Cited by 178Sarcoma Diagnosis and TreatmentCancer Cells and MetastasisVeterinary Oncology Research

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Toward a Drug Development Path That Targets Metastatic Progression in Osteosarcoma

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Khanna, Chand, Fan, Timothy M., Gorlick, Richard, Helman, Lee J., Kleinerman, Eugenie S., Adamson, Peter C., Houghton, Peter J., Tap, William D., Welch, Danny R., Steeg, Patricia S., Merlino, Glenn, Sorensen, Poul H.B., Meltzer, Paul, Kirsch, David G., Janeway, Katherine A., Weigel, Brenda, Randall, Lor, Withrow, Stephen J, Paoloni, Melissa, Kaplan, Rosandra, Teicher, Beverly A., Seibel, Nita L., Smith, Malcolm, Üren, Aykut, Patel, Shreyaskumar R., Trent, Jeffrey, Savage, Sharon A., Mirabello, Lisa, Reinke, Denise, Barkaukas, Donald A., Krailo, Mark, Bernstein, Mark·2014·Clinical Cancer Research

DOI 10.1158/1078-0432.ccr-13-2574PMC PMC4134738

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Abstract

Despite successful primary tumor treatment, the development of pulmonary metastasis continues to be the most common cause of mortality in patients with osteosarcoma. A conventional drug development path requiring drugs to induce regression of established lesions has not led to improvements for patients with osteosarcoma in more than 30 years. On the basis of our growing understanding of metastasis biology, it is now reasonable and essential that we focus on developing therapeutics that target metastatic progression. To advance this agenda, a meeting of key opinion leaders and experts in the metastasis and osteosarcoma communities was convened in Bethesda, Maryland. The goal of this meeting was to provide a “Perspective” that would establish a preclinical translational path that could support the early evaluation of potential therapeutic agents that uniquely target the metastatic phenotype. Although focused on osteosarcoma, the need for this perspective is shared among many cancer types. The consensus achieved from the meeting included the following: the biology of metastatic progression is associated with metastasis-specific targets/processes that may not influence grossly detectable lesions; targeting of metastasis-specific processes is feasible; rigorous preclinical data are needed to support translation of metastasis-specific agents into human trials where regression of measurable disease is not an expected outcome; preclinical data should include an understanding of mechanism of action, validation of pharmacodynamic markers of effective exposure and response, the use of several murine models of effectiveness, and where feasible the inclusion of the dog with naturally occurring osteosarcoma to define the activity of new drugs in the micrometastatic disease setting. Clin Cancer Res; 20(16); 4200–9. ©2014 AACR.

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Tumor Self-Seeding by Circulating Cancer Cells
Kim, M.-Y., Oskarsson, T., Acharyya, S., Nguyen, D. X., Zhang, X. H.-F., Norton, L., & Massagué, J. (2009) · Cell · doi:10.1016/j.cell.2009.11.025 · Cited by 1,335
The translational landscape of mTOR signalling steers cancer initiation and metastasis
Hsieh, A. C., Liu, Y., Edlind, M. P., Ingolia, N. T., Janes, M. R., Sher, A., Shi, E. Y., Stumpf, C. R., Christensen, C., Bonham, M. J., et al. (2012) · Nature · doi:10.1038/nature10912 · Cited by 1,313
Multistep Nature of Metastatic Inefficiency
Luzzi, K. J., MacDonald, I. C., Schmidt, E. E., Kerkvliet, N. I., Morris, V. L., Chambers, A. F., & Groom, A. C. (1998) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)65628-3 · Cited by 1,283
Real-time imaging reveals the single steps of brain metastasis formation.
Kienast, Y., von Baumgarten, L., Fuhrmann, M., Klinkert, W. E. F., Goldbrunner, R., Herms, J., & Winkler, F. (2010) · Nature Medicine · doi:10.1038/nm.2072 · Cited by 1,138
New signals from the invasive front
Christofori, G. (2006) · Nature · doi:10.1038/nature04872 · Cited by 1,018
Osteosarcoma: The Addition of Muramyl Tripeptide to Chemotherapy Improves Overall Survival—A Report From the Children's Oncology Group
Meyers, P. A., Schwartz, C. L., Krailo, M. D., Healey, J. H., Bernstein, M. L., Betcher, D., Ferguson, W. S., Gebhardt, M. C., Goorin, A. M., Harris, M., et al. (2008) · Journal of Clinical Oncology · doi:10.1200/jco.2008.14.0095 · Cited by 752
Self-citation
Metastasis: recent discoveries and novel treatment strategies
Eccles, S. A., & Welch, D. R. (2007) · The Lancet · doi:10.1016/s0140-6736(07)60781-8 · Cited by 737
Self-citation
Preparing the “Soil”: The Premetastatic Niche
Kaplan, R. N., Rafii, S., & Lyden, D. C. (2006) · Cancer Research · doi:10.1158/0008-5472.can-06-2407 · Cited by 681
Self-citation
Translation of new cancer treatments from pet dogs to humans
Paoloni, M., & Khanna, C. (2008) · Nature Reviews Cancer · doi:10.1038/nrc2273 · Cited by 668
Self-citation
Spontaneously Occurring Tumors of Companion Animals as Models for Human Cancer
Vail, D. M., & MacEwen, E. G. (2000) · Cancer Investigation · doi:10.3109/07357900009012210 · Cited by 533

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Fenger, J. M., Rowell, J., Zapata, I., Kisseberth, W. C., London, C. A., & Alvarez, C. E. (2016) · Methods and principles in medicinal chemistry · doi:10.1002/9783527695881.ch9 · Cited by 11
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Sun, J., Hou, Y., Cui, H.-J., Zhang, C. L., Yang, M., Wang, F.-Z., Sun, Z., Fan, C., Sun, B., & Oh, J. R. (2020) · Current Cancer Drug Targets · doi:10.2174/1568009620666200414150353 · Cited by 5
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Long, S. A., Huang, S., Kambala, A., Ren, L., Wilson, J. A., GOETZ, M. A., Hao, X., Yang, X., Goncharova, E. I., Jia, L., et al. (2020) · Chemical Biology & Drug Design · doi:10.1111/cbdd.13762 · Cited by 5
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Alfino, L., Wilczewski‐Shirai, K. C., Cronise, K. E., Coy, J. W., Glapa, K. E., Ehrhart, E. J., Charles, J. B., Duval, D. L., & Regan, D. P. (2021) · Veterinary Pathology · doi:10.1177/0300985821996671 · Cited by 5
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Lizardo, M. M., & Sorensen, P. H. B. (2018) · Journal of Visualized Experiments · doi:10.3791/56332-v · Cited by 1
Self-citation
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Zhang, W., Liang, J., Li, D., Mao, C., Wu, H., Wang, P., Li, Z., Dai, Z., Huang, S., Rong, H., et al. (2024) · Chemical Engineering Science · doi:10.1016/j.ces.2024.120129 · Cited by 1
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Silver, K. I., Mannheimer, J., Saba, C., Hendricks, W. P. D., Wang, G., Day, K. R., Warrier, M., Beck, J. A., Mazcko, C. N., & LeBlanc, A. K. (2024) · Veterinary oncology. · doi:10.1186/s44356-024-00004-1 · Cited by 2
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Zhao, S., Tian, D., Huang, F., Wang, L., Cheng, J., He, Z., Shen, Q., Liang, S., Gong, D., Liu, J., et al. (2025) · Cancer Cell International · doi:10.1186/s12935-025-03659-4 · Cited by 1
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Greengard, E. G., & Weigel, B. J. (2020) · Pediatric oncology · doi:10.1007/978-3-030-51160-9_11 · Cited by 1
Self-citation
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Seiden, E. E., Richardson, S. M., Everitt, L. A., Knafler, G. J., Kinsella, G. P., Walker, A. L., Whiteside, V. A., Buschbach, J. D., Gandhi, D. A., Saadatzadeh, M. R., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.05.22.654354 · Cited by 1
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Lala, N. (2015) · Digital Commons-TMC (Texas Medical Center)
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Foltz, J. A. (2017) · Digital Commons-TMC (Texas Medical Center)
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Mason, N. J., & Panjwani, M. K. (2018) · Wiley eBooks · doi:10.1002/9781118684535.ch18
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Gaspar, N. (2020) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.736286746.793579340
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Bielack, S., Paulussen, M., & Helman, L. J. (2020) · Oxford University Press eBooks · doi:10.1093/med/9780198797210.003.0026
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Self-citation
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Amato, N. S. (2023) · CABI eBooks · doi:10.1079/9781789245820.0005
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Ren, C., Li, M., He, C., & Li, K. (2025) · Asian Journal of Surgery · doi:10.1016/j.asjsur.2025.05.124
Additional file 4 of Osteosarcoma tumors maintain intra-tumoral transcriptional heterogeneity during bone and lung colonization
Rajan, S., Franz, E., McAloney, C. A., Vetter, T. A., Cam, M., Gross, A. C., Taslim, C., Wang, M., Cannon, M. V., Oles, A., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26585433
Additional file 10 of Osteosarcoma tumors maintain intra-tumoral transcriptional heterogeneity during bone and lung colonization
Rajan, S., Franz, E., McAloney, C. A., Vetter, T. A., Cam, M., Gross, A. C., Taslim, C., Wang, M., Cannon, M. V., Oles, A., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26585451
Additional file 14 of Osteosarcoma tumors maintain intra-tumoral transcriptional heterogeneity during bone and lung colonization
Rajan, S., Franz, E., McAloney, C. A., Vetter, T. A., Cam, M., Gross, A. C., Taslim, C., Wang, M., Cannon, M. V., Oles, A., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26585463
Additional file 7 of Osteosarcoma tumors maintain intra-tumoral transcriptional heterogeneity during bone and lung colonization
Rajan, S., Franz, E., McAloney, C. A., Vetter, T. A., Cam, M., Gross, A. C., Taslim, C., Wang, M., Cannon, M. V., Oles, A., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26585442
Additional file 2 of Osteosarcoma tumors maintain intra-tumoral transcriptional heterogeneity during bone and lung colonization
Rajan, S., Franz, E., McAloney, C. A., Vetter, T. A., Cam, M., Gross, A. C., Taslim, C., Wang, M., Cannon, M. V., Oles, A., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26585427
Additional file 16 of Osteosarcoma tumors maintain intra-tumoral transcriptional heterogeneity during bone and lung colonization
Rajan, S., Franz, E., McAloney, C. A., Vetter, T. A., Cam, M., Gross, A. C., Taslim, C., Wang, M., Cannon, M. V., Oles, A., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26585469
Additional file 5 of Osteosarcoma tumors maintain intra-tumoral transcriptional heterogeneity during bone and lung colonization
Rajan, S., Franz, E., McAloney, C. A., Vetter, T. A., Cam, M., Gross, A. C., Taslim, C., Wang, M., Cannon, M. V., Oles, A., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26585436
Additional file 11 of Osteosarcoma tumors maintain intra-tumoral transcriptional heterogeneity during bone and lung colonization
Rajan, S., Franz, E., McAloney, C. A., Vetter, T. A., Cam, M., Gross, A. C., Taslim, C., Wang, M., Cannon, M. V., Oles, A., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26585454
Additional file 12 of Osteosarcoma tumors maintain intra-tumoral transcriptional heterogeneity during bone and lung colonization
Rajan, S., Franz, E., McAloney, C. A., Vetter, T. A., Cam, M., Gross, A. C., Taslim, C., Wang, M., Cannon, M. V., Oles, A., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26585457
Additional file 3 of Osteosarcoma tumors maintain intra-tumoral transcriptional heterogeneity during bone and lung colonization
Rajan, S., Franz, E., McAloney, C. A., Vetter, T. A., Cam, M., Gross, A. C., Taslim, C., Wang, M., Cannon, M. V., Oles, A., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26585430
Additional file 15 of Osteosarcoma tumors maintain intra-tumoral transcriptional heterogeneity during bone and lung colonization
Rajan, S., Franz, E., McAloney, C. A., Vetter, T. A., Cam, M., Gross, A. C., Taslim, C., Wang, M., Cannon, M. V., Oles, A., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26585466
Additional file 6 of Osteosarcoma tumors maintain intra-tumoral transcriptional heterogeneity during bone and lung colonization
Rajan, S., Franz, E., McAloney, C. A., Vetter, T. A., Cam, M., Gross, A. C., Taslim, C., Wang, M., Cannon, M. V., Oles, A., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26585439
Additional file 17 of Osteosarcoma tumors maintain intra-tumoral transcriptional heterogeneity during bone and lung colonization
Rajan, S., Franz, E., McAloney, C. A., Vetter, T. A., Cam, M., Gross, A. C., Taslim, C., Wang, M., Cannon, M. V., Oles, A., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26585472
Additional file 13 of Osteosarcoma tumors maintain intra-tumoral transcriptional heterogeneity during bone and lung colonization
Rajan, S., Franz, E., McAloney, C. A., Vetter, T. A., Cam, M., Gross, A. C., Taslim, C., Wang, M., Cannon, M. V., Oles, A., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26585460
Additional file 1 of Development and analysis of long non-coding RNA-associated competing endogenous RNA network for osteosarcoma metastasis
Fu, Y., Liu, Q., Bao, Q., Wen, J., Liu, Z., Hu, Y., He, G., Peng, C., Xu, Y., & Zhang, W. (2021) · Figshare · doi:10.6084/m9.figshare.14053800
Additional file 8 of Osteosarcoma tumors maintain intra-tumoral transcriptional heterogeneity during bone and lung colonization
Rajan, S., Franz, E., McAloney, C. A., Vetter, T. A., Cam, M., Gross, A. C., Taslim, C., Wang, M., Cannon, M. V., Oles, A., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26585445
Additional file 9 of Osteosarcoma tumors maintain intra-tumoral transcriptional heterogeneity during bone and lung colonization
Rajan, S., Franz, E., McAloney, C. A., Vetter, T. A., Cam, M., Gross, A. C., Taslim, C., Wang, M., Cannon, M. V., Oles, A., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26585448
Additional file 1 of Dog breeds and conformations predisposed to osteosarcoma in the UK: a VetCompass study
O’Neill, D. G., Edmunds, G. L., Urquhart-Gilmore, J., Church, D. B., Rutherford, L., Smalley, M. J., & Brodbelt, D. C. (2023) · Figshare · doi:10.6084/m9.figshare.23583646
Additional file 1 of Osteosarcoma tumors maintain intra-tumoral transcriptional heterogeneity during bone and lung colonization
Rajan, S., Franz, E., McAloney, C. A., Vetter, T. A., Cam, M., Gross, A. C., Taslim, C., Wang, M., Cannon, M. V., Oles, A., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26585424
Additional file 1 of Pharmacological prevention of surgery-accelerated metastasis in an animal model of osteosarcoma
Kallis, M. P., Maloney, C., Blank, B. A., Soffer, S. Z., Symons, M., & Steinberg, B. M. (2020) · Figshare · doi:10.6084/m9.figshare.12228140
Additional file 18 of Osteosarcoma tumors maintain intra-tumoral transcriptional heterogeneity during bone and lung colonization
Rajan, S., Franz, E., McAloney, C. A., Vetter, T. A., Cam, M., Gross, A. C., Taslim, C., Wang, M., Cannon, M. V., Oles, A., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26585475
Comparative Pathology
Sills, S. (2026) · Springer eBooks · doi:10.1007/978-3-032-04454-9_5
Introduction
Wilson-Robles, H. M., Ruple, A., & Selmic, L. E. (2026) · Springer eBooks · doi:10.1007/978-3-032-04454-9_1
Ciblage préclinique CD22 canin pour l'imagerie phénotypique (immuno-TEMP) et la radioimmunothérapie des chiens spontanément atteints de lymphomes B diffus à grandes cellules
Morio, F. (2019) · theses.fr (ABES) · doi:10.70675/cac6fbe0zce9fz4213zafebz4dfcdfd5dde6
A single‐molecule prodrug synergistically suppresses MYC‐amplified osteosarcoma through sequential nitric oxide release and photodynamic therapy
Peng, S., Wu, J., Wang, S., Gao, Y., Guo, X., Li, M., Wu, Y., Wang, Y., Cai, Z., Hua, Y., et al. (2026) · Smart Molecules · doi:10.1002/smo2.70084
The Osteosarcoma Tumor Microenvironment: From Cellular Interactions to Advanced Preclinical Models
Feo, G. D., Paola, A. D., Domenico, O. D., Argenziano, L., Pota, E., Pinto, D. D., Martino, M. D., Marrapodi, M. M., & Rossi, F. (2026) · Cancers · doi:10.3390/cancers18182909
An immunocompetent, multifluorescent resource for real-time analysis of osteosarcoma progression, metastasis, and response to therapy
Leite, T. C., HOU, J., Geng, X., Mancinelli, L., Sedlacek, A. L., Nayak, D. A., Schoedel, K. E., Weiss, K. R., Binder, R. J., Lin, C. P., et al. (2026) · Science Advances · doi:10.1126/sciadv.aed6938

Authors: Khanna, C., Fan, T. M., Gorlick, R., Helman, L. J., Kleinerman, E. S., Adamson, P. C., Houghton, P. J., Tap, W. D., Welch, D. R., Steeg, P. S., Merlino, G., Sorensen, P. H. B., Meltzer, P., Kirsch, D. G., Janeway, K. A., Weigel, B., Randall, L., Withrow, S. J., Paoloni, M., Kaplan, R., Teicher, B. A., Seibel, N. L., Smith, M., Üren, A., Patel, S. R., Trent, J., Savage, S. A., Mirabello, L., Reinke, D., Barkaukas, D. A., Krailo, M., & Bernstein, M.
Affiliations: National Institutes of Health (US)
University of Illinois Urbana-Champaign (US)
Albert Einstein College of Medicine (US)
17Cancer Biology and
Children's Hospital of Philadelphia (US)
Nationwide Children's Hospital (US)
Memorial Sloan Kettering Cancer Center (US)
University of Kansas Medical Center (US)
University of British Columbia (CA)
Duke Medical Center (US)
Harvard University (US)
University of Minnesota (US)
University of Utah (US)
Colorado State University (US)
Georgetown University Medical Center (US)
The University of Texas MD Anderson Cancer Center (US)
Translational Genomics Research Institute (US)
University of Michigan (US)
Children's Oncology Group (US)
University of Southern California (US)
Dalhousie University (CA)
Corresponding author: Fan, Timothy M.
ORCID: Fan, Timothy M.
Gorlick, Richard
Helman, Lee J.
Kleinerman, Eugenie S.
Adamson, Peter C.
Houghton, Peter J.
Tap, William D.
Welch, Danny R.
Steeg, Patricia S.
Merlino, Glenn
Sorensen, Poul H.B.
Meltzer, Paul
Kirsch, David G.
Janeway, Katherine A.
Weigel, Brenda
Kaplan, Rosandra
Teicher, Beverly A.
Seibel, Nita L.
Smith, Malcolm
Üren, Aykut
Patel, Shreyaskumar R.
Trent, Jeffrey
Savage, Sharon A.
Mirabello, Lisa
Reinke, Denise
Krailo, Mark
Bernstein, Mark
Venue: Clinical Cancer Research
Publisher: American Association for Cancer Research (AACR)
Published: 2014-08-13
Volume: 20
Issue: 16
Pages: 4200-4209
ISSN: 1078-0432 (ISSN-L)
1557-3265
DOI: 10.1158/1078-0432.ccr-13-2574
PMC: PMC4134738
OpenAlex: W1974879801
Cited by: 178
References: 66
Citations by year: 2026: 5 · 2025: 8 · 2024: 25 · 2023: 13 · 2022: 6 · 2021: 23 · 2020: 22 · 2019: 13 · 2018: 16 · 2017: 7 · 2016: 20 · 2015: 18 · 2014: 2
FWCI: 12.54
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Clinical Cancer Research (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
eScholarship (California Digital Library) (submittedVersion)
Funders: National Institutes of Health
National Cancer Institute (ZIABC010566, U10-CA98543, U24CA114766, U10CA180899, U10CA180886, U10CA098543, P30CA016672)
National Institute of Allergy and Infectious Diseases (K02AI093866)
Topics: Health Sciences › Medicine › Oncology › Sarcoma Diagnosis and Treatment
Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
Health Sciences › Veterinary › Small Animals › Veterinary Oncology Research
Keywords: osteosarcoma, lung metastasis, metastatic progression, drug development, pharmacodynamic biomarkers, mouse model, micrometastatic disease, mechanism of action
MeSH terms: Animals, Antineoplastic Agents, Bone Neoplasms, Disease Models, Animal, Dogs, Drug Evaluation, Preclinical, Humans, Osteosarcoma, Disease Progression

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Toward a Drug Development Path That Targets Metastatic Progression in Osteosarcoma

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