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PHD2 Targeting Overcomes Breast Cancer Cell Death upon Glucose Starvation in a PP2A/B55α-Mediated Manner

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Broad-spectrum antitumor properties of Withaferin A: a proteomic perspective

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Analysis of CRISPR‐Cas9 screens identifies genetic dependencies in melanoma

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CDC25B partners with PP2A to induce AMPK activation and tumor suppression in triple negative breast cancer

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Pleiotropy of PP2A Phosphatases in Cancer with a Focus on Glioblastoma IDH Wildtype

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Upregulation of miR-614 promotes proliferation and inhibits apoptosis in ovarian cancer by suppressing PPP2R2A expression

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AMOTL2 inhibits JUN Thr239 dephosphorylation by binding PPP2R2A to suppress the proliferation in non-small cell lung cancer cells

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Review of PP2A Tumor Biology and Antitumor Effects of PP2A Inhibitor LB100 in the Nervous System

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miR21 modulates the Hippo signaling pathway via interference with PP2A Bβ to inhibit trophoblast invasion and cause preeclampsia

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Participation of protein metabolism in cancer progression and its potential targeting for the management of cancer

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PP2A B55α inhibits epithelial-mesenchymal transition via regulation of Slug expression in non-small cell lung cancer

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Long-Chain Acylcarnitines Decrease the Phosphorylation of the Insulin Receptor at Tyr1151 Through a PTP1B-Dependent Mechanism

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PP2Ac upregulates PI3K-Akt signaling and induces hepatocyte apoptosis in liver donor after brain death

Xiong, Y., Lan, J., Huang, K., Zhang, Y., Zheng, L., Wang, Y., & Ye, Q. (2019) · APOPTOSIS · doi:10.1007/s10495-019-01570-8 · Cited by 13 · see citing works

Human pancreatic cancer patients with Epithelial-to-Mesenchymal Transition and an aggressive phenotype show a disturbed balance in Protein Phosphatase Type 2A expression and functionality

van Pelt, J. F., Meeusen, B., Derua, R., Guffens, L., Cutsem, E. V., Janssens, V., & Verslype, C. (2023) · Journal of Translational Medicine · doi:10.1186/s12967-023-04145-z · Cited by 11 · see citing works

AKR1B10 dictates c-Myc stability to suppress colorectal cancer metastasis via PP2A nitration

Wu, X., Huang, S., Gao, J., Huang, S., Chen, L., Zhao, Z., Pu, R., Ma, X., Liu, X., He, W., et al. (2025) · Science Advances · doi:10.1126/sciadv.adv6937 · Cited by 10 · see citing works

Targeting PP2A in cancer: an underrated option

Sarais, F., Krempien, F., Koehn, C., Brewing, L., Classen, C. F., Walter, M., & Shokraie, O. (2025) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-025-03560-y · Cited by 8 · see citing works

Silencing of microRNA-106b-5p prevents doxorubicin-mediated cardiotoxicity through modulation of the PR55α/YY1/sST2 signaling axis

Lax, A., Soler, F., del Palacio, M. J. F., Pascual-Oliver, S., Ballester, M. R., Fuster, J. J., Pascual-Figal, D. A., & Lopez, M. (2023) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2023.04.031 · Cited by 8 · see citing works

Unraveling the complexity: A comprehensive analysis of the PP2A in cancer and its potential for novel targeted therapies

Ivovič, D., Kabelíková, P., & Jurkovičová, D. (2023) · Neoplasma · doi:10.4149/neo_2023_230806n411 · Cited by 7 · see citing works

Development and analysis of long non-coding RNA-associated competing endogenous RNA network for osteosarcoma metastasis

Fu, Y., Liu, Q., Bao, Q., Wen, J., Liu, Z., Hu, Y., He, G., Peng, C., Xu, Y., & Zhang, W. (2021) · Hereditas · doi:10.1186/s41065-021-00174-0 · Cited by 6 · see citing works

The effect of lentivirus-mediated SIRT1 gene knockdown in the ATDC5 cell line via inhibition of the Wnt signaling pathway

Yu, F., Yuan, Y., Li, D., Kou, Y., Jiang, B., & Zhang, P. (2018) · Cellular Signalling · doi:10.1016/j.cellsig.2018.09.016 · Cited by 5 · see citing works

p53/FBXL20 axis negatively regulates the protein stability of PR55α, a regulatory subunit of PP2A Ser/Thr phosphatase

Madduri, L. S. V., Brandquist, N. D., Palanivel, C., Talmon, G. A., Baine, M. J., Zhou, S., Enke, C. A., Johnson, K. R., Ouellette, M. M., & Yan, Y. (2021) · Neoplasia · doi:10.1016/j.neo.2021.10.002 · Cited by 5 · see citing works

Loss of PR55α promotes proliferation and metastasis by activating MAPK/AKT signaling in hepatocellular carcinoma

Zhao, J., Chen, G., Li, J., Liu, S., Jin, Q., Zhang, Z., Qi, F., Zhang, J., & Xu, J. (2021) · Cancer Cell International · doi:10.1186/s12935-021-01796-0 · Cited by 5 · see citing works

The balance between B55α and Greatwall expression levels predicts sensitivity to Greatwall inhibition in cancer cells

Zach, R., Annis, M., Martin-Guerrero, S. M., Alatawi, A., Chia, K. H., Meredith, M., Osborn, K., Peter, N., Pearce, W., Booth, J., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-62943-z · Cited by 4 · see citing works

PR55α-controlled protein phosphatase 2A inhibits p16 expression and blocks cellular senescence induction by γ-irradiation

Palanivel, C., Madduri, L. S. V., Hein, A. L., Jenkins, C. B., Graff, B. T., Camero, A. L., Zhou, S., Enke, C. A., Ouellette, M. M., & Yan, Y. (2024) · Aging · doi:10.18632/aging.205619 · Cited by 4 · see citing works

Mismatch repair protein deficiency and its implications on distant metastasis in colorectal cancer: A comprehensive analysis

Fan, C., Fang, C., Wang, W. T., Lv, Z., Zhang, X., Long, F., Jiang, Z., Li, Y., Zhang, H., Zhou, Z., et al. (2024) · Cancer Medicine · doi:10.1002/cam4.6994 · Cited by 4 · see citing works

ETS1 Expression in Diabetic Foot Ulcers: Implications for Fibroblast Phenotype and Wound Healing Through the PP2A/YAP Pathway

Yi, W., Bao, Q., Xu, D., Long, C., Fang, R., Cheng, W., Song, J., & Feng, H. (2024) · Journal of Inflammation Research · doi:10.2147/jir.s477470 · Cited by 3 · see citing works

Glycogen synthase kinase‐3β activity plays a key role in the antitumor effect of nafamostat mesilate in pancreatic cancer cells

Haruki, K., Shiba, H., Shimada, Y., Shirai, Y., Iwase, R., Fujiwara, Y., Uwagawa, T., Ohashi, T., & Yanaga, K. K. (2017) · Annals of Gastroenterological Surgery · doi:10.1002/ags3.12025 · Cited by 3 · see citing works

Wnt Signaling and Genetic Bone Diseases

Lu, Y., & Han, J. (2019) · IntechOpen eBooks · doi:10.5772/intechopen.81070 · Cited by 3 · see citing works

Protein phosphatase 2A as a therapeutic target in pancreatic cancer: past insights, recent advances, and future directions

Shah, V. M., & Sears, R. C. (2025) · Current Opinion in Physiology · doi:10.1016/j.cophys.2025.100849 · Cited by 2 · see citing works

TAM family kinases are potential candidate targets for therapeutic intervention in chronic myeloid leukemia

Yousaf, M., Arif, K., & Khan, D. (2025) · Discover Oncology · doi:10.1007/s12672-025-03632-7 · Cited by 2 · see citing works

PR55α subunit of protein phosphatase 2A supports KRASG12D-driven tumorigenesis that requires YAP activation

Jenkins, C. B., Camero, A. L., Graff, B. T., Madduri, L. S. V., O’Connell, K. A., Hein, A. L., Smith, L. M., Enke, C. A., Dong, J., Hollingsworth, M. A., et al. (2025) · Oncogene · doi:10.1038/s41388-025-03477-y · Cited by 1 · see citing works

A PP2A-mtATR-tBid axis links DNA damage-induced CIP2A degradation to apoptotic dormancy and therapeutic resistance in PDAC

Luo, Y., Biswas, H., Makinwa, Y., Liu, S., Dong, Z., Liu, J., Zhang, J., & Zou, Y. (2025) · Cancer Letters · doi:10.1016/j.canlet.2025.217790 · Cited by 1 · see citing works

Activation of PP2A-B56a leads to aberrant EGFR signaling and proliferative phenotypes in PDAC

Pfeffer, C. M., Clifford, S. J., Karim, S. A., Chianis, E. R. D., N, H. B., Gartenhaus, L. E., Kay, E. F., Baral, G., Hoffman, E. G., Utturkar, S. M., et al. (2026) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-25-0970 · Cited by 1 · see citing works

Comprehensive analysis of the protein phosphatase 2A regulatory subunit B56ε in pan-cancer and its role and mechanism in hepatocellular carcinoma

Wu, H., Huang, Y.-Y., Xu, Y., Xiang, W.-L., Yang, C., Liu, R.-Y., Li, D., Guo, X.-F., Zhang, Z., Bei, C., et al. (2024) · World Journal of Gastrointestinal Oncology · doi:10.4251/wjgo.v16.i2.475 · Cited by 1 · see citing works

A small molecule inhibitor of leucine carboxyl methyltransferase-1 inhibits cancer cell survival

Arosarena, O. A., Sarıbaş, A. S., & Papadopoulos, E. P. (2024) · Frontiers in Drug Discovery · doi:10.3389/fddsv.2024.1278163 · Cited by 1 · see citing works

PPP2R2A promotes Hu sheep pituitary cell proliferation and gonadotropin secretion associated with prolificacy

Xu, H., Cai, Y., Yang, H., Li, S., Chen, P., Wei, Z., Wang, F., Wang, Z., & Zhang, Y. (2024) · Animal Reproduction Science · doi:10.1016/j.anireprosci.2024.107457

Additional file 2 of Loss of PR55α promotes proliferation and metastasis by activating MAPK/AKT signaling in hepatocellular carcinoma

Zhao, J., Chen, G., Li, J., Liu, S., Jin, Q., Zhang, Z., Qi, F., Zhang, J., & Xu, J. (2021) · Figshare · doi:10.6084/m9.figshare.14037694

Additional file 1 of Loss of PR55α promotes proliferation and metastasis by activating MAPK/AKT signaling in hepatocellular carcinoma

Zhao, J., Chen, G., Li, J., Liu, S., Jin, Q., Zhang, Z., Qi, F., Zhang, J., & Xu, J. (2021) · Figshare · doi:10.6084/m9.figshare.14037691

Additional file 1 of Development and analysis of long non-coding RNA-associated competing endogenous RNA network for osteosarcoma metastasis

Fu, Y., Liu, Q., Bao, Q., Wen, J., Liu, Z., Hu, Y., He, G., Peng, C., Xu, Y., & Zhang, W. (2021) · Figshare · doi:10.6084/m9.figshare.14053800

Additional file 1 of Human pancreatic cancer patients with Epithelial-to-Mesenchymal Transition and an aggressive phenotype show a disturbed balance in Protein Phosphatase Type 2A expression and functionality

van Pelt, J., Meeusen, B., Derua, R., Guffens, L., Cutsem, E. V., Janssens, V., & Verslype, C. (2024) · Figshare · doi:10.6084/m9.figshare.26588817

CUE domain-containing 2 promotes diffuse large B-cell lymphoma progression via PP2A-B55β degradation and shapes macrophage-mediated immune responses

Zeng, L.-J., Lü, W.-X., Liang, Y.-Z., Yang, J., Zhu, J.-Y., & Wang, L. (2026) · Molecular Biomedicine · doi:10.1186/s43556-026-00626-x

BindingDB Entry 50018255: Strategies for Targeting Serine/Threonine Protein Phosphatases with Small Molecules in Cancer.

BindingDB (2024) · UC San Diego · doi:10.7270/q2wd44rv

Abstract 5762: PR55-alpha associated PP2A promotes pancreatic tumorigenesis

Yan, Y., Hein, A. L., Seshacharyulu, P., Rachagani, S., Sheinin, Y. M., Ouellette, M. M., Ponnusamy, M. P., & Batra, S. K. (2017) · Cancer Research · doi:10.1158/1538-7445.am2017-5762

Abstract A44: PR55α regulatory subunit of PP2A inhibits the MOB1/LATS cascade and activates YAP in pancreatic cancer cells

Hein, A. L., Brandquist, N. D., Ouellette, C. Y., Seshacharyulu, P., Enke, C. A., Ouellette, M. M., Batra, S. K., & Yan, Y. (2020) · Molecular Cancer Research · doi:10.1158/1557-3125.hippo19-a44

PR55α subunit of protein phosphatase 2A supports KRASG12D-driven tumorigenesis that requires YAP activation

Jenkins, C. B., Camero, A. L., Graff, B. T., Madduri, L. S. V., O’Connell, K. A., Hein, A. L., Smith, L. M., Enke, C. A., Dong, J., Hollingsworth, M. A., et al. (2025) · Oncogene · doi:10.1038/s41388-025-03477-y · Cited by 1 · see citing works

Antagonistic Regulation of MCL-1 Protein Stability by PR55α- and PR61α-Directed PP2A in Pancreatic Cancer

Jegadish, S. K. (2026) · DigitalCommons@UNMC

Abstract PR-008: The role of PP2A-B56α in acinar-to-ductal metaplasia and initiation of pancreatic ductal adenocarcinoma

Tinsley, S. L., Shelley, R. A., Thoma, M. C., Narla, G., Sears, R. C., & Allen-Petersen, B. A. (2020) · Cancer Research · doi:10.1158/1538-7445.panca20-pr-008