Cited by 601Marine Sponges and Natural ProductsMicrobial Natural Products and BiosynthesisIsoquinoline Alkaloid Synthesis

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Marine natural products as anticancer drugs

Simmons, T. Luke, Andrianasolo, Eric, McPhail, Kerry, Flatt, Patricia, Gerwick, William H.·2005·Molecular Cancer Therapeutics

DOI 10.1158/1535-7163.333.4.2

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Abstract

The chemical and biological diversity of the marine environment is immeasurable and therefore is an extraordinary resource for the discovery of new anticancer drugs. Recent technological and methodologic advances in structure elucidation, organic synthesis, and biological assay have resulted in the isolation and clinical evaluation of various novel anticancer agents. These compounds range in structural class from simple linear peptides, such as dolastatin 10, to complex macrocyclic polyethers, such as halichondrin B; equally as diverse are the molecular modes of action by which these molecules impart their biological activity. This review highlights several marine natural products and their synthetic derivatives that are currently undergoing clinical evaluation as anticancer drugs.

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Authors: Simmons, T. L., Andrianasolo, E., McPhail, K., Flatt, P., & Gerwick, W. H.
Affiliations: Oregon State University (US)
ORCID: McPhail, Kerry
Gerwick, William H.
Venue: Molecular Cancer Therapeutics
Publisher: American Association for Cancer Research (AACR)
Published: 2005-02-01
Volume: 4
Issue: 2
Pages: 333-342
ISSN: 1535-7163 (ISSN-L)
1538-8514
DOI: 10.1158/1535-7163.333.4.2
OpenAlex: W2169637929
Cited by: 597
References: 77
Citations by year: 2026: 10 · 2025: 6 · 2024: 13 · 2023: 21 · 2022: 15 · 2021: 31 · 2020: 36 · 2019: 37 · 2018: 25 · 2017: 32 · 2016: 32 · 2015: 40 · 2014: 40 · 2013: 40 · 2012: 42
FWCI: 21.36
Type: journal article
Language: en
Open access: closed
Locations: Molecular Cancer Therapeutics (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Marine Sponges and Natural Products
Life Sciences › Immunology and Microbiology › Applied Microbiology and Biotechnology › Microbial Natural Products and Biosynthesis
Physical Sciences › Chemistry › Organic Chemistry › Isoquinoline Alkaloid Synthesis
Keywords: marine natural products, anticancer agents, dolastatin 10, halichondrin B, macrocyclic polyethers, marine peptides, structure elucidation, organic synthesis, clinical evaluation, mechanism of action
MeSH terms: Trabectedin, Polyether Polyketides, Animals, Antineoplastic Agents, Biological Products, Dioxoles, Ethers, Cyclic, Humans, Isoquinolines, Oceans and Seas, Tyrosine, Macrolides, Tetrahydroisoquinolines, Depsipeptides

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