The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Myeloid Progenitor Cells in the Premetastatic Lung Promote Metastases by Inducing Mesenchymal to Epithelial Transition
Open accessAbstract
Tumors systemically initiate metastatic niches in distant target metastatic organs. These niches, composed of bone marrow–derived hematopoietic cells, provide permissive conditions for future metastases. However, the mechanisms by which these cells mediate outgrowth of metastatic tumor cells are not completely known. Using mouse models of spontaneous breast cancer, we show enhanced recruitment of bone marrow–derived CD11b+Gr1+ myeloid progenitor cells in the premetastatic lungs. Gene expression profiling revealed that the myeloid cells from metastatic lungs express versican, an extracellular matrix proteoglycan. Notably, versican in metastatic lungs was mainly contributed by the CD11b+Ly6Chigh monocytic fraction of the myeloid cells and not the tumor cells or other stromal cells. Versican knockdown in the bone marrow significantly impaired lung metastases in vivo, without impacting their recruitment to the lungs or altering the immune microenvironment. Versican stimulated mesenchymal to epithelial transition of metastatic tumor cells by attenuating phospho-Smad2 levels, which resulted in elevated cell proliferation and accelerated metastases. Analysis of clinical specimens showed elevated versican expression within the metastatic lung of patients with breast cancer. Together, our findings suggest that selectively targeting tumor-elicited myeloid cells or versican represents a potential therapeutic strategy for combating metastatic disease. Cancer Res; 72(6); 1384–94. ©2012 AACR.
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Cites
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Endothelial Progenitor Cells Control the Angiogenic Switch in Mouse Lung Metastasis
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Cited by
Microenvironmental regulation of tumor progression and metastasis
Quail, D. F., & Joyce, J. A. (2013) · Nature Medicine · doi:10.1038/nm.3394 · Cited by 7,994
Tumor-Associated Macrophages: From Mechanisms to Therapy
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Concepts of extracellular matrix remodelling in tumour progression and metastasis
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Targeting macrophages: therapeutic approaches in cancer
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Pre-metastatic niches: organ-specific homes for metastases
Peinado, H., Zhang, H., Matei, I. R., Costa-Silva, B., Hoshino, A., Rodrigues, G., Psaila, B., Kaplan, R. N., Bromberg, J. F., Kang, Y., et al. (2017) · Nature Reviews Cancer · doi:10.1038/nrc.2017.6 · Cited by 1,889
Metadata
- Authors
- Gao, D., Joshi, N., Choi, H., Ryu, S., Hahn, M., Catena, R., Sadik, H., Argani, P., Wagner, P., Vahdat, L. T., Port, J. L., Stiles, B., Sukumar, S., Altorki, N. K., Rafii, S., & Mittal, V.
- Venue
- Cancer Research
- Published
- 2012-03-14
- Volume
- 72
- Issue
- 6
- Pages
- 1384-1394
- ISSN
- 0008-5472 (ISSN-L)
- 1538-7445
- OpenAlex
- W2065678781
- Cited by
- 307
- References
- 9
- FWCI
- 9.74
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Gao, D., Joshi, N., Choi, H., Ryu, S., Hahn, M., Catena, R., Sadik, H., Argani, P., Wagner, P., Vahdat, L. T., Port, J. L., Stiles, B., Sukumar, S., Altorki, N. K., Rafii, S., & Mittal, V. (2012). Myeloid Progenitor Cells in the Premetastatic Lung Promote Metastases by Inducing Mesenchymal to Epithelial Transition. Cancer Research. https://doi.org/10.1158/0008-5472.can-11-2905
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