HIF2α-Dependent Lipid Storage Promotes Endoplasmic Reticulum Homeostasis in Clear-Cell Renal Cell Carcinoma

The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation

Walter, P., & Ron, D. (2011) · Science · doi:10.1126/science.1209038 · Cited by 5,897

Targeting Hypoxia-Inducible Factors for the Treatment of Anemia in Chronic Kidney Disease Patients

Locatelli, F., Fishbane, S. N., Block, G. A., & Macdougall, I. C. (2017) · American Journal of Nephrology · doi:10.1159/000455166 · Cited by 4,836

Comprehensive molecular characterization of clear cell renal cell carcinoma

The Cancer Genome Atlas Research Network (2013) · Nature · doi:10.1038/nature12222 · Cited by 3,485

Triglyceride accumulation protects against fatty acid-induced lipotoxicity

Listenberger, L. L., Han, X., Lewis, S. E., Cases, S., Farese, R. V., Ory, D. S., & Schaffer, J. E. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0630588100 · Cited by 2,075

Activation of a metabolic gene regulatory network downstream of mTOR complex 1

Düvel, K., Yecies, J. L., Menon, S., Raman, P., Lipovsky, A. I., Souza, A. L., Triantafellow, E., Ma, Q., Gorski, R., Cleaver, S., et al. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.06.022 · Cited by 2,020

SUnSET, a nonradioactive method to monitor protein synthesis

Schmidt, E. K., Clavarino, G., Ceppi, M., & Pierre, P. (2009) · Nature Methods · doi:10.1038/nmeth.1314 · Cited by 1,706

Lipid Droplets and Cellular Lipid Metabolism

Walther, T. C., & Farese, R. V. (2012) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-061009-102430 · Cited by 1,701

HIF1α and HIF2α: sibling rivalry in hypoxic tumour growth and progression

Keith, B., Johnson, R. S., & Simon, M. C. (2012) · Nature Reviews Cancer · doi:10.1038/nrc3183 · Cited by 1,693

Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells

Commisso, C., Davidson, S. M., Soydaner-Azeloglu, R. G., Parker, S. J., Kamphorst, J. J., Hackett, S., Grabocka, E., Nofal, M., Drebin, J. A., Thompson, C. B., et al. (2013) · Nature · doi:10.1038/nature12138 · Cited by 1,683

Differential Roles of Hypoxia-Inducible Factor 1α (HIF-1α) and HIF-2α in Hypoxic Gene Regulation

Hu, C.-J., Wang, L.-Y., Chodosh, L. A., Keith, B., & Simon, M. C. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.24.9361-9374.2003 · Cited by 1,386

Altered expression of metabolic pathways in CLL detected by unlabelled quantitative mass spectrometry analysis

Thurgood, L. A., Dwyer, E. S., Lower, K. M., Chataway, T., & Kuss, B. J. (2019) · British Journal of Haematology · doi:10.1111/bjh.15751 · Cited by 23

m6A modification of lipoyltransferase 1 inhibits bladder cancer progression by activating cuproptosis

Du, K., Luo, Y., Zhang, L., Zeng, Y., Dai, Y., Ren, M., Pan, W., Liu, Y., Tian, F., Zhou, L., et al. (2024) · Oncogene · doi:10.1038/s41388-024-03139-5 · Cited by 22

WY-14643 attenuates lipid deposition via activation of the PPARα/CPT1A axis by targeting Gly335 to inhibit cell proliferation and migration in ccRCC

Wang, R., Zhao, J., Jin, J., Tian, Y., Lan, L., Wang, X., Zhu, L., & Wang, J. (2022) · Lipids in Health and Disease · doi:10.1186/s12944-022-01726-7 · Cited by 22

Coalescing lessons from oxygen sensing, tumor metabolism, and epigenetics to target VHL loss in kidney cancer

Chakraborty, A. A. (2020) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2020.03.012 · Cited by 22

Lipidomics and metabolomics as potential biomarkers for breast cancer progression

Carmona, A., Mitri, S., James, T. A., & Ubellacker, J. M. (2024) · npj Metabolic Health and Disease · doi:10.1038/s44324-024-00027-0 · Cited by 21

Lipid droplet storage promotes murine pancreatic tumor growth

Grachan, J. J., Kery, M., Giaccia, A. J., Denko, N. C., & Papandreou, I. (2021) · Oncology Reports · doi:10.3892/or.2021.7972 · Cited by 21

A novel lipid metabolism gene signature for clear cell renal cell carcinoma using integrated bioinformatics analysis

Li, K., Zhu, Y., Cheng, J., Li, A., Liu, Y., Yang, X., Huang, H., Peng, Z., & Xu, H. M. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1078759 · Cited by 21

A novel HIF2A mutation causes dyslipidemia and promotes hepatic lipid accumulation

Gao, F., Yao, Q., Zhu, J., Chen, W., Feng, X., Feng, B., Wu, J., Pacák, K., Rosenblum, J. S., Yu, J., et al. (2023) · Pharmacological Research · doi:10.1016/j.phrs.2023.106851 · Cited by 22

Lipid Droplet-Associated Factors, PNPLA3, TM6SF2, and HSD17B Proteins in Hepatopancreatobiliary Cancer

Sunami, Y., Rebelo, A., & Kleeff, J. H. (2021) · Cancers · doi:10.3390/cancers13174391 · Cited by 21

Loss of HSulf-1: The Missing Link between Autophagy and Lipid Droplets in Ovarian Cancer

Roy, D., Mondal, S., Khurana, A., Jung, D., Hoffmann, R. G., He, X., Kalogera, E., Dierks, T., Hammond, E., Dredge, K. S., et al. (2017) · Scientific Reports · doi:10.1038/srep41977 · Cited by 20

Metabolic ripple effects – deciphering how lipid metabolism in cancer interfaces with the tumor microenvironment

Jonker, P. B., & Muir, A. (2024) · Disease Models & Mechanisms · doi:10.1242/dmm.050814 · Cited by 21

Role of Metabolic Reprogramming of Long non-coding RNA in Clear Cell Renal Cell Carcinoma

Zhang, H., Yu, L., Chen, J., Liu, L., Yang, X., Cui, H., & Genquan, Y. (2022) · Journal of Cancer · doi:10.7150/jca.62683 · Cited by 19

P4HA2: A link between tumor-intrinsic hypoxia, partial EMT and collective migration

Aggarwal, V., Sahoo, S., Donnenberg, V. S., Chakraborty, P., Jolly, M. K., & Sant, S. (2022) · Advances in Cancer Biology - Metastasis · doi:10.1016/j.adcanc.2022.100057 · Cited by 19

S1P signaling, its interactions and cross-talks with other partners and therapeutic importance in colorectal cancer

Sattar, R. S. A., Sumi, M. P., Nimisha, Apurva, A., Kumar, A., Sharma, A. K., Ahmad, E., Ali, A., Mahajan, B., & Saluja, S. S. (2021) · Cellular Signalling · doi:10.1016/j.cellsig.2021.110080 · Cited by 19

PLIN2 promotes HCC cells proliferation by inhibiting the degradation of HIF1α

Liu, W., Liu, X., Liu, Y., Ling, T., Chen, D., Otkur, W., Zhao, H., Ma, M., Ma, K., Dong, B., et al. (2022) · Experimental Cell Research · doi:10.1016/j.yexcr.2022.113244 · Cited by 20

Hif-2α regulates lipid metabolism in alcoholic fatty liver disease through mitophagy

Wu, M., Zhang, G., Liu, T., Shen, J.-H., Cheng, J., Shen, J., Yang, T., Huang, C., & Zhang, L. (2022) · Cell & Bioscience · doi:10.1186/s13578-022-00889-1 · Cited by 18

miR-1182-mediated ALDH3A2 inhibition affects lipid metabolism and progression in ccRCC by activating the PI3K-AKT pathway

Lv, Q., Shi, J., Miao, D., Tan, D., Zhao, C., Xiong, Z., & Zhang, X. (2023) · Translational Oncology · doi:10.1016/j.tranon.2023.101835 · Cited by 18

Current advances on the role of ferroptosis in tumor immune evasion

Gao, C., Zhang, H., & Wang, X. (2024) · Discover Oncology · doi:10.1007/s12672-024-01573-1 · Cited by 18

Hydroxyl-HIF2-alpha is potential therapeutic target for renal cell carcinomas.

Isono, T., Chano, T., Yoshida, T., Kageyama, S., Kawauchi, A., Suzaki, M., & Yuasa, T. (2016) · PubMed Central · Cited by 18

Transcriptome-proteome integration of archival human renal cell carcinoma biopsies enables identification of molecular mechanisms

Koch, E., Finne, K., Eikrem, Ø., Landolt, L. Z., Beisland, C., Leh, S. M., Delaleu, N., Granly, M., Vikse, B. E., Osman, T., et al. (2019) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00424.2018 · Cited by 18

Lipid Metabolism in Cancer Cells

Zheng, M., Wang, W., Liu, J., Zhang, X., & Zhang, R. (2021) · Advances in experimental medicine and biology · doi:10.1007/978-981-33-6785-2_4 · Cited by 19

Exosomal Lipids in Cancer Progression and Metastasis

Ramu, D., & Kim, E. (2025) · Cancer Medicine · doi:10.1002/cam4.70687 · Cited by 17

Viscosity-Sensitive Solvatochromic Fluorescent Probes for Lipid Droplets Staining

Wang, M., Cui, W.-L., Yang, Y.-H., & Wang, J. (2022) · Biosensors · doi:10.3390/bios12100851 · Cited by 17

Serum lipoprotein–derived fatty acids regulate hypoxia-inducible factor

Shao, W., Hwang, J., Liu, C., Mukhopadhyay, D., Zhao, S., Shen, M., Alpergin, E. S. S., Wolfgang, M. J., Farber, S. A., & Espenshade, P. J. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.ra120.015238 · Cited by 17

ADFP promotes cell proliferation in lung adenocarcinoma via Akt phosphorylation

Meng, X., Sun, R., Wang, W., Zhang, N., Cao, S., Liu, B., Fang, P., Deng, S., & Yang, S. (2020) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.16136 · Cited by 17

HIF-2α/LPCAT1 orchestrates the reprogramming of lipid metabolism in ccRCC by modulating the FBXW7-mediated ubiquitination of ACLY

Fei, M., Zhang, Y., Li, H., Xu, Q., Gao, Y., Yang, C., Li, W., Liang, C. Y., Wang, B., & Xiao, H. (2024) · International Journal of Biological Sciences · doi:10.7150/ijbs.103032 · Cited by 16

Perilipin 2 Impacts Acute Kidney Injury via Regulation of PPARα

Xu, S., Lee, E., Sun, Z., Wang, X., Ren, T., Zou, Z., Jin, J., Li, J., Zhang, J., Li, Y., et al. (2021) · Journal of Immunology Research · doi:10.1155/2021/9972704 · Cited by 16

Inhibition of oxygen-sensing prolyl hydroxylases increases lipid accumulation in human primary tubular epithelial cells without inducing ER stress

Schley, G., Grampp, S., & Goppelt‐Struebe, M. (2020) · Cell and Tissue Research · doi:10.1007/s00441-020-03186-w · Cited by 16

HIF2α promotes tumour growth in clear cell renal cell carcinoma by increasing the expression of NUDT1 to reduce oxidative stress

Shi, J., Xiong, Z., Wang, K., Yuan, C., Huang, Y., Xiao, W., Meng, X., Chen, Z., Lv, Q., Miao, D., et al. (2021) · Clinical and Translational Medicine · doi:10.1002/ctm2.592 · Cited by 17

Recent progress in the development of hypoxia-inducible factor 2α (HIF-2α) modulators: Inhibitors, agonists, and degraders (2009–2024)

Cheng, B., Ma, X.-S., Zhou, Y., Liu, J., Fei, X., Pan, W., Peng, X., Wang, W., & Chen, J. (2024) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2024.116645 · Cited by 17

Perilipin2-dependent lipid droplets accumulation promotes metastasis of oral squamous cell carcinoma via epithelial-mesenchymal transition

Zhang, J., Peng, J., Wang, S., Wang, L. P., Sun, Y., Xia, J., Cheng, B., & Hu, Q. (2025) · Cell Death Discovery · doi:10.1038/s41420-025-02314-1 · Cited by 15

Imaging of cancer lipid metabolism in response to therapy

Arlauckas, S. P., Browning, E. A., Poptani, H., & Delikatny, E. J. (2019) · NMR in Biomedicine · doi:10.1002/nbm.4070 · Cited by 15

Biomarker Screening and Prognostic Significance Analysis for Renal Cell Carcinoma

Meng, X., Yuan, H., Li, W., Xiao, W., & Zhang, X. (2021) · International Journal of General Medicine · doi:10.2147/ijgm.s325347 · Cited by 15

Development of a Novel Sphingolipid Signaling Pathway-Related Risk Assessment Model to Predict Prognosis in Kidney Renal Clear Cell Carcinoma

Sun, Y., Xu, Y., Che, X., & Wu, G. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.881490 · Cited by 15

Falcarindiol Purified From Carrots Leads to Elevated Levels of Lipid Droplets and Upregulation of Peroxisome Proliferator-Activated Receptor-γ Gene Expression in Cellular Models

Andersen, C. B., Walther, A. R., Pipó-Ollé, E., Notabi, M. K., Juul, S., Eriksen, M. H., Lovatt, A. L., Cowie, R., Linnet, J., Kobæk-Larsen, M., et al. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.565524 · Cited by 15

FABP5 is a key player in metabolic modulation and NF-κB dependent inflammation driving pleural mesothelioma

Vecchio, E., Gallo, R., Mimmi, S., Gentile, D., Giordano, C., Straface, E., Marino, R., Caiazza, C., Pastore, A., Ruocco, M. R., et al. (2025) · Communications Biology · doi:10.1038/s42003-025-07754-0 · Cited by 15

Lipid droplet - organelle crosstalk and its implication in cancer

Quan, J., Zhang, C., Chen, X., Cai, X., & Luo, X. (2025) · Progress in Biophysics and Molecular Biology · doi:10.1016/j.pbiomolbio.2025.05.002 · Cited by 13

Single-cell multi-omics reveals that FABP1 + renal cell carcinoma drive tumor angiogenesis through the PLG-PLAT axis under fatty acid reprogramming

Wang, Y., Liang, Y., Li, M., Lu, J., Zhou, S., Yu, Y., Yang, C., & Hou, X. (2025) · Molecular Cancer · doi:10.1186/s12943-025-02377-9 · Cited by 13

Emerging roles of metabolic biomarkers in renal cell carcinoma: from molecular mechanisms to clinical implications

Yang, J., Miao, D., Li, X., Zhao, C., Tan, D., Wu, S., Lu, F., Shi, J., Lv, Q., Ruan, H., et al. (2025) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2025.1664292 · Cited by 15

Expression and activation of nuclear hormone receptors result in neuronal differentiation and favorable prognosis in neuroblastoma

Sainero‐Alcolado, L., Mushtaq, M., Liaño-Pons, J., Rodriguez‐Garcia, A., Yuan, Y., Liu, T., Ruiz-Pérez, M. V., Schlisio, S., Bedoya-Reina, O. C., & Arsenian‐Henriksson, M. (2022) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-022-02399-x · Cited by 13

Unfolded protein response at the cross roads of tumourigenesis, oxygen sensing and drug resistance in clear cell renal cell carcinoma

Chee, Y. H., Samali, A., & Robinson, C. M. (2022) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2022.188814 · Cited by 14

LPCAT2-mediated lipid droplet production supports pancreatic cancer chemoresistance and cell motility

Lin, Y., Zhang, X., Wang, Y., & Wei, Y. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.112681 · Cited by 13

High VHL Expression Reverses Warburg Phenotype and Enhances Immunogenicity in Kidney Tumor Cells

Zhu, S., Ding, W., Chen, Y., Wang, W., Xu, R., Liu, C., Liu, X., & Deng, H. (2021) · Genomics Proteomics & Bioinformatics · doi:10.1016/j.gpb.2019.12.002 · Cited by 12

Renoprotective Role of Hypoxia-Inducible Factors and the Mechanism

Li, Q., Liu, F., Xiaoxiao, T., Fu, H., & Mao, J. (2021) · Kidney Diseases · doi:10.1159/000520141 · Cited by 14

A metabolic reprogramming-related prognostic risk model for clear cell renal cell carcinoma: From construction to preliminary application

Zhang, Q., Ding, L., Zhou, T.-R., Zhai, Q., Ni, C., Liang, C., & Li, J. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.982426 · Cited by 12

Transcription-Based Multidimensional Regulation of Fatty Acid Metabolism by HIF1α in Renal Tubules

Li, W., Duan, A., Xing, Y., Xu, L., & Yang, J. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.690079 · Cited by 13

SREBF1 mediates immunoparalysis of dendritic cells in sepsis by regulating lipid metabolism and endoplasmic reticulum stress

Zhang, Y., Wu, F., Li, Y., Liu, J., Zhu, L., Zhang, M., & Lu, Z. (2025) · Cell Communication and Signaling · doi:10.1186/s12964-025-02295-9 · Cited by 12

Mammalian SIRT4 is a tumor suppressor of clear cell renal cell carcinoma by inhibiting cancer proliferation, migration and invasion

Wang, C., Piao, C., Liu, J., Zhang, Z., Zhu, Y., & Kong, C. (2020) · Cancer Biomarkers · doi:10.3233/cbm-191253 · Cited by 12

Enhancement of de novo lipogenesis by the IDH1 and IDH2-dependent reverse TCA cycle maintains the growth and angiogenic capacity of bone marrow-derived endothelial progenitor cells under hypoxia

He, Q., Yu, T., Chen, J., Liang, J., Lin, D., Yan, K., Zi-jing, X., Song, Y., & Chen, Z. (2024) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2024.01.028 · Cited by 11

Alteration of Lipid Metabolism in Hypoxic Cancer Cells

Gonzalez, G. A., Osuji, E., Fiur, N. C., Clark, M. G., Ma, S., Lukov, L. L., & Zhang, C. (2024) · Chemical & Biomedical Imaging · doi:10.1021/cbmi.4c00050 · Cited by 12

Metabolic crosstalk between thermogenic adipocyte and cancer cell: Dysfunction and therapeutics

Dong, K., Wei, G., Sun, H., Gu, D., Liu, J., & Wang, L. (2022) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2022.102322 · Cited by 11

HIF-2α drives an intrinsic vulnerability to ferroptosis in clear cell renal cell carcinomaPreprint

Zou, Y., Palte, M. J., Deik, A., Li, H., Eaton, J. K., Wang, W., Tseng, Y., Deasy, R., Alimova, M., Dančík, V., et al. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/388041 · Cited by 11

Material-Assisted Engineering of Organelles for Biomedical Applications

Liu, J., & Liu, B. (2022) · ACS Materials Letters · doi:10.1021/acsmaterialslett.2c00856 · Cited by 10

Protein aggregation and biomolecular condensation in hypoxic environments (Review)

Li, C., Hao, B., Yang, H., Wang, K., Fan, L., & Xiao, W. (2024) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2024.5357 · Cited by 10

Disruption of lipid metabolism to induce ferroptosis using multifunctional fibrate-Pt( iv ) prodrugs for cancer treatment

Sun, P., Wang, J.-Q., Xie, Q., Ren, X.-L., Qiao, X., & Xu, J. (2024) · Inorganic Chemistry Frontiers · doi:10.1039/d4qi00386a · Cited by 10

Cancer stem cells: advances in the glucose, lipid and amino acid metabolism

Kong, W., Gao, Y., Zhao, S., & Yang, H. (2023) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-023-04861-6 · Cited by 10

The Radiogenomic Landscape of Clear Cell Renal Cell Carcinoma: Insights into Lipid Metabolism through Evaluation of ADFP Expression

Greco, F., Panunzio, A., Bernetti, C., Tafuri, A., Zobel, B. B., & Mallio, C. A. (2024) · Diagnostics · doi:10.3390/diagnostics14151667 · Cited by 10

MSRB3 promotes the progression of clear cell renal cell carcinoma via regulating endoplasmic reticulum stress

Ye, X., Liang, T., Deng, C., Li, Z., & Yan, D. (2019) · Pathology - Research and Practice · doi:10.1016/j.prp.2019.152780 · Cited by 10

Low neighbor of Brca1 gene expression predicts poor clinical outcome and resistance of sunitinib in clear cell renal cell carcinoma

Xiao, W., Xiong, Z., Yuan, C., Bao, L., Liu, D., Yang, X. W., Li, W., Tong, J., Qu, Y., Liu, L., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.21999 · Cited by 10

The role of metabolic reprogramming in kidney cancer

Chen, Z., & Zhang, X. (2024) · Frontiers in Oncology · doi:10.3389/fonc.2024.1402351 · Cited by 11

Osalmid sensitizes clear cell renal cell carcinoma to navitoclax through a STAT3/BCL-XL pathway

Xue, Y., Chen, T., Ma, Z., Pu, X., Xu, J., Zhai, S., Du, X., Ji, Y., Simon, M. C., Zhai, W., et al. (2025) · Cancer Letters · doi:10.1016/j.canlet.2025.217514 · Cited by 9

Inside anticancer therapy resistance and metastasis. Focus on CD36

Lambrescu, I. M., Gaina, G. F., Ceafalan, L. C., & Hinescu, M. E. (2024) · Journal of Cancer · doi:10.7150/jca.90457 · Cited by 11

TBC1D5 reverses the capability of HIF-2α in tumor progression and lipid metabolism in clear cell renal cell carcinoma by regulating the autophagy

Huang, Y., Xiong, Z., Wang, J., Gao, Y., Cao, Q., Wang, D., Shi, J., Chen, Z., & Yang, X. W. (2024) · Journal of Translational Medicine · doi:10.1186/s12967-024-05015-y · Cited by 9

MFN2 suppresses the accumulation of lipid droplets and the progression of clear cell renal cell carcinoma

Cai, Z., Luo, W., Wang, H., Zhu, R., Yuan, Y., Zhan, X., Xie, M., Zhuang, H., Chen, H., Xu, Y., et al. (2024) · Cancer Science · doi:10.1111/cas.16151 · Cited by 10

Development of a mechanically matched silk scaffolded 3D clear cell renal cell carcinoma model

Abbott, A., Bond, K., Chiba, T., Sims‐Lucas, S., Oxburgh, L. H., & Coburn, J. M. (2021) · Materials Science and Engineering C · doi:10.1016/j.msec.2021.112141 · Cited by 9

Decrease of Intracellular Glutamine by STF-62247 Results in the Accumulation of Lipid Droplets in von Hippel-Lindau Deficient Cells

Johnson, M., Nowlan, S., Şahin, G., Barnett, D. A., Joy, A. P., Touaibia, M., Čuperlović‐Culf, M., Avizonis, D. Z., & Turcotte, S. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.841054 · Cited by 10

Adipogenic Transdifferentiation and Regulatory Factors Promote the Progression and the Immunotherapy Response of Renal Cell Carcinoma: Insights From Integrative Analysis

Wang, S., Wei, X., Ji, C., Wang, Y., Zhang, X., Cong, R., & Song, N. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.781932 · Cited by 9

Characterization of Fatty Acid Metabolism in Lung Adenocarcinoma

Wang, S., Chen, A., Zhu, W., Feng, D., Wei, J., Li, Q., Shi, X., Lv, X., & Liu, M. (2022) · Frontiers in Genetics · doi:10.3389/fgene.2022.905508 · Cited by 9

Targeting Metabolic Pathways in Kidney Cancer

Hoerner, C. R., Miao, S. Y., Hsieh, J. J.-D., & Fan, A. C. (2020) · The Cancer Journal · doi:10.1097/ppo.0000000000000472 · Cited by 9

Taxus chinensis var. mairei (Lemée et Lévl) Cheng et L.K. Fu overcomes the resistance to osimertinib in EGFR-mutant non-small-cell lung cancer via suppression of ERK1/2-related cholesterol biosynthesis

Dai, S., Zhang, G.-C.-X., Xiang, Y., Liu, Y., Wang, H., Zhao, F., & Shu, Q. (2024) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2024.118586 · Cited by 8

Lipid metabolism reprogramming in renal cell carcinomas

Abduljabbar, M. K., Merza, M., Aziz, A., Menon, S. V., Kaur, M., Aminov, Z., Rab, S. O., Hjazi, A. M., Mustafa, Y. F., & Gabel, B. C. (2024) · Medical Oncology · doi:10.1007/s12032-024-02484-5 · Cited by 9

Lipid droplet-associated hydrolase (LDAH) knockdown enhances TAG hydrolysis and promotes ovarian cancer progression and chemoresistance

Deswal, B., Nallanthighal, S., Nikpayam, E., Minhas, Z., Paul, A., Goo, Y., & Cheon, D. (2025) · Oncogenesis · doi:10.1038/s41389-025-00566-1 · Cited by 8

mTOR inhibition reprograms cellular lipid homeostasis by inducing alternative lipid uptake and promoting cholesterol transport

Shin, S., Han, M.-J., Patel, I., Welsh, A. M., Sverdlov, M. S., Cho, W., Cologna, S. M., Roux, P. P., & Yoon, S.-O. (2025) · Molecular Cell · doi:10.1016/j.molcel.2025.08.021 · Cited by 12

HIF1A-repressed PUS10 regulates NUDC/Cofilin1 dependent renal cell carcinoma migration by promoting the maturation of miR-194-5p

Luo, W., Xu, Z., Wang, H., Lu, Z., Ding, L., Wang, R., Xie, H., Zheng, Q., Lin, Y., Zhou, Z., et al. (2023) · Cell & Bioscience · doi:10.1186/s13578-023-01094-4 · Cited by 8

Genetic and Epigenetic Characteristics in Isolated Pancreatic Metastases of Clear-Cell Renal Cell Carcinoma

Sellner, F., Compérat, É., & Klimpfinger, M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242216292 · Cited by 8

Adaptation mechanisms in cancer: Lipid metabolism under hypoxia and nutrient deprivation as a target for novel therapeutic strategies (Review)

Koizume, S., & Miyagi, Y. (2025) · Molecular Medicine Reports · doi:10.3892/mmr.2025.13448 · Cited by 10

Integrative Analysis of the Predictive Value of Perilipin Family on Clinical Significance, Prognosis and Immunotherapy of Glioma

Li, X., Kang, K., Shen, L., Shen, L., & Zhou, Y. (2023) · Biomedicines · doi:10.3390/biomedicines11041009 · Cited by 8

Through a Clear Cell, Darkly: HIF2α/PLIN2–Maintained Fat Droplets Protect ccRCCs from ER Stress

Sim, J., & Johnson, R. S. (2015) · Cancer Discovery · doi:10.1158/2159-8290.cd-15-0480 · Cited by 8

Stress-responsive HILPDA is necessary for thermoregulation during fasting

VandeKopple, M. J., Wu, J., Baer, L. A., Bal, N. C., Maurya, S. K., Kalyanasundaram, A., Periasamy, M., Stanford, K. I., Giaccia, A. J., Denko, N. C., et al. (2017) · Journal of Endocrinology · doi:10.1530/joe-17-0289 · Cited by 8

Abundance of TRAIL attenuated by HIF2α and c-FLIP affects malignancy in renal cell carcinomas

Isono, T., Chano, T., Yoshida, T., Kageyama, S., Kawauchi, A., Yonese, J., & Yuasa, T. (2018) · Oncotarget · doi:10.18632/oncotarget.25214 · Cited by 9

HIF2α, Hepcidin and their crosstalk as tumour-promoting signalling

Formica, V., Riondino, S., Morelli, C., Guerriero, S., D’Amore, F., Grazia, A. D., Blanco, G. D. V., Sica, G. S., Arkenau, H., Monteleone, G., et al. (2023) · British Journal of Cancer · doi:10.1038/s41416-023-02266-2 · Cited by 8

Molecular subtyping and characterization of clear cell renal cell carcinoma by tumor differentiation trajectories

Pan, X., Chen, W., Xu, D., Guan, W., Li, L., Chen, J., Chen, W., Dong, K., Ye, J., Gan, S., et al. (2023) · iScience · doi:10.1016/j.isci.2023.108370 · Cited by 7

Targeting lipid reprogramming in the tumor microenvironment by traditional Chinese medicines as a potential cancer treatment

Zuo, Q., Wu, Y., Hu, Y., Shao, C., Liang, Y., Chen, L., Guo, Q., Ping, H., & Chen, Q. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e30807 · Cited by 7

Quantitative Phase Imaging Detecting the Hypoxia-Induced Patterns in Healthy and Neoplastic Human Colonic Epithelial Cells

Buzalewicz, I., Mrozowska, M., Kmiecik, A. M., Kulus, M., Haczkiewicz-Leśniak, K., Dzięgiel, P., Podhorska‐Okołów, M., & Zadka, Ł. (2022) · Cells · doi:10.3390/cells11223599 · Cited by 7

TRPM2 facilitates tumor progression of clear cell renal cell carcinoma by relieving Endoplasmic Reticulum Stress

Yuan, H., Li, W., Lou, N., Yu, T., Meng, X., Xiao, W., & Zhang, X. (2022) · International Journal of Medical Sciences · doi:10.7150/ijms.77944 · Cited by 7

Identify CTBP1-DT as an immunological biomarker that promotes lipid synthesis and apoptosis resistance in KIRC

Li, H., Fei, M., Zhang, Y., Xu, Q., Feng, R., Cao, J., Qu, Y., & Xiao, H. (2024) · Gene · doi:10.1016/j.gene.2024.148403 · Cited by 7

Adaptations of lipid metabolism in low-grade clear cell renal cell carcinoma are linked to cholesteryl ester accumulation

Fresnedo, O., Lopez-Gomez, J. A., Ceniceros, C., Larrinaga, G., Saiz, A., Mosteiro, L., Navarro-Imaz, H., & Rueda, Y. (2025) · Scientific Reports · doi:10.1038/s41598-025-09664-x · Cited by 6

Downregulation of RNA binding protein 47 predicts low survival in patients and promotes the development of renal cell malignancies through RNA stability modification

Wang, C., Li, W., Meng, X., Yuan, H., Yu, T., Yang, W., Ni, D., Liu, L., & Xiao, W. Q. (2023) · Molecular Biomedicine · doi:10.1186/s43556-023-00148-w · Cited by 6

In silico repurposing the Rac1 inhibitor NSC23766 for treating PTTG1-high expressing clear cell renal carcinoma

Hsieh, Y., Liu, T., & Yang, P. (2019) · Pathology - Research and Practice · doi:10.1016/j.prp.2019.03.002 · Cited by 6

The Identification of Key Gene Expression Signature and Biological Pathways in Metastatic Renal Cell Carcinoma

Bao, L., Zhao, Y., Liu, C., Cao, Q., Huang, Y., Chen, K., & Song, Z. (2020) · Journal of Cancer · doi:10.7150/jca.38379 · Cited by 7

Improved VPS4B O-GlcNAc modification triggers lipid droplets transferring from adipocytes to nasopharyngeal carcinoma cells

Yin, H., Shan, Y., Zhu, Q., Yuan, L., Ju, F., Shi, Y., Han, Y., Wu, R. J., Xia, T., Zhang, K., et al. (2025) · Cancer & Metabolism · doi:10.1186/s40170-025-00393-3 · Cited by 5

Lipid droplets in the tumor microenvironment: Biogenesis, functional diversity, and therapeutic targeting

Zhong, J., Liu, Y., Wang, C., Li, S., Bian, X.-W., & Ping, Y. (2025) · Chinese Medical Journal · doi:10.1097/cm9.0000000000003916 · Cited by 5

VHL synthetic lethality screens uncover CBF-β as a negative regulator of STING

Bertlin, J. A. C., Pauzaite, T., Liang, Q., Wit, N., Williamson, J. C., Sia, J. J., Matheson, N. J., Ortmann, B. M., Mitchell, T. J., Speak, A. O., et al. (2026) · Nature Communications · doi:10.1038/s41467-026-70517-w · Cited by 4

Activating transcription factor 3 is a new biomarker correlation with renal clear cell carcinoma progression

Yang, Z., Hou, Y., Li, J., Xu, D., Yang, Z., & Wang, X. (2024) · International Journal of Immunopathology and Pharmacology · doi:10.1177/03946320241227320 · Cited by 5

Mitochondrial lipid metabolism in metastatic breast cancer

Ruidas, B. (2024) · Mitochondrial Communications · doi:10.1016/j.mitoco.2024.07.001 · Cited by 6

Similarities in Blood Mononuclear Cell Membrane Phospholipid Profiles during Malignancy

Hakobyan, G., Davtyan, H., Harutyunyan, K., Alexanyan, K. A., Amirkhanyan, Y., Gharibyan, A. L., Asatryan, L., & Tadevosyan, Y. (2018) · Medical Sciences · doi:10.3390/medsci6040105 · Cited by 5

Potential Links Between YB-1 and Fatty Acid Synthesis in Clear Cell Renal Carcinoma

MCauley, C., Anang, V., Cole, B., & Simmons, G. E., Jr. (2020) · Medical Research Archives · doi:10.18103/mra.v8i10.2273 · Cited by 5

Glycolysis on F-18 FDG PET/CT Is Superior to Amino Acid Metabolism on C-11 Methionine PET/CT in Identifying Advanced Renal Cell Carcinoma at Staging

Lee, S. H., Park, J. S., Kim, H. J., Kim, D., Lee, S. H., Ham, W. S., Han, W. K., Choi, Y. D., & Yun, M. (2021) · Cancers · doi:10.3390/cancers13102381 · Cited by 5

Lipophagy-ICAM-1 pathway associated with fatty acid and oxygen deficiencies is involved in poor prognoses of ovarian clear cell carcinoma

Koizume, S., Takahashi, T., Nakamura, Y., Yoshihara, M., Ota, Y., Sato, S., Tadokoro, H., Yokose, T., Kato, H., Miyagi, E., et al. (2022) · British Journal of Cancer · doi:10.1038/s41416-022-01808-4 · Cited by 5

High Expression of DNTTIP1 Predicts Poor Prognosis in Clear Cell Renal Cell Carcinoma

Wang, X., Li, W., Lou, N., Han, W., Hai, B., Xiao, W., & Zhang, X. (2023) · Pharmacogenomics and Personalized Medicine · doi:10.2147/pgpm.s382843 · Cited by 5

Clear-Cell Renal Cell Carcinoma

In, E. R. H., Qiu, B., Ackerman, D., Sanchez, D. J., Li, B., Ochocki, J. D., Grazioli, A., Bobrovnikova-Marjon, E. V., Diehl, J. A., Keith, B., et al. (2016)

Abstract PR04: HIF-2α dependent lipid storage promotes endoplasmic reticulum homeostasis in clear cell renal cell carcinoma

Qiu, B., Ackerman, D., Sanchez, D. J., Li, B., Ochocki, J. D., Grazioli, A., Bobrovnikova-Marjon, E. V., Diehl, J. A., Keith, B., & Simon, M. C. (2016) · Molecular Cancer Research · doi:10.1158/1557-3125.metca15-pr04 · Cited by 1

Tumor promoting functions of lipid storage in clear cell renal cell carcinoma

Qiu, B. (2015) · ScholarlyCommons (University of Pennsylvania)

Additional file 1 of HIF-2α/LINC02609/APOL1-mediated lipid storage promotes endoplasmic reticulum homeostasis and regulates tumor progression in clear-cell renal cell carcinoma

Xiao, H., Qu, Y., Li, H., Zhang, Y., Fei, M., Liang, C., Yang, H., & Zhang, X. (2024) · Figshare · doi:10.6084/m9.figshare.25052259

HIF-2α/LINC02609/APOL1-mediated lipid storage promotes endoplasmic reticulum homeostasis and regulates tumor progression in clear-cell renal cell carcinoma

Xiao, H., Qu, Y., Li, H., Zhang, Y., Fei, M., Liang, C. Y., Yang, H., & Zhang, X. (2024) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-023-02940-6 · Cited by 40