positive Feedback Loop Involving Hyaluronan, Phosphoinositide 3-Kinase, and ErbB2*♦

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Heparanase Gene Silencing, Tumor Invasiveness, Angiogenesis, and Metastasis

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Hyaluronan-mediated CD44 Interaction with RhoGEF and Rho Kinase Promotes Grb2-associated Binder-1 Phosphorylation and Phosphatidylinositol 3-Kinase Signaling Leading to Cytokine (Macrophage-Colony Stimulating Factor) Production and Breast Tumor Progression

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Heparanase Induces Vascular Endothelial Growth Factor Expression: Correlation with p38 Phosphorylation Levels and Src Activation

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The over-expression of HAS2, Hyal-2 and CD44 is implicated in the invasiveness of breast cancer

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Regulation of Multidrug Resistance in Cancer Cells by Hyaluronan

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Processing of the Human Heparanase Precursor and Evidence That the Active Enzyme Is a Heterodimer

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Radiation dose, chemotherapy and risk of osteosarcoma after solid tumours during childhood

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CD44 Attenuates Metastatic Invasion during Breast Cancer Progression

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Targeted Delivery of Doxorubicin by HPMA Copolymer-Hyaluronan Bioconjugates

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Hyaluronan metabolism: a major paradox in cancer biology

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Heparanase-1 expression is associated with the metastatic potential of breast cancer

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CD44-Mediated Oncogenic Signaling and Cytoskeleton Activation During Mammary Tumor Progression

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Heparanase promotes growth, angiogenesis and survival of primary breast tumors

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Antisense-Mediated Suppression of Hyaluronan Synthase 2 Inhibits the Tumorigenesis and Progression of Breast Cancer

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A hyaluronan synthase suppressor, 4‐methylumbelliferone, inhibits liver metastasis of melanoma cells

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Immunohistochemical Detection of c-erbB-2 and p53 in Benign Breast Disease and Breast Cancer Risk

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Expression of Heparanase by Primary Breast Tumors Promotes Bone Resorption in the Absence of Detectable Bone Metastases

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Role of promoter methylation in regulation of the mammalian heparanase gene

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Human heparanase nuclear localization and enzymatic activity

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Regulation of heparanase gene expression by estrogen in breast cancer.

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Tumor suppressor p53 regulates heparanase gene expression

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Hyaluronidase reduces human breast cancer xenografts in SCID mice

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Early Growth Response Gene 1 (EGR1) Regulates Heparanase Gene Transcription in Tumor Cells

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Inhibition of heparanase activity and heparanase‐induced angiogenesis by suramin analogues

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CD44 Expression Is Associated with Increased Survival in Node-Negative Invasive Breast Carcinoma

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Characterization of the Heparan Sulfate and Chondroitin Sulfate Assembly Sites in CD44

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Serum hyaluronan (hyaluronic acid) in breast cancer patients

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Proteoglycans: Pericellular and Cell Surface Multireceptors that Integrate External Stimuli in the Mammary Gland

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Breast Cancer Stromal Myxoid Changes Are Associated with Tumor Invasion and Metastasis: A Central Role for Hyaluronan

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Expression of cell adhesion molecules, CD44s and E‐cadherin, and microvessel density in invasive micropapillary carcinoma of the breast

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Expression of CD44s, CD44v3 and CD44v6 in benign and malignant breast lesions: correlation and colocalization with hyaluronan

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Trans-activation of heparanase promoter by ETS transcription factors

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Hyaluronan-CD44 Promotes Phospholipase C–Mediated Ca2+ Signaling and Cisplatin Resistance in Head and Neck Cancer

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Expression of a CD44 variant and VEGF-C and the implications for lymphatic metastasis and long-term prognosis of human breast cancer.

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Clinicopathological associations of CD44 mRNA and protein expression in primary breast carcinomas

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Ductal carcinoma in situ of the breast and heparanase-1 expression: A molecular explanation for more aggressive subtypes

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COX-2 induction by heparanase in the progression of breast cancer

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The role of CD44v3 expression in female breast carcinomas.

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Phase I and Pharmacokinetic Evaluation of Intravenous Hyaluronic Acid in Combination with Doxorubicin or 5-Fluorouracil

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Residual breast cancers after conventional therapy display mesenchymal as well as tumor-initiating features

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Significance of CD90+ Cancer Stem Cells in Human Liver Cancer

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Fibroblast heterogeneity in the cancer wound

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The JAK2/STAT3 signaling pathway is required for growth of CD44+CD24– stem cell–like breast cancer cells in human tumors

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Interstitial Fluid and Lymph Formation and Transport: Physiological Regulation and Roles in Inflammation and Cancer

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Conquering the Hypoxia Limitation for Photodynamic Therapy

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Targeting and delivery of platinum-based anticancer drugs

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Endogenous toll‐like receptor ligands and their biological significance

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CD44, a therapeutic target for metastasising tumours

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TLR signaling by tumor and immune cells: a double-edged sword

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Catalase-Integrated Hyaluronic Acid as Nanocarriers for Enhanced Photodynamic Therapy in Solid Tumor

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Interstitial guidance of cancer invasion

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Fusion of tumour cells with bone marrow-derived cells: a unifying explanation for metastasis

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The activation and physiological functions of the proprotein convertases

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Breast cancer metastasis

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A review of nanotechnology-based approaches for breast cancer and triple-negative breast cancer

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Photodynamic therapy: Innovative approaches for antibacterial and anticancer treatments

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Chemical Synthesis of Glycosaminoglycans

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Enzyme-triggered size shrink and laser-enhanced NO release nanoparticles for deep tumor penetration and combination therapy

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Self-assembled hyaluronic acid nanoparticles as a potential drug carrier for cancer therapy: synthesis, characterization, and in vivo biodistribution

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The Hyaluronan Receptors CD44 and Rhamm (CD168) Form Complexes with ERK1,2 That Sustain High Basal Motility in Breast Cancer Cells

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Hyaluronic acid and albumin based nanoparticles for drug delivery

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Cancer Stem Cell Hierarchy in Glioblastoma Multiforme

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Risk of Cancer in Patients With Autoimmune Pancreatitis

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High numbers of macrophages, especially M2‐like ( CD 163‐positive), correlate with hyaluronan accumulation and poor outcome in breast cancer

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Cell-surface and mitotic-spindle RHAMM: moonlighting or dual oncogenic functions?

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CD44 isoforms are heterogeneously expressed in breast cancer and correlate with tumor subtypes and cancer stem cell markers

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Proteomic Analysis of Microvesicles Derived from Human Colorectal Cancer Cells

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Hyaluronic acid-coated PEI-PLGA nanoparticles mediated co-delivery of doxorubicin and miR-542-3p for triple negative breast cancer therapy

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