The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Cancer Prevention and Treatment with Resveratrol: From Rodent Studies to Clinical Trials
Abstract
Resveratrol (3,4′,5-trihydroxy-trans-stilbene) is a dietary polyphenol derived from grapes, berries, peanuts, and other plant sources. During the last decade, resveratrol has been shown to possess a fascinating spectrum of pharmacologic properties. Multiple biochemical and molecular actions seem to contribute to resveratrol effects against precancerous or cancer cells. Resveratrol affects all three discrete stages of carcinogenesis (initiation, promotion, and progression) by modulating signal transduction pathways that control cell division and growth, apoptosis, inflammation, angiogenesis, and metastasis. The anticancer property of resveratrol has been supported by its ability to inhibit proliferation of a wide variety of human tumor cells in vitro. These in vitro data have led to numerous preclinical animal studies to evaluate the potential of this drug for cancer chemoprevention and chemotherapy. This review provides concise, comprehensive data from preclinical in vivo studies in various rodent models of human cancers, highlighting the related mechanisms of action. Bioavailability, pharmacokinetic, and potential toxicity studies of resveratrol in humans and ongoing interventional clinical trials are also presented. The conclusion describes directions for future resveratrol research to establish its activity and utility as a human cancer preventive and therapeutic drug.
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Cancer chemopreventive activity of resveratrol, a natural product derived from grapes
Jang, M., Cai, L., Udeani, G. O., Slowing, K. V., Thomas, C. F., Beecher, C. W. W., Fong, H. H. S., Farnsworth, N. R., Kinghorn, A. D., Mehta, R. G., et al. (1997) · Science · doi:10.1126/science.275.5297.218 · Cited by 4,935 · cited 1×
“(12), the first animal study of the chemopreventive effects of resveratrol was reported in a two-stage mouse skin carcinogenesis model.”
BackgroundResveratrol improves health and survival of mice on a high-calorie diet
Baur, J. A., Pearson, K. J., Price, N. L., Jamieson, H. A., Lerin, C., Kalra, A., Prabhu, V. V., Allard, J. S., Lopez-Lluch, G., Lewis, K., et al. (2006) · Nature · doi:10.1038/nature05354 · Cited by 4,290
Lagouge, M., Argmann, C., Gerhart-Hines, Z., Meziane, H., Lerin, C., Daussin, F., Messadeq, N., Milne, J., Lambert, P., Elliott, P., et al. (2006) · Cell · doi:10.1016/j.cell.2006.11.013 · Cited by 4,057
Inhibition of cancer growth by resveratrol is related to its low bioavailability
Asensi, M., Medina, I., Ortega, A., Carretero, J., Baño, M. C., Obrador, E., & Estrela, J. M. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)00911-5 · Cited by 388
Afaq, F., Adhami, V. M., & Ahmad, N. (2003) · Toxicology and Applied Pharmacology · doi:10.1016/s0041-008x(02)00014-5 · Cited by 262
Kapadia, G. J., Azuine, M. A., Tokuda, H., Takasaki, M., Mukainaka, T., Konoshima, T., & Nishino, H. (2002) · Pharmacological Research · doi:10.1006/phrs.2002.0992 · Cited by 238
Cited by
Anticancer Efficacy of Polyphenols and Their Combinations
Niedzwiecki, A., Roomi, M., Kalinovsky, T., & Rath, M. (2016) · Nutrients · doi:10.3390/nu8090552 · Cited by 538
Resveratrol: French Paradox Revisited
Catalgol, B., Batirel, S., Taga, Y., & Ozer, N. K. (2012) · Frontiers in Pharmacology · doi:10.3389/fphar.2012.00141 · Cited by 449
Tili, E., Michaille, J.-J., Alder, H., Volinia, S., Delmas, D., Latruffe, N., & Croce, C. M. (2010) · Biochemical Pharmacology · doi:10.1016/j.bcp.2010.07.003 · Cited by 237
Resveratrol Reduces Prostate Cancer Growth and Metastasis by Inhibiting the Akt/MicroRNA-21 Pathway
Sheth, S., Jajoo, S., Kaur, T., Mukherjea, D., Sheehan, K., Rybak, L. P., & Ramkumar, V. (2012) · PLoS ONE · doi:10.1371/journal.pone.0051655 · Cited by 225
Role of Drug Delivery System in Improving the Bioavailability of Resveratrol
Saleem, Z., Rehman, K., & Hamid Akash, M. S. (2022) · Current Pharmaceutical Design · doi:10.2174/1381612828666220705113514 · Cited by 34
Metadata
- Authors
- Bishayee, A.
- Venue
- Cancer Prevention Research
- Published
- 2009-05-01
- Volume
- 2
- Issue
- 5
- Pages
- 409-418
- ISSN
- 1940-6207 (ISSN-L)
- 1940-6215
- OpenAlex
- W2112479759
- Cited by
- 528
- References
- 6
- FWCI
- 23.71
- Type
- journal article
- Language
- en
- Open access
- closed
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