The DOI matches its Crossref record; 41 of the 42 references it cites were found in a registry or an index.
The Role of Myc-Induced Protein Synthesis in Cancer
Open accessAbstract
Deregulation in different steps of translational control is an emerging mechanism for cancer formation. One example of an oncogene with a direct role in control of translation is the Myc transcription factor. Myc directly increases protein synthesis rates by controlling the expression of multiple components of the protein synthetic machinery, including ribosomal proteins and initiation factors of translation, Pol III and rDNA. However, the contribution of Myc-dependent increases in protein synthesis toward the multistep process leading to cancer has remained unknown. Recent evidence strongly suggests that Myc oncogenic signaling may monopolize the translational machinery to elicit cooperative effects on cell growth, cell cycle progression, and genome instability as a mechanism for cancer initiation. Moreover, new genetic tools to restore aberrant increases in protein synthesis control are now available, which should enable the dissection of important mechanisms in cancer that rely on the translational machinery. [Cancer Res 2009;69(23):8839–43]
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“Notably, MYC is a well-established regulator of ribosome biogenesis and protein translation, including cap-dependent translation, and can rewire translational control in tumor cells when it is overexpressed (29–31).”
From Cotargeting a MYC/eIF4A-survival axis improves the efficacy of KRAS inhibitors in lung cancer (2023) · cites this paper as [29]
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MYC oncogenes and human neoplastic disease
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Active-Site Inhibitors of mTOR Target Rapamycin-Resistant Outputs of mTORC1 and mTORC2
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How Common Are Extraribosomal Functions of Ribosomal Proteins?
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c-Myc binds to human ribosomal DNA and stimulates transcription of rRNA genes by RNA polymerase I
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Drosophila myc Regulates Cellular Growth during Development
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c-Myc associates with ribosomal DNA and activates RNA polymerase I transcription
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Metadata
- Authors
- Ruggero, D.
- Affiliations
- University of California, San Francisco (US)
- Corresponding author
- Ruggero, Davide
- ORCID
- Ruggero, Davide
- Venue
- Cancer Research
- Published
- 2009-11-30
- Volume
- 69
- Issue
- 23
- Pages
- 8839-8843
- ISSN
- 0008-5472 (ISSN-L)
- 1538-7445
- PMC
- PMC2880919
- OpenAlex
- W2093199938
- Cited by
- 186
- References
- 42
- Citations by year
- 2026: 7 · 2025: 7 · 2024: 13 · 2023: 10 · 2022: 8 · 2021: 12 · 2020: 12 · 2019: 7 · 2018: 13 · 2017: 6 · 2016: 5 · 2015: 10 · 2014: 18 · 2013: 13 · 2012: 19
- FWCI
- 1.15
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Cancer Research (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Sandler Foundation
- National Institutes of Health (NIH-R01)
- University of California, San Francisco
- National Heart, Lung, and Blood Institute (R01HL085572)
- National Cancer Institute (R01CA140456)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Keywords
- MYC oncogene, translational regulation, protein synthesis, ribosomal proteins, translation initiation factors, ribosomal DNA, genomic instability, cell cycle progression, tumor initiation, translation machinery
- MeSH terms
- Animals, Humans, Neoplasms, Protein Biosynthesis, Gene Expression Regulation, Neoplastic, Genes, myc, Proto-Oncogene Proteins c-myc
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