Rethinking the Warburg Effect with Myc Micromanaging Glutamine Metabolism
Open accessAbstract
The MYC oncogene, which is frequently deregulated in human cancers, encodes a master transcription factor c-Myc (herein termed Myc) that integrates cell proliferation with metabolism through its regulation of thousands of genes including microRNAs (miRNA). In addition to its known function in regulating the cell cycle and glucose metabolism, recent studies document a role for Myc in stimulating glutamine catabolism, in part through the repression of miRNAs miR-23a and miR-23b. These observations suggest an additional level of complexity in tumor metabolism, which includes the commensal metabolic relationship between hypoxic and nonhypoxic regions of tumors as well as the surrounding stroma. Thus, a reevaluation of cancer metabolism considering glutamine catabolism with a better understanding of the tumor histological complexity is needed before cancer metabolism can be effectively targeted in therapy. Cancer Res; 70(3); 859–62
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Cancer cells driven by oncogenic MYC, K-Ras, and PIK3CA require glutamine for survival and display extensive anabolic utilization of glutamine.
“Notably, cancer cells driven by oncogenic MYC, K-Ras, and PIK3CA require glutamine for their survival and display extensive anabolic utilization of glutamine29,174,175”
From Glutamine reliance in cell metabolism (2020) · cites this paper as [174]
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- Authors
- Dang, C. V.
- Affiliations
- Johns Hopkins University (US)
- Corresponding author
- Dang, Chi V.
- ORCID
- Dang, Chi V.
- Venue
- Cancer Research
- Published
- 2010-01-31
- Volume
- 70
- Issue
- 3
- Pages
- 859-862
- ISSN
- 0008-5472 (ISSN-L)
- 1538-7445
- PMC
- PMC2818441
- OpenAlex
- W2070371419
- Cited by
- 379
- References
- 20
- Citations by year
- 2026: 1 · 2025: 7 · 2024: 11 · 2023: 15 · 2022: 14 · 2021: 17 · 2020: 22 · 2019: 18 · 2018: 26 · 2017: 24 · 2016: 35 · 2015: 33 · 2014: 36 · 2013: 36 · 2012: 41
- FWCI
- 12.09
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Cancer Research (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Cancer Institute (CA 57341, R01CA057341, CA 51497, R37CA051497, R01CA051497)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Amino Acid Enzymes and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
- Keywords
- Warburg effect, MYC oncogene, glutamine metabolism, glutamine catabolism, microRNA repression, miR-23a, miR-23b, cancer metabolism, tumor hypoxia, tumor stroma
- MeSH terms
- Animals, Citric Acid Cycle, Glucose, Glutamine, Humans, Mitochondria, Models, Biological, Neoplasms, Gene Expression Regulation, Neoplastic, Proto-Oncogene Proteins c-myc, MicroRNAs
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