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Cited by 88Ovarian function and disordersNutritional Studies and DietDiabetes, Cardiovascular Risks, and Lipoproteins

Effects of Dietary Approach to Stop Hypertension diet on androgens, antioxidant status and body composition in overweight and obese women with polycystic ovary syndrome: a randomised controlled trial

Azadi‐Yazdi, M., Karimi‐Zarchi, M., Salehi‐Abargouei, A., Fallahzadeh, H., Nadjarzadeh, A.·2017·Journal of Human Nutrition and Dietetics
DOI 10.1111/jhn.12433
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Abstract

Background: Polycystic ovary syndrome (PCOS) is the most common endocrine disease in reproductive age women. The present study aimed to determine the effects of Dietary Approaches to Stop Hypertension (DASH) diet on reproductive hormones, plasma total antioxidant status and anthropometric indices in overweight and obese PCOS women. Methods: In this randomised controlled clinical trial, 60 women with PCOS were randomly assigned to one of two diets with energy restriction: the DASH diet and a control diet. The DASH and control diets consisted of 50–55% carbohydrate, 15–20% protein and 25–30% total fat. The DASH diet was designed to be rich in vegetables, fruits, whole grains and low‐fat dairy products, as well as low in saturated fats, cholesterol, refined grains and sweets. In the present study, the anthropometric indices, body composition, total testosterone, androstenedione, sex hormone binding globulin (SHBG), free androgen index and 2,2′‐diphenyl‐1‐picryylhydrazyl (DPPH) scavenging activity were measured before and after 3 months. Results: The consumption of DASH diet compared to the control diet was associated with a significant reduction in weight [−5.78 (1.91) kg versus −4.34 (2.87) kg, P = 0.032], body mass index (BMI) [−2.29 (0.15) kg m–2 versus −1.69 (0.20) kg m–2, P = 0.02], fat mass [−3.23(1.66) kg versus −2.13 (1.26) kg, P = 0.008] and serum androstenedione [−1.75 (1.39) ng mL–1 versus −1.02 (0.72) ng mL–1, P‐value = 0.019]. Increased concentrations of SHBG [28.80 (21.71) versus 11.66(18.82) nmol L–1, P = 0.003) and DPPH scavenging activity [30.23% (19.09) versus 12.97% (25.12) were also found in the DASH group. Conclusions: The DASH diet could improve weight loss, BMI and fat mass. Furthermore, it could result in a significant reduction in serum androstenedione and a significant increase in antioxidant status and SHBG.

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  • Four trials mentioning trial registration were considered to have a low risk of reporting bias.

    “Four trials mentioning trial registration (37, 38, 41, 42) were considered to have a low risk of reporting bias (Fig. 2).”

    From Effect of Diet on Insulin Resistance in Polycystic Ovary Syndrome (2020) · cites this paper as [41]

  • Five studies (227 participants) reported changes in waist circumference.

    “In total, 5 studies (227 participants) mentioned the changes in WC (32, 35, 39, 41, 45).”

    From Effect of Diet on Insulin Resistance in Polycystic Ovary Syndrome (2020) · cites this paper as [41]

  • Three trials (108 participants) analyzed waist-to-hip ratio, and no significant changes were observed (MD = -0.01, 95% CI -0.02 to 0.00; P = .20; I2 = 0%).

    “Three trials (108 participants) were involved in the analysis (32, 35, 41), and no significant changes were observed (MD = –0.01, 95% CI –0.02 to 0.00; P = .20; I2 = 0%) (Fig. 3).”

    From Effect of Diet on Insulin Resistance in Polycystic Ovary Syndrome (2020) · cites this paper as [41]

  • Several studies demonstrated that the DASH diet had beneficial effects on markers of insulin resistance, inflammation, oxidative stress, and on hormonal profile (reduced androgens, anti-Müllerian hormone).

    “In fact, several studies demonstrated that DASH diet had beneficial effect on markers of IR, inflammation, oxidative stress, and on hormonal profile (reduced androgens, anti-Müllerian hormone) [34–37].”

    From Ketogenic Diet as Medical Prescription in Women with Polycystic Ovary Syndrome (PCOS) (2023) · cites this paper as [36]

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Authors
Azadi‐Yazdi, M., Karimi‐Zarchi, M., Salehi‐Abargouei, A., Fallahzadeh, H., & Nadjarzadeh, A.
Affiliations
Shahid Sadoughi University of Medical Sciences and Health Services (IR)
Corresponding author
Nadjarzadeh, A.
ORCID
Venue
Journal of Human Nutrition and Dietetics
Publisher
Wiley
Published
2016-11-07
Volume
30
Issue
3
Pages
275-283
ISSN
  • 0952-3871 (ISSN-L)
  • 1365-277X
DOI
10.1111/jhn.12433
OpenAlex
W2556985196
Cited by
88
References
51
Citations by year
2026: 7 · 2025: 12 · 2024: 11 · 2023: 15 · 2022: 4 · 2021: 23 · 2020: 9 · 2019: 3 · 2018: 2 · 2017: 2
FWCI
3.10
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Journal of Human Nutrition and Dietetics (publishedVersion)
  • PubMed (publishedVersion)
Funders
Shahid Sadoughi University of Medical sciences
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Keywords
polycystic ovary syndrome, DASH diet, dietary intervention, androgens, sex hormone-binding globulin, free androgen index, antioxidant status, body composition, obesity, overweight women, weight loss, androstenedione, testosterone, fat mass, caloric restriction, sex hormones, oxidative stress, insulin resistance, insulin sensitivity
MeSH terms
Dietary Approaches To Stop Hypertension, Adult, Androgens, Androstenedione, Antioxidants, Blood Glucose, Body Composition, Female, Humans, Insulin, Insulin Resistance, Obesity, Polycystic Ovary Syndrome, Sex Hormone-Binding Globulin, Testosterone, Biomarkers, Weight Loss, Body Mass Index, Overweight, Young Adult

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