β1 Integrin Inhibition Dramatically Enhances Radiotherapy Efficacy in Human Breast Cancer Xenografts
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β1 Integrin signaling has been shown to mediate cellular resistance to apoptosis after exposure to ionizing radiation (IR). Other signaling molecules that increase resistance include Akt, which promotes cell survival downstream of β1 integrin signaling. We previously showed that β1 integrin inhibitory antibodies (e.g., AIIB2) enhance apoptosis and decrease growth in human breast cancer cells in three-dimensional laminin-rich extracellular matrix (lrECM) cultures and in vivo. Here, we asked whether AIIB2 could synergize with IR to modify Akt-mediated IR resistance. We used three-dimensional lrECM cultures to test the optimal combination of AIIB2 with IR treatment of two breast cancer cell lines, MCF-7 and HMT3522-T4-2, as well as T4-2 myr-Akt breast cancer colonies or HMT3522-S-1, which form normal organotypic structures in three-dimensional lrECM. Colonies were assayed for apoptosis and β1 integrin/Akt signaling pathways were evaluated using Western blot. In addition, mice bearing MCF-7 xenografts were used to validate the findings in three-dimensional lrECM. We report that AIIB2 increased apoptosis optimally post-IR by down-regulating Akt in breast cancer colonies in three-dimensional lrECM. In vivo, addition of AIIB2 after IR significantly enhanced tumor growth inhibition and apoptosis compared with either treatment alone. Remarkably, the degree of tumor growth inhibition using AIIB2 plus 2 Gy radiation was similar to that of 8 Gy alone. We previously showed that AIIB2 had no discernible toxicity in mice; here, its addition allowed for a significant reduction in the IR dose that was necessary to achieve comparable growth inhibition and apoptosis in breast cancer xenografts in vivo. [Cancer Res 2008;68(11):4398–405]
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Antibodies against integrins β1, β6 and β8 selectively impair TGF-β1 activation.
“Antibodies against integrins β1, β6 and β8 were shown to selectively impair TGF-β1 activation85,313–315”
From TGFβ biology in cancer progression and immunotherapy (2021) · cites this paper as [315]
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Hynes (2002) · doi:10.1016/s0092-8674(02)00971-6 · Cited by 8,606 · see citing works
Giancotti, F. G., & Ruoslahti, E. (1999) · Science · doi:10.1126/science.285.5430.1028 · Cited by 3,869 · see citing works
Weaver, V. M., Petersen, O. W., Wang, F., Larabell, C. A., Briand, P., Damsky, C., & Bissell, M. J. (1997) · The Journal of Cell Biology · doi:10.1083/jcb.137.1.231 · Cited by 1,483 · see citing works
Self-citationWerb, Z., Tremble, P., Behrendtsen, O., Crowley, E., & Damsky, C. H. (1989) · The Journal of Cell Biology · doi:10.1083/jcb.109.2.877 · Cited by 1,057 · see citing works
Damiano, J. S., Cress, A. E., Hazlehurst, L., Shtil, A. A., & Dalton, W. S. (1999) · Blood · doi:10.1182/blood.v93.5.1658 · Cited by 899 · see citing works
Brognard, J., Clark, A. S., Ni, Y., & Dennis, P. A. (2001) · PubMed · Cited by 885 · see citing works
The Akt-mTOR tango and its relevance to cancer
Hay, N. (2005) · Cancer Cell · doi:10.1016/j.ccr.2005.08.008 · Cited by 816 · see citing works
Weaver, V. M., Lelièvre, S. A., Lakins, J. N., Chrenek, M. A., Jones, J., Giancotti, F. G., Werb, Z., & Bissell, M. J. (2002) · Cancer Cell · doi:10.1016/s1535-6108(02)00125-3 · Cited by 794 · see citing works
Self-citationWang, F., Weaver, V. M., Petersen, O. W., Larabell, C. A., Dedhar, S., Briand, P., Lupu, R., & Bissell, M. J. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.25.14821 · Cited by 653 · see citing works
Self-citationPark, C. C., Mitsumori, M., Nixon, A. J., Recht, A., Connolly, J. L., Gelman, R. S., Silver, B., Hetelekidis, S., Abner, A. L., Harris, J. R., et al. (2000) · Journal of Clinical Oncology · doi:10.1200/jco.2000.18.8.1668 · Cited by 547 · see citing works
Self-citationRadiation and the microenvironment – tumorigenesis and therapy
Barcellos‐Hoff, M. H., Park, C., & Wright, E. G. (2005) · Nature reviews. Cancer · doi:10.1038/nrc1735 · Cited by 513 · see citing works
Self-citationHall, D. E., Reichardt, L. F., Crowley, E., Holley, B., Moezzi, H., Sonnenberg, A., & Damsky, C. H. (1990) · The Journal of Cell Biology · doi:10.1083/jcb.110.6.2175 · Cited by 376 · see citing works
Park, C. C., Zhang, H., Pallavicini, M., Gray, J. W., Baehner, F., Park, C. J., & Bissell, M. J. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-3071 · Cited by 326 · see citing works
Self-citationIntegrin signaling inhibits paclitaxel-induced apoptosis in breast cancer cells
Aoudjit, F., & Vuori, K. (2001) · Oncogene · doi:10.1038/sj.onc.1204554 · Cited by 325 · see citing works
Kohn, A. D., Barthel, A., Kovacina, K. S., Boge, A., Wallach, B. J., Summers, S. A., Birnbaum, M. J., Scott, P., Lawrence, J. C., & Roth, R. A. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.19.11937 · Cited by 304 · see citing works
Briand, P., PETERSEN, O. W., & van Deurs, B. (1987) · In Vitro Cellular & Developmental Biology - Plant · doi:10.1007/bf02623578 · Cited by 241 · see citing works
Increased β1 Integrin Is Associated with Decreased Survival in Invasive Breast Cancer
Yao, E. S., Zhang, H., Chen, Y., Lee, B., Chew, K., Moore, D. A., & Park, C. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-2768 · Cited by 227 · see citing works
Self-citationLiu, H. S., Radisky, D. C., Wang, F., & Bissell, M. J. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200306090 · Cited by 222 · see citing works
Self-citationWeaver, V. M., Lelièvre, S. A., Lakins, J. N., Chrenek, M. A., Jones, J., Giancotti, F. G., Werb, Z., & Bissell, M. J. (2002) · University of North Texas Digital Library (University of North Texas) · doi:10.1016/s1535-6108%2802%2900125-3 · Cited by 208 · see citing works
Self-citationDamiano, J., Hazlehurst, L., & Dalton, W. (2001) · Leukemia · doi:10.1038/sj.leu.2402179 · Cited by 197 · see citing works
Gupta, A., Cerniglia, G. J., Mick, R., Ahmed, M. S., Bakanauskas, V. J., Muschel, R. J., & McKenna, W. G. (2003) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/s0360-3016(03)00214-1 · Cited by 184 · see citing works
Kim, I., Bae, S.-S., Fernandes, A., Wu, J., Muschel, R. J., McKenna, W. G., Birnbaum, M. J., & Bernhard, E. J. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-0513 · Cited by 179 · see citing works
Tomaselli, K. J., Damsky, C. H., & Reichardt, L. F. (1988) · The Journal of Cell Biology · doi:10.1083/jcb.107.3.1241 · Cited by 166 · see citing works
Cordes, N., Seidler, J. F., Durzok, R., Geinitz, H., & Brakebusch, C. (2005) · Oncogene · doi:10.1038/sj.onc.1209164 · Cited by 155 · see citing works
Edwards, E., Geng, L., Tan, J., Onishko, H. M., Donnelly, E. F., & Hallahan, D. E. (2002) · PubMed · Cited by 152 · see citing works
Hodkinson, P. S., Elliott, T., Wong, W. S., Rintoul, R. C., MacKinnon, A. C., Haslett, C., & Sethi, T. (2006) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401849 · Cited by 137 · see citing works
Integrin-mediated targeting of drug delivery to irradiated tumor blood vessels
Hallahan, D. E., Geng, L., Qu, S., Scarfone, C., Giorgio, T. D., Donnelly, E. F., Gao, X., & Clanton, J. A. (2003) · Cancer Cell · doi:10.1016/s1535-6108(02)00238-6 · Cited by 134 · see citing works
Cordes, N., & Meineke, V. (2003) · Strahlentherapie und Onkologie · doi:10.1007/s00066-003-1074-4 · Cited by 128 · see citing works
Lee, C. M., Fuhrman, C. B., Planelles, V., Peltier, M. R., Gaffney, D. K., Soisson, A. P., Dodson, M. K., Tolley, H. D., Green, C. L., & Zempolich, K. A. (2006) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-05-1084 · Cited by 128 · see citing works
Liang, K., Jin, W., Knuefermann, C., Schmidt, M., Mills, G. B., Ang, K. K., Milas, L., & Fan, Z. (2003) · PubMed · Cited by 111 · see citing works
It Takes a Tissue to Make a Tumor: Epigenetics, Cancer and the Microenvironment
Barcellos‐Hoff, M. H. (2001) · Journal of Mammary Gland Biology and Neoplasia · doi:10.1023/a:1011317009329 · Cited by 106 · see citing works
Choi, S.-Y., Kim, M., Kang, C., Bae, S., Cho, C.-K., Soh, J., Kim, J., Kang, S., Chung, H. Y., Lee, Y., et al. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m512000200 · Cited by 93 · see citing works
PKB/Akt mediates radiosensitization by the signaling inhibitor LY294002 in human malignant gliomas
Nakamura, J. L., Karlsson, A., Arvold, N. D., GOTTSCHALK, A. R., Pieper, R. O., Stokoe, D., & Haas-Kogan, D. A. (2005) · Journal of Neuro-Oncology · doi:10.1007/s11060-004-1718-y · Cited by 90 · see citing works
Cordes, N., Bläse, M., Meineke, V., & Beuningen, D. V. (2002) · International Journal of Radiation Biology · doi:10.1080/09553000110117340 · Cited by 85 · see citing works
Ionizing radiation induces heritable disruption of epithelial cell interactions
Park, C. C., Henshall-Powell, R. L., Erickson, A., Talhouk, R., Parvin, B., Bissell, M. J., & Barcellos‐Hoff, M. H. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1832185100 · Cited by 70 · see citing works
Self-citationHandschel, J. G., Prott, F., Sunderkötter, C. H., Metze, D., Meyer, U., & Joos, U. (1999) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/s0360-3016(99)00202-3 · Cited by 65 · see citing works
Onoda, J. M., Piechocki, M. P., & Honn, K. V. (1992) · Radiation Research · doi:10.2307/3578372 · Cited by 59 · see citing works
Zingg, D., Riesterer, O., Fabbro, D., Glanzmann, C., Bodis, S. B., & Pruschy, M. N. (2004) · Cancer Research · doi:10.1158/0008-5472.can-03-3369 · Cited by 54 · see citing works
Choi, J.-A., Park, M.-T., Kang, C.-M., Um, H., Bae, S., Lee, K.-H., Kim, T., Kim, J., Cho, C.-K., Lee, Y., et al. (2004) · Oncogene · doi:10.1038/sj.onc.1206982 · Cited by 53 · see citing works
A mechanism of drug resistance to tamoxifen in breast cancer
Schafer, J. M., Bentrem, D. J., Takei, H., Gajdos, C., Badve, S., & Jordan, V. C. (2002) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/s0960-0760(02)00251-0 · Cited by 41 · see citing works
Li, T., Ito, H., HAYASHI, M., Furutani, A., Matsuzaki, M., & Hamano, K. (2004) · Cardiovascular Research · doi:10.1016/j.cardiores.2004.08.019 · Cited by 36 · see citing works
Morozevich, G. E., Kozlova, N. I., Preobrazhenskaya, M. E., Ушакова, Н. А., Eltsov, I. A., Shtil, A. A., & Berman, A. E. (2006) · Biochemistry (Moscow) · doi:10.1134/s000629790605004x · Cited by 30 · see citing works
Seidler, J., Durzok, R., Brakebusch, C., & Cordes, N. (2005) · Radiotherapy and Oncology · doi:10.1016/j.radonc.2005.06.018 · Cited by 25 · see citing works
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The biology and function of fibroblasts in cancer
Kalluri, R. (2016) · Nature Reviews Cancer · doi:10.1038/nrc.2016.73 · Cited by 4,366 · see citing works
Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling
Levental, K. R., Yu, H., Kass, L., Lakins, J. N., Egeblad, M., Erler, J. T., Fong, S. F. T., Csiszar, K., Giaccia, A., Weninger, W., et al. (2009) · Cell · doi:10.1016/j.cell.2009.10.027 · Cited by 4,101 · see citing works
The Tumour Microenvironment after Radiotherapy: Mechanisms of Resistance and Recurrence
Barker, H. E., Paget, J. T. E., Khan, A. A., & Harrington, K. J. (2015) · Nature Reviews Cancer · doi:10.1038/nrc3958 · Cited by 2,144 · see citing works
Tumor microenvironment and therapeutic response
Wu, T., & Dai, Y. (2017) · Cancer Letters · doi:10.1016/j.canlet.2016.01.043 · Cited by 1,802 · see citing works
Bissell, M. J., & Hines, W. C. (2011) · Nature Medicine · doi:10.1038/nm.2328 · Cited by 1,516 · see citing works
Self-citationEvery step of the way: integrins in cancer progression and metastasis
Hamidi, H., & Ivaska, J. (2018) · Nature Reviews Cancer · doi:10.1038/s41568-018-0038-z · Cited by 1,493 · see citing works
Extracellular Matrix in the Tumor Microenvironment and Its Impact on Cancer Therapy
Henke, E., Nandigama, R., & Ergün, S. (2020) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2019.00160 · Cited by 1,142 · see citing works
Targeting the tumour stroma to improve cancer therapy
Valkenburg, K. C., de Groot, A. E., & Pienta, K. J. (2018) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-018-0007-1 · Cited by 1,084 · see citing works
Extracellular matrix and its therapeutic potential for cancer treatment
Huang, J., Zhang, L., Wan, D., Zhou, L., Zheng, S., Lin, S., & Qiao, Y. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00544-0 · Cited by 962 · see citing works
TGFβ biology in cancer progression and immunotherapy
Derynck, R., Turley, S. J., & Akhurst, R. J. (2021) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-020-0403-1 · Cited by 944 · see citing works
Fibroblast heterogeneity in the cancer wound
Öhlund, D., Elyada, E., & Tuveson, D. A. (2014) · The Journal of Experimental Medicine · doi:10.1084/jem.20140692 · Cited by 975 · see citing works
Inflammatory microenvironment remodelling by tumour cells after radiotherapy
McLaughlin, M., Patin, E. C., Pedersen, M., Wilkins, A. C., Dillon, M. T., Melcher, A. A., & Harrington, K. J. (2020) · Nature reviews. Cancer · doi:10.1038/s41568-020-0246-1 · Cited by 901 · see citing works
Environment-mediated drug resistance: A major contributor to minimal residual disease
Meads, M. B., Gatenby, R. A., & Dalton, W. S. (2009) · Nature Reviews Cancer · doi:10.1038/nrc2714 · Cited by 892 · see citing works
Microenvironmental regulation of therapeutic response in cancer
Klemm, F., & Joyce, J. A. (2014) · Trends in Cell Biology · doi:10.1016/j.tcb.2014.11.006 · Cited by 789 · see citing works
The tumor microenvironment is a dominant force in multidrug resistance
Correia, A. L., & Bissell, M. J. (2012) · Drug Resistance Updates · doi:10.1016/j.drup.2012.01.006 · Cited by 455 · see citing works
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Hirata, E., & Sahai, E. (2017) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a026781 · Cited by 422 · see citing works
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Prakash, J., & Shaked, Y. (2024) · Cancer Discovery · doi:10.1158/2159-8290.cd-24-0002 · Cited by 391 · see citing works
Understanding and targeting resistance mechanisms in cancer
Lei, Z., Qin, T., Teng, Q., Wurpel, J. N. D., Zeng, L., Pan, Y., & Chen, Z. (2023) · MedComm · doi:10.1002/mco2.265 · Cited by 378 · see citing works
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Lovitt, C. J., Shelper, T., & Avery, V. M. (2018) · BMC Cancer · doi:10.1186/s12885-017-3953-6 · Cited by 339 · see citing works
Weigelt, B., Ghajar, C. M., & Bissell, M. J. (2014) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2014.01.001 · Cited by 347 · see citing works
Self-citationWeigelt, B., Lo, A. T., Park, C. C., Gray, J. W., & Bissell, M. J. (2009) · Breast Cancer Research and Treatment · doi:10.1007/s10549-009-0502-2 · Cited by 336 · see citing works
Self-citationFocal adhesion signaling and therapy resistance in cancer
Eke, I., & Cordes, N. (2014) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2014.07.009 · Cited by 331 · see citing works
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Budi, E. H., Schaub, J. R., Decaris, M. L., Turner, S., & Derynck, R. (2021) · The Journal of Pathology · doi:10.1002/path.5680 · Cited by 309 · see citing works
Advanced Cell Culture Techniques for Cancer Drug Discovery
Lovitt, C. J., Shelper, T., & Avery, V. M. (2014) · Biology · doi:10.3390/biology3020345 · Cited by 280 · see citing works
Mechanism-based cancer therapy: resistance to therapy, therapy for resistance
Ramos, P. M., & Bentires‐Alj, M. (2014) · Oncogene · doi:10.1038/onc.2014.314 · Cited by 276 · see citing works
Eke, I., Deuse, Y., Hehlgans, S., Gurtner, K., Krause, M., Baumann, M. A., Shevchenko, A., Sandfort, V., & Cordes, N. (2012) · Journal of Clinical Investigation · doi:10.1172/jci61350 · Cited by 220 · see citing works
Adaptive Mechanisms of Tumor Therapy Resistance Driven by Tumor Microenvironment
Wu, P., Gao, W. Q., Su, M., Nice, E. C., Zhang, W., Lin, J., & Xie, N. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.641469 · Cited by 212 · see citing works
Integrin Signaling in Cancer Cell Survival and Chemoresistance
Aoudjit, F., & Vuori, K. (2012) · Chemotherapy Research and Practice · doi:10.1155/2012/283181 · Cited by 217 · see citing works
Pancreatic Stellate Cells Radioprotect Pancreatic Cancer Cells through β1-Integrin Signaling
Mantoni, T. S., Lunardi, S., Al‐Assar, O., Masamune, A., & Brunner, T. B. (2011) · Cancer Research · doi:10.1158/0008-5472.can-10-1633 · Cited by 206 · see citing works
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Muschler, J. L., & Streuli, C. H. (2010) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a003202 · Cited by 200 · see citing works
Nam, J.-M., Onodera, Y., Bissell, M. J., & Park, C. C. (2010) · Cancer Research · doi:10.1158/0008-5472.can-09-2319 · Cited by 196 · see citing works
Self-citationMetabolic crosstalk in the breast cancer microenvironment
Dias, A. S., Almeida, C. R., Helguero, L. A., & Duarte, I. F. (2019) · European Journal of Cancer · doi:10.1016/j.ejca.2019.09.002 · Cited by 198 · see citing works
Integrins in cancer: Emerging mechanisms and therapeutic opportunities
Liu, F., Wu, Q., Dong, Z., & Liu, K. (2023) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2023.108458 · Cited by 202 · see citing works
Donlon, N., Power, R. F., Hayes, C., Reynolds, J. V., & Lysaght, J. (2021) · Cancer Letters · doi:10.1016/j.canlet.2020.12.045 · Cited by 192 · see citing works
Hongisto, V., Jernström, S., Fey, V., Mpindi, J.-P., Kleivi Sahlberg, K., Kallioniemi, O., & Perälä, M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0077232 · Cited by 181 · see citing works
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Barkan, D., & Chambers, A. F. (2011) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-11-0642 · Cited by 181 · see citing works
Li, J. J. X., Tsang, J. Y., & Tse, G. M.-K. (2021) · Cancers · doi:10.3390/cancers13164233 · Cited by 181 · see citing works
Integrins as therapeutic targets in the organ-specific metastasis of human malignant melanoma
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Huang, C., Park, C. C., Hilsenbeck, S. G., Ward, R., Rimawi, M. F., Wang, Y.-C., Shou, J., Bissell, M. J., Osborne, C. K., & Schiff, R. (2011) · Breast Cancer Research · doi:10.1186/bcr2936 · Cited by 165 · see citing works
Self-citationCarbonell, W. S., DeLay, M., Jahangiri, A., Park, C. C., & Aghi, M. K. (2013) · Cancer Research · doi:10.1158/0008-5472.can-13-0011 · Cited by 163 · see citing works
Self-citationThe Pathobiology of Collagens in Glioma
Payne, L. S., & Huang, P. H. (2013) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-13-0236 · Cited by 140 · see citing works
Kim, H. S., Kim, S. C., Kim, S. J., Park, C. H., Jeung, H., Kim, Y. B., Ahn, J. B., Chung, H. C., & Rha, S. Y. (2012) · BMC Genomics · doi:10.1186/1471-2164-13-348 · Cited by 136 · see citing works
Self-citationBioengineering 3D environments for cancer models
Alemany‐Ribes, M., & Semino, C. E. (2014) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2014.06.004 · Cited by 132 · see citing works
Radiobiology goes 3D: How ECM and cell morphology impact on cell survival after irradiation
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Huck, L., Pontier, S. M., Zuo, D., & Muller, W. J. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1003034107 · Cited by 131 · see citing works
Zschenker, O., Streichert, T., Hehlgans, S., & Cordes, N. (2012) · PLoS ONE · doi:10.1371/journal.pone.0034279 · Cited by 129 · see citing works
Lander, V. E., Belle, J. I., Kingston, N. L., Herndon, J. M., Hogg, G. D., Liu, X., Kang, L.-I., Knolhoff, B. L., Bogner, S. J., Baer, J. M., et al. (2022) · Cancer Discovery · doi:10.1158/2159-8290.cd-22-0192 · Cited by 114 · see citing works
Truong, H. H., Xiong, J., Ghotra, V. P. S., Nirmala, E., Haazen, L. C. J. M., Dévédec, S. E. L., Balcioglu, H. E., He, S., Snaar-Jagalska, E. B., Vreugdenhil, E., et al. (2014) · Science Signaling · doi:10.1126/scisignal.2004751 · Cited by 115 · see citing works
Krisnawan, V. E., Stanley, J. A., Schwarz, J. K., & DeNardo, D. G. (2020) · Cancers · doi:10.3390/cancers12102916 · Cited by 114 · see citing works
Hellevik, T., Pettersen, I., Berg, V., Winberg, J., Moe, B. T., Bartnes, K., Paulssen, R. H., Busund, L., Bremnes, R. M., Chalmers, A. J., et al. (2012) · Radiation Oncology · doi:10.1186/1748-717x-7-59 · Cited by 112 · see citing works
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Deville, S. S., & Cordes, N. (2019) · Frontiers in Oncology · doi:10.3389/fonc.2019.01376 · Cited by 103 · see citing works
Drug resistance in cancer: molecular mechanisms and emerging treatment strategies
Li, J., Hu, J., Yang, Y., Zhang, H., Liu, Y., Fang, Y., Qu, L., Lin, A., Luo, P., Jiang, A., et al. (2025) · Molecular Biomedicine · doi:10.1186/s43556-025-00352-w · Cited by 114 · see citing works
Self-citationdos Santos, P. B., Zanetti, J. S., Ribeiro‐Silva, A., & Beltrão, E. I. U. F. D. P. (2012) · Diagnostic Pathology · doi:10.1186/1746-1596-7-104 · Cited by 100 · see citing works
Arya, A. D., Hallur, P. M., Karkisaval, A. G., Gudipati, A., Rajendiran, S., Dhavale, V., Ramachandran, B., Aravindakshan, J., Gundiah, N., & Chaubey, A. (2016) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.6b06309 · Cited by 99 · see citing works
PINCH1 regulates Akt1 activation and enhances radioresistance by inhibiting PP1α
Eke, I., Koch, U., Hehlgans, S., Sandfort, V., Stanchi, F., Zips, D., Baumann, M. A., Shevchenko, A., Pilarsky, C. P., Haase, M., et al. (2010) · Journal of Clinical Investigation · doi:10.1172/jci41078 · Cited by 96 · see citing works
Lahlou, H., & Muller, W. J. (2011) · Breast Cancer Research · doi:10.1186/bcr2905 · Cited by 96 · see citing works
Caveolin-1 mediated radioresistance of 3D grown pancreatic cancer cells
Hehlgans, S., Eke, I., Storch, K., Haase, M., Baretton, G. B., & Cordes, N. (2009) · Radiotherapy and Oncology · doi:10.1016/j.radonc.2009.07.004 · Cited by 94 · see citing works
Simultaneous β1 integrin-EGFR Targeting and Radiosensitization of Human Head and Neck Cancer
Eke, I., Zscheppang, K., Dickreuter, E., Hickmann, L., Mazzeo, E., Unger, K., Krause, M., & Cordes, N. (2015) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/dju419 · Cited by 91 · see citing works
Kirsch, D. G., Diehn, M., Kesarwala, A. H., Maity, A. M., Morgan, M. A., Schwarz, J. K., Bristow, R. G., Demaria, S., Eke, I., Griffin, R. J., et al. (2017) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djx231 · Cited by 91 · see citing works
Self-citationAhmed, K. M., Zhang, H., & Park, C. C. (2013) · Cancer Research · doi:10.1158/0008-5472.can-12-3537 · Cited by 90 · see citing works
Self-citationThe CD10 Enzyme Is a Key Player to Identify and Regulate Human Mammary Stem Cells
Bachelard-Cascales, É., Chapellier, M., Delay, E., Pochon, G., Voeltzel, T., Puisieux, A., de Fromentel, C. C., & Maguer‐Satta, V. (2010) · Stem Cells · doi:10.1002/stem.435 · Cited by 89 · see citing works
Cross-activating c-Met/β1 integrin complex drives metastasis and invasive resistance in cancer
Jahangiri, A., Nguyen, A. T., Chandra, A., Sidorov, M. K., Yagnik, G., Rick, J. W., Han, S. W., Chen, W. C., Flanigan, P. M., Schneidman‐Duhovny, D., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1701821114 · Cited by 86 · see citing works
Self-citationCollective cancer invasion forms an integrin-dependent radioresistant niche
Haeger, A., Alexander, S., Vullings, M., Kaiser, F. M. P., Hulsbergen-Veelken, C. A. R., Flucke, U. E., Koehl, G. E., Hirschberg, M., Flentje, M. P., Hoffman, R. M., et al. (2019) · The Journal of Experimental Medicine · doi:10.1084/jem.20181184 · Cited by 81 · see citing works
Martínková, E., Maglott, A., Leger, D. Y., Bonnet, D., Stiborová, M., Takeda, K., Martin, S., & Dontenwill, M. (2010) · International Journal of Cancer · doi:10.1002/ijc.25187 · Cited by 81 · see citing works
Baltes, F., Pfeifer, V., Silbermann, K., Caspers, J., von Rekowski, K. W., Schlesinger, M., & Bendas, G. (2020) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2020.118663 · Cited by 79 · see citing works
Targeting of β1 integrins impairs DNA repair for radiosensitization of head and neck cancer cells
Dickreuter, E., Eke, I., Krause, M., Borgmann, K., van Vugt, M. A. T. M., & Cordes, N. (2015) · Oncogene · doi:10.1038/onc.2015.212 · Cited by 77 · see citing works
Carbonic Anhydrase IX (CAIX), Cancer, and Radiation Responsiveness
Ward, C., Meehan, J., Gray, M., Kunkler, I. H., Langdon, S. P., & Argyle, D. J. (2018) · Metabolites · doi:10.3390/metabo8010013 · Cited by 76 · see citing works
xCT inhibition sensitizes tumors to γ-radiation via glutathione reduction
Cobler, L., Zhang, H., Suri, P., Park, C., & Timmerman, L. (2018) · Oncotarget · doi:10.18632/oncotarget.25794 · Cited by 72 · see citing works
Self-citationA cell–ECM screening method to predict breast cancer metastasis
Barney, L. E., Dandley, E. C., Jansen, L. E., Reich, N. G., Mercurio, A. M., & Peyton, S. R. (2014) · Integrative Biology · doi:10.1039/c4ib00218k · Cited by 69 · see citing works
β1 and β4 integrins: from breast development to clinical practice
Nisticò, P., Modugno, F. D., Spada, S., & Bissell, M. J. (2014) · Breast Cancer Research · doi:10.1186/s13058-014-0459-x · Cited by 69 · see citing works
Self-citationDesmoplasia in Pancreatic Cancer. Can We Fight It?
Merika, E., Syrigos, K. N., & Saif, M. W. (2012) · Gastroenterology Research and Practice · doi:10.1155/2012/781765 · Cited by 68 · see citing works
Howe, G. A., & Addison, C. (2012) · Cell Adhesion & Migration · doi:10.4161/cam.20077 · Cited by 67 · see citing works
The cancer cell adhesion resistome: mechanisms, targeting and translational approaches
Dickreuter, E., & Cordes, N. (2016) · Biological Chemistry · doi:10.1515/hsz-2016-0326 · Cited by 66 · see citing works
Caromile, L. A., Dortche, K., Rahman, M., Grant, C. L., Stoddard, C. E., Ferrer, F. A., & Shapiro, L. H. (2017) · Science Signaling · doi:10.1126/scisignal.aag3326 · Cited by 66 · see citing works
Cancer-Associated Fibroblasts in Breast Cancer Treatment Response and Metastasis
Fernández‐Nogueira, P., Fuster, G., Gutiérrez-Uzquiza, Á., Gascón, P., Carbó, N., & Bragado, P. (2021) · Cancers · doi:10.3390/cancers13133146 · Cited by 59 · see citing works
How integrins control breast biology
Glukhova, M. A., & Streuli, C. H. (2013) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2013.06.010 · Cited by 59 · see citing works
Hou, S., Isaji, T., Hang, Q., Im, S., Fukuda, T., & Gu, J. (2016) · Scientific Reports · doi:10.1038/srep18430 · Cited by 60 · see citing works
β1 Integrin as a Prognostic and Predictive Marker in Triple-Negative Breast Cancer
Yin, H., Wu, C., Lin, C., Chai, C., Hou, M., Chang, S., Tsai, H., Hung, W., Pan, M., & Luo, C. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17091432 · Cited by 57 · see citing works
Lee, M. Y., Lee, H., Seo, W. D., Park, K. H., & Lee, Y. (2010) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/j.ijrobp.2009.11.022 · Cited by 56 · see citing works
Li, R., Shi, Y., Zhao, S., Shi, T., & Zhang, G. (2018) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2018.11.003 · Cited by 54 · see citing works
Cancer-Associated Fibroblasts: Implications for Cancer Therapy
Maia, A. R. R., & Wiemann, S. (2021) · Cancers · doi:10.3390/cancers13143526 · Cited by 58 · see citing works
Goel, H. L., Sayeed, A., Breen, M., Zarif, M. J., Garlick, D. S., Leav, I., Davis, R. J., FitzGerald, T. J., Morrione, A., Hsieh, C., et al. (2013) · Journal of Cellular Physiology · doi:10.1002/jcp.24323 · Cited by 52 · see citing works
Xiang, X., Phung, Y., Feng, M., Nagashima, K., Zhang, J., Broaddus, V. C., Hassan, R., FitzGerald, D., & Ho, M. (2011) · PLoS ONE · doi:10.1371/journal.pone.0014640 · Cited by 51 · see citing works
Hehlgans, S., Eke, I., & Cordes, N. (2012) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/j.ijrobp.2012.01.065 · Cited by 51 · see citing works
β1 integrin targeting to enhance radiation therapy
Nam, J.-M., Chung, Y., Hsu, H. C., & Park, C. C. (2009) · International Journal of Radiation Biology · doi:10.3109/09553000903232876 · Cited by 51 · see citing works
Self-citationIdentifying and targeting tumor-initiating cells in the treatment of breast cancer
Wei, W., & Lewis, M. T. (2015) · Endocrine Related Cancer · doi:10.1530/erc-14-0447 · Cited by 51 · see citing works
Caveolin-1: an essential modulator of cancer cell radio-and chemoresistance.
Hehlgans, S., & Cordes, N. (2011) · Europe PMC (PubMed Central) · Cited by 51 · see citing works
Isolation and characterization of squamous carcinoma cells resistant to photodynamic therapy
Sanabria, L. N. M., Cogno, I. S., Rodríguez, M. E., Sanz-Rodrı́guez, F., Zamarrón, A., Gilaberte, Y., Carrasco, E., Rivarola, V. A., & Juarranz, Á. (2011) · Journal of Cellular Biochemistry · doi:10.1002/jcb.23145 · Cited by 50 · see citing works
Role of Tumor Microenvironment in Cancer Stem Cells Resistance to Radiotherapy
Taeb, S., Ashrafizadeh, M., Zarrabi, A., Rezapoor, S., Musa, A. E., Farhood, B., & Najafi, M. (2021) · Current Cancer Drug Targets · doi:10.2174/1568009622666211224154952 · Cited by 49 · see citing works
3D matrix-based cell cultures: Automated analysis of tumor cell survival and proliferation
Eke, I., Hehlgans, S., Sandfort, V., & Cordes, N. (2015) · International Journal of Oncology · doi:10.3892/ijo.2015.3230 · Cited by 47 · see citing works
Integrin Signaling as a Cancer Drug Target
Danen, E. H. J. (2013) · ISRN Cell Biology · doi:10.1155/2013/135164 · Cited by 47 · see citing works
miR-134 suppresses the migration and invasion of non-small cell lung cancer by targeting ITGB1
Qin, Q., Wei, F., Zhang, J., & Li, B. (2017) · Oncology Reports · doi:10.3892/or.2017.5350 · Cited by 46 · see citing works
Dünker, N., & Jendrossek, V. (2019) · Cancers · doi:10.3390/cancers11101499 · Cited by 49 · see citing works
Robertson, C. (2016) · Experimental Cell Research · doi:10.1016/j.yexcr.2015.11.009 · Cited by 45 · see citing works
The mesenchymal tumor microenvironment
Cukierman, E., & Bassi, D. (2012) · Cell Adhesion & Migration · doi:10.4161/cam.20210 · Cited by 45 · see citing works
Miniaturized pre-clinical cancer models as research and diagnostic tools
Håkanson, M., Cukierman, E., & Charnley, M. (2013) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2013.11.010 · Cited by 45 · see citing works
- Authors
- Park, C. C., Zhang, H. J., Yao, E. S., Park, C. J., & Bissell, M. J.
- Affiliations
- University of California, San Francisco (US)
- Lawrence Berkeley National Laboratory (US)
- Venue
- Cancer Research
- Published
- 2008-06-01
- Volume
- 68
- Issue
- 11
- Pages
- 4398-4405
- ISSN
- 0008-5472 (ISSN-L)
- 1538-7445
- PMC
- PMC3719863
- OpenAlex
- W1968324001
- Cited by
- 220
- References
- 43
- Citations by year
- 2026: 6 · 2025: 3 · 2024: 8 · 2023: 10 · 2022: 12 · 2021: 15 · 2020: 9 · 2019: 10 · 2018: 12 · 2017: 14 · 2016: 13 · 2015: 13 · 2014: 20 · 2013: 19 · 2012: 18
- FWCI
- 8.20
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Cancer Research (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- University of North Texas Digital Library (University of North Texas) (submittedVersion)
- OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information) (submittedVersion)
- Funders
- U.S. Department of Defense (DE-AC02-05CH11231)
- U.S. Department of Energy (-AC02-05CH11231, DE-AC03-?, AC03-76SF00098, DEAC03-76SF00098, 05CH11231, DE AC02 05CH11231, DE-AC02-)
- National Institutes of Health (DE-AC02–05CH11231, NIH P50, DE-AC03- 76SF00098)
- University of California, San Francisco
- National Cancer Institute (R01CA124891, CA64786-09, CA-58207, R37CA064786, P50CA058207, R01CA064786, CA CA58207-08, DE-AC02-05CH11231)
- Biological and Environmental Research (05CH11231, DE-AC02 − 05CH11231, AC02-05CH11231)
- Topics
- Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Effects of Radiation Exposure
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
- Keywords
- beta1 integrin, radiotherapy, breast cancer, Akt signaling, radioresistance (biology), apoptosis, MCF-7 xenografts, tumor growth inhibition, radiosensitization
- MeSH terms
- Breast, Breast Neoplasms, Cell Line, Cell Separation, Humans, Transplantation, Heterologous, Blotting, Western, Treatment Outcome, Apoptosis, Microscopy, Confocal, Integrin beta1, In Situ Nick-End Labeling, Cell Proliferation
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