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Cited by 62Cancer survivorship and careCardiovascular and exercise physiologyExercise and Physiological Responses

Hemoglobin and aerobic fitness changes with supervised exercise training in breast cancer patients receiving chemotherapy

Dolan, Lianne B., Gelmon, Karen, Courneya, Kerry S., Mackey, John R., Segal, Roanne J., Lane, Kirstin, Reid, Robert D., McKenzie, Donald C.·2010·Cancer Epidemiology, Biomarkers & Prevention
DOI 10.1158/1055-9965.epi-10-0521
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Abstract

Background: Aerobic exercise training (AET) is known to increase RBC production; however, this has not been evaluated in breast cancer patients undergoing adjuvant chemotherapy. The purpose of this study was to examine the changes in hemoglobin (Hb) levels in the Supervised Trial of Aerobic versus Resistance Training (START) and to determine its association with changes in VO2peak. Methods: Two hundred and forty-two breast cancer patients initiating chemotherapy were randomized to usual care (n = 82), resistance exercise (RET, n = 82), or AET (n = 78) groups for the duration of their chemotherapy (median, 17 weeks). Supervised exercise was thrice weekly based on standard AET and RET prescriptions. Aerobic fitness (VO2peak) and Hb concentration were measured at baseline and end of chemotherapy. Results: Regardless of the exercise group, Hb declined over the course of chemotherapy (13.4 ± 10.0 to 11.8 ± 11.5 g/dL, P < 0.01). Both AET and RET groups had significant, moderate correlations between the change in VO2peak and Hb (AET: r = 0.49, P < 0.001; RET: r = 0.39, P = 0.001). Conclusion: The results indicate that regular exercise does not protect against the decline in Hb associated with chemotherapy in breast cancer patients, but resulted in a stronger association between Hb and VO2peak. Impact: Even with the chemotherapy-induced decline in Hb, breast cancer patients can maintain their aerobic capacity by participating in regular aerobic exercise. Further studies are required to determine safe intensity levels that may stimulate the maintenance of Hb levels in breast cancer patients. Cancer Epidemiol Biomarkers Prev; 19(11); 2826–32. ©2010 AACR.

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Crossref · 10.1158/1055-9965.epi-10-0521

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  • Aerobic exercise during adjuvant chemotherapy does not appear to stimulate greater red blood cell production, so improvements in cardiorespiratory fitness depend on other central and peripheral adaptations.

    “Aerobic exercise during adjuvant chemotherapy does not appear to stimulate greater production of red blood cells(92), so improvements in cardiorespiratory fitness are contingent on other central (i.e., cardiac function, plasma volume) and peripheral adaptations (i.e., improved vascularization and mitochondrial enzyme function)(93).”

    From Exercise Guidelines for Cancer Survivors: Consensus Statement from International Multidisciplinary Roundtable (2019) · cites this paper as [92]

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Authors
Dolan, L. B., Gelmon, K., Courneya, K. S., Mackey, J. R., Segal, R. J., Lane, K., Reid, R. D., & McKenzie, D. C.
Affiliations
Camosun College (CA)
ORCID
Venue
Cancer Epidemiology, Biomarkers & Prevention
Publisher
American Association for Cancer Research (AACR)
Published
2010-11-01
Volume
19
Issue
11
Pages
2826-2832
ISSN
  • 1055-9965 (ISSN-L)
  • 1538-7755
DOI
10.1158/1055-9965.epi-10-0521
OpenAlex
W2138427434
Cited by
62
References
35
Citations by year
2026: 1 · 2025: 1 · 2023: 1 · 2022: 5 · 2021: 6 · 2020: 7 · 2019: 3 · 2018: 5 · 2017: 8 · 2016: 6 · 2015: 5 · 2014: 4 · 2013: 5 · 2012: 4
FWCI
1.42
Type
journal article
Language
en
Open access
closed
Locations
  • Cancer Epidemiology Biomarkers & Prevention (publishedVersion)
  • PubMed (publishedVersion)
Funders
Canadian Institutes of Health Research
Topics
  • Health Sciences › Medicine › Oncology › Cancer survivorship and care
  • Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
  • Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
Keywords
hemoglobin, aerobic exercise training, resistance training, breast cancer, adjuvant chemotherapy, cardiorespiratory fitness, peak oxygen uptake, chemotherapy-induced anemia, erythropoiesis, exercise during cancer treatment
MeSH terms
Adult, Aged, Antineoplastic Agents, Breast Neoplasms, Exercise Therapy, Female, Hemoglobins, Humans, Middle Aged, Oxygen Consumption, Physical Fitness, Exercise, Resistance Training

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