The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
AACR Centennial Series: The Biology of Cancer Metastasis: Historical Perspective
Open accessAbstract
Metastasis resistant to therapy is the major cause of death from cancer. Despite almost 200 years of study, the process of tumor metastasis remains controversial. Stephen Paget initially identified the role of host-tumor interactions on the basis of a review of autopsy records. His “seed and soil” hypothesis was substantiated a century later with experimental studies, and numerous reports have confirmed these seminal observations. An improved understanding of the metastatic process and the attributes of the cells selected by this process is critical for the treatment of patients with systemic disease. In many patients, metastasis has occurred by the time of diagnosis, so metastasis prevention may not be relevant. Treating systemic disease and identifying patients with early disease should be our goal. Revitalized research in the past three decades has focused on new discoveries in the biology of metastasis. Even though our understanding of molecular events that regulate metastasis has improved, the contributions and timing of molecular lesion(s) involved in metastasis pathogenesis remain unclear. Review of the history of pioneering observations and discussion of current controversies should increase understanding of the complex and multifactorial interactions between the host and selected tumor cells that contribute to fatal metastasis and should lead to the design of successful therapy. Cancer Res; 70(14); 5649–69. ©2010 AACR.
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Self-citationTumors: Wounds That Do Not Heal
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Inflammation-induced cancer: Crosstalk between tumours, immune cells and microorganisms
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History of myeloid-derived suppressor cells
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Self-citationApoptosis, autophagy, necroptosis, and cancer metastasis
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Metadata
- Authors
- Talmadge, J. E., & Fidler, I. J.
- Venue
- Cancer Research
- Published
- 2010-07-14
- Volume
- 70
- Issue
- 14
- Pages
- 5649-5669
- ISSN
- 0008-5472 (ISSN-L)
- 1538-7445
- OpenAlex
- W2144744111
- Cited by
- 1,169
- References
- 12
- FWCI
- 32.05
- Type
- journal article
- Language
- en
- Open access
- bronze
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