Functionalized micellar systems for cancer targeted drug delivery
Abstract
Polymer micelles are rapidly becoming a powerful nanomedicine platform for cancer therapeutic applications due to their small size (10-100 nm), in vivo stability, ability to solubilize water insoluble anticancer drugs, and prolonged blood circulation times. Recent data from clinical trials with three micelle formulations have highlighted these and other pharmacokinetic advantages with reduced systemic toxicity and patient morbidity compared to conventional drug formulation. While the initial anti-tumor efficacy of these systems seems promising, a strong research impetus has been placed on micelle functionalization in order to achieve tumor targeting and site-specific drug release, with the hope of reaching a more pronounced tumor response. Hence, the purpose of this review is to draw attention to the new developments of multi-functional polymer micelles for cancer therapy with special focus on tumor targeting and controlled drug release strategies.
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Polymer nanomicelles enhance drug stability by dampening elimination through mononuclear phagocyte systems and promoting prolonged blood circulation.
“Polymer nanomicelles also enhance the drug stability by dampening the elimination through mononuclear phagocyte systems and promoting prolonged blood circulation [10].”
From From design to Deployment: The innovative role of nanomicelles in targeted ophthalmic therapeutics (2025) · cites this paper as [10]
Active nanomicelles can target cells based on relationships with particular targets and conjugation with locally functioning signal protein.
“These active nanomicelles can target cells based on (1) relationships with particular targets and (2) conjugation with locally functioning signal protein [116].”
From Recent Advances in Nanomicelles Delivery Systems. (2020) · cites this paper as [116]
Cites
Tuerk, C., & Gold, L. (1990) · Science · doi:10.1126/science.2200121 · Cited by 10,421 · see citing works
In vitro selection of RNA molecules that bind specific ligands
Ellington, A. D., & Szostak, J. W. (1990) · Nature · doi:10.1038/346818a0 · Cited by 9,845 · see citing works
Requirement of Vascular Integrin α <sub>v</sub> β <sub>3</sub> for Angiogenesis
Brooks, P. C., Clark, R. A. F., & Cheresh, D. A. (1994) · Science · doi:10.1126/science.7512751 · Cited by 3,020 · see citing works
Carbohydrate-Specific Receptors of the Liver
Ashwell, G., & Harford, J. (1982) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.51.070182.002531 · Cited by 1,914 · see citing works
Micellar Nanocarriers: Pharmaceutical Perspectives
Torchilin, V. P. (2006) · Pharmaceutical Research · doi:10.1007/s11095-006-9132-0 · Cited by 1,910 · see citing works
Structure and design of polymeric surfactant-based drug delivery systems
Torchilin, V. P. (2001) · Journal of Controlled Release · doi:10.1016/s0168-3659(01)00299-1 · Cited by 1,824 · see citing works
Targeted nanoparticle-aptamer bioconjugates for cancer chemotherapy in vivo
Farokhzad, O. C., Cheng, J., Teply, B. A., Sherifi, I., Jon, S., Kantoff, P. W., Richie, J. P., & Langer, R. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0601755103 · Cited by 1,667 · see citing works
Block copolymer micelles: preparation, characterization and application in drug delivery
Gaucher, G., Dufresne, M.-H., Sant, V. P., Kang, N., Maysinger, D., & Leroux, J.-C. (2005) · Journal of Controlled Release · doi:10.1016/j.jconrel.2005.09.034 · Cited by 1,498 · see citing works
Gabizón, A., Catane, R., Uziely, B., Kaufman, B., Safra, T., Cohen, R., Martin, F., Huang, A., & Barenholz, Y. (1994) · PubMed · Cited by 1,382 · see citing works
Bae, Y., Fukushima, S., Harada, A., & Kataoka, K. (2003) · Angewandte Chemie International Edition · doi:10.1002/anie.200250653 · Cited by 1,329 · see citing works
In situ-forming hydrogels--review of temperature-sensitive systems
Ruel-Gariépy, E., & Leroux, J.-C. (2004) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2004.03.019 · Cited by 1,297 · see citing works
Polymeric micelles—A new generation of colloidal drug carriers
Jones, M.-C., & Leroux, J.-C. (1999) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/s0939-6411(99)00039-9 · Cited by 1,256 · see citing works
Multifunctional polymeric micelles as cancer-targeted, MRI-ultrasensitive drug delivery systems
Nasongkla, N., Bey, E., Ren, J., Ai, H., Khemtong, C., Guthi, J. S., Chin, S.-F., Sherry, A. D., Boothman, D. A., & Gao, J. (2006) · Nano Letters · doi:10.1021/nl061412u · Cited by 1,238 · see citing works
Self-citationHeating the patient: a promising approach?
van der Zee, J. (2002) · Annals of Oncology · doi:10.1093/annonc/mdf280 · Cited by 1,222 · see citing works
Healing sound: the use of ultrasound in drug delivery and other therapeutic applications
Mitragotri, S. (2005) · Nature reviews. Drug discovery · doi:10.1038/nrd1662 · Cited by 952 · see citing works
Nanoparticle-Aptamer Bioconjugates
Farokhzad, O. C., Jon, S., Khademhosseini, A., Tran, T.-N., LaVan, D. A., & Langer, R. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-2550 · Cited by 897 · see citing works
Oxidation-responsive polymeric vesicles
Napoli, A., Valentini, M., Tirelli, N., et al. (2004) · Nature Materials · doi:10.1038/nmat1081 · Cited by 889 · see citing works
Ross, J. F., Chaudhuri, P. K., & Ratnam, M. (1994) · Cancer · doi:10.1002/1097-0142(19940501)73:9 · Cited by 886 · see citing works
Block copolymer micelles as vehicles for drug delivery
Kataoka, K., Kwon Glenn, S., Masayuki, Y., Teruo, O., & Sakurai, Y. (1993) · Journal of Controlled Release · doi:10.1016/0168-3659(93)90172-2 · Cited by 878 · see citing works
Tumor Regression by Targeted Gene Delivery to the Neovasculature
Hood, J. D., Bednarski, M. D., Frausto, R. F., Guccione, S., Reisfeld, R. A., Xiang, R., & Cheresh, D. A. (2002) · Science · doi:10.1126/science.1070200 · Cited by 858 · see citing works
Block copolymer micelles as long-circulating drug vehicles
Kwon, G. S., & Kataoka, K. (1995) · Advanced Drug Delivery Reviews · doi:10.1016/0169-409x(95)00031-2 · Cited by 825 · see citing works
Kim, T.-Y., Kim, D.-W., Chung, J.-Y., Shin, S. G., Kim, S.-C., Heo, D. S., Kim, N. K., & Bang, Y.-J. (2004) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-03-0655 · Cited by 821 · see citing works
Bae, Y., Nishiyama, N., Fukushima, S., Koyama, H., Yasuhiro, M., & Kataoka, K. (2005) · Bioconjugate Chemistry · doi:10.1021/bc0498166 · Cited by 742 · see citing works
Block copolymer micelles for delivery of gene and related compounds
Kakizawa, Y., & Kataoka, K. (2002) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(02)00017-0 · Cited by 739 · see citing works
Pluronic® block copolymers for overcoming drug resistance in cancer
Kabanov, A. V., Batrakova, E. V., & Alakhov, V. Y. (2002) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(02)00047-9 · Cited by 637 · see citing works
Phase I clinical trial and pharmacokinetic evaluation of NK911, a micelle-encapsulated doxorubicin
Matsumura, Y., Hamaguchi, T., Ura, T., Muro, K., Yamada, Y., Shimada, Y., Shirao, K., Okusaka, T., Ueno, H., Ikeda, M., et al. (2004) · British Journal of Cancer · doi:10.1038/sj.bjc.6602204 · Cited by 623 · see citing works
Polymeric micelle for tumor pH and folate-mediated targeting
Lee, E. (2003) · Journal of Controlled Release · doi:10.1016/s0168-3659(03)00239-6 · Cited by 620 · see citing works
Folate receptor targeted biodegradable polymeric doxorubicin micelles
Yoo, H. S., & Park, T. G. (2004) · Journal of Controlled Release · doi:10.1016/j.jconrel.2004.02.003 · Cited by 620 · see citing works
Super pH-Sensitive Multifunctional Polymeric Micelle
Lee, E. S., Na, K., & Bae, Y. H. (2005) · Nano Letters · doi:10.1021/nl0479987 · Cited by 611 · see citing works
Chung, J. E., Yokoyama, M., Yamato, M., Aoyagi, T., Sakurai, Y., & Okano, T. (1999) · Journal of Controlled Release · doi:10.1016/s0168-3659(99)00029-2 · Cited by 599 · see citing works
Haubner, R., Gratias, R., Diefenbach, B., Goodman, S. L., Jonczyk, A., & Kessler, H. (1996) · Journal of the American Chemical Society · doi:10.1021/ja9603721 · Cited by 585 · see citing works
Doxorubicin loaded pH-sensitive polymeric micelles for reversal of resistant MCF-7 tumor
Lee, E. S., Na, K., & Bae, Y. H. (2005) · Journal of Controlled Release · doi:10.1016/j.jconrel.2004.12.018 · Cited by 577 · see citing works
pH-Responsive Copolymer Assemblies for Controlled Release of Doxorubicin
Gillies, E. R., & Fréchet, J. M. J. (2005) · Bioconjugate Chemistry · doi:10.1021/bc049851c · Cited by 551 · see citing works
Targeted polymeric micelles for delivery of poorly soluble drugs
Torchilin, V. P. (2004) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-004-4153-5 · Cited by 543 · see citing works
“SMART” Drug Delivery Systems: Double-Targeted pH-Responsive Pharmaceutical Nanocarriers
Sawant, R. M., Hurley, J. P., Salmaso, S., Kale, A., Tolcheva, E., Levchenko, T. S., & Torchilin, V. P. (2006) · Bioconjugate Chemistry · doi:10.1021/bc060080h · Cited by 540 · see citing works
Immunomicelles: Targeted pharmaceutical carriers for poorly soluble drugs
Torchilin, V. P., Lukyanov, A. N., Gao, Z., & Papahadjopoulos‐Sternberg, B. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0931428100 · Cited by 538 · see citing works
Extracellular pH distribution in human tumours
Engin, K., Leeper, D. B., Cater, J. R., et al. (1995) · International Journal of Hyperthermia · doi:10.3109/02656739509022457 · Cited by 532 · see citing works
Polymeric Micelles for Delivery of Poorly Water-Soluble Compounds
Kwon, G. S. (2003) · Critical Reviews in Therapeutic Drug Carrier Systems · doi:10.1615/critrevtherdrugcarriersyst.v20.i5.20 · Cited by 502 · see citing works
Poly(l-histidine)–PEG block copolymer micelles and pH-induced destabilization
Lee, E. S., Shin, H. J., Na, K., & Bae, Y. H. (2003) · Journal of Controlled Release · doi:10.1016/s0168-3659(03)00205-0 · Cited by 452 · see citing works
Phase I clinical and pharmacokinetic study of taxol.
Wiernik, P. H., Schwartz, E. L., Strauman, J. J., Dutcher, J. P., Lipton, R. B., & Paietta, E. M. (1987) · PubMed · Cited by 452 · see citing works
Bae, Y., Jang, W., Nishiyama, N., Fukushima, S., & Kataoka, K. (2005) · Molecular BioSystems · doi:10.1039/b500266d · Cited by 445 · see citing works
Yoo, H. S., & Park, T. G. (2004) · Journal of Controlled Release · doi:10.1016/j.jconrel.2004.08.017 · Cited by 443 · see citing works
Morphogenic Effect of Solvent on Crew-Cut Aggregates of Apmphiphilic Diblock Copolymers
Yu, Y., Zhang, L., & Eisenberg, A. (1998) · Macromolecules · doi:10.1021/ma971254g · Cited by 439 · see citing works
cRGD‐Functionalized Polymer Micelles for Targeted Doxorubicin Delivery
Nasongkla, N., Shuai, X., Ai, H., Weinberg, B. D., Pink, J. J., Boothman, D. A., & Gao, J. (2004) · Angewandte Chemie International Edition · doi:10.1002/anie.200460800 · Cited by 434 · see citing works
Self-citationKwon, G., Suwa, S., Yokoyama, M., Okano, T., Sakurai, Y., & Kataoka, K. (1994) · Journal of Controlled Release · doi:10.1016/0168-3659(94)90118-x · Cited by 409 · see citing works
Goren, D., Horowitz, A. T., Tzemach, D., Tarshish, M., Zalipsky, S., & Gabizón, A. (2000) · PubMed · Cited by 402 · see citing works
pH‐Triggered Thermally Responsive Polymer Core–Shell Nanoparticles for Drug Delivery
Soppimath, K. S., Tan, D., & Yang, Y. ‐. (2005) · Advanced Materials · doi:10.1002/adma.200401057 · Cited by 390 · see citing works
Danson, S., Ferry, D., Alakhov, V, Margison, J., Kerr, D., Jowle, D., Brampton, M., Halbert, G., & Ranson, M. (2004) · British Journal of Cancer · doi:10.1038/sj.bjc.6601856 · Cited by 382 · see citing works
Pluronic® block copolymers: novel functional molecules for gene therapy
Kabanov, A. V., Lemieux, P., Vinogradov, S. V., & Alakhov, V. Y. (2002) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(02)00018-2 · Cited by 376 · see citing works
Inner core segment design for drug delivery control of thermo-responsive polymeric micelles
Chung, J. E., Yokoyama, M., & Okano, T. (2000) · Journal of Controlled Release · doi:10.1016/s0168-3659(99)00242-4 · Cited by 364 · see citing works
The mechanisms and dynamics of αvβ3 integrin clustering in living cells
Cluzel, C., Saltel, F., Lussi, J. W., Paulhe, F., Imhof, B. A., & Wehrle‐Haller, B. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200503017 · Cited by 351 · see citing works
Weitman, S. D., Weinberg, A. G., Coney, L. R., et al. (1992) · PubMed · Cited by 335 · see citing works
Control of amphiphilic block copolymer morphologies using solution conditions
Choucair, A., & Eisenberg, A. (2003) · The European Physical Journal E · doi:10.1140/epje/e2003-00002-5 · Cited by 333 · see citing works
Acetals as pH-Sensitive Linkages for Drug Delivery
Gillies, E. R., Goodwin, A. P., & Fréchet, J. M. J. (2004) · Bioconjugate Chemistry · doi:10.1021/bc049853x · Cited by 332 · see citing works
Controlled and targeted tumor chemotherapy by micellar-encapsulated drug and ultrasound
Gao, Z., Fain, H. D., & Rapoport, N. Y. (2004) · Journal of Controlled Release · doi:10.1016/j.jconrel.2004.09.021 · Cited by 328 · see citing works
Doxorubicin-conjugated biodegradable polymeric micelles having acid-cleavable linkages
Yoo, H. S., Lee, E. A., & Park, T. G. (2002) · Journal of Controlled Release · doi:10.1016/s0168-3659(02)00088-3 · Cited by 324 · see citing works
Thermosensitive and biodegradable polymeric micelles for paclitaxel delivery
Soga, O., van Nostrum, C. F., Fens, M., Rijcken, C. J. F., Schiffelers, R. M., Storm, G., & Hennink, W. E. (2005) · Journal of Controlled Release · doi:10.1016/j.jconrel.2004.12.009 · Cited by 319 · see citing works
Chung, J. E., Yokoyama, M., Aoyagi, T., Sakurai, Y., & Okano, T. (1998) · Journal of Controlled Release · doi:10.1016/s0168-3659(97)00244-7 · Cited by 319 · see citing works
Kabanov, A. V., Chekhonin, V. P., Alakhov, V. Y., Batrakova, E. V., Lebedev, A. S., Melik-Nubarov, N. S., Arzhakov, S. A., Levashov, A. V., Morozov, G. V., Severin, E. S., et al. (1989) · FEBS Letters · doi:10.1016/0014-5793(89)81689-8 · Cited by 296 · see citing works
Shen, H., Zhang, L., & Eisenberg, A. (1999) · Journal of the American Chemical Society · doi:10.1021/ja983712m · Cited by 274 · see citing works
Kohori, F., Sakai, K., Aoyagi, T., Yokoyama, M., Sakurai, Y., & Okano, T. (1998) · Journal of Controlled Release · doi:10.1016/s0168-3659(98)00023-6 · Cited by 273 · see citing works
Park, E. K., Lee, S. B., & Lee, Y. M. (2004) · Biomaterials · doi:10.1016/j.biomaterials.2004.04.008 · Cited by 265 · see citing works
Liu, S. Q., Tong, Y. W., & Yang, Y.-Y. (2005) · Biomaterials · doi:10.1016/j.biomaterials.2005.01.030 · Cited by 265 · see citing works
Polymer micelle with cross-linked ionic core
Bronich, T. K., Keifer, P. A., Shlyakhtenko, L. S., & Kabanov, A. V. (2005) · Journal of the American Chemical Society · doi:10.1021/ja043042m · Cited by 264 · see citing works
A new approach towards acid sensitive copolymer micelles for drug delivery
Gillies, E. R., & Fréchet, J. M. J. (2003) · Chemical Communications · doi:10.1039/b304251k · Cited by 252 · see citing works
Shenoy, D. B., Little, S. R., Langer, R., & Amiji, M. M. (2005) · Pharmaceutical Research · doi:10.1007/s11095-005-8343-0 · Cited by 246 · see citing works
Park, E. K., Kim, S. Y., Lee, S. B., & Lee, Y. M. (2005) · Journal of Controlled Release · doi:10.1016/j.jconrel.2005.09.039 · Cited by 239 · see citing works
Integrin targeting using RGD‐PEI conjugates for in vitro gene transfer
Kunath, K., Merdan, T., Hegener, O., Häberlein, H., & Kissel, T. (2003) · The Journal of Gene Medicine · doi:10.1002/jgm.382 · Cited by 231 · see citing works
Marin, A., Sun, H., Husseini, G. A., Pitt, W. G., Christensen, D. A., & Rapoport, N. Y. (2002) · Journal of Controlled Release · doi:10.1016/s0168-3659(02)00262-6 · Cited by 213 · see citing works
Potineni, A., Lynn, D. M., Langer, R., & Amiji, M. M. (2003) · Journal of Controlled Release · doi:10.1016/s0168-3659(02)00374-7 · Cited by 201 · see citing works
Tang, Y., Liu, S., Armes, S. P., & Billingham, N. Ć. (2003) · Biomacromolecules · doi:10.1021/bm030026t · Cited by 199 · see citing works
Leroux, J., Roux, E., Garrec, D. L., Hong, K., & Drummond, D. C. (2001) · Journal of Controlled Release · doi:10.1016/s0168-3659(01)00263-2 · Cited by 199 · see citing works
Nanomolar Small Molecule Inhibitors for αvβ6, αvβ5, and αvβ3 Integrins
Goodman, S. L., Hölzemann, G., Sulyok, G. A. G., & Kessler, H. (2002) · Journal of Medicinal Chemistry · doi:10.1021/jm0102598 · Cited by 197 · see citing works
Pharmacokinetics and metabolism of epidoxorubicin and doxorubicin in humans.
Mross, K. B., Maessen, P. A., van der Vijgh, W. J. F., Gall, H. E., Boven, E., & Pinedo, H. M. (1988) · Journal of Clinical Oncology · doi:10.1200/jco.1988.6.3.517 · Cited by 193 · see citing works
Shenoy, D. B., Little, S. R., Langer, R., & Amiji, M. M. (2005) · Molecular Pharmaceutics · doi:10.1021/mp0500420 · Cited by 193 · see citing works
Drug delivery in polymeric micelles: from in vitro to in vivo
Rapoport, N. Y. (2003) · Journal of Controlled Release · doi:10.1016/s0168-3659(03)00218-9 · Cited by 191 · see citing works
Primary Hepatocellular Carcinoma
Wands, J. R., & Blum, H. E. (1991) · New England Journal of Medicine · doi:10.1056/nejm199109053251010 · Cited by 182 · see citing works
Yasugi, K., NAKAMURA, T., Nagasaki, Y., Kato, M., & Kataoka, K. (1999) · Macromolecules · doi:10.1021/ma991066l · Cited by 176 · see citing works
The EPR Effect and Polymeric Drugs: A Paradigm Shift for Cancer Chemotherapy in the 21st Century
Maeda, H., Greish, K. F., & Fang, J. Q. (2005) · Advances in polymer science · doi:10.1007/12_026 · Cited by 173 · see citing works
Nagasaki, Y., Yasugi, K., Yamamoto, Y., Harada, A., & Kataoka, K. (2001) · Biomacromolecules · doi:10.1021/bm015574q · Cited by 171 · see citing works
Weissig, V., Whiteman, K. R., & Torchilin, V. P. (1998) · Pharmaceutical Research · doi:10.1023/a:1011951016118 · Cited by 170 · see citing works
Chung, J. E., Yokoyama, M., Suzuki, K., Aoyagi, T., Sakurai, Y., & Okano, T. (1997) · Colloids and Surfaces B Biointerfaces · doi:10.1016/s0927-7765(97)00015-5 · Cited by 169 · see citing works
Nakayama, M., & Okano, T. (2005) · Biomacromolecules · doi:10.1021/bm050232w · Cited by 169 · see citing works
Benahmed, A., Ranger, M., & Leroux, J. (2001) · Pharmaceutical Research · doi:10.1023/a:1011054930439 · Cited by 150 · see citing works
Wermuth, J., Goodman, S. L., Jonczyk, A., & Kessler, H. (1997) · Journal of the American Chemical Society · doi:10.1021/ja961908l · Cited by 137 · see citing works
Dalhaimer, P., Engler, A. J., Parthasarathy, R., & Discher, D. E. (2004) · Biomacromolecules · doi:10.1021/bm049884v · Cited by 136 · see citing works
JEONG, Y., SEO, S., Park, I., Lee, H., Kang, I., Akaike, T., & CHO, C. (2005) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2005.02.027 · Cited by 136 · see citing works
Ultrasonically activated chemotherapeutic drug delivery in a rat model.
Nelson, J. L., Roeder, B. L., Carmen, J. C., Roloff, F., & Pitt, W. G. (2002) · PubMed · Cited by 135 · see citing works
Cyclic RGD Peptides Containing β-Turn Mimetics
Haubner, R., Schmitt, W., Hölzemann, G., Goodman, S. L., Jonczyk, A., & Kessler, H. (1996) · Journal of the American Chemical Society · doi:10.1021/ja9608757 · Cited by 135 · see citing works
pH-Sensitive Nanogel Possessing Reactive PEG Tethered Chains on the Surface
Hayashi, H., Iijima, M., Kataoka, K., et al. (2004) · Macromolecules · doi:10.1021/ma049199g · Cited by 132 · see citing works
Ligand-directed targeting of genes to the site of disease
Wickham, T. J. (2003) · Nature Medicine · doi:10.1038/nm0103-135 · Cited by 126 · see citing works
Rapoport, N. Y., Herron, J. N., Pitt, W. G., & Pitina, L. (1999) · Journal of Controlled Release · doi:10.1016/s0168-3659(98)00149-7 · Cited by 123 · see citing works
Liu, X.-M., Pramoda, K. P., Yang, Y. Y., Chow, S. Y., & He, C. (2003) · Biomaterials · doi:10.1016/j.biomaterials.2003.09.028 · Cited by 122 · see citing works
Tumor angiogenesis and the role of vascular cell integrin alphavbeta3.
Varner, J. A., & Cheresh, D. A. (1996) · PubMed · Cited by 115 · see citing works
Jule, E., Nagasaki, Y., & Kataoka, K. (2002) · Bioconjugate Chemistry · doi:10.1021/bc025598+ · Cited by 110 · see citing works
Cummings, J., & McArdle, C. (1986) · British Journal of Cancer · doi:10.1038/bjc.1986.141 · Cited by 109 · see citing works
Single Molecule Visualization of Stable, Stiffness-Tunable, Flow-Conforming Worm Micelles
Dalhaimer, P., Bates, F. S., & Discher, D. E. (2003) · Macromolecules · doi:10.1021/ma034120d · Cited by 109 · see citing works
Ultrasonic activated drug delivery from Pluronic P-105 micelles
Munshi, N., Rapoport, N. Y., & Pitt, W. G. (1997) · Cancer Letters · doi:10.1016/s0304-3835(97)00218-8 · Cited by 109 · see citing works
Kopec̆ek, J., & Duncan, R. (1987) · Journal of Controlled Release · doi:10.1016/0168-3659(87)90085-x · Cited by 109 · see citing works
Polyion Complex Micelles Encapsulating Light-Harvesting Ionic Dendrimer Zinc Porphyrins
Stapert, H. R., Nishiyama, N., Jiang, D., Aida, T., & Kataoka, K. (2000) · Langmuir · doi:10.1021/la000423e · Cited by 104 · see citing works
Optimizing pH-responsive Polymeric Micelles for Drug Delivery in a Cancer Photodynamic Therapy Model
Garrec, D. L., Taillefer, J., van Lier, J. E., Lenaerts, V., & Leroux, J. (2002) · Journal of drug targeting · doi:10.1080/1061186021000001887 · Cited by 101 · see citing works
Kinetics of ultrasonic release of doxorubicin from pluronic P105 micelles
Husseini, G. A., Rapoport, N. Y., Christensen, D. A., Pruitt, J. D., & Pitt, W. G. (2002) · Colloids and Surfaces B Biointerfaces · doi:10.1016/s0927-7765(01)00273-9 · Cited by 100 · see citing works
Husseini, G. A., Christensen, D. A., Rapoport, N. Y., & Pitt, W. G. (2002) · Journal of Controlled Release · doi:10.1016/s0168-3659(02)00203-1 · Cited by 99 · see citing works
Interfacial Solubilization of Model Amphiphilic Molecules in Block Copolymer Micelles
Choucair, A., & Eisenberg, A. (2003) · Journal of the American Chemical Society · doi:10.1021/ja036667d · Cited by 95 · see citing works
A Polymer Micelle Responding to the Protein Kinase A Signal
Katayama, Y., Sonoda, T., & Maeda, M. (2001) · Macromolecules · doi:10.1021/ma010966a · Cited by 90 · see citing works
Jansen, R. W., Molema, G., Ching, T. L., Oosting, R., Harms, G., Moolenaar, F., Hardonk, M. J., & Meijer, D. K. F. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)49994-2 · Cited by 88 · see citing works
Rüegg, C., Dormond, O., & Foletti, A. (2002) · Endothelium · doi:10.1080/10623320213635 · Cited by 82 · see citing works
Stabilization of Pluronic P-105 Micelles with an Interpenetrating Network of N,N-Diethylacrylamide
Pruitt, J. D., Husseini, G. A., Rapoport, N. Y., & Pitt, W. G. (2000) · Macromolecules · doi:10.1021/ma0008544 · Cited by 81 · see citing works
Liu, X., Yang, Y. Y., & Leong, K. W. (2003) · Journal of Colloid and Interface Science · doi:10.1016/s0021-9797(03)00691-x · Cited by 69 · see citing works
Block copolymer micelles as a solution for drug delivery problems
Torchilin, V. P. (2005) · Expert Opinion on Therapeutic Patents · doi:10.1517/13543776.15.1.63 · Cited by 68 · see citing works
Rapoport, N. Y., Smirnov, A. I., Timoshin, A. A., Pratt, A. M., & Pitt, W. G. (1997) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1997.0176 · Cited by 65 · see citing works
Taillefer, J., Brasseur, N., van Lier, J. E., Lenaerts, V., Garrec, D. L., & Leroux, J. (2001) · Journal of Pharmacy and Pharmacology · doi:10.1211/0022357011775352 · Cited by 65 · see citing works
Miyazaki, S., Yokouchi, C., & Takada, M. (1988) · Journal of Pharmacy and Pharmacology · doi:10.1111/j.2042-7158.1988.tb07001.x · Cited by 64 · see citing works
Sequestration and Ultrasound-Induced Release of Doxorubicin from Stabilized Pluronic P105 Micelles
Pruitt, J. D., & Pitt, W. G. (2002) · Drug Delivery · doi:10.1080/10717540260397873 · Cited by 63 · see citing works
Jule, E., Nagasaki, Y., & Kataoka, K. (2002) · Langmuir · doi:10.1021/la0258042 · Cited by 60 · see citing works
Design of superactive and selective integrin receptor antagonists containing the RGD sequence
Kessler, H., Diefenbach, B., Finsinger, D., Geyer, A., Gurrath, M., Goodman, S. L., Hölzemann, G., Haubner, R., Jonczyk, A., Müller, G., et al. (1995) · Letters in Peptide Science · doi:10.1007/bf00119142 · Cited by 60 · see citing works
Goto, M., Yura, H., Chia-Wun, C., Akira, K., Shinoda, T., Atsushi, M., Kojima, S., Kobayashi, K., & Akaike, T. (1994) · Journal of Controlled Release · doi:10.1016/0168-3659(94)90169-4 · Cited by 55 · see citing works
Lynn, D. M., Amiji, M. M., & Langer, R. (2001) · PubMed · Cited by 54 · see citing works
Investigating the mechanism of acoustically activated uptake of drugs from Pluronic micelles
Husseini, G. A., Runyan, C. M., & Pitt, W. G. (2002) · BMC Cancer · doi:10.1186/1471-2407-2-20 · Cited by 53 · see citing works
Tetrakis(trimethylsilyl)cyclobutadiene and Tetrakis(trimethylsilyl)tetrahedrane
Maier, G., Neudert, J., & Wolf, O. (2001) · Angewandte Chemie International Edition · doi:10.1002/1521-3773(20010504)40:9 · Cited by 46 · see citing works
Teti, A. M., Migliaccio, S., & Baron, R. (2002) · Calcified Tissue International · doi:10.1007/s00223-001-2071-1 · Cited by 37 · see citing works
Architectural and Structural Optimization of the Protective Polymer Layer for Enhanced Targeting
Chen, C.-C., & Dormidontova, E. E. (2005) · Langmuir · doi:10.1021/la047109v · Cited by 32 · see citing works
Farson, D. A., MCGUINNESS, R. P., Dull, T., Limoli, K. L., Lazar, R., Jalali, S., REDDY, S., Pennathur-Das, R., Broad, D., & Finer, M. H. (1999) · The Journal of Gene Medicine · doi:10.1002/(sici)1521-2254(199905/06)1:3 · Cited by 28 · see citing works
Synthetic cell elements from block copolymers – hydrodynamic aspects
Dalhaimer, P., Bates, F. S., Aranda‐Espinoza, H., et al. (2003) · Comptes Rendus Physique · doi:10.1016/s1631-0705(03)00028-8 · Cited by 23 · see citing works
Kwon, G. S., Yokoyama, M., Okano, T., et al. (1994) · Journal of Controlled Release · doi:10.1016/0168-3659(94)90203-8 · Cited by 20 · see citing works
van Halteren, H. K., Peters, H. M., van Krieken, J. H., Coebergh, J. W. W., Roumen, R. M. H., van der Worp, E., Wagener, J. T., & Vreugdenhil, G. (2001) · Cancer · doi:10.1002/1097-0142(20010501)91:9 · Cited by 9 · see citing works
Taillefer (2000) · doi:10.1002/(sici)1520-6017(200001)89:1
Flagged first, then by citations
Cited by
Sorted by citations
Nanoparticle therapeutics: an emerging treatment modality for cancer
Davis, M. E., Chen, Z., & Shin, D. M. (2008) · Nature Reviews Drug Discovery · doi:10.1038/nrd2614 · Cited by 4,233 · see citing works
Kamaly, N., Yameen, B., Wu, J., & Farokhzad, O. C. (2016) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00346 · Cited by 3,070 · see citing works
Nicolas, J., Mura, S., Brambilla, D., Mackiewicz, N., & Couvreur, P. (2013) · Chem. Soc. Rev. · doi:10.1039/c2cs35265f · Cited by 1,270 · see citing works
Smart nanocarrier-based drug delivery systems for cancer therapy and toxicity studies: A review
Hossen, S., Hossain, M. K., Basher, M. K., Mia, M. N. H., Rahman, M. T., & Uddin, M. J. (2019) · Journal of Advanced Research · doi:10.1016/j.jare.2018.06.005 · Cited by 998 · see citing works
Multifunctional polymeric micelles for delivery of drugs and siRNA
Jhaveri, A. M., & Torchilin, V. P. (2014) · Frontiers in Pharmacology · doi:10.3389/fphar.2014.00077 · Cited by 466 · see citing works
Polymeric micelles: nanocarriers for cancer-targeted drug delivery
Zhang, Y., Huang, Y., & Li, S. (2014) · AAPS PharmSciTech · doi:10.1208/s12249-014-0113-z · Cited by 367 · see citing works
Micelles structure development as a strategy to improve smart cancer therapy
Hanafy, N., El-Kemary, M., & Leporatti, S. (2018) · Cancers · doi:10.3390/cancers10070238 · Cited by 287 · see citing works
Osada, K., Christie, R. J., & Kataoka, K. (2009) · Journal of The Royal Society Interface · doi:10.1098/rsif.2008.0547.focus · Cited by 218 · see citing works
Tang, R., Ji, W., Panus, D., Palumbo, R. N., & Wang, C. (2011) · Journal of Controlled Release · doi:10.1016/j.jconrel.2010.12.005 · Cited by 202 · see citing works
Role of cellular uptake in the reversal of multidrug resistance by PEG-b-PLA polymeric micelles
Xiao, L., Xiong, X., Sun, X., Zhu, Y., Yang, H., Chen, H., Gan, L., Xu, H., & Yang, X. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2011.03.071 · Cited by 169 · see citing works
Blanco, E., Bey, E. A., Dong, Y., Weinberg, B. D., Sutton, D. M., Boothman, D. A., & Gao, J. (2007) · Journal of Controlled Release · doi:10.1016/j.jconrel.2007.04.014 · Cited by 165 · see citing works
Self-citationRecent Advances in Nanomicelles Delivery Systems.
Tawfik, S. M., Azizov, S., Elmasry, M. R., Sharipov, M., & Lee, Y.-I. (2020) · Nanomaterials · doi:10.3390/nano11010070 · Cited by 156 · see citing works
“These active nanomicelles can target cells based on (1) relationships with particular targets and (2) conjugation with locally functioning signal protein [116].”
BackgroundWang, T., Yang, S., Mei, L. A., Parmar, C. K., Gillespie, J. W., Praveen, K. P., Petrenko, V. A., & Torchilin, V. P. (2014) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-14-0052 · Cited by 35 · see citing works
From design to Deployment: The innovative role of nanomicelles in targeted ophthalmic therapeutics
Sun, M., Wang, J., Fan, W., Wang, K., Wang, Y., Zhang, J., Ding, S., Zhang, C., Feng, Z., Wang, Y.-G., et al. (2025) · Materials today. Bio · doi:10.1016/j.mtbio.2025.102537 · Cited by 7 · see citing works
“Polymer nanomicelles also enhance the drug stability by dampening the elimination through mononuclear phagocyte systems and promoting prolonged blood circulation [10].”
- Authors
- Sutton, D., Nasongkla, N., Blanco, E., & Gao, J.
- Affiliations
- The University of Texas at Dallas (US)
- University of California, San Francisco (US)
- Harold C. Simmons Comprehensive Cancer Center (US)
- Corresponding author
- Gao, Jinming
- Venue
- Pharmaceutical Research
- Published
- 2007-03-24
- Volume
- 24
- Issue
- 6
- Pages
- 1029-1046
- ISSN
- 0724-8741 (ISSN-L)
- 1573-904X
- OpenAlex
- W2122400711
- Cited by
- 557
- References
- 127
- Citations by year
- 2026: 8 · 2025: 13 · 2024: 13 · 2023: 14 · 2022: 18 · 2021: 27 · 2020: 22 · 2019: 15 · 2018: 20 · 2017: 35 · 2016: 31 · 2015: 40 · 2014: 40 · 2013: 46 · 2012: 64
- FWCI
- 2.12
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Pharmaceutical Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- University of Texas Southwestern Medical Center
- National Institutes of Health
- National Cancer Institute (R01CA090696)
- National Institute of Biomedical Imaging and Bioengineering (R21EB005394)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Physical Sciences › Materials Science › Polymers and Plastics › Dendrimers and Hyperbranched Polymers
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Keywords
- polymeric micelles, anticancer drug delivery, tumor targeting, controlled drug release, nanomedicine, site-specific drug release, pharmacokinetics, systemic toxicity
- MeSH terms
- Animals, Antineoplastic Agents, Humans, Micelles, Polymers, Mice
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