Cited by 557Nanoparticle-Based Drug DeliveryDendrimers and Hyperbranched PolymersAdvanced Drug Delivery Systems

Functionalized micellar systems for cancer targeted drug delivery

Sutton, Damon, Nasongkla, Norased, Blanco, Elvin, Gao, Jinming·2007·Pharmaceutical Research

Abstract

Polymer micelles are rapidly becoming a powerful nanomedicine platform for cancer therapeutic applications due to their small size (10-100 nm), in vivo stability, ability to solubilize water insoluble anticancer drugs, and prolonged blood circulation times. Recent data from clinical trials with three micelle formulations have highlighted these and other pharmacokinetic advantages with reduced systemic toxicity and patient morbidity compared to conventional drug formulation. While the initial anti-tumor efficacy of these systems seems promising, a strong research impetus has been placed on micelle functionalization in order to achieve tumor targeting and site-specific drug release, with the hope of reaching a more pronounced tumor response. Hence, the purpose of this review is to draw attention to the new developments of multi-functional polymer micelles for cancer therapy with special focus on tumor targeting and controlled drug release strategies.

Integrity signals

Registry

Crossref · 10.1007/s11095-006-9223-y

Cites

127 of 127 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Polymer nanomicelles enhance drug stability by dampening elimination through mononuclear phagocyte systems and promoting prolonged blood circulation.

    “Polymer nanomicelles also enhance the drug stability by dampening the elimination through mononuclear phagocyte systems and promoting prolonged blood circulation [10].”
  • Active nanomicelles can target cells based on relationships with particular targets and conjugation with locally functioning signal protein.

    “These active nanomicelles can target cells based on (1) relationships with particular targets and (2) conjugation with locally functioning signal protein [116].”

    From Recent Advances in Nanomicelles Delivery Systems. (2020) · cites this paper as [116]

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Sutton, D., Nasongkla, N., Blanco, E., & Gao, J.
Affiliations
  • The University of Texas at Dallas (US)
  • University of California, San Francisco (US)
  • Harold C. Simmons Comprehensive Cancer Center (US)
Corresponding author
Gao, Jinming
Venue
Pharmaceutical Research
Published
2007-03-24
Volume
24
Issue
6
Pages
1029-1046
ISSN
  • 0724-8741 (ISSN-L)
  • 1573-904X
OpenAlex
W2122400711
Cited by
557
References
127
Citations by year
2026: 8 · 2025: 13 · 2024: 13 · 2023: 14 · 2022: 18 · 2021: 27 · 2020: 22 · 2019: 15 · 2018: 20 · 2017: 35 · 2016: 31 · 2015: 40 · 2014: 40 · 2013: 46 · 2012: 64
FWCI
2.12
Type
journal article
Language
en
Open access
closed
Locations
  • Pharmaceutical Research (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • University of Texas Southwestern Medical Center
  • National Institutes of Health
  • National Cancer Institute (R01CA090696)
  • National Institute of Biomedical Imaging and Bioengineering (R21EB005394)
Topics
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
  • Physical Sciences › Materials Science › Polymers and Plastics › Dendrimers and Hyperbranched Polymers
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
Keywords
polymeric micelles, anticancer drug delivery, tumor targeting, controlled drug release, nanomedicine, site-specific drug release, pharmacokinetics, systemic toxicity
MeSH terms
Animals, Antineoplastic Agents, Humans, Micelles, Polymers, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review