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Norepinephrine Up-regulates the Expression of Vascular Endothelial Growth Factor, Matrix Metalloproteinase (MMP)-2, and MMP-9 in Nasopharyngeal Carcinoma Tumor Cells
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Recent studies using ovarian cancer cells have shown that the catecholamine hormones norepinephrine (norepi) and epinephrine (epi) may influence cancer progression by modulating the expression of matrix metalloproteinases (MMP) and vascular endothelial growth factor (VEGF). The purpose of this study is to determine if the stress hormone norepi can influence the expression of MMP-2, MMP-9, and VEGF in nasopharyngeal carcinoma (NPC) tumors by using three NPC tumor cell lines. The NPC cell lines HONE-1, HNE-1, and CNE-1 were treated with norepi. The effects of norepi on MMP-2, MMP-9, and VEGF synthesis were measured by ELISA; functional MMP activity was measured by the invasive potential of the cells using a membrane invasion culture system whereas functional activity of VEGF was analyzed using a human umbilical vein endothelial cell tube formation assay. Norepi treatment increased MMP-2, MMP-9, and VEGF levels in culture supernatants of HONE-1 cells, which could be inhibited by the β-blocker propranolol. Norepi induced the invasiveness of all NPC cell lines in a dose-dependent manner, which was blocked by CMT-3, an MMP inhibitor, and propranolol. Norepi stimulated the release of functional angiogenic VEGF by HONE-1 cells as well. Finally, HONE-1 cells were shown to express β-adrenergic receptors as did seven of seven NPC biopsies examined. The data suggest that catecholamine hormones produced by the sympathetic-adrenal medullary axis may affect NPC tumor progression, in part, through modulation of key angiogenic cytokines. (Cancer Res 2006; 66(21): 10357-64)
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“It is known within the cancer literature that stress levels of NE increase MMP-9 and MMP-2 that increase invasive potential of the tumor cells (Sood et al, 2006;Yang et al, 2006).”
From Repeated Social Defeat, Neuroinflammation, and Behavior: Monocytes Carry the Signal (2017) · cites this paper as Yang et al, 2006
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Cites
Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method
Livak, K. J., & Schmittgen, T. D. (2001) · Methods · doi:10.1006/meth.2001.1262 · Cited by 180,860
NF-κB: linking inflammation and immunity to cancer development and progression
Karin, M., & Greten, F. R. (2005) · Nature reviews. Immunology · doi:10.1038/nri1703 · Cited by 3,175
Stress-induced immune dysfunction: implications for health
Glaser, R., & Kiecolt-Glaser, J. K. (2005) · Nature Reviews Immunology · doi:10.1038/nri1571 · Cited by 2,190
Self-citationStress, depression, the immune system, and cancer
Reiche, E. M. V., Nunes, S. O. V., & Morimoto, H. K. (2004) · The Lancet Oncology · doi:10.1016/s1470-2045(04)01597-9 · Cited by 1,364
Chronic stress promotes tumor growth and angiogenesis in a mouse model of ovarian carcinoma
Thaker, P. H., Han, L. Y., Kamat, A. A., Arevalo, J. M., Takahashi, R., Lu, C., Jennings, N. B., Armaiz-Pena, G., Bankson, J. A., Ravoori, M., et al. (2006) · Nature Medicine · doi:10.1038/nm1447 · Cited by 1,320
Self-citationSlowing of wound healing by psychological stress
Kiecolt-Glaser, J. K., Marucha, P. T., Mercado, A. M., Malarkey, W. B., & Glaser, R. (1995) · The Lancet · doi:10.1016/s0140-6736(95)92899-5 · Cited by 1,104
Self-citationHow stress influences the immune response
Padgett, D. A., & Glaser, R. (2003) · Trends in Immunology · doi:10.1016/s1471-4906(03)00173-x · Cited by 1,059
Self-citationA mechanism converting psychosocial stress into mononuclear cell activation
Bierhaus, A., Wolf, J., Andrassy, M., Rohleder, N., Humpert, P. M., Petrov, D., Ferstl, R., von Eynatten, M., Wendt, T., Rudofsky, G., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0438019100 · Cited by 927
The biology of vascular endothelial growth factors
Tammela, T., Enholm, B., Alitalo, K. K., & Paavonen, K. (2005) · Cardiovascular Research · doi:10.1016/j.cardiores.2004.12.002 · Cited by 859
Epstein–Barr virus in the pathogenesis of NPC
Raab‐Traub, N. (2002) · Seminars in Cancer Biology · doi:10.1016/s1044579x0200086x · Cited by 577
Research works printed but not linked: 1
- Lewis CE, O'Brien RM, Barraclough J, editors. Psychoimmunology of cancer. 2nd ed. Oxford: Oxford University Press; 2002.
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Cole, S. W., & Sood, A. K. (2011) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-11-0641 · Cited by 713
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Moreno‐Smith, M., Lutgendorf, S. K., & Sood, A. K. (2010) · Future Oncology · doi:10.2217/fon.10.142 · Cited by 522
Self-citationMelhem‐Bertrandt, A., Chávez‐MacGregor, M., Lei, X. J., Brown, E. N., Lee, R. T., Meric‐Bernstam, F., Sood, A. K., Conzen, S. D., Hortobágyi, G. N., & Gonzalez-Angulo, A. M. (2011) · Journal of Clinical Oncology · doi:10.1200/jco.2010.33.4441 · Cited by 471
Self-citationIs cancer triggered by altered signalling of nicotinic acetylcholine receptors?
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Sleire, L., Førde, H. E., Netland, I. A., Leiss, L., Skeie, B. S., & Enger, P. Ø. (2017) · Pharmacological Research · doi:10.1016/j.phrs.2017.07.013 · Cited by 329
Yang, E. V., Kim, S.-J., Donovan, E. L., Chen, M., Gross, A. C., Marketon, J. I. W., Barsky, S. H., & Glaser, R. (2008) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2008.10.005 · Cited by 325
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Self-citationLemeshow, S. A., Sørensen, H. T., Phillips, G. S., Yang, E. V., Antonsen, S., Riis, A. H., Lesinski, G. B., Jackson, R., & Glaser, R. (2011) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-11-0249 · Cited by 208
Self-citationCampbell, J. P., Karolak, M. R., Ma, Y., Perrien, D. S., Masood-Campbell, S. K., Penner, N. L., Munoz, S. A., Zijlstra, A., Yang, X., Sterling, J. A. R., et al. (2012) · PLoS Biology · doi:10.1371/journal.pbio.1001363 · Cited by 203
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Li, C., Li, X., Miao, Y., Wang, Q., Jiang, W., Xu, C. D., Li, J., Han, J., Zhang, F., Gong, B., et al. (2009) · Nucleic Acids Research · doi:10.1093/nar/gkp667 · Cited by 191
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Self-citationPark, S. Y., Kang, J. H., Jeong, K. J., Lee, J., Han, J. W., Choi, W. S., Kim, Y. K., Kang, J., Park, C. G., & Lee, H. Y. (2010) · International Journal of Cancer · doi:10.1002/ijc.25589 · Cited by 135
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Partecke, L. I., Speerforck, S., Käding, A., Seubert, F., Kühn, S., Lorenz, E., Schwandke, S., Sendler, M., Keßler, W., Trung, D. N., et al. (2016) · Pancreatology · doi:10.1016/j.pan.2016.03.005 · Cited by 136
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Moretti, S., Massi, D., Farini, V., Baroni, G., Parri, M., Innocenti, S., Cecchi, R., & Chiarugi, P. (2013) · Laboratory Investigation · doi:10.1038/labinvest.2012.175 · Cited by 119
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Neeman, E., Zmora, O., & Ben‐Eliyahu, S. (2012) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-12-1087 · Cited by 113
Chang, A., Le, C. P., Walker, A. K., Creed, S. J., Pon, C. K., Albold, S., Carroll, D., Halls, M. L., Lane, J. R., Riedel, B., et al. (2016) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2016.06.011 · Cited by 119
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Calvani, M., Pelon, F., Comito, G., Taddei, M. L., Moretti, S., Innocenti, S., Nassini, R., Gerlini, G., Borgognoni, L., Bambi, F., et al. (2014) · Oncotarget · doi:10.18632/oncotarget.2652 · Cited by 109
Sørensen, G. V., Ganz, P. A., Cole, S. W., Pedersen, L. H., Sørensen, H. T., Cronin-Fenton, D. P., Garne, J. P., Christiansen, P., Lash, T. L., & Ahern, T. P. (2013) · Journal of Clinical Oncology · doi:10.1200/jco.2012.43.9190 · Cited by 106
Ji, Y., Chen, S., Li, K., Xiao, X., Zheng, S., & Xu, T. (2013) · Cell Division · doi:10.1186/1747-1028-8-1 · Cited by 104
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Che (2010) · Oncology Reports · doi:10.3892/or_00001032 · Cited by 95
Pan, W., Li, P., Guo, Z., Huang, Q., & Gao, Y. (2015) · Pediatric Blood & Cancer · doi:10.1002/pbc.25453 · Cited by 94
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Loebig, M., Klement, J., Schmoller, A., Betz, S., Heuck, N., Schweiger, U., Peters, A., Schultes, B., & Oltmanns, K. M. (2010) · PLoS ONE · doi:10.1371/journal.pone.0012610 · Cited by 91
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Metadata
- Authors
- Yang, E. V., Sood, A. K., Chen, M., Li, Y., Eubank, T. D., Marsh, C. B., Jewell, S., Flavahan, N. A., Morrison, C., Yeh, P.-E., Lemeshow, S., & Glaser, R.
- Affiliations
- Institute for Behavioral Medicine (US)
- The University of Texas MD Anderson Cancer Center (US)
- 4The Dorothy M. Davis Heart and Lung Research Institute, Departments of
- The Ohio State University Wexner Medical Center (US)
- 3Comprehensive Cancer Center,
- Venue
- Cancer Research
- Published
- 2006-11-01
- Volume
- 66
- Issue
- 21
- Pages
- 10357-10364
- ISSN
- 0008-5472 (ISSN-L)
- 1538-7445
- OpenAlex
- W2138150045
- Cited by
- 407
- References
- 50
- Citations by year
- 2026: 9 · 2025: 13 · 2024: 14 · 2023: 14 · 2022: 16 · 2021: 20 · 2020: 22 · 2019: 23 · 2018: 14 · 2017: 15 · 2016: 27 · 2015: 17 · 2014: 24 · 2013: 35 · 2012: 39
- FWCI
- 9.33
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Cancer Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ohio State University (CA16058)
- National Heart, Lung, and Blood Institute (R01HL067176, HL067176)
- National Cancer Institute (CA100243, CA10929801, CA16058, R01CA100243, CA 11079301, P30CA016058)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Stress, Anesthesia, and Immune Response
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Protease and Inhibitor Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Keywords
- norepinephrine, nasopharyngeal carcinoma, vascular endothelial growth factor, MMP-2, MMP-9, tumor invasion, angiogenesis, beta-adrenergic receptors, propranolol, catecholamines, tumor progression
- MeSH terms
- Biopsy, Humans, Nasopharyngeal Neoplasms, Neoplasm Invasiveness, Norepinephrine, Receptors, Adrenergic, beta, Up-Regulation, Gene Expression Regulation, Neoplastic, Matrix Metalloproteinase 2, Matrix Metalloproteinase 9, Vascular Endothelial Growth Factor A, Cell Line, Tumor, Matrix Metalloproteinase 14
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