The Role of Myc-Induced Protein Synthesis in Cancer

Proliferation, cell cycle and apoptosis in cancer

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The c-Myc target gene network

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MYC oncogenes and human neoplastic disease

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Active-Site Inhibitors of mTOR Target Rapamycin-Resistant Outputs of mTORC1 and mTORC2

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Expression analysis with oligonucleotide microarrays reveals that MYC regulates genes involved in growth, cell cycle, signaling, and adhesion

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How Common Are Extraribosomal Functions of Ribosomal Proteins?

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c-Myc binds to human ribosomal DNA and stimulates transcription of rRNA genes by RNA polymerase I

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Drosophila myc Regulates Cellular Growth during Development

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dMyc Transforms Cells into Super-Competitors

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c-Myc associates with ribosomal DNA and activates RNA polymerase I transcription

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Suppression of Myc oncogenic activity by ribosomal protein haploinsufficiency

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Phenotypes of c-Myc-deficient rat fibroblasts isolated by targeted homologous recombination.

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Myc-dependent regulation of ribosomal RNA synthesis during Drosophila development

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c-Myc enhances protein synthesis and cell size during B lymphocyte development

Iritani, B. M., & Eisenman, R. N. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.23.13180 · Cited by 364

C-Myc 5′ untranslated region contains an internal ribosome entry segment

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Cyclins D1 and D2 mediate Myc‐induced proliferation via sequestration of p27Kip1 and p21Cip1

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Identification and Characterization of a Novel Cell Cycle–Regulated Internal Ribosome Entry Site

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The transcriptional program of a human B cell line in response to Myc

Schuhmacher, M. (2001) · Nucleic Acids Research · doi:10.1093/nar/29.2.397 · Cited by 306

Ribosomal protein L24 defect in Belly spot and tail (Bst), a mouse Minute

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Elevated levels of cyclin D1 protein in response to increased expression of eukaryotic initiation factor 4E

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Identification of c-myc responsive genes using rat cDNA microarray.

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14-3-3σ controls mitotic translation to facilitate cytokinesis

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Cell cycle activation by c-myc in a Burkitt lymphoma model cell line

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MAD1 and c‐MYC regulate UBF and rDNA transcription during granulocyte differentiation

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Induction of ribosomal genes and hepatocyte hypertrophy by adenovirus-mediated expression of c-Myc in vivo

Kim, S., Li, Q., Dang, C. V., & Lee, L. A. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.200372597 · Cited by 187

A role for c-Myc in the regulation of ribosomal RNA processing

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Cell-cycle-dependent translational control.

Pyronnet, S., & Sonenberg, N. (2001) · Current Opinion in Genetics and Development · doi:10.1016/s0959-437x(00)00150-7 · Cited by 176

Ablation of Ribosomal Protein L22 Selectively Impairs αβ T Cell Development by Activation of a p53-Dependent Checkpoint

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Ribosomal Protein S6 Gene Haploinsufficiency Is Associated with Activation of a p53-Dependent Checkpoint during Gastrulation

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The PITSLRE/CDK11p58 protein kinase promotes centrosome maturation and bipolar spindle formation

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Myc induces the nucleolin and BN51 genes: possible implications in ribosome biogenesis

Greasley, P. J. (2000) · Nucleic Acids Research · doi:10.1093/nar/28.2.446 · Cited by 126

Modulation of T‐lymphocyte development, growth and cell size by the Myc antagonist and transcriptional repressor Mad1

Iritani, B. M., Delrow, J. J., Grandori, C., Gomez, I. G., Klacking, M., Carlos, L. S., & Eisenman, R. N. (2002) · The EMBO Journal · doi:10.1093/emboj/cdf492 · Cited by 97

CDK11p58 is required for the maintenance of sister chromatid cohesion

Hu, D., Valentine, M. B., Kidd, V. J., & Lahti, J. M. (2007) · Journal of Cell Science · doi:10.1242/jcs.007963 · Cited by 96

Activation by c-Myc of transcription by RNA polymerases I, II and III

Gomez-Roman, N., Felton-Edkins, Z. A., Kenneth, N. S., Goodfellow, S. J., Athineos, D., Zhang, J., Ramsbottom, B. A., Innes, F., Kantidakis, T., Kerr, E. R., et al. (2006) · Biochemical Society Symposia · doi:10.1042/bss0730141 · Cited by 95

Accumulation of c-Myc and proteasomes at the nucleoli of cells containing elevated c-Myc protein levels

Arabi, A., Rustum, C., Hallberg, E., & Wright, A. P. H. (2003) · Journal of Cell Science · doi:10.1242/jcs.00370 · Cited by 94

The p53 Tumor Suppressor Causes Congenital Malformations in Rpl24-Deficient Mice and Promotes Their Survival

Barkić, M., Crnomarković, S., Grabušić, K., Bogetić, I., Panić, L., Tamarut, S., Brdovčak, M. C., Jerić, I., Vidak, S., & Volarević, S. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.01588-08 · Cited by 92

Regulation of the cell-cycle-dependent internal ribosome entry site of the PITSLRE protein kinase: roles of Unr (upstream of N-ras) protein and phosphorylated translation initiation factor eIF-2α

Tinton, S. A., Schepens, B., Bruynooghe, Y., Beyaert, R., & Cornelis, S. (2004) · Biochemical Journal · doi:10.1042/bj20040963 · Cited by 87

A DNA microarray screen for genes involved in c-MYC and N-MYC oncogenesis in human tumors

Schuldiner, O., & Benvenisty, N. (2001) · Oncogene · doi:10.1038/sj.onc.1204459 · Cited by 67

Loss of Protooncogene c-Myc Function Impedes G1 Phase Progression Both before and after the Restriction Point

Schorl, C., & Sedivy, J. M. (2003) · Molecular Biology of the Cell · doi:10.1091/mbc.e02-10-0649 · Cited by 52

Experimental phenocopy of a Minute maternal-effect mutation alters blastoderm determination in embryos of Drosophila melanogaster

Boring, L. F., Sinervo, B., & Schubiger, G. (1989) · Developmental Biology · doi:10.1016/0012-1606(89)90231-5 · Cited by 22

c-Myc overexpression increases cell size and impairs cartilage differentiation during chick limb development.

Piedra, M., Delgado, M. D., Ros, M. A., & León, J. (2002) · PubMed · Cited by 22

Molecular Genetics of Colorectal Cancer

Fearon, E. R. (2011) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev-pathol-011110-130235 · Cited by 1,805

Transcriptional Amplification in Tumor Cells with Elevated c-Myc

Lin, C. Y., Lovén, J., Rahl, P. B., Paranal, R. M., Burge, C. B., Bradner, J. E., Lee, T. I., & Young, R. A. (2012) · Cell · doi:10.1016/j.cell.2012.08.026 · Cited by 1,543

MYC, Metabolism, and Cancer

Stine, Z. E., Walton, Z. E., Altman, B. J., Hsieh, A. L., & Dang, C. V. (2015) · Cancer Discovery · doi:10.1158/2159-8290.cd-15-0507 · Cited by 1,435

The tumorigenicity of human embryonic and induced pluripotent stem cells

Ben-David, U., & Benvenisty, N. (2011) · Nature Reviews Cancer · doi:10.1038/nrc3034 · Cited by 889

Activation of mTORC2 by Association with the Ribosome

Zinzalla, V., Stracka, D., Oppliger, W., & Hall, M. N. (2011) · Cell · doi:10.1016/j.cell.2011.02.014 · Cited by 648

Review The Role of Myc-Induced Protein Synthesis in Cancer

Ruggero, D. (2016)

Myc, Oncogenic Protein Translation, and the Role of Polyamines

Franson, A. T., & Hogarty, M. D. (2018) · Medical Sciences · doi:10.3390/medsci6020041 · Cited by 35

Abstract IA8: Novel insights into synthetic lethal interactions in cancer: Common nodes in protein synthesis control and nucleotide metabolism

Ruggero, D. (2013) · Cancer Research · doi:10.1158/1538-7445.fbcr13-ia8

Examining Myc-Dependent Translation Changes in Cellular Homeostasis and Cancer

Kovalski, J. R., Xu, Y., & Ruggero, D. (2021) · Methods in molecular biology · doi:10.1007/978-1-0716-1476-1_13 · Cited by 4

Myc coordinates transcription and translation to enhance transformation and suppress invasiveness

Elkon, R., Loayza‐Puch, F., Korkmaz, G., Lopes, R., Breugel, P. C. V., Bleijerveld, O. B., Altelaar, M. A. F., Wolf, E., Lorenzin, F., Eilers, M., et al. (2015) · EMBO Reports · doi:10.15252/embr.201540717 · Cited by 57