Cited by 601Marine Sponges and Natural ProductsMicrobial Natural Products and BiosynthesisIsoquinoline Alkaloid Synthesis

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Marine natural products as anticancer drugs

Simmons, T. Luke, Andrianasolo, Eric, McPhail, Kerry, Flatt, Patricia, Gerwick, William H.·2005·Molecular Cancer Therapeutics

DOI 10.1158/1535-7163.333.4.2

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Abstract

The chemical and biological diversity of the marine environment is immeasurable and therefore is an extraordinary resource for the discovery of new anticancer drugs. Recent technological and methodologic advances in structure elucidation, organic synthesis, and biological assay have resulted in the isolation and clinical evaluation of various novel anticancer agents. These compounds range in structural class from simple linear peptides, such as dolastatin 10, to complex macrocyclic polyethers, such as halichondrin B; equally as diverse are the molecular modes of action by which these molecules impart their biological activity. This review highlights several marine natural products and their synthetic derivatives that are currently undergoing clinical evaluation as anticancer drugs.

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Environmental genome shotgun sequencing of the sargasso sea
Venter, J. C., Remington, K., Heidelberg, J. F., Halpern, A. L., Rusch, D., Eisen, J. A., Wu, D., Paulsen, I., Nelson, K. E., Nelson, W., et al. (2004) · Science · doi:10.1126/science.1093857 · Cited by 4,376
Natural products as sources of new drugs over the period 1981–2002
Newman, D. J., Cragg, G. M., & Snader, K. M. (2003) · Journal of Natural Products · doi:10.1021/np030096l · Cited by 3,082
Marine Natural Products and Related Compounds in Clinical and Advanced Preclinical Trials
Newman, D. J., & Cragg, G. M. L. (2004) · Journal of Natural Products · doi:10.1021/np040031y · Cited by 758
Tubulin as a target for anticancer drugs: Agents which interact with the mitotic spindle
Jordan, A. M., Hadfield, J. A., Lawrence, N. J., & McGown, A. T. (1998) · Medicinal Research Reviews · doi:10.1002/(sici)1098-1128(199807)18:4 · Cited by 678
The isolation and structure of a remarkable marine animal antineoplastic constituent: dolastatin 10
Pettit, G. R., Kamano, Y., Herald, C. L., Tuinman, A. A., Boettner, F. E., Kizu, H., Schmidt, J. M., Baczynskyj, L., Tomer, K. B., & Bontems, R. J. (1987) · Journal of the American Chemical Society · doi:10.1021/ja00256a070 · Cited by 583
Ecteinascidins 729, 743, 745, 759A, 759B, and 770: potent antitumor agents from the Caribbean tunicate Ecteinascidia turbinata
RINEHART, K. L. J., Holt, T. G., Fregeau, N. L., Stroh, J. G., Keifer, P. A., Sun, F.-R., Li, L. H., & Martin, D. G. (1990) · The Journal of Organic Chemistry · doi:10.1021/jo00302a007 · Cited by 493
In vitro and in vivo anticancer activities of synthetic macrocyclic ketone analogues of halichondrin B.
Towle, M. J., Salvato, K. A., Budrow, J., Wels, B. F., Kuznetsov, G., Aalfs, K. K., Welsh, S., Zheng, W., Seletsky, B. M., Palme, M. H., et al. (2001) · PubMed · Cited by 483
Palytoxin: A New Marine Toxin from a Coelenterate
Moore, R. E., & Scheuer, P. J. (1971) · Science · doi:10.1126/science.172.3982.495 · Cited by 482
Natural products ? a simple model to explain chemical diversity
Firn, R. D., & Jones, C. G. (2003) · Natural Product Reports · doi:10.1039/b208815k · Cited by 467
Halichondrin B and homohalichondrin B, marine natural products binding in the vinca domain of tubulin. Discovery of tubulin-based mechanism of action by analysis of differential cytotoxicity data
Bai, R., Paull, K. D., Herald, C. L., Malspeis, L., Pettit, G. R., & Hamel, E. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)98491-7 · Cited by 380

Show all 77 references

Research works printed but not linked: 3

Armand JP, Ady-Vago N, Faivre S, et al. Phase I and Pharmacokinetic Study of Aplidine (APL) given as a 24-hour continuous infusion every other week (q2w) in patients (pts) with solid tumor (ST) and lymphoma (NHL). Proceedings of the 2001 American Society of Clinical Oncology Annual Meeting. Abstr #47. In 2001.
Dileo P, Casali PG, Bacci G, et al. Phase II evaluation of 3-hr infusion ET-743 in patients with recurrent sarcomas. Proceedings of the 2002 ASCO Annual Meeting. Abstr #1628. In 2002.
Kimura T, Synold T, Mahaffey CM, et al. E7389, a novel antimicrotubule agent with potent p53-independent induction of p27, Bcl2 phosphorylation and cytotoxicity in non-small cell lung cancer (NSCLC). Proceedings of the American Society of Clinical Oncology. Abstr. # 2804. In 2003. p. 697.

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Authors: Simmons, T. L., Andrianasolo, E., McPhail, K., Flatt, P., & Gerwick, W. H.
Affiliations: Oregon State University (US)
ORCID: McPhail, Kerry
Gerwick, William H.
Venue: Molecular Cancer Therapeutics
Publisher: American Association for Cancer Research (AACR)
Published: 2005-02-01
Volume: 4
Issue: 2
Pages: 333-342
ISSN: 1535-7163 (ISSN-L)
1538-8514
DOI: 10.1158/1535-7163.333.4.2
OpenAlex: W2169637929
Cited by: 597
References: 77
Citations by year: 2026: 10 · 2025: 6 · 2024: 13 · 2023: 21 · 2022: 15 · 2021: 31 · 2020: 36 · 2019: 37 · 2018: 25 · 2017: 32 · 2016: 32 · 2015: 40 · 2014: 40 · 2013: 40 · 2012: 42
FWCI: 21.36
Type: journal article
Language: en
Open access: closed
Locations: Molecular Cancer Therapeutics (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Marine Sponges and Natural Products
Life Sciences › Immunology and Microbiology › Applied Microbiology and Biotechnology › Microbial Natural Products and Biosynthesis
Physical Sciences › Chemistry › Organic Chemistry › Isoquinoline Alkaloid Synthesis
Keywords: marine natural products, anticancer agents, dolastatin 10, halichondrin B, macrocyclic polyethers, marine peptides, structure elucidation, organic synthesis, clinical evaluation, mechanism of action
MeSH terms: Trabectedin, Polyether Polyketides, Animals, Antineoplastic Agents, Biological Products, Dioxoles, Ethers, Cyclic, Humans, Isoquinolines, Oceans and Seas, Tyrosine, Macrolides, Tetrahydroisoquinolines, Depsipeptides

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