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Cited by 286

The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.

Targeting Tumor Antigens to Secreted Membrane Vesicles In vivo Induces Efficient Antitumor Immune Responses

Open access
Zeelenberg, Ingrid S., Ostrowski, Matias, Krumeich, Sophie, Bobrie, Angélique, Jancic, Carolina, Boissonnas, Alexandre, Delcayre, Alain, Le Pecq, Jean-Bernard, Combadière, Béhazine, Amigorena, Sebastian, Théry, Clotilde·2008·Cancer Research
DOI 10.1158/0008-5472.can-07-3163
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Abstract

Expression of non-self antigens by tumors can induce activation of T cells in vivo, although this activation can lead to either immunity or tolerance. CD8+ T-cell activation can be direct (if the tumor expresses MHC class I molecules) or indirect (after the capture and cross-presentation of tumor antigens by dendritic cells). The modes of tumor antigen capture by dendritic cells in vivo remain unclear. Here we examine the immunogenicity of the same model antigen secreted by live tumors either in association with membrane vesicles (exosomes) or as a soluble protein. We have artificially addressed the antigen to secreted vesicles by coupling it to the factor VIII–like C1C2 domain of milk fat globule epidermal growth factor-factor VIII (MFG-E8)/lactadherin. We show that murine fibrosarcoma tumor cells that secrete vesicle-bound antigen grow slower than tumors that secrete soluble antigen in immunocompetent, but not in immunodeficient, host mice. This growth difference is due to the induction of a more potent antigen-specific antitumor immune response in vivo by the vesicle-bound than by the soluble antigen. Finally, in vivo secretion of the vesicle-bound antigen either by tumors or by vaccination with naked DNA protects against soluble antigen-secreting tumors. We conclude that the mode of secretion can determine the immunogenicity of tumor antigens and that manipulation of the mode of antigen secretion may be used to optimize antitumor vaccination protocols. [Cancer Res 2008;68(4):1228–35]

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Crossref · 10.1158/0008-5472.can-07-3163

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Metadata

Authors
Zeelenberg, I. S., Ostrowski, M., Krumeich, S., Bobrie, A., Jancic, C., Boissonnas, A., Delcayre, A., Le Pecq, J.-B., Combadière, B., Amigorena, S., & Théry, C.
Venue
Cancer Research
Publisher
American Association for Cancer Research (AACR)
Published
2008-02-15
Volume
68
Issue
4
Pages
1228-1235
ISSN
  • 0008-5472 (ISSN-L)
  • 1538-7445
DOI
10.1158/0008-5472.can-07-3163
OpenAlex
W2124589099
Cited by
286
References
32
FWCI
4.97
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Targeting Tumor Antigens to Secreted Membrane Vesicles In vivo Induces Efficient Antitumor Immune Responses. https://app.cochat.ai/papers/10.1158/0008-5472.can-07-3163
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Zeelenberg, I. S., Ostrowski, M., Krumeich, S., Bobrie, A., Jancic, C., Boissonnas, A., Delcayre, A., Le Pecq, J.-B., Combadière, B., Amigorena, S., & Théry, C. (2008). Targeting Tumor Antigens to Secreted Membrane Vesicles In vivo Induces Efficient Antitumor Immune Responses. Cancer Research. https://doi.org/10.1158/0008-5472.can-07-3163

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.