Cited by 187RNA and protein synthesis mechanismsPI3K/AKT/mTOR signaling in cancerCancer-related Molecular Pathways

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The Role of Myc-Induced Protein Synthesis in Cancer

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Ruggero, Davide·2009·Cancer Research

DOI 10.1158/0008-5472.can-09-1970PMC PMC2880919

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Abstract

Deregulation in different steps of translational control is an emerging mechanism for cancer formation. One example of an oncogene with a direct role in control of translation is the Myc transcription factor. Myc directly increases protein synthesis rates by controlling the expression of multiple components of the protein synthetic machinery, including ribosomal proteins and initiation factors of translation, Pol III and rDNA. However, the contribution of Myc-dependent increases in protein synthesis toward the multistep process leading to cancer has remained unknown. Recent evidence strongly suggests that Myc oncogenic signaling may monopolize the translational machinery to elicit cooperative effects on cell growth, cell cycle progression, and genome instability as a mechanism for cancer initiation. Moreover, new genetic tools to restore aberrant increases in protein synthesis control are now available, which should enable the dissection of important mechanisms in cancer that rely on the translational machinery. [Cancer Res 2009;69(23):8839–43]

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Authors: Ruggero, D.
Affiliations: University of California, San Francisco (US)
Corresponding author: Ruggero, Davide
ORCID: Ruggero, Davide
Venue: Cancer Research
Publisher: American Association for Cancer Research (AACR)
Published: 2009-11-30
Volume: 69
Issue: 23
Pages: 8839-8843
ISSN: 0008-5472 (ISSN-L)
1538-7445
DOI: 10.1158/0008-5472.can-09-1970
PMC: PMC2880919
OpenAlex: W2093199938
Cited by: 186
References: 42
Citations by year: 2026: 7 · 2025: 7 · 2024: 13 · 2023: 10 · 2022: 8 · 2021: 12 · 2020: 12 · 2019: 7 · 2018: 13 · 2017: 6 · 2016: 5 · 2015: 10 · 2014: 18 · 2013: 13 · 2012: 19
FWCI: 1.15
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Cancer Research (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: Sandler Foundation
National Institutes of Health (NIH-R01)
University of California, San Francisco
National Heart, Lung, and Blood Institute (R01HL085572)
National Cancer Institute (R01CA140456)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
Keywords: MYC oncogene, translational regulation, protein synthesis, ribosomal proteins, translation initiation factors, ribosomal DNA, genomic instability, cell cycle progression, tumor initiation, translation machinery
MeSH terms: Animals, Humans, Neoplasms, Protein Biosynthesis, Gene Expression Regulation, Neoplastic, Genes, myc, Proto-Oncogene Proteins c-myc

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The Role of Myc-Induced Protein Synthesis in Cancer

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