Increased susceptibility of Nrf2 knockout mice to colitis-associated colorectal cancer
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Abstract
The nuclear factor-erythroid 2-related factor 2 (Nrf2) plays a critical role in protecting various tissues against inflammation, which is a potential risk factor for colorectal and other cancers. Our previously published mouse model work showed that Nrf2 helps protect against dextran sulfate sodium (DSS)-induced colitis/inflammation, and others have shown that Nrf2 helps protect against inflammation-associated colorectal carcinogenesis (aberrant crypt foci). The present study extended these important earlier findings by exploring the role of Nrf2 in colitis-associated colorectal cancer in a mouse model involving azoxymethane/DSS-induced colorectal carcinogenesis in Nrf2 knockout mice. Azoxymethane/DSS-treated Nrf2 knockout mice had increased incidence, multiplicity, and size of all colorectal tumors, including adenomas, versus treated wild-type (WT) mice, and the proportion of tumors that were adenocarcinoma was much higher in knockout (80%) versus WT (29%) mice. Compared with WT mice, knockout mice also had increased markers of inflammation in tumor tissue (cyclooxygenase-2 and 5-lipoxygenase expressions and prostaglandin E(2) and leukotriene B(4) levels) and in inflamed colonic mucosa (nitrotyrosine expression), supporting the association of knockout mouse tumor formation with inflammation. The phase II detoxifying/antioxidant enzymes NAD(P)H-quinone reductase 1 and UDP-glucurosyltransferase 1A1 were elevated in the normal mucosa of WT, but not Nrf 2 knockout, mice treated with azoxymethane/DSS. Our findings show that Nrf2 plays a critical role in protecting against inflammation-associated colorectal cancer.
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Tissue and plasma from Nrf2KO mice present higher levels of inflammation at 4 months of age.
“Our data show that tissue and plasma from Nrf2KO mice present higher levels of inflammation at 4 month of age (measured by the cytokine levels), corroborating previous reports (Ishii et al., 2005; Khor et al., 2008).”
From Rapamycin inhibits the secretory phenotype of senescent cells by a Nrf2-independent mechanism (2017) · cites this paper as Khor et al., 2008
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Cites
The risk of colorectal cancer in ulcerative colitis: a meta-analysis
Eaden, J., Abrams, K. R., & Mayberry, J. F. (2001) · Gut · doi:10.1136/gut.48.4.526 · Cited by 2,948 · see citing works
Christakis, D., Richards, J. A., Zimmerman, F. J., Garrison, M. M., Xu, D., & Yapanel, U. H. (2009) · Cited by 2,290 · see citing works
Ulcerative Colitis and Colorectal Cancer
Ekbom, A., Helmick, C. G., Zack, M. M., & Adami, H. (1990) · New England Journal of Medicine · doi:10.1056/nejm199011013231802 · Cited by 1,794 · see citing works
Itzkowitz, S. H., & Yio, X. (2004) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00079.2004 · Cited by 1,272 · see citing works
Nrf2 is a critical regulator of the innate immune response and survival during experimental sepsis
Thimmulappa, R. K. (2006) · Journal of Clinical Investigation · doi:10.1172/jci25790 · Cited by 1,028 · see citing works
Genetic ablation of Nrf2 enhances susceptibility to cigarette smoke–induced emphysema in mice
Rangasamy, T., Cho, C. Y., Thimmulappa, R. K., Zhen, L., Srisuma, S., Kensler, T. W., Yamamoto, M. P., Petrache, I., Tuder, R. M., & Biswal, S. S. (2004) · Journal of Clinical Investigation · doi:10.1172/jci21146 · Cited by 993 · see citing works
Prostaglandins, Arachidonic Acid, and Inflammation
Kuehl, F. A., & Egan, R. W. (1980) · Science · doi:10.1126/science.6254151 · Cited by 710 · see citing works
Nrf2-Deficient Mice Have an Increased Susceptibility to Dextran Sulfate Sodium–Induced Colitis
Khor, T. O., Huang, M., Kwon, K. H., Chan, J. Y., Reddy, B. S., & Kong, A. T. (2006) · Cancer Research · doi:10.1158/0008-5472.can-06-3562 · Cited by 530 · see citing works
Self-citationUlcerative colitis and colorectal cancer
Ekbom, A. (1991) · Biomedicine & Pharmacotherapy · doi:10.1016/0753-3322(91)90009-i · Cited by 419 · see citing works
Choi, P. M., & Zelig, M. P. (1994) · Gut · doi:10.1136/gut.35.7.950 · Cited by 385 · see citing works
Xu, C., Huang, M., Shen, G., Yuan, X., Lin, W., Khor, T. O., Conney, A. H., & Kong, A. T. (2006) · Cancer Research · doi:10.1158/0008-5472.can-06-0300 · Cited by 379 · see citing works
Self-citationPancreatitis is a risk factor for pancreatic cancer
Bansal, P., & Sonnenberg, A. (1995) · Gastroenterology · doi:10.1016/0016-5085(95)90291-0 · Cited by 286 · see citing works
Screening and surveillance colonoscopy in chronic Crohn's colitis
Friedman, S., Rubin, P., Bodian, C., Goldstein, E. S., Harpaz, N., & Present, D. H. (2001) · Gastroenterology · doi:10.1053/gast.2001.22449 · Cited by 246 · see citing works
Inflammation, chromosomal instability, and cancer: the schistosomiasis model.
Rosin, M. P., Anwar, W. A. R., & Ward, A. J. (1994) · PubMed · Cited by 228 · see citing works
Ju, J., Hong, J., Zhou, J.-N., Pan, Z., Bose, M., Liao, J., Yang, G., Liu, Y. Y., Hou, Z., Lin, Y., et al. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-1949 · Cited by 219 · see citing works
Self-citationOckaili, R. A., Natarajan, R., Salloum, F. N., Fisher, B. J., Jones, D. G., Fowler, A. A., & Kukreja, R. C. (2005) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00089.2005 · Cited by 214 · see citing works
Osburn, W. O., Karim, B. O., Dolan, P. M., Liu, G., Yamamoto, M. P., Huso, D. L., & Kensler, T. W. (2007) · International Journal of Cancer · doi:10.1002/ijc.22943 · Cited by 197 · see citing works
Lewis, J. T., Talwalkar, J. A., Rosen, C. B. B., Smyrk, T. C., & Abraham, S. C. (2007) · The American Journal of Surgical Pathology · doi:10.1097/01.pas.0000213435.99492.8a · Cited by 186 · see citing works
The Role of Cyclooxygenase 2 in Ulcerative Colitis-Associated Neoplasia
Agoff, S. N., Brentnall, T. A., Crispin, D. A., Taylor, S. L., Raaka, S., Haggitt, R. C., Reed, M. W., Afonina, I. A., Rabinovitch, P. S., Stevens, A. C., et al. (2000) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64587-7 · Cited by 170 · see citing works
What Role Does Helicobacter pylori Play in Gastric Cancer?
Asaka, M., Takeda, H., Sugiyama, T., & Kato, M. (1997) · Gastroenterology · doi:10.1016/s0016-5085(97)80013-3 · Cited by 156 · see citing works
Kiemer, A. K., Bildner, N., Weber, N. C., & Vollmar, A. M. (2003) · Endocrinology · doi:10.1210/en.2002-220610 · Cited by 76 · see citing works
Solving the viral-chemical puzzle of human liver carcinogenesis.
Harris, C. C. (1994) · PubMed · Cited by 28 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Role of nrf2 in oxidative stress and toxicity
Ma, Q. (2013) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-011112-140320 · Cited by 4,903 · see citing works
The emerging role of the Nrf2–Keap1 signaling pathway in cancerPreprint
Jaramillo, M. C., & Zhang, D. D. (2013) · Genes & Development · doi:10.1101/gad.225680.113 · Cited by 1,304 · see citing works
NRF2 and cancer: the good, the bad and the importance of context
Sporn, M. B., & Liby, K. T. (2012) · Nature Reviews Cancer · doi:10.1038/nrc3278 · Cited by 1,067 · see citing works
The cytoprotective role of the Keap1–Nrf2 pathway
Baird, L., & Dinkova‐Kostova, A. T. (2011) · Archives of Toxicology · doi:10.1007/s00204-011-0674-5 · Cited by 1,029 · see citing works
Molecular basis of the Keap1–Nrf2 system
Suzuki, T., & Yamamoto, M. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.06.006 · Cited by 995 · see citing works
Oxidative stress response and Nrf2 signaling in aging
Zhang, H., Davies, K. J. A., & Forman, H. J. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.05.036 · Cited by 804 · see citing works
Nrf2, the Master Regulator of Anti-Oxidative Responses
Vomund, S., Schäfer, A., Parnham, M., Brüne, B., & Von Knethen, A. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18122772 · Cited by 752 · see citing works
Tian, T., Wang, Z., & Zhang, J. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/4535194 · Cited by 726 · see citing works
Brusatol enhances the efficacy of chemotherapy by inhibiting the Nrf2-mediated defense mechanism
Ren, D., Villeneuve, N. F., Jiang, T., Wu, T., Lau, A., Toppin, H. A., & Zhang, D. D. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1014275108 · Cited by 673 · see citing works
Oxidative stress and dietary phytochemicals: Role in cancer chemoprevention and treatment
Chikara, S., Nagaprashantha, L. D., Singhal, J., Horne, D. A., Awasthi, S., & Singhal, S. S. (2017) · Cancer Letters · doi:10.1016/j.canlet.2017.11.002 · Cited by 561 · see citing works
Cancer Chemoprevention Mechanisms Mediated Through the Keap1–Nrf2 Pathway
Hayes, J. D., McMahon, M. J., Chowdhry, S., & Dinkova‐Kostova, A. T. (2010) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3221 · Cited by 540 · see citing works
Nrf2: friend or foe for chemoprevention?
Kensler, T. W., & Wakabayashi, N. (2009) · Carcinogenesis · doi:10.1093/carcin/bgp231 · Cited by 487 · see citing works
Zhu, H., & Li, Y. R. (2012) · Experimental Biology and Medicine · doi:10.1258/ebm.2011.011358 · Cited by 432 · see citing works
Rapamycin inhibits the secretory phenotype of senescent cells by a Nrf2-independent mechanism
Wang, R., Yu, Z., Sunchu, B., Shoaf, J., Dang, I., Zhao, S., Caples, K., Bradley, L., Beaver, L. M., Ho, E., et al. (2017) · Aging Cell · doi:10.1111/acel.12587 · Cited by 360 · see citing works
Transforming Growth Factor-β-Induced Cell Plasticity in Liver Fibrosis and Hepatocarcinogenesis
Fabregat, I., & Caballero‐Díaz, D. (2018) · Frontiers in Oncology · doi:10.3389/fonc.2018.00357 · Cited by 352 · see citing works
Molecular Basis of Electrophilic and Oxidative Defense: Promises and Perils of Nrf2
Ma, Q., & He, X. (2012) · Pharmacological Reviews · doi:10.1124/pr.110.004333 · Cited by 317 · see citing works
Targeting NRF2 signaling for cancer chemoprevention
Kwak, M.-K., & Kensler, T. W. (2009) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2009.08.028 · Cited by 306 · see citing works
miR-200a Regulates Nrf2 Activation by Targeting Keap1 mRNA in Breast Cancer Cells
Eades, G. L., Yang, M., Yao, Y., Zhang, Y., & Zhou, Q. Y. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.275495 · Cited by 305 · see citing works
Inflammatory Bowel Disease: Mechanisms, Redox Considerations, and Therapeutic Targets
Biasi, F., Leonarduzzi, G., Oteiza, P. I., & Poli, G. (2013) · Antioxidants and Redox Signaling · doi:10.1089/ars.2012.4530 · Cited by 301 · see citing works
The Nrf2/HO‐1 Axis in Cancer Cell Growth and Chemoresistance
Furfaro, A. L., Traverso, N., Domenicotti, C., Piras, S., Moretta, L., Marinari, U. M., Pronzato, M. A., & Nitti, M. (2015) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/1958174 · Cited by 295 · see citing works
Oncogenic KRAS Confers Chemoresistance by Upregulating NRF2
Tao, S., Wang, S., Moghaddam, S. J., Ooi, A., Chapman, E., Wong, P. K., & Zhang, D. D. (2014) · Cancer Research · doi:10.1158/0008-5472.can-14-1439 · Cited by 291 · see citing works
Redox signaling in the gastrointestinal tract
Pérez, S., Taléns‐Visconti, R., Rius‐Pérez, S., Finamor, I., & Sastre, J. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.12.048 · Cited by 274 · see citing works
Liu, X., Zhang, X., Ding, Y., Zhou, W., Tao, L., Lü, P., Wang, Y., & Hu, R. (2016) · Antioxidants and Redox Signaling · doi:10.1089/ars.2015.6615 · Cited by 259 · see citing works
Satoh, H., Moriguchi, T., Takai, J., Ebina, M., & Yamamoto, M. P. (2013) · Cancer Research · doi:10.1158/0008-5472.can-12-4499 · Cited by 251 · see citing works
The Science behind Microgreens as an Exciting New Food for the 21st Century
Choe, U., Yu, L. L., & Wang, T. T. Y. (2018) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.8b03096 · Cited by 277 · see citing works
Lee, J. H., Khor, T. O., Shu, L., Su, Z., Fuentes, F., & Kong, A. T. (2012) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2012.09.008 · Cited by 248 · see citing works
Self-citationNrf2, a Guardian of Healthspan and Gatekeeper of Species Longevity
Lewis, K. N., Mele, J., Hayes, J. D., & Buffenstein, R. (2010) · Integrative and Comparative Biology · doi:10.1093/icb/icq034 · Cited by 247 · see citing works
Khor, T. O., Huang, Y. S., Wu, T., Shu, L., Lee, J. H., & Kong, A. T. (2011) · Biochemical Pharmacology · doi:10.1016/j.bcp.2011.07.065 · Cited by 245 · see citing works
Self-citationNrf2 protects against airway disorders
Cho, H., & Kleeberger, S. R. (2009) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2009.07.024 · Cited by 237 · see citing works
Nrf2 Expression Is Regulated by Epigenetic Mechanisms in Prostate Cancer of TRAMP Mice
Yu, S., Khor, T. O., Cheung, K., Li, W., Wu, T., Huang, Y. S., Foster, B. A., Kan, Y. W., & Kong, A. T. (2010) · PLoS ONE · doi:10.1371/journal.pone.0008579 · Cited by 228 · see citing works
Self-citationNrf2: control of sensitivity to carcinogens
Slocum, S. L., & Kensler, T. W. (2011) · Archives of Toxicology · doi:10.1007/s00204-011-0675-4 · Cited by 219 · see citing works
Cancer cell signaling pathways targeted by spice-derived nutraceuticals
Sung, B., Prasad, S., Yadav, V. R., & Aggarwal, B. B. (2012) · Nutrition and Cancer · doi:10.1080/01635581.2012.630551 · Cited by 204 · see citing works
Zhang, C., Su, Z., Khor, T. O., Shu, L., & Kong, A. T. (2013) · Biochemical Pharmacology · doi:10.1016/j.bcp.2013.02.010 · Cited by 202 · see citing works
Self-citationNrf2-deficiency creates a responsive microenvironment for metastasis to the lung
Satoh, H., Moriguchi, T., Taguchi, K., Takai, J., Maher, J. M., Suzuki, T., Winnard, P. T., Raman, V., Ebina, M., Nukiwa, T., et al. (2010) · Carcinogenesis · doi:10.1093/carcin/bgq105 · Cited by 197 · see citing works
Dietary antiaging phytochemicals and mechanisms associated with prolonged survival
Si, H., & Liu, D. (2014) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2014.02.001 · Cited by 196 · see citing works
Hu, R., Saw, C. L. L., Yu, R., & Kong, A. T. (2010) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3276 · Cited by 187 · see citing works
Self-citationFuentes, F., Paredes‐Gonzalez, X., & Kong, A. T. (2015) · Current Pharmacology Reports · doi:10.1007/s40495-015-0017-y · Cited by 185 · see citing works
Self-citationKang, K. A., Piao, M. J., Hyun, Y. J., Zhen, A. X., Cho, S. J., Ahn, M. J., Yi, J. M., & Hyun, J. W. (2019) · Experimental & Molecular Medicine · doi:10.1038/s12276-019-0238-y · Cited by 179 · see citing works
Wondrak, G. T., Villeneuve, N. F., Lamore, S. D., Bause, A. S., Jiang, T., & Zhang, D. D. (2010) · Molecules · doi:10.3390/molecules15053338 · Cited by 173 · see citing works
Kundu, J. K., & Surh, Y. (2010) · Pharmaceutical Research · doi:10.1007/s11095-010-0096-8 · Cited by 173 · see citing works
Anticancer Activity of Sulforaphane: The Epigenetic Mechanisms and the Nrf2 Signaling Pathway
Su, X., Jiang, X. M., Meng, L., Dong, X., Shen, Y., & Xin, Y. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/5438179 · Cited by 172 · see citing works
Metabolism and Tissue Distribution of Sulforaphane in Nrf2 Knockout and Wild-Type Mice
Clarke, J., Hsu, A., Williams, D. E., Dashwood, R. H., Stevens, J. F., Yamamoto, M. P., & Ho, E. (2011) · Pharmaceutical Research · doi:10.1007/s11095-011-0500-z · Cited by 169 · see citing works
Zhu, J., Wang, H., Chen, F., Fu, J., Xu, Y., Hou, Y., Kou, H. H., Zhai, C., Nelson, M. B., Zhang, Q., et al. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.09.010 · Cited by 162 · see citing works
Piotrowska, M., Świerczyński, M., Fichna, J., & Piechota-Polańczyk, A. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.105243 · Cited by 162 · see citing works
Hepatic stem cells and transforming growth factor β in hepatocellular carcinoma
Majumdar, A., Curley, S. A., Wu, X., Brown, P. H., Hwang, J. P., Shetty, K., Yao, Z., He, A. R., Li, S., Katz, L. H., et al. (2012) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2012.114 · Cited by 161 · see citing works
Dual roles of NRF2 in tumor prevention and progression: Possible implications in cancer treatment
Moon, E. J., & Giaccia, A. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2014.11.009 · Cited by 160 · see citing works
Su, Z., Zhang, C., Lee, J. H., Shu, L., Wu, T., Khor, T. O., Conney, A. H., Lu, Y.-P., & Kong, A. T. (2014) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-13-0313-t · Cited by 143 · see citing works
Self-citationYeligar, S. M., Machida, K., & Kalra, V. K. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.138636 · Cited by 137 · see citing works
Tao, S., de la Vega, M. R., Chapman, E., Ooi, A., & Zhang, D. D. (2017) · Molecular Carcinogenesis · doi:10.1002/mc.22745 · Cited by 136 · see citing works
Gallic acid attenuates dextran sulfate sodium-induced experimental colitis in BALB/c mice
Pandurangan, A. K., Norhaizan, M. E., Mohebali, N., & Looi, C. Y. (2015) · Drug Design Development and Therapy · doi:10.2147/dddt.s86345 · Cited by 133 · see citing works
Regulation of antioxidants in cancer
Hecht, F., Zocchi, M., Alimohammadi, F., & Harris, I. S. (2023) · Molecular Cell · doi:10.1016/j.molcel.2023.11.001 · Cited by 135 · see citing works
Pandurangan, A. K., & Esa, N. M. (2014) · Asian Pacific Journal of Cancer Prevention · doi:10.7314/apjcp.2014.15.14.5501 · Cited by 131 · see citing works
Mahmoud, A. M., Mohammed, H. M., Khadrawy, S. M., & Galaly, S. R. (2017) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2017.09.015 · Cited by 129 · see citing works
Adesso, S., Russo, R., Quaroni, A., Autore, G., & Marzocco, S. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19030800 · Cited by 127 · see citing works
Senger, D. R., Li, D., Jaminet, S.-C., & Cao, S. (2016) · PLOS ONE · doi:10.1371/journal.pone.0148042 · Cited by 124 · see citing works
Chen, H., Qian, Y., Jiang, C., Tang, L., Yu, J., Zhang, L., Dai, Y., & Jiang, G. Z. (2023) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2023.166984 · Cited by 127 · see citing works
Li, J., Chen, H., Wang, B., Cai, C., Yang, X., Chai, Z., & Feng, W. (2017) · Scientific Reports · doi:10.1038/srep43126 · Cited by 122 · see citing works
Zhang, Y.-B., Yan, T., Sun, D., Xie, C., Wang, T., Liu, X., Wang, J., Wang, Q., Luo, Y., Wang, P., et al. (2019) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2019.12.012 · Cited by 120 · see citing works
Induction of NRF2‐mediated gene expression by dietary phytochemical flavones apigenin and luteolin
Paredes‐Gonzalez, X., Fuentes, F., Jeffery, S., Saw, C. L. L., Shu, L., Su, Z., & Kong, A. T. (2015) · Biopharmaceutics & Drug Disposition · doi:10.1002/bdd.1956 · Cited by 118 · see citing works
Self-citationNrf2 Knockout Attenuates the Anti-Inflammatory Effects of Phenethyl Isothiocyanate and Curcumin
Boyanapalli, S. S. S., Paredes‐Gonzalez, X., Fuentes, F., Zhang, C., Guo, Y., Pung, D., Saw, C. L. L., & Kong, A. T. (2014) · Chemical Research in Toxicology · doi:10.1021/tx500234h · Cited by 113 · see citing works
Self-citationp62/ SQSTM 1—Dr. Jekyll and Mr. Hyde that prevents oxidative stress but promotes liver cancer
Taniguchi, K., Yamachika, S., He, F., & Karin, M. (2016) · FEBS Letters · doi:10.1002/1873-3468.12301 · Cited by 112 · see citing works
Myeloid-Derived Suppressor Cell Survival and Function Are Regulated by the Transcription Factor Nrf2
Beury, D. W., Carter, K. A., Nelson, C. E., Sinha, P., Hanson, E. M., Nyandjo, M., Fitzgerald, P., Majeed, A., Wali, N., & Ostrand‐Rosenberg, S. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1501785 · Cited by 111 · see citing works
Amin, A., Gad, A. Y., Salilew‐Wondim, D., Prastowo, S., Held-Hoelker, E., Hoelker, M., Rings, F., Tholen, E., Neuhoff, C., Looft, C., et al. (2014) · Molecular Reproduction and Development · doi:10.1002/mrd.22316 · Cited by 109 · see citing works
Bai, X., Gou, X., Cai, P., Xu, C., Cao, L., Zhao, Z., Huang, M., & Jin, J. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/2432416 · Cited by 108 · see citing works
Self-citationRetractedResveratrol and resveratrol nano-delivery systems in the treatment of inflammatory bowel disease
Gowd, V., Kanika, Jori, C., Chaudhary, A. A., Rudayni, H. A., Rashid, S., & Khan, R. (2022) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2022.109101 · Cited by 108 · see citing works
Chartoumpekis, D. V., & Kensler, T. W. (2013) · Current Diabetes Reviews · doi:10.2174/1573399811309020005 · Cited by 104 · see citing works
Curcumin: a therapeutic strategy in cancers by inhibiting the canonical WNT/β-catenin pathway
Vallée, A., Lecarpentier, Y., & Vallée, J.-N. (2019) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-019-1320-y · Cited by 104 · see citing works
The role of Nrf2 in the pathogenesis and treatment of ulcerative colitis
Peng, S., Shen, L., Yu, X., Zhang, L., Xu, K., Xia, Y., Zha, L., Wu, J., & Luo, H. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1200111 · Cited by 103 · see citing works
Li, W., Guo, Y., Zhang, C., Wu, R., Yang, Y., Gaspar, J. M., & Kong, A. T. (2016) · Chemical Research in Toxicology · doi:10.1021/acs.chemrestox.6b00413 · Cited by 101 · see citing works
Self-citationZuo, Q., Wu, R., Xiao, X., Yang, C., Yang, Y., Wang, C., Lin, L., & Kong, A. T. (2018) · Journal of Cellular Biochemistry · doi:10.1002/jcb.27275 · Cited by 100 · see citing works
Self-citationTargeted Deletion of Nrf2 Reduces Urethane-Induced Lung Tumor Development in Mice
Bauer, A. K., Cho, H., Miller‐DeGraff, L., Walker, C., Helms, K. L., Fostel, J. M., Yamamoto, M. P., & Kleeberger, S. R. (2011) · PLoS ONE · doi:10.1371/journal.pone.0026590 · Cited by 95 · see citing works
Nrf2 target genes are induced under marginal selenium-deficiency
Müller, M. F., Banning, A., Brigelius‐Flohé, R., & Kipp, A. P. (2010) · Genes & Nutrition · doi:10.1007/s12263-010-0168-8 · Cited by 95 · see citing works
Vallée, A., Lecarpentier, Y., & Vallée, J.-N. (2019) · Cells · doi:10.3390/cells8070726 · Cited by 92 · see citing works
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Khurana, N., & Sikka, S. C. (2018) · Cancers · doi:10.3390/cancers10100352 · Cited by 91 · see citing works
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Wagner, A. E., Will, O., Sturm, C., Lipinski, S., Rosenstiel, P. C., & Rimbach, G. H. (2013) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2013.07.009 · Cited by 91 · see citing works
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Schäfer, H., Geismann, C., Arlt, A., & Sebens, S. (2014) · OncoTargets and Therapy · doi:10.2147/ott.s36624 · Cited by 90 · see citing works
Erdélyi, I., Levenkova, N., Lin, E. Y., Pinto, J. T., Lipkin, M., Quimby, F. W., & Holt, P. R. (2009) · Journal of Nutrition · doi:10.3945/jn.108.104125 · Cited by 90 · see citing works
Jeddi, F., Soozangar, N., Sadeghi, M. R., Somi, M. H., & Samadi, N. (2017) · DNA repair · doi:10.1016/j.dnarep.2017.03.008 · Cited by 90 · see citing works
Nrf2 Mutagenic Activation Drives Hepatocarcinogenesis
Ngo, H. K. C., Kim, D., Cha, Y., Na, H., & Surh, Y. (2017) · Cancer Research · doi:10.1158/0008-5472.can-16-3538 · Cited by 88 · see citing works
Emerging Pathological Engagement of Ferroptosis in Gut Diseases
Gao, W., Zhang, T., & Wu, H. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/4246255 · Cited by 88 · see citing works
Cheung, K. L., Lee, J. H., Khor, T. O., Wu, T., Li, G. X., Chan, J. Y., Yang, C. S., & Kong, A. T. (2012) · Molecular Carcinogenesis · doi:10.1002/mc.21950 · Cited by 87 · see citing works
Self-citationLong, M., Tao, S., Rojo de la Vega, M., Jiang, T., Wen, Q., Park, S. L., Zhang, D. D., & Wondrak, G. T. (2015) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-14-0359 · Cited by 86 · see citing works
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Self-citationWu, X., Song, M., Gao, Z., Sun, Y., Wang, M., Li, F., Zheng, J., & Xiao, H. (2017) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2016.12.020 · Cited by 84 · see citing works
Chen, H., Fu, J., Chen, H., Hu, Y., Soroka, D. N., Prigge, J. R., Schmidt, E. E., Yan, F., Major, M. B., Chen, X. L., et al. (2014) · Chemical Research in Toxicology · doi:10.1021/tx500211x · Cited by 84 · see citing works
Shen, T., Jiang, T., Long, M., Chen, J., Ren, D.-M., Wong, P. K., Chapman, E., Zhou, B., & Zhang, D. D. (2015) · Antioxidants and Redox Signaling · doi:10.1089/ars.2014.6074 · Cited by 83 · see citing works
Lippmann, D., Lehmann, C., Florian, S., Barknowitz, G., Haack, M., Mewis, I., Wiesner‐Reinhold, M., Schreiner, M., Glatt, H. R., Brigelius‐Flohé, R., et al. (2014) · Food & Function · doi:10.1039/c3fo60676g · Cited by 83 · see citing works
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Chen, H., & Chen, R. (2016) · Frontiers in Oncology · doi:10.3389/fonc.2016.00113 · Cited by 82 · see citing works
Chen, F., Wang, H., Zhu, J., Zhao, R., Xue, P., Zhang, Q., Nelson, M. B., Qu, W., Feng, B., & Pi, J. (2017) · British Journal of Cancer · doi:10.1038/bjc.2017.317 · Cited by 81 · see citing works
Trivedi, P. P., & Jena, G. (2013) · Food and Chemical Toxicology · doi:10.1016/j.fct.2013.06.019 · Cited by 80 · see citing works
Kim, H., Ramirez, C. N., Su, Z., & Kong, A. T. (2015) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2015.09.014 · Cited by 78 · see citing works
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Sadeghi, M. R., Jeddi, F., Soozangar, N., Somi, M. H., & Samadi, N. (2017) · Tumor Biology · doi:10.1177/1010428317705510 · Cited by 76 · see citing works
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Jeddi, F., Soozangar, N., Sadeghi, M. R., Somi, M. H., Shirmohamadi, M., Eftekhar-Sadat, A.-T., & Samadi, N. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2017.10.129 · Cited by 75 · see citing works
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Cheng, D., Gao, L., Su, S., Sargsyan, D., Wu, R., Raskin, I., & Kong, A. T. (2019) · The AAPS Journal · doi:10.1208/s12248-019-0301-6 · Cited by 75 · see citing works
Self-citationKavitha, K., Thiyagarajan, P., Nandhini, J. R., Mishra, R., & Nagini, S. (2013) · Biochimie · doi:10.1016/j.biochi.2013.05.004 · Cited by 74 · see citing works
Inhibiting Ferroptosis: A Novel Approach for Ulcerative Colitis Therapeutics
Huang, J., Zhang, J., Ma, J., Ma, J., Liu, J., Wang, F., & Tang, X. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/9678625 · Cited by 73 · see citing works
Zinc and Selenium in Inflammatory Bowel Disease: Trace Elements with Key Roles?
Vaghari‐Tabari, M., Jafari-Gharabaghlou, D., Sadeghsoltani, F., Hassanpour, P., Qujeq, D., Rashtchizadeh, N., & Ghorbanihaghjo, A. (2020) · Biological Trace Element Research · doi:10.1007/s12011-020-02444-w · Cited by 71 · see citing works
Epigenetic Regulation by Sulforaphane: Opportunities for Breast and Prostate Cancer Chemoprevention
Atwell, L. L., Beaver, L. M., Shannon, J., Williams, D. E., Dashwood, R. H., & Ho, E. (2015) · Current Pharmacology Reports · doi:10.1007/s40495-014-0002-x · Cited by 71 · see citing works
Ostrand‐Rosenberg, S., Beury, D. W., Parker, K. H., & Horn, L. A. (2019) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-019-02388-8 · Cited by 71 · see citing works
Rajendran, P., Dashwood, W., Li, L., Kang, Y., Kim, E., Johnson, G. S., Fischer, K. A., Löhr, C. V., Williams, D. E., Ho, E., et al. (2015) · Clinical Epigenetics · doi:10.1186/s13148-015-0132-y · Cited by 70 · see citing works
- Authors
- Khor, T. O., Huang, M.-T., Prawan, A., Liu, Y., Hao, X., Yu, S., Cheung, W. K. L., Chan, J. Y., Reddy, B. S., Yang, C. S., & Kong, A.-N.
- Affiliations
- Rutgers, The State University of New Jersey (US)
- Corresponding author
- Kong, Ah-Ng
- Venue
- Cancer Prevention Research
- Published
- 2008-07-25
- Volume
- 1
- Issue
- 3
- Pages
- 187-191
- ISSN
- 1940-6207 (ISSN-L)
- 1940-6215
- PMC
- PMC3580177
- OpenAlex
- W2141004419
- Cited by
- 306
- References
- 22
- Citations by year
- 2026: 6 · 2025: 9 · 2024: 9 · 2023: 17 · 2022: 18 · 2021: 10 · 2020: 23 · 2019: 28 · 2018: 21 · 2017: 34 · 2016: 22 · 2015: 22 · 2014: 18 · 2013: 16 · 2012: 16
- FWCI
- 5.07
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Cancer Prevention Research (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Cancer Institute (R01CA073674)
- National Institute of Environmental Health Sciences (P30ES005022)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics, phytochemicals, and oxidative stress
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Bioactive Compounds and Antitumor Agents
- Keywords
- Nrf2, colitis-associated colorectal cancer, Nrf2 knockout mice, inflammation-associated carcinogenesis, colorectal adenoma, cyclooxygenase-2, 5-lipoxygenase, prostaglandin E2, leukotriene B4, nitrotyrosine, UDP-glucuronosyltransferase 1A1, phase II enzymes, antioxidant defense
- MeSH terms
- Adenocarcinoma, Adenoma, Animals, Azoxymethane, Colitis, Male, Mice, Inbred C57BL, Colorectal Neoplasms, Gene Expression Regulation, Neoplastic, Dextran Sulfate, Mice, Knockout, Cytoprotection, Genetic Predisposition to Disease, NF-E2-Related Factor 2, Mice, Cyclooxygenase 2
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