The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
RAE1 Ligands for the NKG2D Receptor Are Regulated by STING-Dependent DNA Sensor Pathways in Lymphoma
Open accessAbstract
The immunoreceptor NKG2D originally identified in natural killer (NK) cells recognizes ligands that are upregulated on tumor cells. Expression of NKG2D ligands (NKG2DL) is induced by the DNA damage response (DDR), which is often activated constitutively in cancer cells, revealing them to NK cells as a mechanism of immunosurveillance. Here, we report that the induction of retinoic acid early transcript 1 (RAE1) ligands for NKG2D by the DDR relies on a STING-dependent DNA sensor pathway involving the effector molecules TBK1 and IRF3. Cytosolic DNA was detected in lymphoma cell lines that express RAE1 and its occurrence required activation of the DDR. Transfection of DNA into ligand-negative cells was sufficient to induce RAE1 expression. Irf3+/−;Eμ-Myc mice expressed lower levels of RAE1 on tumor cells and showed a reduced survival rate compared with Irf3+/+;Eμ-Myc mice. Taken together, our results suggest that genomic damage in tumor cells leads to activation of STING-dependent DNA sensor pathways, thereby activating RAE1 and enabling tumor immunosurveillance. Cancer Res; 74(8); 2193–203. ©2014 AACR.
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Molecular Mechanisms of Mammalian DNA Repair and the DNA Damage Checkpoints
Sancar, A., Lindsey-Boltz, L. A., Ünsal-Kaçmaz, K., & Linn, S. (2004) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.73.011303.073723 · Cited by 3,317
IRF Family of Transcription Factors as Regulators of Host Defense
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The DNA damage pathway regulates innate immune system ligands of the NKG2D receptor
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Guerra, N., Tan, Y. X., Joncker, N. T., Choy, A., Gallardo, F., Xiong, N., Knoblaugh, S., Cado, D., Greenberg, N. R., & Raulet, D. H. (2008) · Immunity · doi:10.1016/j.immuni.2008.02.016 · Cited by 850
Self-citationSubstrate Specificities and Identification of Putative Substrates of ATM Kinase Family Members
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A novel ligand for the NKG2D receptor activates NK cells and macrophages and induces tumor immunity
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Greten, F. R., & Grivennikov, S. I. (2019) · Immunity · doi:10.1016/j.immuni.2019.06.025 · Cited by 3,806
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Metadata
- Authors
- Lam, A. R., Le Bert, N., Ho, S. S. W., Shen, Y. J., Tang, M. L. F., Xiong, G. M., Croxford, J. L., Koo, C. X., Ishii, K. J., Akira, S., Raulet, D. H., & Gasser, S.
- Venue
- Cancer Research
- Published
- 2014-04-15
- Volume
- 74
- Issue
- 8
- Pages
- 2193-2203
- ISSN
- 0008-5472 (ISSN-L)
- 1538-7445
- OpenAlex
- W2090998580
- Cited by
- 179
- References
- 6
- FWCI
- 4.15
- Type
- journal article
- Language
- en
- Open access
- green
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- Lam, A. R., Le Bert, N., Ho, S. S. W., Shen, Y. J., Tang, M. L. F., Xiong, G. M., Croxford, J. L., Koo, C. X., Ishii, K. J., Akira, S., Raulet, D. H., & Gasser, S. (2014). RAE1 Ligands for the NKG2D Receptor Are Regulated by STING-Dependent DNA Sensor Pathways in Lymphoma. Cancer Research. https://doi.org/10.1158/0008-5472.can-13-1703
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