Marine natural products as anticancer drugs

Environmental genome shotgun sequencing of the sargasso sea

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Natural products as sources of new drugs over the period 1981–2002

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Marine Natural Products and Related Compounds in Clinical and Advanced Preclinical Trials

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Tubulin as a target for anticancer drugs: Agents which interact with the mitotic spindle

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The isolation and structure of a remarkable marine animal antineoplastic constituent: dolastatin 10

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Ecteinascidins 729, 743, 745, 759A, 759B, and 770: potent antitumor agents from the Caribbean tunicate Ecteinascidia turbinata

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In vitro and in vivo anticancer activities of synthetic macrocyclic ketone analogues of halichondrin B.

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Palytoxin: A New Marine Toxin from a Coelenterate

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Natural products ? a simple model to explain chemical diversity

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Halichondrin B and homohalichondrin B, marine natural products binding in the vinca domain of tubulin. Discovery of tubulin-based mechanism of action by analysis of differential cytotoxicity data

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Formal Synthesis of Dictyostatin and Synthesis of Two Dictyostatin Analogues

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The role of sponge-bacteria interactions: the sponge Aplysilla rosea challenged by its associated bacterium Streptomyces ACT-52A in a controlled aquarium system

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An Overview on Glyco-Macrocycles: Potential New Lead and their Future in Medicinal Chemistry

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Mode of Action of Diterpene and Characterization of Related Metabolites from the Soft Coral, Xenia elongata

Andrianasolo, E. H., Haramaty, L., White, E., Lutz, R. A., & Falkowski, P. G. (2014) · Marine Drugs · doi:10.3390/md12021102 · Cited by 18

Vasodilatation effect of farnesylacetones, active constituents of Sargassum siliquastrum, on the basilar and carotid arteries of rabbits

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Marine natural products

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Divergent Synthesis of Revised Apratoxin E, 30-epi-Apratoxin E, and 30S/30R-Oxoapratoxin E

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Isolation, structural assignment and synthesis of (SE)-2-methyloctyl 3-(4-methoxyphenyl) propenoate from the marine soft coralSarcophyton ehrenbergi

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Antimycobacterial Activity from Cyanobacterial Extracts and Phytochemical Screening of Methanol Extract ofHapalosiphon.

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Saringosterol acetate isolated from Hizikia fusiforme, an edible brown alga, suppressed hepatocellular carcinoma growth and metastasis in a zebrafish xenograft model

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The apoptosis-inducing activity towards leukemia and lymphoma cells in a cyanobacterial culture collection is not associated with mouse bioassay toxicity

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Cyclic tetrapyrrolic photosensitizers from Cladophora patentiramea (Cladophoraceae, Chlorophyta) and Turbinaria conoides (Sargassaceae, Phaeophyta) for photodynamic therapy

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Biological Diversity and Sustainable Resources Use

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Halogenated natural products in birds associated with the marine environment: A review

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Sansalvamide induces pancreatic cancer growth arrest through changes in the cell cycle.

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Photosynthetic Conversion of CO2 Into Pinene Using Engineered Synechococcus sp. PCC 7002

Yang, R., Zhu, L., Li, T., Zhu, L., Ye, Z., & Zhang, D. (2021) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2021.779437 · Cited by 16

Marine cytotoxins: callers for the various dances of death

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Total Synthesis of Kanamienamide

Reddy, D. P., Zhang, N., Yu, Z., Wang, Z., & He, Y. (2017) · The Journal of Organic Chemistry · doi:10.1021/acs.joc.7b01984 · Cited by 16

Stereocontrolled Synthesis as an Enabling Tool for the Configurational Assignment of Marine Polyketide Natural Products

Lam, N. Y. S., & Paterson, I. (2019) · European Journal of Organic Chemistry · doi:10.1002/ejoc.201901243 · Cited by 16

Up‐regulation of p53 and mitochondrial signaling pathway in apoptosis by a combination of cox‐2 inhibitor, celecoxib and dolastatin 15, a marine mollusk linear peptide in experimental colon carcinogenesis

Piplani, H., Vaish, V., Rana, C., & Sanyal, S. N. (2012) · Molecular Carcinogenesis · doi:10.1002/mc.21925 · Cited by 16

Diversity of bacteria and polyketide synthase associated with marine sponge Haliclona sp.

Khan, S. T., Musarrat, J., Al-Khedhairy, A. A., & Shin‐ya, K. (2013) · Annals of Microbiology · doi:10.1007/s13213-013-0652-7 · Cited by 16

The Synechocystis sp. PCC6803 Sfp‐Type Phosphopantetheinyl Transferase Does Not Possess Characteristic Broad‐Range Activity

Roberts, A. A., Copp, J. N., Marahiel, M. A., & Neilan, B. A. (2009) · ChemBioChem · doi:10.1002/cbic.200900095 · Cited by 17

Marine-derived pipeline anticancer natural products: a review of their pharmacotherapeutic potential and molecular mechanisms

Ali‐Seyed, M., & Ayesha, S. (2021) · Future Journal of Pharmaceutical Sciences · doi:10.1186/s43094-021-00350-z · Cited by 18

Cyanobacteria derived compounds: Emerging drugs for cancer management

Shahid, A., Khurshid, M., Aslam, B., Muzammil, S., Mehwish, H. M., Rajoka, M. S. R., Hayat, H. F., Sarfraz, M. H., Razzaq, M. K., Nisar, M. A., et al. (2021) · Journal of Basic Microbiology · doi:10.1002/jobm.202100459 · Cited by 16

Nanosynthesis, phycochemical constituents, and pharmacological properties of cyanobacterium Oscillatoria sp.

Bishoyi, A. K., Mandhata, C. P., Sahoo, C. R., Paidesetty, S. K., & Padhy, R. N. (2023) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-023-02719-8 · Cited by 15

Marine actinomycetes: An endless source of potentially therapeutic novel secondary metabolites and other bioactive compounds

Chinnathambi, A., Salmen, S. H., Al-Garadi, M. A., Wainwright, M., & Alharbi, S. A. (2023) · Journal of King Saud University - Science · doi:10.1016/j.jksus.2023.102931 · Cited by 15

Amino Acid-Derived Metabolites from the Ascidian Aplidium sp.

Won, T. H., Kim, C., Lee, S., Rho, B. J., Lee, S. K., Oh, D., Oh, K., & Shin, J. (2015) · Marine Drugs · doi:10.3390/md13063836 · Cited by 15

The Application of Delivery Systems for DNA Methyltransferase Inhibitors

Lim, S. P., Neilsen, P. M., Kumar, R., Abell, A. D., & Callen, D. F. (2011) · BioDrugs · doi:10.2165/11592770-000000000-00000 · Cited by 15

Marine Derived Bioactive Compounds for Breast and Prostate Cancer Treatment: A Review

Kalimuthu, S., Venkatesan, J., & Kim, S. (2014) · Current Bioactive Compounds · doi:10.2174/1573407210666140327212945 · Cited by 15

Natural Product Sources of Drugs: Plants, Microbes, Marine Organisms, and Animals

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Polyphyllin G exhibits antimicrobial activity and exerts anticancer effects on human oral cancer OECM-1 cells by triggering G2/M cell cycle arrest by inactivating cdc25C-cdc2

Cai, X., Guo, L., Pei, F., Chang, X., & Zhang, R. (2018) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2018.01.008 · Cited by 17

Functional and Nutraceutical Ingredients From Marine Resources

Binsi, P. K., & Zynudheen, A. A. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-816687-1.00004-7 · Cited by 15

Secondary Metabolites from Gorgonian Corals of the Genus Eunicella: Structural Characterizations, Biological Activities, and Synthetic Approaches

Matulja, D., Kolympadi, M., Ambrožič, G., Laclef, S., Pavelić, S. K., & Marković, D. (2019) · Molecules · doi:10.3390/molecules25010129 · Cited by 15

Various In Vitro Bioactivities of Secondary Metabolites Isolated from the Sponge Hyrtios aff. Erectus from the Red Sea Coast of Egypt

Nabil-Adam, A., Shreadah, M. A., Moneam, N. M. A. E., & El-Assar, S. A. (2020) · Turkish Journal of Pharmaceutical Sciences · doi:10.4274/tjps.galenos.2018.72677 · Cited by 15

Recent advances in isolation, synthesis, and evaluation of bioactivities of bispyrroloquinone alkaloids of marine origin

Nijampatnam, B., Dutta, S., & Velu, S. E. (2015) · Chinese Journal of Natural Medicines · doi:10.1016/s1875-5364(15)30052-2 · Cited by 15

Synthesis and SAR of Lehualide B: A Marine-Derived Natural Product with Potent Anti-Multiple Myeloma Activity

Jeso, V., Yang, C., Cameron, M. D., Cleveland, J. L., & Micalizio, G. C. (2013) · ACS Chemical Biology · doi:10.1021/cb300582s · Cited by 15

Sepia ink oligopeptide induces apoptosis and growth inhibition in human lung cancer cells

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A facile synthesis of bispyrroloquinone and bispyrroloiminoquinone ring system of marine alkaloids

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Studies directed toward the synthesis of caylobolide A: convergent synthesis of C21–C40 subunit

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Potential candidates from marine and terrestrial resources targeting mitochondrial inhibition: Insights from the molecular approach

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Chemical Constituents and Biological Properties of the Marine Soft Coral Nephthea: A Review (Part 1)

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Molecular docking analysis of aplysin analogs targeting survivin protein

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Elemental composition of freshwater sponges Drulia uruguayensis and Drulia cristata collected in the Tapajós River

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A brief review of potent anti-CNS tumourics from marine sponges: covering the period from 1994 to 2014

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Heteroatom‐Interchanged Isomers of Lissoclinamide 5: Copper(II) Complexation, Halide Binding, and Biological Activity

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Recent Developments Towards the Synthesis of Varitriol: An Antitumour Agent from Marine Derived Fungus Emericella Variecolor

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Cytotoxic effects of Fisturalin-3 and 11-Deoxyfisturalin-3 on Jurkat and U937 cell lines

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Ring-Closing Metathesis and Glycosylation Reactions: Synthesis and Biophysical Studies of Polyether-Linked Carbohydrate-Based Macrocyclic Nucleosides

Das, S. N., Rana, R., Chatterjee, S., Kumar, G. S., & Mandal, S. B. (2014) · The Journal of Organic Chemistry · doi:10.1021/jo501857k · Cited by 13

Serine Protease from Nereis virens Inhibits H1299 Lung Cancer Cell Proliferation via the PI3K/AKT/mTOR Pathway

Chen, Y., Tang, Y., Tang, Y., Yang, Z., & Ding, G. (2019) · Marine Drugs · doi:10.3390/md17060366 · Cited by 13

Antiproliferative and antioxidant properties of nematocysts crude venom from jellyfish Acromitus flagellatus against human cancer cell lines

Hemavathi, M., Raja, K., & Chinnasamy, A. (2021) · Saudi Journal of Biological Sciences · doi:10.1016/j.sjbs.2020.12.047 · Cited by 13

Detection of the enzymatically-active polyhydroxyalkanoate synthase subunit gene, phaC, in cyanobacteria via colony PCR

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Scalable synthesis of the unusual amino acid segment (ADMOA unit) of marine anti-inflammatory peptide: solomonamide A

Kavitha, N., & Chandrasekhar, S. (2015) · Organic & Biomolecular Chemistry · doi:10.1039/c5ob00481k · Cited by 13

Oceans

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Enduspeptides A-F, six new cyclic depsipeptides from a coal mine derived Streptomyces sp.

Chen, Y., Liu, R., Li, T., Huang, S., Kong, L., & Yang, M. (2016) · Tetrahedron · doi:10.1016/j.tet.2016.12.033 · Cited by 13

Hepatoprotective Activity of Chitosan Nanocarriers Loaded with the Ethyl Acetate Extract of a Stenotrophomonas sp. Bacteria Associated with the Red Sea Sponge Amphimedon ochracea in CCl4 Induced Hepatotoxicty in Rats

AbdelMonein, N. M., Yacout, G. A., Aboul-Ela, H. M., & Shreadah, M. A. (2017) · Advances in Bioscience and Biotechnology · doi:10.4236/abb.2017.81003 · Cited by 13

Natural-Derived Molecules as a Potential Adjuvant in Chemotherapy: Normal Cell Protectors and Cancer Cell Sensitizers

Islam, M. T., Mubarak, M. S., Hossain, R., Jain, D., Khan, R. A., & Saikat, A. S. M. (2021) · Anti-Cancer Agents in Medicinal Chemistry · doi:10.2174/1871520621666210623104227 · Cited by 14

Marine Invertebrates: Sponges

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Totalsynthese des marinen Diterpenoids Blumiolid C

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A conventional approach to the total synthesis of (−)-varitriol

Vamshikrishna, K., & Pabbaraja, S. (2012) · Tetrahedron Asymmetry · doi:10.1016/j.tetasy.2012.10.010 · Cited by 12

Evaluation of immunomodulatory activity of extracts from marine animals

Akerkar, A. S., Ponkshe, C. A., Indap, M. M., & Marg, S. B. S. (2009) · Cited by 12

Histone deacetylase inhibitor thailandepsin-A activates Notch signaling and suppresses neuroendocrine cancer cell growthin vivo

Jang, S., Janssen, A., Aburjania, Z., Robers, M. B., Harrison, A. D., Dammalapati, A., Cheng, Y., Chen, H., & Jaskula‐Sztul, R. (2017) · Oncotarget · doi:10.18632/oncotarget.19993 · Cited by 12

Iridium-Catalyzed Reductive Allylation of Esters

Xie, L., Rogers, J. J., Anastasiou, I., Leitch, J. A., & Dixon, D. J. (2019) · Organic Letters · doi:10.1021/acs.orglett.9b02119 · Cited by 12

Antiproliferative Activity of Pyracantha and Paullinia Plant Extracts on Aggressive Breast and Hepatocellular Carcinoma Cells

Kaushik, N., Yang, H., Jeong, S., Kaushik, N. K., Bhartiya, P., Nguyen, L. N., Choi, E. H., & Kim, J. H. (2020) · Applied Sciences · doi:10.3390/app10217543 · Cited by 12

Natural Products of Marine Origin for the Treatment of Colorectal and Pancreatic Cancers: Mechanisms and Potential

Fares, N., & Luzzatto‐Knaan, T. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23148048 · Cited by 12

Phylogenetic Tree Analysis of the Cold‐Hot Nature of Traditional Chinese Marine Medicine for Possible Anticancer Activity

Fu, X., Song, X., Li, X., Wong, K. K., Li, J., Zhang, F., Wang, C., & Wang, Z. (2017) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2017/4365715 · Cited by 12

Bioactive Compounds from Marine Sponge Associates: Antibiotics from Bacillus Sp.

Santhi, L. S., Talluri, V. P., Nagendra, S. Y., & Radha Krishna, E. (2017) · Natural Products Chemistry & Research · doi:10.4172/2329-6836.1000266 · Cited by 12

Synthesis and anti-tumor activity of marine alkaloids

Zhou, S., Huang, G., & Chen, G. (2021) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2021.128009 · Cited by 12

Enhancing the production of an antifungal compound from Anabaena laxa through modulation of environmental conditions and its characterization

Gupta, V., Prasanna, R., Cameotra, S. S., Dureja, P., Singh, R. N., & Sharma, J. (2013) · Process Biochemistry · doi:10.1016/j.procbio.2013.04.002 · Cited by 12

Recent Advancements in Bioactive Natural Products and Nanoparticle-Mediated Drug Delivery in Cancer Therapy

Bhajan, S. K., Bishwas, A. K., Dutta, B., Bala, A., Aktary, N., Park, S., Rahman, M., Choi, M. S., Choi, J., Akter, S., et al. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27031356 · Cited by 12

Seaweed-derived laminarin and alginate as potential chemotherapeutical agents: An updated comprehensive review considering cancer treatment

Pradhan, B., & Ki, J. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.136593 · Cited by 11

Discovery and development of synthetic tricyclic pyrroloquinone (TPQ) alkaloid analogs for human cancer therapy

Wang, W., Nijampatnam, B., Velu, S. E., & Zhang, R. (2016) · Frontiers of Chemical Science and Engineering · doi:10.1007/s11705-016-1562-6 · Cited by 11

Total Synthesis of Neuritogenic Alkynes: Lembehyne B and Key Intermediate of Lembehyne A

D'yakonov, V. A., Makarov, A. A., Dzhemileva, L. U., Andreev, E. N., & Dzhemilev, U. M. (2017) · ChemistrySelect · doi:10.1002/slct.201601988 · Cited by 11

The Rigidins: Isolation, Bioactivity, and Total Synthesis—Novel Pyrrolo[2,3-d]Pyrimidine Analogues Using Multicomponent Reactions

van der Westhuyzen, A. E., Frolova, L. V., Kornienko, A., & van Otterlo, W. A. L. (2018) · The Alkaloids. Chemistry and biology/The alkaloids. Chemistry and biology · doi:10.1016/bs.alkal.2017.12.003 · Cited by 11

The Sea as a Source of New Drugs

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Pyridinoacridine alkaloids of marine origin: NMR and MS spectral data, synthesis, biosynthesis and biological activity

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Antiprotozoal Activity AgainstPlasmodium falciparum. andTrypanosoma cruzi. of Aeroplysinin-1 Isolated from the New SpongeAplysina chiriquensis.

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Bioactive Peptides from Marine Processing Byproducts

Hayes, M., & Flower, D. (2013) · doi:10.1002/9781118412893.ch3 · Cited by 11

Therapeutic Peptides for Treatment of Lung Diseases: Infection, Fibrosis, and Cancer

Li, S., Li, Y., Liu, Y., Wu, Y., Wang, Q., Jin, L., & Zhang, D. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24108642 · Cited by 11

Marine Bacteria: A Source of Novel Bioactive Natural Products

Zha, X., Ji, R., & Zhou, S. (2023) · Current Medicinal Chemistry · doi:10.2174/0929867331666230821102521 · Cited by 10

Bioassays for Bioactivity Screening

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Interaction of Thalassia testudinum Metabolites with Cytochrome P450 Enzymes and Its Effects on Benzo(a)pyrene-Induced Mutagenicity

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Genetic and Histopathological Alterations in Caco-2 and HuH-7 Cells Treated with Secondary Metabolites of Marine fungi

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Advance on Marine Antitumor Active Products

Wang, S. (2007) · Shipin yu yaopin