Marine natural products as anticancer drugs

Environmental genome shotgun sequencing of the sargasso sea

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Natural products as sources of new drugs over the period 1981–2002

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Marine Natural Products and Related Compounds in Clinical and Advanced Preclinical Trials

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The isolation and structure of a remarkable marine animal antineoplastic constituent: dolastatin 10

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Ecteinascidins 729, 743, 745, 759A, 759B, and 770: potent antitumor agents from the Caribbean tunicate Ecteinascidia turbinata

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In vitro and in vivo anticancer activities of synthetic macrocyclic ketone analogues of halichondrin B.

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Palytoxin: A New Marine Toxin from a Coelenterate

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Natural products ? a simple model to explain chemical diversity

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Halichondrin B and homohalichondrin B, marine natural products binding in the vinca domain of tubulin. Discovery of tubulin-based mechanism of action by analysis of differential cytotoxicity data

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Tracing metal concentrations in egg strings of sea hare, Dolabella auricularia from Pujada Bay

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Fastidious Anatomization of Biota Procured Compounds on Cancer Drug Discovery

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In vivo and in vitro antitumor effects of Helix desertorum hemolymph by inducing cell cycle arrest and apoptosis

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Sitotoksisitas Ekstrak Aseton Dan Kandungan Fukosantin Rumput Laut Sargassum

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Natural products in chemotherapy of cancers

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An organic extract from ascidian Ciona robusta induces cytotoxic autophagy in human malignant cell lines

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Antitumor activity of edible fishes (Channa striata and Anabas testudineus) and gastropods (Helix aspersa and Pila virens) rudimentary mucus against HT-29 cell line and its biochemical properties

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Discovery and Synthesis of Conjugated Fatty Acids from Natural Products

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Advances of Microtubule-Targeting Small Molecular Anticancer Agents from Marine Origin

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ANALYSIS OF BIOACTIVE CONSTITUENTS FROM A NEW STREPTOMYCES VARIABILIS STRAIN SU5 BY GAS CHROMATOGRAPHY - MASS SPECTROMETRY

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Phenolic Compounds of Sponge-associated Fungi (Lecanicillium evansii)

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Other Approaches to Targeted Therapy

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Photosynthetic Platform Strain Selection

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Antimicrobial activity studies from poisonous short nosed tripod fish, Triacanthus biaculeatus (Bloch, 1786) from Visakhapatnam coastal waters, India

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Extracts from egg strings of sea hare (Dolabella auricularia): Yield, antioxidant activity, zoochemical profile, and toxicity

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Actividad antibacteriana de extractos metanólicos de pepino de mar (Pattalus mollis) frente a bacterias patógenas

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Saving the pharmacy of the sea: How does global change affect species with bioactive potential in the Mediterranean?

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Enzyme Inhibitors from Marine Invertebrates

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Identification of Red Sea lionfish venom-protein and assessing its anti- cancer efficacy

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Pharmacology, Biodiversity and

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NMR in drug discovery. From screening to structure-based design of antitumoral agents

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Application of Fungal Cyclic Peptides and Metabolites

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Potential Novel Therapeutics: Some Biological Aspects of Marine‐derived Bioactive Peptides

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Marine Peptides and Proteins with Cytotoxic and Antitumoral Properties

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Activators and Inhibitors of ADAM‐10 for Management of Cancer and Alzheimer's Disease

Kulkarni, P., Haldar, M. K., & Mallik, S. (2014) · doi:10.1002/9783527684403.ch5 · Cited by 1

Evaluation of the antioxidant activity and antitumor activity of marine invertebrates extracts

Braga, T. F. R. (2014) · Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) · Cited by 1

Towards Synthesis of Simplified Analogues of Pateamine A

Xu, T. (2020) · doi:10.26686/wgtn.17151140.v1 · Cited by 1

Marine Bioprospecting to Improve Knowledge of the Biological Sciences and Industrial Processes

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Optimization of fermentation conditions through response surface methodology for Indole-3-acetic acid production by Marine Sponge Callyspongia diffusa associated Pseudomonas fluorescens BCPBMS-1Preprint

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The Characterization of TA-289, a Novel Antifungal from Fusarium sp.

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Designed and Developed Delivery Systems Containing Extracted Astaxanthin from Crawfish, Procambarus clarkii, Using a Novel Combined Ethanol Flaxseed Oil Ultrasound Assisted Closed Extraction System and Its Anticancer Activity in Vitro

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Recherche bioguidée de molécules anticancéreuses issues de microalgues marines

Pasquet, V. (2011) · theses.fr (ABES) · doi:10.70675/0fa9f584z5c31z4314z887cza263fc876be0 · Cited by 1

Antarctic marine benthic invertebrates: chemical ecology, bioactivity and biodiversity

Taboada, S. (2012) · Tesis Doctorals en Xarxa (Consorci de Serveis Universitaris de Catalunya) · Cited by 1

Investigation of microbial extracts as a source of neurological agents

Malmo, J. M. (2010)

Bioprospecting for antimicrobial activity at the hydrothermal vent site in Eyjafjörður

Eyþórsdóttir, A. (2007) · Skemman

Secondary Metabolites from Antarctic Marine Invertebrates and their Potential as Drug Leads

Landolfa, S. (2011) · Digital Commons - University of South Florida (University of South Florida)

Chemical Investigation of the Antarctic Marine Invertebrates Synoicum adareanum and Artemisina plumosa

Noguez, J. H. (2010)

Identification of novel compounds in Undaria pinnatifida with anti-cancer potential

Wang, S. (2012) · Tuwhera (Auckland University of Technology)

Stereoselective Total Synthesis of Iso‐Cladospolide B and the 12 Membered‐Macrolactone (6S,12R)‐6‐Hydroxy‐12‐methyloxacyclododecane‐2,5‐dione

Kumar, P. V. A., Mallula, V. S., & Krishna, P. R. (2015) · Helvetica Chimica Acta · doi:10.1002/hlca.201500030

Biotecnología: la “superciencia” moderna

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Estudo químico e avaliação da atividade citotóxica das ascídias 'Didemnum psammatodes' (Sluiter, 1885) e 'Eudistoma vannamei' Millar, 1977 (Tunicata: Ascidiacea)

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In Vivo Antitumor Activity of Meretrix meretrix Glycopeptide

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Characterization of D-boroAla as a novel broad-spectrum antibacterial agent targeting D-Ala-D-Ala ligase & designer linkers: Model reactions and linear free energy relationships in the reactivitiy and design of solid-phase linkers

Putty, S. (2014) · MOspace Institutional Repository (University of Missouri)

Aislamiento, purificación y elucidación de productos naturales con actividad antitumoral a partir de organismos marinos. Axinyssmide A y Axinyssmide C

Centeno, A. G., & Molinero, L. C. (2013) · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas)

Natural Product Analysis of Coastal Marine Species of New Zealand

Hales, R. J. (2013) · Research Commons (University of Waikato)

ASSESSMENT OF IN VITRO ANTICANCER ACTIVITY OF THE MARINE GASTROPOD CYPRAEA ARABICA (L.1758)

Subavathy, P., & Diaz, J. H. J. (2015)

Isolation of secondary fungal metabolites and their influence on sphingolipid metabolism

Mathematisch-naturwissenschaftlichen Fakultät, I. (2007)

Research in the 1970s: The Fourth Generation

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Chemical ecological insights into metabolites of the New Zealand marine sponge, Cliona celata

Webb, N. (2015) · Research Commons (University of Waikato)

Toksisitas Ekstrak Senyawa Bioaktif dari Bakteri yang Berasosiasi dengan Spons dan Analisis DNA yang Berperan dalam Biosintesisnya

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The Natural Resistance of Cancer Cells to Natural Inhibitors of Carcinogenesis: A Philosophy Emerging from the Prokaryotic to Eukaryotic Kingdom. New Hope Above Expectation

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CDAC - Development of a curated database of anticancer compounds from marine resources

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DRUGS FROM THE SEA: A REVIEW OF MARINE DRUGS IN THE PIPELINE AND THE CHALLENGES FACED BY RESEARCHERS IN MARINE DRUG DEVELOPMENT.

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Epigenetics in cancer : basic and translational aspects.

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Secondary Metabolites from Marine Sources: Review

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Antimicrobial Activity of Endophytic Fungi from Xylaria Species

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Characterization of cytotoxic compound from marine sediment derived new actinomycete Streptomyces coelicolor strain SU5

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POTENTIAL ANTICANCER ACTIVITY IN-VITRO FROM EXTRACT OF Turbinaria decurrens Bory

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Mitochondrial Pro-Apoptotic Properties of Sinularia compressa from Persian Gulf against Breast Cancer Cells and Its Chemical Composition

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Bioactive Marine Peptides

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Design and Synthesis of a Highly Simplified Pateamine Analogue

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Pharmacology, Biodiversity and

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Efeito de prodigininas na migração e no potencial invasivo de linhagens de melanoma sensíveis e resistentes ao vemurafenibe.

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Symbiotic microbial interactions in fish gut

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Data from Potent in vitro and in vivo anticancer activities of des-methyl, des-amino pateamine A, a synthetic analogue of marine natural product pateamine A

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Data from Potent in vitro and in vivo anticancer activities of des-methyl, des-amino pateamine A, a synthetic analogue of marine natural product pateamine A

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FAIRNESS, EQUITY AND EFFICIENCY FOR THE CONVENTION ON BIOLOGICAL DIVERSITY AND THE NAGOYA PROTOCOL: ANALYSIS OF A RODENT, A SNAIL, A SPONGE AND A VIRUS. PART 2

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Effect of 5-o-(n-boc-l-alanine)-renieramycin t in the suppression of lung cancer stem cells

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Anti-cancer effects of renieramycin T on human non-small cell lung cancer cells

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Spirulina: A Living Library of Anticancer Phytochemicals

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Health Promoting Effects of Marine Molluscs: An Overview

Meshram Leena, N. (2023) · International Journal of Zoological Investigations · doi:10.33745/ijzi.2023.v09i02.088

Evaluation of kinetic effects of Gliotoxin in different breast cancer cell lines

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Optimization of Ultrasound-assisted Extraction of Total Carotenoids from Orange Coral "Astroides calycularis" by Response Surface Methodology

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INVITRO SCREENING OF ANTIFUNGAL POTENTIAL OF CRUDE EXTRACTS OF THE MARINE GASTROPOD, TURBINELLA PYRUM

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Natural products from marine cyanobacteria for drug discovery

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Synthetic strategies for the preparation of quinone-based materials

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Determination of Anticancer Property of Mangrove Microbiome

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Avaliação da capacidade citotóxica de macroalgas da costa de Peniche (Portugal) em células tumorais humanas

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Arguments en faveur de l'existence d'une activité pro-apoptotique des lamellarines vis-à-vis des cellules tumorales par ciblage mitochondrial

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Modern Scope, Outcomes, and Potential Application of Marine-Derived Natural Bioactives to Advance the Field of Neuroscience

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Recent Advances in Marine Natural Products as Antibacterial Agents: Structural Elucidation, Pharmacological Activities, and Structure-Activity Relationship (2020–2024)

Yang, Z., Hu, J., Huang, Z., Du, Y., Zhou, B., Hua, Y., Emam, M., & Wang, H. (2026) · MarineMedicine · doi:10.64187/mm.2026.v2.i1.007

Développement d'une plateforme informatique hétérogène appliquée à la pharmacognosie

Blondeau, S. (2011) · doi:10.70675/b169d9faz00f4z43e4z8502z99fe6aa98948

Mécanisme d'action de nouveaux agents alkylants ciblant l'ADN ou les protéines

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Caractérisation de molécules issues de microorganismes associés aux organismes marins, capables d'agir sur les cellules métastatiques du cancer du sein

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Synthèse et évaluation biologique des activités anti-biofilm d'analogues d'hémibastadine à noyau 1,2,3-triazole

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Etude de la modulation de voies de mort cellulaire programmée par des molécules marines

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Total Synthesis of Microsclerodermin D

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Novel sugar-conjugated Knoevenagel condensate curcumin derivatives as promising bioactive hybrids with antimalarial potential

Jamil, S. N. H., Oka, N., Ali, A. H., Ng, Y. H., Marzuki, N. F. N., Feroz, S. R., Lam, S. D., Mahmud, F., Zakaria, Y., & Latip, J. (2026) · RSC Advances · doi:10.1039/d5ra09343k

Antioxidant, Anti-Inflammatory and Anticancer Peptides from Extreme Marine Environments

Zakariya, M., Montuori, E., Kopp, G., Coppola, A., Giordano, D., Bruno, S., & Lauritano, C. (2026) · Antioxidants · doi:10.3390/antiox15050615

Therapeutic Potential of Anticancer Peptides: From Discovery to Clinical Application

Mumtaz, T., Hafeez, A. B., Matejczuk, K., & Ahmad, J. (2026) · International Journal of Peptide Research and Therapeutics · doi:10.1007/s10989-026-10847-x

Marine Natural Product-Derived Tri-iodinated 2-Benzoylquinazolin-4(3 H )-one Alkaloid as a Potent and Selective Agent against MRSA

Li, P.-J., Gao, J.-X., Li, H., Sun, J., Wang, C., Lv, L.-X., Wei, M., Liu, X., Liu, J., & Shao, C. (2026) · Journal of Natural Products · doi:10.1021/acs.jnatprod.6c00727

Therapeutic potential of marine sponge–derived bioactive compounds: a review

Barzkar, N., Babich, O., & Сухих, С. А. (2026) · Frontiers in Marine Science · doi:10.3389/fmars.2026.1774652

Re-examining the necessity of natural products in cancer therapy: Challenges and future perspectives

Manishkumar, P. K., Rameshbhai, S. V., Mandal, A. K., Patel, B., Deoghare, C., & Patel, O. P. (2026) · Pharmacological Research - Natural Products · doi:10.1016/j.prenap.2026.100886

BindingDB Entry 50018746: Recent advances in chemistry and bioactivity of marine cyanobacteria Moorea species.

BindingDB (2024) · UC San Diego · doi:10.7270/q2377dxp

BindingDB Entry 50031626: Gymnochromes E and F, cytotoxic phenanthroperylenequinones from a deep-water crinoid, Holopus rangii.

BindingDB (2010) · UC San Diego · doi:10.7270/q2vq32tb

BindingDB Entry 50043815: Optimization, pharmacophore modeling and 3D-QSAR studies of sipholanes as breast cancer migration and proliferation inhibitors.

BindingDB (2014) · UC San Diego · doi:10.7270/q23f4r4f

BindingDB Entry 50015658: From natural products to HDAC inhibitors: An overview of drug discovery and design strategy.

BindingDB (2023) · UC San Diego · doi:10.7270/q25m69nw

BindingDB Entry 50047032: Novel Microtubule-Targeting 7-Deazahypoxanthines Derived from Marine Alkaloid Rigidins with Potent in Vitro and in Vivo Anticancer Activities.

BindingDB (2017) · UC San Diego · doi:10.7270/q2pv6n7q

Anticancer agent-based marine natural products and related compounds

Chen, J., Wu, Q., Rowley, D. C., Al-Kareef, A. M. Q., & Wang, H. (2015) · Journal of Asian Natural Products Research · doi:10.1080/10286020.2014.996140 · Cited by 27

Marine Natural Products with High Anticancer Activities

Matulja, D., Wittine, K., Malatesti, N., Laclef, S., Turks, M., Kolympadi, M., Ambrožič, G., & Marković, D. (2020) · Current Medicinal Chemistry · doi:10.2174/0929867327666200113154115 · Cited by 59

Marine Drugs: A Hidden Wealth and a New Epoch for Cancer Management

Shakeel, E., Arora, D., Jamal, Q. M. S., Akhtar, S., Khan, M. K. A., Kamal, M. A., Siddiqui, M. H., Lohani, M., & Arif, J. M. (2017) · Current Drug Metabolism · doi:10.2174/1389200218666170221105402 · Cited by 9

Marine natural products as a source of novel anticancer drugs: an updated review (2019–2023)

El-Seedi, H. R., Refaey, M. S., Elias, N., El-Mallah, M. F., Albaqami, F. F., Dergaa, I., Du, M., Salem, M. F., Tahir, H. E., Daglia, M., et al. (2025) · Natural Products and Bioprospecting · doi:10.1007/s13659-024-00493-5 · Cited by 55

Advance on Marine Antitumor Active Products

Wang, S. (2007) · Shipin yu yaopin