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Cited by 85Estrogen and related hormone effectsEndometrial and Cervical Cancer TreatmentsBreast Cancer Treatment Studies

Steroid sulfatase and estrogen sulfotransferase in human endometrial carcinoma

Utsunomiya, Hiroki, Ito, Kiyoshi, Suzuki, Takashi, Kitamura, Takako, Kaneko, Chika, Nakata, Taisuke, Niikura, Hitoshi, Okamura, Kunihiro +2 more·2004·Clinical Cancer Research
DOI 10.1158/1078-0432.ccr-04-0040
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Abstract

Purpose: Intratumoral metabolism and synthesis of estrogens are considered to play important roles in the pathogenesis and/or development of human endometrial carcinoma. Steroid sulfatase hydrolyzes biologically inactive estrogen sulfates to active estrogens, whereas estrogen sulfotransferase sulfonates estrogens to estrogen sulfates. However, the status of steroid sulfatase and/or estrogen sulfotransferase in human endometrial carcinoma has not been examined. Experimental Design: We first examined the expression of steroid sulfatase and estrogen sulfotransferase in 6 normal endometrium and 76 endometrial carcinoma using immunohistochemistry to elucidate the possible involvement of steroid sulfatase and estrogen sulfotransferase. We then evaluated the enzymatic activity and the semiquantitative analysis of mRNA using reverse transcription-PCR in 21 endometrial carcinomas. We correlated these findings with various clinicopathological parameters including the expression of aromatase, 17β-hydroxysteroid dehydrogenase type 1 and type 2. Results: Steroid sulfatase and estrogen sulfotransferase immunoreactivity was detected in 65 of 76 (86%) and 22 of 76 (29%) cases, respectively. Results of immunoreactivity for steroid sulfatase and estrogen sulfotransferase were significantly correlated with those of enzymatic activity and semiquantitative analysis of mRNA. No significant correlations were detected among the expression of the enzymes involved in intratumoral estrogen metabolism. There was a significant correlation between steroid sulfatase/estrogen sulfotransferase ratio and clinical outcomes of the patients. However, there were no significant differences between steroid sulfatase or estrogen sulfotransferase and estrogen receptor, progesterone receptor, Ki67, histologic grade, or clinical outcomes of the patients. Conclusions: Results of our study demonstrated that increased steroid sulfatase and decreased estrogen sulfotransferase expression in human endometrial carcinomas may result in increased availability of biologically active estrogens and may be related to estrogen-dependent biological features of carcinoma.

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  • Increased immunoexpression of aromatase, STS and 17βHSD enzymes has been reported in endometrial hyperplasia and endometrial cancer.

    “Sasano and collaborators have developed novel antibodies and reported evidence of increased immunoexpression of aromatase [81], STS [82] and 17βHSD enzymes [83] in endometrial hyperplasia and EC.”

    From Endometrial Intracrinology: Oestrogens, Androgens and Endometrial Disorders (2018) · cites this paper as [82]

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Authors
Utsunomiya, H., Ito, K., Suzuki, T., Kitamura, T., Kaneko, C., Nakata, T., Niikura, H., Okamura, K., Yaegashi, N., & Sasano, H.
Affiliations
  • 1Departments of Obstetrics and Gynecology and
  • Tohoku University (JP)
  • 3Kyowa Hakko Kogyo Co., Ltd., Tokyo, Japan
ORCID
Venue
Clinical Cancer Research
Publisher
American Association for Cancer Research (AACR)
Published
2004-09-01
Volume
10
Issue
17
Pages
5850-5856
ISSN
  • 1078-0432 (ISSN-L)
  • 1557-3265
DOI
10.1158/1078-0432.ccr-04-0040
OpenAlex
W2156177150
Cited by
85
References
46
Citations by year
2023: 2 · 2022: 2 · 2021: 4 · 2020: 1 · 2019: 3 · 2018: 6 · 2017: 4 · 2016: 7 · 2015: 3 · 2014: 4 · 2013: 5 · 2012: 4
FWCI
2.68
Type
journal article
Language
en
Open access
closed
Locations
  • Clinical Cancer Research (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
  • Health Sciences › Medicine › Obstetrics and Gynecology › Endometrial and Cervical Cancer Treatments
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Breast Cancer Treatment Studies
Keywords
endometrial cancer, steroid sulfatase, estrogen sulfotransferase, estrogen sulfates, aromatase, 17β-hydroxysteroid dehydrogenase, estrogen receptor, progesterone receptor, Ki-67, histologic grade, clinicopathological correlation, prognosis
MeSH terms
Adenocarcinoma, Aromatase, Endometrium, Estrogens, Female, Humans, Immunoenzyme Techniques, Middle Aged, Neoplasm Staging, Neoplasms, Hormone-Dependent, Prognosis, Receptors, Estrogen, Risk Factors, RNA, Messenger, 17-Hydroxysteroid Dehydrogenases, Sulfotransferases, Carcinoma, Endometrioid, Reverse Transcriptase Polymerase Chain Reaction, Steryl-Sulfatase

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