Genome-Wide Association Study of Circadian Rhythmicity in 71,500 UK Biobank Participants and Polygenic Association with Mood Instability
Open accessPublished version of a preprint
Abstract
Abstract Background Circadian rhythms are fundamental to health and are particularly important for mental wellbeing. Disrupted rhythms of rest and activity are recognised as risk factors for major depressive disorder and bipolar disorder. Methods We conducted a genome-wide association study (GWAS) of low relative amplitude (RA), an objective measure of circadian rhythmicity derived from the accelerometer data of 71 500 UK Biobank participants. Polygenic risk scores (PRS) for low RA were used to investigate potential associations with psychiatric phenotypes. Outcomes Two independent genetic loci were associated with low RA, within genomic regions for Neurofascin ( NFASC ) and Solute Carrier Family 25 Member 17 ( SLC25A17 ). A secondary GWAS of RA as a continuous measure identified a locus within Meis Homeobox 1 ( MEIS1 ). There were no significant genetic correlations between low RA and any of the psychiatric phenotypes assessed. However, PRS for low RA was significantly associated with mood instability across multiple PRS thresholds (at PRS threshold 0·05: OR=1·02, 95% CI=1·01-1·02, p=9·6×10 −5 ), and with major depressive disorder (at PRS threshold 0·1: OR=1·03, 95% CI=1·01-1·05, p=0·025) and neuroticism (at PRS threshold 0·5: Beta=0·02, 95% CI=0·007-0·04, p=0·021). Interpretation Overall, our findings contribute new knowledge on the complex genetic architecture of circadian rhythmicity and suggest a putative biological link between disrupted circadian function and mood disorder phenotypes, particularly mood instability, but also major depressive disorder and neuroticism.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
A comprehensive phenome-wide approach to disrupted rest-activity cycles from accelerometry in the UK Biobank has not yet been established.
“Although a few disease-specific studies, limited to patients with mood disorders7,8, have measured the degree of disrupted rest-activity cycles from accelerometry in the UKBB, a comprehensive phenome-wide approach has not yet been established.”
From Diurnal rhythms of wrist temperature are associated with future disease risk in the UK Biobank (2023) · cites this paper as [7]
A total of 92,325 participants passed quality control after exclusions based on failed calibration, insufficient data, or crossing over daylight savings time.
“A total of 92,325 participants passed quality control after exclusions based on failed calibration (n = 2826), insufficient data (n = 4258) or crossing over daylight savings time (n = 4279), following prior experiments7,8,20.”
From Diurnal rhythms of wrist temperature are associated with future disease risk in the UK Biobank (2023) · cites this paper as [7]
Quantum dots have also been used to model the mechanism by which anti-acetylcholine receptor antibodies contribute to the neuromuscular disorder myasthenia gravis.
“They have also been used to model the mechanism by which anti-acetylcholine receptor antibodies contribute to the neuromuscular disorder myasthenia gravis 210 .”
From Quantum effects in the brain: A review (2020) · cites this paper as [210]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
1 retracted
Davis, K. A. S., Coleman, J. R. I., Adams, M. J., Allen, N. E., Breen, G. D., Cullen, B., Dickens, C. M., Fox, E., Graham, N., Holliday, J., et al. (2018) · BJPsych Open · doi:10.1192/bjo.2018.12 · Cited by 236 · see citing works
Self-citationRetractedControlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing
Benjamini, Y., & Hochberg, Y. (1995) · Journal of the Royal Statistical Society Series B: Statistical Methodology · doi:10.1111/j.2517-6161.1995.tb02031.x · Cited by 109,482 · see citing works
PLINK: a tool set for whole-genome association and population-based linkage analyses.
Purcell, S., Neale, B., Todd-Brown, K., Thomas, L., Ferreira, M. A. R., Bender, D., Maller, J., Sklar, P., de Bakker, P. I. W., Daly, M. J., et al. (2007) · The American Journal of Human Genetics · doi:10.1086/519795 · Cited by 34,089 · see citing works
Sudlow, C., Gallacher, J., Allen, N., Beral, V., Burton, P., Danesh, J., Downey, P., Elliott, P., Green, J., Landray, M., et al. (2015) · PLOS Medicine · doi:10.1371/journal.pmed.1001779 · Cited by 12,728 · see citing works
Self-citationAdjusting batch effects in microarray expression data using empirical Bayes methods
Johnson, W. E., Li, C., & Rabinovic, A. (2007) · Biostatistics · doi:10.1093/biostatistics/kxj037 · Cited by 8,658 · see citing works
Mendelian randomization: genetic anchors for causal inference in epidemiological studies
Davey Smith, G., & Hemani, G. (2014) · Human Molecular Genetics · doi:10.1093/hmg/ddu328 · Cited by 4,677 · see citing works
An atlas of genetic correlations across human diseases and traits
ReproGen Consortium, Bulik-Sullivan, B., Psychiatric Genomics Consortium, Genetic Consortium for Anorexia Nervosa of the Wellcome Trust Case Control Consortium 3, Finucane, H. K., Anttila, V., Gusev, A., Day, F. R., Loh, P.-R., Duncan, L., et al. (2015) · Nature Genetics · doi:10.1038/ng.3406 · Cited by 4,255 · see citing works
Functional mapping and annotation of genetic associations with FUMA
Watanabe, K., Taskesen, E., van Bochoven, A., & Posthuma, D. (2017) · Nature Communications · doi:10.1038/s41467-017-01261-5 · Cited by 4,083 · see citing works
Fry, A., Littlejohns, T. J., Sudlow, C., Doherty, N., Adamska, L., Sprosen, T., Collins, R., & Allen, N. E. (2017) · American Journal of Epidemiology · doi:10.1093/aje/kwx246 · Cited by 3,979 · see citing works
MAGMA: Generalized Gene-Set Analysis of GWAS Data
de Leeuw, C. A., Mooij, J. M., Heskes, T., & Posthuma, D. (2015) · PLOS Computational Biology · doi:10.1371/journal.pcbi.1004219 · Cited by 3,653 · see citing works
A revised version of the Psychoticism scale
Eysenck, S. B. G., Eysenck, H. J., & Barrett, P. (1985) · Personality and Individual Differences · doi:10.1016/0191-8869(85)90026-1 · Cited by 3,094 · see citing works
Efficient Bayesian mixed-model analysis increases association power in large cohorts
Loh, P.-R., Tucker, G., Bulik-Sullivan, B. K., Vilhjálmsson, B. J., Finucane, H. K., Salem, R. M., Chasman, D. I., Ridker, P. M., Neale, B. M., Berger, B., et al. (2015) · Nature Genetics · doi:10.1038/ng.3190 · Cited by 1,507 · see citing works
Transcriptional architecture and chromatin landscape of the core circadian clock in mammals
Koike, N., Yoo, S.-H., Huang, H.-C., Kumar, V., Lee, C., Kim, T.-K., & Takahashi, J. S. (2012) · Science · doi:10.1126/science.1226339 · Cited by 1,464 · see citing works
Molecular analysis of mammalian circadian rhythms
Reppert, S. M., & Weaver, D. R. (2001) · Annual Review of Physiology · doi:10.1146/annurev.physiol.63.1.647 · Cited by 1,444 · see citing works
The role and validity of actigraphy in sleep medicine: an update
Sadeh, A. (2011) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2010.10.001 · Cited by 1,415 · see citing works
Pipkins, H. R., Bradshaw, J. L., Keller, L. E., Swiatlo, E., & McDaniel, L. S. (2017) · PLOS ONE · doi:10.1371/journal.pone.0179159 · Cited by 1,338 · see citing works
Townsend, P. (1987) · Journal of Social Policy · doi:10.1017/s0047279400020341 · Cited by 1,294 · see citing works
Doherty, A., Jackson, D., Hammerla, N., Plötz, T., Olivier, P., Granat, M. H., White, T., van Hees, V. T., Trenell, M. I., Owen, C. G., et al. (2017) · PLOS ONE · doi:10.1371/journal.pone.0169649 · Cited by 1,250 · see citing works
Self-citationWellcome Trust Case Control Consortium, Ferreira, M. A. R., O'Donovan, M. C., Meng, Y. A., Jones, I. R., Ruderfer, D. M., Jones, L., Fan, J., Kirov, G., Perlis, R. H., et al. (2008) · Nature Genetics · doi:10.1038/ng.209 · Cited by 1,237 · see citing works
Yang, B.-J., Han, X., Yin, L.-L., Xing, M., Xu, Z. H., & Xue, H. (2016) · Nature Communications · doi:10.1038/ncomms11388 · Cited by 1,203 · see citing works
Limb proportions show developmental plasticity in response to embryo movement
Pollard, A., Charlton, B., Hutchinson, J. R., Gustafsson, T., McGonnell, I., Timmons, J., & Pitsillides, A. (2017) · Scientific Reports · doi:10.1038/srep41926 · Cited by 1,188 · see citing works
Sleep and circadian rhythm disruption in psychiatric and neurodegenerative disease
Wulff, K., Gatti, S., Wettstein, J. G., & Foster, R. G. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2868 · Cited by 1,055 · see citing works
Zheng, J., Erzurumluoglu, A. M., Elsworth, B. L., Kemp, J. P., Howe, L., Haycock, P. C., Hemani, G., Tansey, K., Laurin, C., Early Genetics and Lifecourse Epidemiology (EAGLE) Eczema Consortium, et al. (2017) · Bioinformatics · doi:10.1093/bioinformatics/btw613 · Cited by 869 · see citing works
Jones, S. E., Lane, J. M., Wood, A. R., van Hees, V. T., Tyrrell, J., Beaumont, R. N., Jeffries, A. R., Dashti, H. S., Hillsdon, M., Ruth, K. S., et al. (2019) · Nature Communications · doi:10.1038/s41467-018-08259-7 · Cited by 691 · see citing works
Circadian genes, rhythms and the biology of mood disorders
McClung, C. A. (2007) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2007.02.003 · Cited by 666 · see citing works
Using false discovery rates for multiple comparisons in ecology and evolution
Pike, N. (2010) · Methods in Ecology and Evolution · doi:10.1111/j.2041-210x.2010.00061.x · Cited by 631 · see citing works
Dashti, H. S., Jones, S. E., Wood, A. R., Lane, J. M., van Hees, V. T., Wang, H., Rhodes, J. A., Song, Y., Patel, K., Anderson, S. G., et al. (2018) · doi:10.1101/274977 · Cited by 614 · see citing works
Genome-wide genetic data on ~500,000 UK Biobank participantsPreprint
Bycroft, C., Freeman, C., Petkova, D., Band, G., Elliott, L. T., Sharp, K., Motyer, A., Vukcevic, D., Delaneau, O., O’Connell, J., et al. (2017) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/166298 · Cited by 606 · see citing works
Dashti, H. S., Jones, S. E., Wood, A. R., Lane, J. M., van Hees, V. T., Wang, H., Rhodes, J. A., Song, Y., Patel, K., Anderson, S. G., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-08917-4 · Cited by 595 · see citing works
The Autism Spectrum Disorders Working Group of The Psychiatric Genomics Consortium (2017) · Molecular Autism · doi:10.1186/s13229-017-0137-9 · Cited by 587 · see citing works
Renalase is a novel, soluble monoamine oxidase that regulates cardiac function and blood pressure
Xu, J., Li, G., Wang, P., Velázquez, H., Yao, X., Li, Y., Wu, Y., Peixoto, A. J., Crowley, S. T., & Désir, G. V. (2005) · Journal of Clinical Investigation · doi:10.1172/jci24066 · Cited by 464 · see citing works
Circadian rest—activity rhythm disturbances in alzheimer's disease
Someren, E. J. W. V., Hagebeuk, E. E. O., Lijzenga, C., Scheltens, P., Rooij, S. E. J. A. D., Jonker, C., Pot, A. M., Mirmiran, M., & Swaab, D. F. (1996) · Biological Psychiatry · doi:10.1016/0006-3223(95)00370-3 · Cited by 453 · see citing works
A Genome-wide RNAi Screen for Modifiers of the Circadian Clock in Human Cells
Zhang, E. E., Liu, A. C., Hirota, T., Miraglia, L. J., Welch, G. L., Pongsawakul, P. Y., Liu, X., Atwood, A., Huss, J. W., Janes, J. O., et al. (2009) · Cell · doi:10.1016/j.cell.2009.08.031 · Cited by 432 · see citing works
Lyall, L. M., Wyse, C. A., Graham, N., Ferguson, A., Lyall, D. M., Cullen, B., Celis Morales, C. A., Biello, S. M., Mackay, D., Ward, J., et al. (2018) · The Lancet Psychiatry · doi:10.1016/s2215-0366(18)30139-1 · Cited by 418 · see citing works
Self-citationCircadian rhythms, sleep deprivation, and human performance
Goel, N., Basner, M., Rao, H., & Dinges, D. F. (2013) · Progress in Molecular Biology and Translational Science · doi:10.1016/b978-0-12-396971-2.00007-5 · Cited by 400 · see citing works
Jones, S. E., Tyrrell, J., Wood, A. R., Beaumont, R. N., Ruth, K. S., Tuke, M. A., Yaghootkar, H., Hu, Y., Teder-Laving, M., Hayward, C., et al. (2016) · PLOS Genetics · doi:10.1371/journal.pgen.1006125 · Cited by 388 · see citing works
Strengths and Limitations of Period Estimation Methods for Circadian Data
Zieliński, T., Moore, A., Troup, E., Halliday, K., & Millar, A. J. (2014) · PLoS ONE · doi:10.1371/journal.pone.0096462 · Cited by 344 · see citing works
Biochemistry and genetics of inherited disorders of peroxisomal fatty acid metabolism
Veldhoven, P. P. V. (2010) · Journal of Lipid Research · doi:10.1194/jlr.r005959 · Cited by 328 · see citing works
Hu, Y., Shmygelska, A., Tran, D., Eriksson, N., Tung, J. Y., & Hinds, D. A. (2016) · Nature Communications · doi:10.1038/ncomms10448 · Cited by 321 · see citing works
Lane, J. M., Vlasac, I., Anderson, S. G., Kyle, S. D., Dixon, W. G., Bechtold, D. A., Gill, S., Little, M. A., Luik, A., Loudon, A., et al. (2016) · Nature Communications · doi:10.1038/ncomms10889 · Cited by 312 · see citing works
Genetic studies of accelerometer-based sleep measures yield new insights into human sleep behaviour
Jones, S. E., van Hees, V. T., Mazzotti, D. R., Marques-Vidal, P., Sabia, S., van der Spek, A., Dashti, H. S., Engmann, J., Kocevska, D., Tyrrell, J., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-09576-1 · Cited by 300 · see citing works
Davis, M. Y., Trinh, K., Thomas, R. E., Yu, S., Germanos, A. A., Whitley, B. N., Sardi, S. P., Montine, T. J., & Pallanck, L. J. (2016) · PLoS Genetics · doi:10.1371/journal.pgen.1005944 · Cited by 294 · see citing works
Ng, T. H., Chung, K., Ho, F. Y., Yeung, W., Yung, K.-P., & Lam, T.-H. (2014) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2014.06.006 · Cited by 283 · see citing works
The Genotype-Tissue Expression (GTEx) project
Lonsdale, J., Thomas, J., Salvatore, M., Phillips, R., Lo, E., Shad, S., Hasz, R., Walters, G., Garcia, F., Young, N., et al. (2013) · Nature Genetics · doi:10.1038/ng.2653 · Cited by 263 · see citing works
Taillard, J., Philip, P., Coste, O., Sagaspe, P., & Bioulac, B. H. (2003) · Journal of Sleep Research · doi:10.1046/j.0962-1105.2003.00369.x · Cited by 250 · see citing works
Activity monitoring in patients with depression: A systematic review
Burton, C., McKinstry, B., Szentagotai Tătar, A., Serrano-Blanco, A., Pagliari, C., & Wolters, M. (2013) · Journal of Affective Disorders · doi:10.1016/j.jad.2012.07.001 · Cited by 249 · see citing works
Bischoff, F. R., Krebber, H., Kempf, T., Hermes, I., & Ponstingl, H. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.5.1749 · Cited by 248 · see citing works
Evening types are prone to depression
Merikanto, I., Lahti, T., Kronholm, E., Peltonen, M., Laatikainen, T., Vartiainen, E., Salomaa, V., & Partonen, T. (2013) · Chronobiology International · doi:10.3109/07420528.2013.784770 · Cited by 237 · see citing works
Nonparametric methods in actigraphy: An update
Gonçalves, B. S. B., Cavalcanti, P., Tavares, G. R., Campos, T. F., & Araújo, J. F. (2014) · Sleep Science · doi:10.1016/j.slsci.2014.09.013 · Cited by 195 · see citing works
Clock Genes and Altered Sleep–Wake Rhythms: Their Role in the Development of Psychiatric Disorders
Charrier, A., Olliac, B., Roubertoux, P. L., & Tordjman, S. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18050938 · Cited by 182 · see citing works
Circadian Rhythm Dysregulation in Bipolar Spectrum Disorders
Alloy, L. B., Ng, T. H., Titone, M. K., & Boland, E. M. (2017) · Current Psychiatry Reports · doi:10.1007/s11920-017-0772-z · Cited by 167 · see citing works
Consequences of Circadian Disruption on Cardiometabolic Health
Reutrakul, S., & Knutson, K. L. (2015) · Sleep Medicine Clinics · doi:10.1016/j.jsmc.2015.07.005 · Cited by 163 · see citing works
Sigurdardottir, L. G., Valdimarsdottir, U. A., Fall, K., Rider, J. R., Lockley, S. W., Schernhammer, E., & Mucci, L. A. (2012) · Cancer Epidemiology, Biomarkers & Prevention · doi:10.1158/1055-9965.epi-12-0116 · Cited by 162 · see citing works
Genetics of circadian rhythms and mood spectrum disorders
Étain, B., Milhiet, V., Bellivier, F., & Leboyer, M. (2011) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2011.07.007 · Cited by 162 · see citing works
The human gene <i>SLC25A17</i> encodes a peroxisomal transporter of coenzyme A, FAD and NAD+
Agrimi, G., Russo, A., Scarcia, P., & Palmieri, F. (2012) · Biochemical Journal · doi:10.1042/bj20111420 · Cited by 154 · see citing works
Copines: a ubiquitous family of Ca2+-dependent phospholipid-binding proteins
Tomsig, J. L., & Creutz, C. E. (2002) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-002-8522-7 · Cited by 143 · see citing works
McCarthy, M. J., Wei, H., Marnoy, Z., Darvish, R. M., McPhie, D. L., Cohen, B. M., & Welsh, D. K. (2013) · Translational Psychiatry · doi:10.1038/tp.2013.90 · Cited by 137 · see citing works
Mood instability: significance, definition and measurement
Broome, M., Saunders, K., Harrison, P. J., & Marwaha, S. (2015) · British Journal of Psychiatry · doi:10.1192/bjp.bp.114.158543 · Cited by 136 · see citing works
Sleep in remitted bipolar disorder: A naturalistic case-control study using actigraphy
Geoffroy, P. A., Boudebesse, C., Bellivier, F., Lajnef, M., Henry, C., Leboyer, M., Scott, J. L., & Étain, B. (2014) · Journal of Affective Disorders · doi:10.1016/j.jad.2014.01.012 · Cited by 126 · see citing works
Sleep- and circadian rhythm–associated pathways as therapeutic targets in bipolar disorder
Bellivier, F., Geoffroy, P.-A., Etain, B., & Scott, J. (2015) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2015.1018822 · Cited by 104 · see citing works
Clock gene variants in mood and anxiety disorders
Partonen, T. (2012) · Journal of Neural Transmission · doi:10.1007/s00702-012-0810-2 · Cited by 99 · see citing works
Xiong, L., Catoire, H., Dion, P. A., Gaspar, C., Lafrenière, R. G., Girard, S., Levchenko, А., Rivière, J., Fiori, L. M., St‐Onge, J., et al. (2009) · Human Molecular Genetics · doi:10.1093/hmg/ddn443 · Cited by 93 · see citing works
Pagani, L., Clair, P. A. S., Teshiba, T. M., Service, S. K., Fears, S. C., Araya, C., Araya, X., Bejarano, J., Ramirez, M., Castrillón, G., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1513525113 · Cited by 88 · see citing works
Ward, J., Strawbridge, R. J., Bailey, M. E. S., Graham, N., Ferguson, A., Lyall, D. M., Cullen, B., Pidgeon, L. M., Cavanagh, J., Mackay, D., et al. (2017) · Translational Psychiatry · doi:10.1038/s41398-017-0012-7 · Cited by 86 · see citing works
Self-citationEvidence of a DHA Signature in the Lipidome and Metabolome of Human Hepatocytes
Ghini, V., Nunzio, M. D., Tenori, L., Valli, V., Danesi, F., Capozzi, F., Luchinat, C., & Bordoni, A. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18020359 · Cited by 80 · see citing works
Désir, G. V. (2008) · Current Opinion in Nephrology & Hypertension · doi:10.1097/mnh.0b013e3282f521ba · Cited by 79 · see citing works
Jacquet, B. V., Muthusamy, N., Sommerville, L. J., Xiao, G., Liang, H., Zhang, Y., Holtzman, M. J., & Ghashghaei, H. T. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.0171-11.2011 · Cited by 60 · see citing works
Modeling Strengthens Molecular Link between Circadian Polymorphisms and Major Mood Disorders
Liberman, A. R., Halitjaha, L., Ay, A. A., & Ingram, K. K. (2018) · Journal of Biological Rhythms · doi:10.1177/0748730418764540 · Cited by 59 · see citing works
Thaxton, C., Pillai, A. M., Pribisko, A. L., Labasque, M., Dupree, J. L., Faivre‐Sarrailh, C., & Bhat, M. A. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.5951-09.2010 · Cited by 57 · see citing works
Eveningness relates to burnout and seasonal sleep and mood problems among young adults
Merikanto, I., Suvisaari, J., Lahti, T. A., & Partonen, T. (2015) · Nordic Journal of Psychiatry · doi:10.3109/08039488.2015.1053519 · Cited by 51 · see citing works
Genetics of long-term treatment outcome in bipolar disorder
Fabbri, C., & Serretti, A. (2015) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2015.08.008 · Cited by 44 · see citing works
Morningness – eveningness and treatment response in major depressive disorder
Corruble, E., Frank, E., Gressier, F., Courtet, P., Bayle, F., Llorca, P., Vaïva, G., & Gorwood, P. A. P. M. (2013) · Chronobiology International · doi:10.3109/07420528.2013.834924 · Cited by 43 · see citing works
Taylor, A. M., Saifetiarova, J., & Bhat, M. A. (2017) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2017.00011 · Cited by 32 · see citing works
Genome-Wide Scan for Copy Number Variation Association with Age at Onset of Alzheimer's Disease
Szigeti, K., Lal, D., Li, Y., Doody, R. S., Wilhelmsen, K. C., Li, Y., Liu, S., & Ma, C. (2012) · Journal of Alzheimer s Disease · doi:10.3233/jad-2012-121285 · Cited by 31 · see citing works
Association of Renalase SNPs rs2296545 and rs2576178 with the Risk of Hypertension: A Meta-Analysis
Lv, Y.-B., Wang, Y., Ma, W., Yan, D.-Y., Zheng, W., Chu, C., Guo, T., Yuan, Z., & Mu, J. (2016) · PLoS ONE · doi:10.1371/journal.pone.0158880 · Cited by 31 · see citing works
Reduced Amplitude of the 24 Hour Activity Rhythm
Bullock, B., & Murray, G. (2013) · Clinical Psychological Science · doi:10.1177/2167702613490158 · Cited by 30 · see citing works
Dmitrzak‐Węglarz, M., Pawlak, J., Wiłkość-Dębczyńska, M., Miechowicz, I., Maciukiewicz, M., Ciarkowska, W., Zaremba, D., & Hauser, J. (2016) · Acta Neurobiologiae Experimentalis · doi:10.21307/ane-2017-003 · Cited by 28 · see citing works
Frohnert, B. I., Laimighofer, M., Krumsiek, J., Theis, F. J., Winkler, C., Norris, J. M., Ziegler, A., Rewers, M., & Steck, A. K. (2017) · Pediatric Diabetes · doi:10.1111/pedi.12543 · Cited by 25 · see citing works
Regulation of MEIS1 by distal enhancer elements in acute leukemia
Wang, Q.-F., Li, Y. J., Dong, J.-F., Li, B., Kaberlein, J. J., Zhang, L., Arimura, F. E., Luo, R. T., Ni, J., He, F., et al. (2013) · Leukemia · doi:10.1038/leu.2013.260 · Cited by 21 · see citing works
GREGG, W. R. (1934) · Science · doi:10.1126/science.80.2077.349 · Cited by 20 · see citing works
Nagano, M., Hoshino, D., Koshiba, S., Shuo, T., Koshikawa, N., Tomizawa, T., Hayashi, F., Tochio, N., Harada, T., Akizawa, T., et al. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.199430 · Cited by 17 · see citing works
Merikanto, I., Kuula, L., Makkonen, T., Bódizs, R., Halonen, R., Heinonen, K., Lahti, J. M. T., Räikkönen, K., & Pesonen, A. (2017) · Scientific Reports · doi:10.1038/s41598-017-13846-7 · Cited by 15 · see citing works
Jones, S. E., Lane, J. M., Wood, A. R., van Hees, V. T., Tyrrell, J., Beaumont, R. N., Jefferies, A., Dashti, H. S., Hillsdon, M. M., Ruth, K. S., et al. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/303941 · Cited by 15 · see citing works
Jones, S. E., Hees, V. T. V., Mazzotti, D. R., Marques-Vidal, P., Sabia, S., der Spek, A. V., Dashti, H. S., Engmann, J., Kocevska, D., Tyrrell, J., et al. (2018) · doi:10.1101/303925 · Cited by 14 · see citing works
Increased activity of surviving locus ceruleus neurons in Alzheimer's disease
Moser (1999) · Pure Amsterdam UMC · doi:10.1002/1531-8249(199901)45:1
Flagged first, then by citations
4 of the 89 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Navigating Challenges and Opportunities in Multi-Omics Integration for Personalized Healthcare
Mohr, A. E., Ortega-Santos, C. P., Whisner, C. M., Klein-Seetharaman, J., & Jasbi, P. (2024) · Biomedicines · doi:10.3390/biomedicines12071496 · Cited by 311 · see citing works
Genome-wide association study of multisite chronic pain in UK Biobank
Johnston, K. J. A., Adams, M. J., Nicholl, B. I., Ward, J., Strawbridge, R. J., Ferguson, A., McIntosh, A. M., Bailey, M. E. S., & Smıth, D. J. (2019) · PLoS Genetics · doi:10.1371/journal.pgen.1008164 · Cited by 263 · see citing works
Self-citationGenetics of circadian rhythms and sleep in human health and disease
Lane, J. M., Qian, J., Mignot, E., Redline, S., Scheer, F. A. J. L., & Saxena, R. (2023) · Nature Reviews Genetics · doi:10.1038/s41576-022-00519-z · Cited by 236 · see citing works
The sleep–circadian interface: A window into mental disorders
Meyer, N., Lok, R., Schmidt, C., Kyle, S. D., McClung, C. A., Cajochen, C., Scheer, F. A. J. L., Jones, M. W., & Chellappa, S. L. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2214756121 · Cited by 173 · see citing works
McCarthy, M. J., Gottlieb, J. F., Gonzalez, R., McClung, C. A., Alloy, L. B., Cain, S., Dulcis, D., Etain, B., Frey, B. N., Garbazza, C., et al. (2022) · Bipolar Disorders · doi:10.1111/bdi.13165 · Cited by 136 · see citing works
Circadian depression: A mood disorder phenotype
Carpenter, J. S., Crouse, J. J., Scott, E. M., Naismith, S. L., Wilson, C., Scott, J., Merikangas, K. R., & Hickie, I. B. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.02.045 · Cited by 114 · see citing works
Feng, H., Yang, L., Ai, S., Liu, Y., Zhang, W., Lei, B., Chen, J., Liu, Y., Chan, J. W. Y., Chan, N. Y., et al. (2023) · The Lancet Healthy Longevity · doi:10.1016/s2666-7568(23)00056-9 · Cited by 88 · see citing works
The role of sleep and wakefulness in myelin plasticity
de Vivo, L., & Bellesi, M. (2019) · Glia · doi:10.1002/glia.23667 · Cited by 80 · see citing works
pyActigraphy: Open-source python package for actigraphy data visualization and analysis
Hammad, G. H., Reyt, M., Beliy, N., Baillet, M., Deantoni, M., Lesoinne, A., Muto, V., & Schmidt, C. (2021) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1009514 · Cited by 78 · see citing works
Longitudinal change of sleep timing: association between chronotype and longevity in older adults
Didikoğlu, A., Maharani, A., Payton, A., Pendleton, N., & Canal, M. M. (2019) · Chronobiology International · doi:10.1080/07420528.2019.1641111 · Cited by 77 · see citing works
Quantum effects in the brain: A review
Adams, B., & Petruccione, F. (2020) · AVS Quantum Science · doi:10.1116/1.5135170 · Cited by 80 · see citing works
Wainberg, M., Jones, S. E., Beaupre, L. M., Hill, S. L., Felsky, D., Rivas, M. A., Lim, A. S. P., Ollila, H. M., & Tripathy, S. J. (2021) · PLOS Medicine · doi:10.1371/journal.pmed.1003782 · Cited by 64 · see citing works
Rapid-acting antidepressants and the circadian clock
Sato, S., Bunney, B. G., Mendoza-Viveros, L., Bunney, W. E., Borrelli, E., Sassone‐Corsi, P., & Orozco-Solís, R. (2021) · Neuropsychopharmacology · doi:10.1038/s41386-021-01241-w · Cited by 65 · see citing works
Diurnal rhythms of wrist temperature are associated with future disease risk in the UK Biobank
Brooks, T. G., Lahens, N. F., Grant, G. R., Sheline, Y. I., FitzGerald, G. A., & Skarke, C. (2023) · Nature Communications · doi:10.1038/s41467-023-40977-5 · Cited by 57 · see citing works
Mishra, H. K., Ying, N. M., Luis, A., Wei, H., Nguyen, M., Nakhla, T. S., Vandenburgh, S. A., Alda, M., Berrettini, W. H., Brennand, K., et al. (2021) · Molecular Psychiatry · doi:10.1038/s41380-021-01048-7 · Cited by 51 · see citing works
Sexual dimorphism in the response to chronic circadian misalignment on a high-fat diet
Anderson, S. T., Meng, H., Brooks, T. G., Tang, S. Y., Lordan, R., Sengupta, A., Nayak, S., Mřela, A., Sarantopoulou, D., Lahens, N. F., et al. (2023) · Science Translational Medicine · doi:10.1126/scitranslmed.abo2022 · Cited by 48 · see citing works
McCarthy, M. J. (2018) · Psychiatric Genetics · doi:10.1097/ypg.0000000000000215 · Cited by 47 · see citing works
Vitaterna, M. H., Shimomura, K., & Jiang, P. (2019) · Neurologic Clinics · doi:10.1016/j.ncl.2019.05.002 · Cited by 36 · see citing works
Role of MEIS1 in restless legs syndrome: From GWAS to functional studies in mice
Salminen, A. V., Lam, D. D., & Winkelmann, J. (2019) · Advances in pharmacology · doi:10.1016/bs.apha.2019.03.003 · Cited by 33 · see citing works
Statistical mechanics of clock gene networks underlying circadian rhythms
Sun, L., Dong, A., Griffin, C. H., & Wu, R. (2021) · Applied Physics Reviews · doi:10.1063/5.0029993 · Cited by 26 · see citing works
The impact of lithium on circadian rhythms and implications for bipolar disorder pharmacotherapy
Rohr, K. E., & McCarthy, M. J. (2022) · Neuroscience Letters · doi:10.1016/j.neulet.2022.136772 · Cited by 27 · see citing works
Genomic perspectives on the circadian clock hypothesis of psychiatric disorders
von Schantz, M., Leocádio-Miguel, M. A., McCarthy, M. J., Papiol, S., & Landgraf, D. (2020) · Advances in genetics · doi:10.1016/bs.adgen.2020.11.005 · Cited by 25 · see citing works
Ho, A. M., Winham, S. J., Armasu, S. M., Blacker, C. J., Millischer, V., Lavebratt, C., Overholser, J. C., Jurjus, G., Dieter, L., Mahajan, G., et al. (2019) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2019.05.030 · Cited by 26 · see citing works
Significant role of gene–gene interactions of clock genes in mood disorder
Park, M., Kim, S. A., Yee, J., Shin, J., Lee, K. Y., & Joo, E.-J. (2019) · Journal of Affective Disorders · doi:10.1016/j.jad.2019.06.056 · Cited by 23 · see citing works
Federoff, M., McCarthy, M. J., Anand, A., Berrettini, W. H., Bertram, H. S., Bhattacharjee, A. K., Calkin, C. V., Conroy, C. M., Coryell, W. H., D’Arcangelo, N., et al. (2021) · Bipolar Disorders · doi:10.1111/bdi.13162 · Cited by 23 · see citing works
24-h Activity Rhythms and Health in Older Adults
de Feijter, M., Lysen, T., & Luik, A. (2020) · Current Sleep Medicine Reports · doi:10.1007/s40675-020-00170-2 · Cited by 22 · see citing works
Chu, X., Liu, L., Wen, Y. F., Li, P., Cheng, B., Cheng, S., Zhang, L., Ma, M., Qi, X., Liang, C., et al. (2020) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2020.02.012 · Cited by 21 · see citing works
Stronger Associations Between Sleep and Mental Health in Adults with Autism: A UK Biobank Study
Henderson, L. M., Clair, M. S., Knowland, V. C. P., van Rijn, E., Walker, S., & Gaskell, M. G. (2021) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-021-05382-1 · Cited by 21 · see citing works
Selection of genetic instruments in Mendelian randomisation studies of sleep traits
Paz, V., Dashti, H. S., Burgess, S., & Garfield, V. (2023) · Sleep Medicine · doi:10.1016/j.sleep.2023.10.036 · Cited by 23 · see citing works
CARE as a wearable derived feature linking circadian amplitude to human cognitive functions
Cui, S., Lin, Q., Gui, Y., Zhang, Y., Lu, H. J., Zhao, H., Wang, X., Li, X., & Jiang, F. (2023) · npj Digital Medicine · doi:10.1038/s41746-023-00865-0 · Cited by 19 · see citing works
Using Chronobiological Phenotypes to Address Heterogeneity in Bipolar Disorder
Gonzalez, R., Gonzalez, S., & McCarthy, M. J. (2019) · Complex Psychiatry · doi:10.1159/000506636 · Cited by 17 · see citing works
Hickie, I. B., Merikangas, K. R., Carpenter, J. S., Iorfino, F., Scott, E. M., Scott, J. L., & Crouse, J. J. (2023) · Bipolar Disorders · doi:10.1111/bdi.13304 · Cited by 16 · see citing works
Huang, Y., Liu, Y., Wu, Y., Tang, Y., Liu, S., Xiao, L., Zhang, M., Tao, S., Xie, M., Dai, M., et al. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.956265 · Cited by 14 · see citing works
Multiscale neurobiological correlates of human neuroticism
Xu, Q., Liu, F., Qin, W., Jiang, T., & Yu, C. (2020) · Human Brain Mapping · doi:10.1002/hbm.25153 · Cited by 11 · see citing works
Sirignano, L., Streit, F., Frank, J., Zillich, L., Witt, S. H., Rietschel, M., & Foo, J. C. (2022) · Scientific Reports · doi:10.1038/s41598-022-19720-5 · Cited by 10 · see citing works
Kreuzer, K., Birkl-Toeglhofer, A. M., Haybaeck, J., Reiter, A., Dalkner, N., Fellendorf, F. T., Maget, A., Platzer, M., Seidl, M., Mendel, L.-M., et al. (2024) · Neuropsychobiology · doi:10.1159/000538781 · Cited by 9 · see citing works
MENG, Q., Cui, E., Leroux, A., Mowry, E. M., Lindquist, M. A., & Crainiceanu, C. M. (2023) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000003260 · Cited by 9 · see citing works
The solute carrier SLC25A17 sustains peroxisomal redox homeostasis in diverse mammalian cell lines
Costa, C. F., Lismont, C., Chornyi, S., Koster, J., Li, H., Hussein, M. A. F., Veldhoven, P. P. V., Waterham, H. R., & Fransen, M. (2023) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2023.12.035 · Cited by 6 · see citing works
Weng, B., Chen, H., Chen, H., Wang, N., Feng, H., Yang, K., & Tan, X. (2026) · American Journal of Preventive Cardiology · doi:10.1016/j.ajpc.2026.101414 · Cited by 5 · see citing works
Polygenic score for neuroticism is related to sleep difficulties
Stéphan, Y., Sutin, A. R., Luchetti, M., & Terracciano, A. (2020) · Genes Brain & Behavior · doi:10.1111/gbb.12644 · Cited by 5 · see citing works
Data-driven modelling approach to circadian temperature rhythm profiles in free-living conditions
Lipsanen, J. O., Kuula, L., Elovainio, M. J., Partonen, T., & Pesonen, A. (2021) · Scientific Reports · doi:10.1038/s41598-021-94522-9 · Cited by 5 · see citing works
pyActigraphy: open-source python package for actigraphy data visualisation and analysisPreprint
Hammad, G. H., Reyt, M., Beliy, N., Baillet, M., Deantoni, M., Lesoinne, A., Muto, V., & Schmidt, C. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.12.03.400226 · Cited by 5 · see citing works
The Interplay Between Sleep and Mental Health: A Genetic Perspective
Kozhemiako, N., Mita, C., Panagiotaropoulou, G., Lewis, K. S., Sofer, T., & Purcell, S. (2025) · Biological Psychiatry · doi:10.1016/j.biopsych.2025.06.024 · Cited by 4 · see citing works
Palmu, R., Koskinen, S. V. P., & Partonen, T. (2022) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2022.03.048 · Cited by 4 · see citing works
Landvreugd, A., Pool, R., Nivard, M. G., & Bartels, M. (2024) · Journal of Biological Rhythms · doi:10.1177/07487304241230577 · Cited by 4 · see citing works
Polygenic Risk Scores and Bipolar Disorder
Bengesser, S., & Reininghaus, E. Z. (2018) · Journal of Psychiatry and Brain Science · doi:10.20900/jpbs.20180013 · Cited by 3 · see citing works
Shim, J., & Onnela, J.-P. “. (2026) · BMC Digital Health · doi:10.1186/s44247-026-00256-x · Cited by 2 · see citing works
Wang, X.-L., & Serchov, T. (2026) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2026.106700 · Cited by 2 · see citing works
Liu, P. Z., Raizen, D. M., Skarke, C., Brooks, T. G., & Anafi, R. C. (2024) · SLEEP · doi:10.1093/sleep/zsae243 · Cited by 2 · see citing works
Relationship between Polygenic Risk Score and the Hypnotics in Bipolar I Disorder
Lee, H. W., Lee, B.-H., Shekhtman, T., Park, Y., & Kelsoe, J. R. (2024) · Clinical Psychopharmacology and Neuroscience · doi:10.9758/cpn.23.1152 · Cited by 1 · see citing works
Wie körpernahe und implantierte Systeme die Medizin und die Gesundheitsversorgung verändern
Marschollek, M., & Wolf, K.-H. (2021) · Springer eBooks · doi:10.1007/978-3-658-30882-7_7 · Cited by 1 · see citing works
Ferreira, F. P., & Daly, A. (2022) · Proceedings - IEEE Symposium on Computer-Based Medical Systems · doi:10.1109/cbms55023.2022.00046 · Cited by 1 · see citing works
Circadian rhythm and host genetics
Odriozola, A., González, A., Álvarez‐Herms, J., & Corbi, F. (2024) · Advances in genetics · doi:10.1016/bs.adgen.2024.02.001 · Cited by 1 · see citing works
Ju, P., Yu, F., Xiang, S., Wang, W., Sun, Y., Wang, W., Ding, Y., Luo, C., Jiang, P., & Chen, J. (2025) · BMC Biology · doi:10.1186/s12915-025-02333-5 · Cited by 1 · see citing works
Circadian Rhythms in Bipolar Disorder Patient-Derived Neurons Predict Lithium Response
Mishra, H. K., Ying, N. M., Luis, A., Wei, H., Nguyen, M., Nakhla, T. S., Vandenburgh, S., Alda, M., Berrettini, W. H., Brennand, K., et al. (2021) · Biological Psychiatry · doi:10.1016/j.biopsych.2021.02.193 · Cited by 1 · see citing works
CARE: a novel wearable-derived feature linking circadian amplitude to human cognitive functionsPreprint
Cui, S., Lin, Q., Gui, Y., Zhang, Y., Lu, H., Zhao, H., Wang, X., Li, X., & Jiang, F. (2023) · medRxiv · doi:10.1101/2023.04.06.23288232 · Cited by 1 · see citing works
Sirignano, L., Streit, F., Frank, J., Zillich, L., Witt, S. H., Rietschel, M., & Foo, J. C. (2021) · Research Square · doi:10.21203/rs.3.rs-763448/v1
Circadian Rhythm and Polygenic Risk Scores
Park, Y. (2022) · Chronobiology in Medicine · doi:10.33069/cim.2022.0007
Lung cancer prediction and analysis by regression models
Yu, X. (2023) · International Conference on Mechatronic Engineering and Artificial Intelligence (MEAI) · doi:10.1117/12.2672648
Mania and Bipolar Spectrum Disorders
Gruber, J., Cosgrove, V. E., Dodd, A., Dutra, S. J., Hinshaw, S. P., Ibonie, S. G., Kahawage, P. N., Meyer, T. D., Murray, G., Nusslock, R., et al. (2023) · Oxford University Press eBooks · doi:10.1093/med-psych/9780197542521.003.0010
Sleep regulation and host genetics
Odriozola, A., González, A., Álvarez‐Herms, J., & Corbi, F. (2024) · Advances in genetics · doi:10.1016/bs.adgen.2024.02.002
Penichet, D. (2025) · Journal of Biological Rhythms · doi:10.1177/07487304241308633
Qiu, J., Zhu, T., Qin, K., & Zhang, W. (2025) · BMC Psychiatry · doi:10.1186/s12888-025-06510-2 · Cited by 2 · see citing works
Maddox, M. A., Walsh, R. F. L., Smith, L. T., Olino, T. M., Zee, P. C., Nusslock, R., & Alloy, L. B. (2025) · Journal of Youth and Adolescence · doi:10.1007/s10964-025-02224-6 · Cited by 1 · see citing works
Li, Z., & Chen, L. (2025) · Genome biology · doi:10.1186/s13059-025-03767-4
Coppens, G., Cramer, A. B. G., Vanhorebeek, I., Güiza, F., Wouters, P. J., Chaves, I., de Hoog, M., Dulfer, K., Joosten, K. F. M., den Berghe, G. V., et al. (2025) · Clinical Epigenetics · doi:10.1186/s13148-025-02027-3
Zafrilla-López, M., Herrera-Escartín, D., Guardiola-Ripoll, M., García-Fernández, A., Acosta-Díez, M., Giménez‐Palomo, A., Sáiz, P. A., García-Portilla, M. P., Jiménez, E., Papiol, S., et al. (2026) · Neuropsychobiology · doi:10.1159/000551565
Multi ancestry genome wide association meta analysis of urinary aMT6s levels
Żebrowska, M., Zhang, Z., Chuang, G.-T., Evans, D. S., Valliere, J., Maher, M., Hu, J., Richmond, R., Turman, C., Hart, J. E., et al. (2026) · Scientific Reports · doi:10.1038/s41598-026-49491-2
Xue, X., Adelsheim, Z., Gorczyca, M. T., Wei, H., Leone, M. J., Logan, R., & McCarthy, M. J. (2026) · Biological Psychiatry · doi:10.1016/j.biopsych.2026.07.015
Jex, J., Downs, A. L., Kamhout, S., Wright, I. D., Wright, A., Zhang, V., & Duraccio, K. M. (2026) · Frontiers in Sleep · doi:10.3389/frsle.2026.1826938
- Authors
- Ferguson, A., Lyall, L. M., Ward, J., Strawbridge, R. J., Cullen, B., Graham, N., Niedzwiedz, C. L., Johnston, K. J. A., MacKay, D., Biello, S. M., Pell, J. P., Cavanagh, J., McIntosh, A. M., Doherty, A., Bailey, M. E. S., Lyall, D. M., Wyse, C. A., & Smith, D. J.
- Affiliations
- University of Glasgow (GB)
- Karolinska Institutet (SE)
- University of Edinburgh (GB)
- University of Oxford (GB)
- Royal College of Surgeons in Ireland (IE)
- Corresponding author
- Ferguson, Amy
- ORCID
- Venue
- EBioMedicine
- Publisher
- Elsevier BV
- Published
- 2018-09
- Volume
- 35
- Pages
- 279-287
- ISSN
- 2352-3964 (ISSN-L)
- PMC
- PMC6154782
- OpenAlex
- W2809445594
- Cited by
- 70
- References
- 89
- Citations by year
- 2026: 8 · 2025: 7 · 2024: 8 · 2023: 10 · 2022: 7 · 2021: 12 · 2020: 8 · 2019: 8 · 2018: 2
- FWCI
- 4.12
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- EBioMedicine (publishedVersion, cc-by)
- bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam) (acceptedVersion, cc-by-sa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Oxford University Research Archive (ORA) (University of Oxford) (submittedVersion, cc-by)
- Edinburgh Research Explorer (University of Edinburgh) (submittedVersion, cc-by)
- Funders
- British Heart Foundation
- Brain and Behavior Research Foundation (173096)
- Department of Health and Social Care
- Pfizer
- University of Glasgow (MR/K501335/1)
- Janssen Biotech (MR/R024774/1)
- Sackler Trust
- Medical Research Council
- Scottish Government
- H. Lundbeck A/S
- Royal College of Physicians of Edinburgh (173558)
- NIHR Oxford Biomedical Research Centre
- UK Research and Innovation (MR/S003061/1)
- GlaxoSmithKline foundation
- Pfizer UK
- Northwest Regional Development Agency
- Wellcome Trust
- BHF Centre of Research Excellence, Oxford
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Keywords
- circadian rhythmicity, rest-activity rhythm, relative amplitude, mood instability, major depressive disorder, bipolar disorder, polygenic risk score, neurofascin, MEIS1, neuroticism, genetic architecture, accelerometer-measured activity
- MeSH terms
- Adult, Aged, Mental Disorders, Circadian Rhythm, Humans, Middle Aged, Phenotype, Biological Specimen Banks, Mood Disorders, Multifactorial Inheritance, Polymorphism, Single Nucleotide, Quantitative Trait Loci, Genome-Wide Association Study
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
