The DOI matches its Crossref record; 51 of the 51 references it cites were found in a registry or an index.
HIF2α-Dependent Lipid Storage Promotes Endoplasmic Reticulum Homeostasis in Clear-Cell Renal Cell Carcinoma
Open accessPublished version of a preprint
Abstract
Two hallmarks of clear-cell renal cell carcinoma (ccRCC) are constitutive hypoxia-inducible factor (HIF) signaling and abundant intracellular lipid droplets (LD). However, regulation of lipid storage and its role in ccRCC are incompletely understood. Transcriptional profiling of primary ccRCC samples revealed that expression of the LD coat protein gene PLIN2 was elevated in tumors and correlated with HIF2α, but not HIF1α, activation. HIF2α-dependent PLIN2 expression promoted lipid storage, proliferation, and viability in xenograft tumors. Mechanistically, lipid storage maintained integrity of the endoplasmic reticulum (ER), which is functionally and physically associated with LDs. Specifically, PLIN2-dependent lipid storage suppressed cytotoxic ER stress responses that otherwise result from elevated protein synthetic activity characteristic of ccRCC cells. Thus, in addition to promoting ccRCC proliferation and anabolic metabolism, HIF2α modulates lipid storage to sustain ER homeostasis, particularly under conditions of nutrient and oxygen limitation, thereby promoting tumor cell survival. Significance: We demonstrate that HIF2α promotes lipid storage, ER homeostasis, and cell viability in ccRCC via upregulation of the LD coat protein PLIN2, revealing a novel function for the well-documented “clear-cell” phenotype and identifying ER stress as a targetable vulnerability created by HIF2α/PLIN2 suppression in this common renal malignancy. Cancer Discov; 5(6); 652–67. ©2015 AACR. See related commentary by Sim and Johnson, p. 584. This article is highlighted in the In This Issue feature, p. 565
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Fatty acid synthesis induced by HIF-2α is crucial for cell viability in ccRCC by sustaining endoplasmic reticulum (ER) homeostasis77.”
From Glutamine reliance in cell metabolism (2020) · cites this paper as [77]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation
Walter, P., & Ron, D. (2011) · Science · doi:10.1126/science.1209038 · Cited by 5,897
Targeting Hypoxia-Inducible Factors for the Treatment of Anemia in Chronic Kidney Disease Patients
Locatelli, F., Fishbane, S. N., Block, G. A., & Macdougall, I. C. (2017) · American Journal of Nephrology · doi:10.1159/000455166 · Cited by 4,836
Comprehensive molecular characterization of clear cell renal cell carcinoma
The Cancer Genome Atlas Research Network (2013) · Nature · doi:10.1038/nature12222 · Cited by 3,485
Triglyceride accumulation protects against fatty acid-induced lipotoxicity
Listenberger, L. L., Han, X., Lewis, S. E., Cases, S., Farese, R. V., Ory, D. S., & Schaffer, J. E. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0630588100 · Cited by 2,075
Activation of a metabolic gene regulatory network downstream of mTOR complex 1
Düvel, K., Yecies, J. L., Menon, S., Raman, P., Lipovsky, A. I., Souza, A. L., Triantafellow, E., Ma, Q., Gorski, R., Cleaver, S., et al. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.06.022 · Cited by 2,020
SUnSET, a nonradioactive method to monitor protein synthesis
Schmidt, E. K., Clavarino, G., Ceppi, M., & Pierre, P. (2009) · Nature Methods · doi:10.1038/nmeth.1314 · Cited by 1,706
Lipid Droplets and Cellular Lipid Metabolism
Walther, T. C., & Farese, R. V. (2012) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-061009-102430 · Cited by 1,701
HIF1α and HIF2α: sibling rivalry in hypoxic tumour growth and progression
Keith, B., Johnson, R. S., & Simon, M. C. (2012) · Nature Reviews Cancer · doi:10.1038/nrc3183 · Cited by 1,693
Self-citationMacropinocytosis of protein is an amino acid supply route in Ras-transformed cells
Commisso, C., Davidson, S. M., Soydaner-Azeloglu, R. G., Parker, S. J., Kamphorst, J. J., Hackett, S., Grabocka, E., Nofal, M., Drebin, J. A., Thompson, C. B., et al. (2013) · Nature · doi:10.1038/nature12138 · Cited by 1,683
Differential Roles of Hypoxia-Inducible Factor 1α (HIF-1α) and HIF-2α in Hypoxic Gene Regulation
Hu, C.-J., Wang, L.-Y., Chodosh, L. A., Keith, B., & Simon, M. C. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.24.9361-9374.2003 · Cited by 1,386
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Items 301–400 of 400
Han, X., Kim, L. C., Lesner, N. P., Cai, X., Le, T. N. V., & Simon, M. C. (2025) · Cancer & Metabolism · doi:10.1186/s40170-025-00389-z · Cited by 4
Self-citationWang, J., Luo, H., He, Q., Shao, H., Cai, X., Cao, Y., Wang, Y., & Wang, D. (2025) · Cell Death Discovery · doi:10.1038/s41420-025-02766-5 · Cited by 4
Immunobiology and Metabolic Pathways of Renal Cell Carcinoma
Braun, D. A., & Chakraborty, A. A. (2023) · Hematology/Oncology Clinics of North America · doi:10.1016/j.hoc.2023.04.012 · Cited by 4
Zheng, J., Lu, W., Wang, C., Chen, S., Zhang, Q., & Su, C. (2024) · Aging · doi:10.18632/aging.205974 · Cited by 5
Wang, N., Xu, Z., Zhang, L., Lu, Y., Wang, Y., Yan, L., Cao, H., Wang, L., & Shao, F. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1615601 · Cited by 4
STBD1 mediates the crosstalk between glycogen and lipid droplets in clear cell renal cell carcinoma
Wang, H., Xiao, T., Zhuang, H., Liu, Y., Jin, K., Li, J., Li, J., Gao, Y., Yue, D., Cui, W., et al. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.116429 · Cited by 4
Xiang, Y., Zhang, C., Wang, J., Cheng, Y., Wang, K., Wang, L., Tong, Y., & Yan, D. (2024) · International Journal of Colorectal Disease · doi:10.1007/s00384-024-04686-9 · Cited by 4
Lu, Y., Chen, W., Xuan, Y., Li, X., Wu, S., Wang, H., Guo, T., Wang, C., Tian, S., Li, H., et al. (2024) · Discover Oncology · doi:10.1007/s12672-024-01485-0 · Cited by 5
Pivotal biomarker expression and drug screening in advanced ccRCC
Xiao, W., Chen, K., & Zhang, X. (2020) · Clinical and Translational Medicine · doi:10.1002/ctm2.114 · Cited by 4
Yao, Q., Zhang, X., Wei, C., Chen, H., Xu, Q., Chen, J., & Chen, D. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e17224 · Cited by 4
Potential Susceptibility Loci Identified for Renal Cell Carcinoma by Targeting Obesity-Related Genes
Shu, X., Purdue, M. P., Ye, Y., Tu, H., Wood, C. G., Tannir, N. M., Wang, Z., Albanes, D., Gapstur, S. M., Stevens, V. L., et al. (2017) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-17-0141 · Cited by 4
Greco, F., Panunzio, A., Cerroni, L., Cea, L., Bernetti, C., Tafuri, A., Zobel, B. B., & Mallio, C. A. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252312587 · Cited by 3
Zhang, Y., Wang, X., Wang, J., Ma, K., Jia, L., Liu, B., Yuan, X., Li, Q., Wang, Q., Li, Q., et al. (2025) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-025-03600-7 · Cited by 3
Celada, L., Cubiella, T., San‐Juan‐Guardado, J., Suárez‐Priede, Á., Gomez-Suarez, N., Salerno, L., Murias, E., Torres, M. D. S., Weiner, J. A., Herrada‐Manchón, H., et al. (2026) · Cell Death and Disease · doi:10.1038/s41419-026-08643-y · Cited by 3
Zou, C., Wang, Y. J., Chen, Q., Shi, J., Wu, X., & Luo, Q. (2026) · Frontiers in Oncology · doi:10.3389/fonc.2026.1745024 · Cited by 3
Hong, Y., Wang, Y., Chen, Q., & Wang, Y. (2026) · npj gut and liver. · doi:10.1038/s44355-026-00060-4 · Cited by 3
Ma, W., Chen, Y., Chen, G., Yang, L., Lu, Y., Dong, X. D., Li, D., & Gan, W. (2025) · Cell Communication and Signaling · doi:10.1186/s12964-025-02117-y · Cited by 3
Cholesterol accumulation in ccRCC: the role of ccRCC-initiating VHL-HIFα pathway
Mohtar, M. A., Yusuf, S. N. H. M., & Syafruddin, S. E. (2024) · EBioMedicine · doi:10.1016/j.ebiom.2024.105112 · Cited by 3
Cancer RNome: Evolution and Sustenance
Arora, M., & Kaul, D. (2018) · Springer eBooks · doi:10.1007/978-981-13-1568-8_3 · Cited by 3
Huang, B., Yu, H., Wen, Z., Dong, J., Jin, S., & Li, H. (2025) · Lipids in Health and Disease · doi:10.1186/s12944-025-02746-9 · Cited by 2
Dalal, P., Singhal, R., Hu, B., Stark, D. C., Rossiter, N. J., Jain, C., Sajjakulnukit, P., Lyssiotis, C. A., & Shah, Y. M. (2026) · Cancer & Metabolism · doi:10.1186/s40170-026-00421-w · Cited by 2
Obesity-driven metabolic reprogramming and immune dysfunction in renal cancer
Ogbonna, H. N., & Norian, L. A. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1866875 · Cited by 2
Development of prognostic signatures and risk index related to lipid metabolism in ccRCC
Chen, W., Zhao, Z., Zhou, H., Dong, S., Li, X., Hu, S. C., Zhong, S., & Chen, K. (2024) · Frontiers in Oncology · doi:10.3389/fonc.2024.1378095 · Cited by 2
Susanto, H., Taufiq, A., Listyorini, D. I., Handaya, A. Y., & Pertiwi, M. P. (2019) · IOP Conference Series Materials Science and Engineering · doi:10.1088/1757-899x/515/1/012054 · Cited by 2
Cassisa, A., Colpani, F., Rinaldi, R., & Cima, L. (2018) · American Journal of Dermatopathology · doi:10.1097/dad.0000000000001195 · Cited by 2
Bacigalupa, Z. A., Brown, W. A., Krystofiak, E., Wolf, M. M., Hongo, R. A., Landis, M. D., Amason, E. K., Beckermann, K. E., Rathmell, J. C., & Rathmell, W. K. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.04.21.489116 · Cited by 2
Lipid droplets: a candidate new research field for epithelial ovarian cancer
Koizume, S., Takahashi, T., & Miyagi, Y. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1437161 · Cited by 1
Dou, Y. (2025) · New cell · doi:10.61958/ncjt1177 · Cited by 1
Interplay between cancer cell lipotypes and disease states
Wang, X., & Zou, Y. (2025) · Trends in cancer · doi:10.1016/j.trecan.2025.10.009 · Cited by 1
The role of bHLH-PAS transcription factors in endoplasmic reticulum stress
Krauze, I., Krzystek‐Korpacka, M., Maciejewska, K., & Greb‐Markiewicz, B. (2025) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2025.1730502 · Cited by 1
Rodriguez, W., & Cristea, I. M. (2026) · Viruses · doi:10.3390/v18030288 · Cited by 2
Chen, S.-T., Zhou, D.-R., Ge, Y.-J., Chang, L., Guo, S.-H., Wu, G.-S., & Feng, N. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1817492 · Cited by 1
He, H., Liu, X.-D., & Jonasch, E. W. (2026) · MedScience · doi:10.1007/s11684-025-1136-4 · Cited by 1
Jia, Y., Dong, X., Yang, F., Zhou, L., & Long, H. (2024) · BMC Nephrology · doi:10.1186/s12882-024-03735-3 · Cited by 1
Yang, J. (2025) · Pathology - Research and Practice · doi:10.1016/j.prp.2025.155870 · Cited by 1
Naeini, M. M., Pang, M., Rohatgi, N., Kadioglu, S., Ghoshdastider, U., DiNatale, R. G., Mano, R., Hakimi, A. A., & Skanderup, A. J. (2026) · Communications Medicine · doi:10.1038/s43856-026-01436-6 · Cited by 1
Lipid metabolism and signaling in cancer
Piccinin, E., Ntambi, J. M., & Moschetta, A. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-819404-1.00022-1 · Cited by 1
Microbial and epigenetic factors in the pathogenesis of nasopharyngeal carcinoma
Zhou, X. (2015) · Figshare
Therapeutic Exploitation of Metabolic Checkpoints In Cancer Cells
Patel, D. (2017) · CUNY Academic Works (City University of New York)
Neumann, C. K. A., Massey, W. J., Orabi, D., Zhang, R., Silver, D. J., Lathia, J. D., & Brown, J. M. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.02.10.942458
Huang, Z., Salama, P., Shao, W., Zhang, J., & Huang, K. (2020) · arXiv (Cornell University) · doi:10.48550/arxiv.2008.03776
Fatty acid synthesis and prostate cancer
Koltai, T., Reshkin, S. J., Baltazar, F., & Fliegel, L. (2021) · Elsevier eBooks · doi:10.1016/b978-0-323-90528-2.00004-7
Mihailović, S., Dzamic, Z. M., & Pljesa-Ercegovac, M. S. (2022) · Medicinski podmladak · doi:10.5937/mp73-35557
Xue, F., Wang, H., Jiang, T., Wu, X., Chen, N., & Wu, Q. (2023) · Research Square · doi:10.21203/rs.3.rs-2728545/v1
Yang, Z., Hou, Y., Li, J., Xu, D., Yang, Z., & Wang, X. (2023) · Research Square · doi:10.21203/rs.3.rs-2848531/v1
Sainero‐Alcolado, L., Mushtaq, M., Liaño-Pons, J., Rodríguez‐García, A., Yuan, Y., Liu, T., Ruiz-Pérez, M. V., Schlisio, S., Bedoya-Reina, O. C., & Arsenian‐Henriksson, M. (2022) · Figshare · doi:10.6084/m9.figshare.20335355
Sainero‐Alcolado, L., Mushtaq, M., Liaño-Pons, J., Rodríguez‐García, A., Yuan, Y., Liu, T., Ruiz-Pérez, M. V., Schlisio, S., Bedoya-Reina, O. C., & Arsenian‐Henriksson, M. (2022) · Figshare · doi:10.6084/m9.figshare.20335358
Metabolic Reprogramming of Clear Cell Renal Cell Carcinoma and Its Clinical Significance
周, 文. (2024) · Advances in Clinical Medicine · doi:10.12677/acm.2024.1451486
A causal relationship between the lipidome and central nervous system tumorsPreprint
Li, Y., Lin, L., Zhang, W., Wang, Y., & GUAN, Y. (2024) · Research Square · doi:10.21203/rs.3.rs-4397285/v1
Celada, L., Cubiella, T., Salerno, L., San‐Juan‐Guardado, J., Murías, E., Torres, M. D. S., Suárez‐Priede, Á., Weiner, J. A., Herrada‐Manchón, H., Fernández, M. A., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.08.26.609687
Network regularized Accelerated Failure Time Models for Robust Biomarker IdentificationPreprint
Liu, Y., Huse, J. T., & Kannan, K. S. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.05.30.657087
Chemical Shift MR Imaging of Adrenal and Renal Masses
Wentland, A. L., Elsayes, K. M., & Schieda, N. (2025) · Magnetic Resonance Imaging Clinics of North America · doi:10.1016/j.mric.2025.07.001
Liu, Y., He, J., Lyu, D., Yang, X., Zhang, H., Tu, S., Yao, Y., Wei, M., Li, Y., Zhao, Z., et al. (2025) · Frontiers in Oncology · doi:10.3389/fonc.2025.1537805
Lipid droplet biology in health and disease
Lees, R. N., How, S., Quilez, S., Landers, S., Rodriguez, S. A., Bernasconi, A. E., Ostler, J. J., & Pham, A. H. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-19116-9.00005-1
Mu, Z., Fu, H., Guo, S., Zhang, Z., Wang, Z., Wang, H., & Yin, J. (2025) · Medicine · doi:10.1097/md.0000000000044562
A Causal Relationship Between the Lipidome and Central Nervous System Tumors
Zhang, W., Li, Y., Lin, L., Wang, Y., & Guan, Y. (2025) · World Neurosurgery · doi:10.1016/j.wneu.2025.124590
Wang, Z., Chao, Z., Wang, Q., Zou, F., Song, T., Xu, L., Ning, J., & Cheng, F. (2024) · Figshare · doi:10.6084/m9.figshare.26673225
Lin, H., Fu, L., Li, P., Zhu, J., Xu, Q., Wang, Y., Mumin, M. A., Zhou, X., Chen, Y., Shu, G., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26591399
Lin, H., Fu, L., Li, P., Zhu, J., Xu, Q., Wang, Y., Mumin, M. A., Zhou, X., Chen, Y., Shu, G., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26591408
Luo, W., Xu, Z., Wang, H., Lu, Z., Ding, L., Wang, R., Xie, H., Zheng, Q., Lin, Y., Zhou, Z., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26611487
Huang, Y., Xiong, Z., Wang, J., Gao, Y., Cao, Q., Wang, D., Shi, J., Chen, Z., & Yang, X. (2024) · Figshare · doi:10.6084/m9.figshare.26686527
Wang, Z., Chao, Z., Wang, Q., Zou, F., Song, T., Xu, L., Ning, J., & Cheng, F. (2024) · Figshare · doi:10.6084/m9.figshare.26673231
Wang, Z., Chao, Z., Wang, Q., Zou, F., Song, T., Xu, L., Ning, J., & Cheng, F. (2024) · Figshare · doi:10.6084/m9.figshare.26673228
Lin, H., Fu, L., Li, P., Zhu, J., Xu, Q., Wang, Y., Mumin, M. A., Zhou, X., Chen, Y., Shu, G., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26591405
Sainero‐Alcolado, L., Mushtaq, M., Liaño-Pons, J., Rodriguez‐Garcia, A., Yuan, Y., Liu, T., Ruiz-Pérez, M. V., Schlisio, S., Bedoya-Reina, O. C., & Arsenian‐Henriksson, M. (2022) · Figshare · doi:10.6084/m9.figshare.20335361
Nguyen, T. T. M., Nguyen, T. H., Kim, H. S., Dao, T. T. P., Moon, Y., Seo, M., Kang, S., Mai, V.-H., An, Y. J., 정초록, et al. (2023) · Figshare · doi:10.6084/m9.figshare.22598942
Lin, H., Fu, L., Li, P., Zhu, J., Xu, Q., Wang, Y., Mumin, M. A., Zhou, X., Chen, Y., Shu, G., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26591402
Luo, W., Xu, Z., Wang, H., Lu, Z., Ding, L., Wang, R., Xie, H., Zheng, Q., Lin, Y., Zhou, Z., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26611481
Wang, Z., Chao, Z., Wang, Q., Zou, F., Song, T., Xu, L., Ning, J., & Cheng, F. (2024) · Figshare · doi:10.6084/m9.figshare.26673219
Huang, Y., Xiong, Z., Wang, J., Gao, Y., Cao, Q., Wang, D., Shi, J., Chen, Z., & Yang, X. (2024) · Figshare · doi:10.6084/m9.figshare.25310122
Xiao, H., Qu, Y., Li, H., Zhang, Y., Fei, M., Liang, C., Yang, H., & Zhang, X. (2024) · Figshare · doi:10.6084/m9.figshare.25052259
Wang, Z., Chao, Z., Wang, Q., Zou, F., Song, T., Xu, L., Ning, J., & Cheng, F. (2024) · Figshare · doi:10.6084/m9.figshare.26673234
Xiao, H., Qu, Y., Li, H., Zhang, Y., Fei, M., Liang, C., Yang, H., & Zhang, X. (2024) · Figshare · doi:10.6084/m9.figshare.25052467
Liu, R., Feng, Y., Deng, Y., Zou, Z., Ye, J., Cai, Z., Zhu, X., Liang, Y., Lu, J., Zhang, H., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14746861
Huang, Y., Xiong, Z., Wang, J., Gao, Y., Cao, Q., Wang, D., Shi, J., Chen, Z., & Yang, X. (2024) · Figshare · doi:10.6084/m9.figshare.25310214
Huang, Y., Xiong, Z., Wang, J., Gao, Y., Cao, Q., Wang, D., Shi, J., Chen, Z., & Yang, X. (2024) · Figshare · doi:10.6084/m9.figshare.26686524
Huang, Y., Xiong, Z., Wang, J., Gao, Y., Cao, Q., Wang, D., Shi, J., Chen, Z., & Yang, X. (2024) · Figshare · doi:10.6084/m9.figshare.26686521
Wang, Z., Chao, Z., Wang, Q., Zou, F., Song, T., Xu, L., Ning, J., & Cheng, F. (2024) · Figshare · doi:10.6084/m9.figshare.26673222
Luo, W., Xu, Z., Wang, H., Lu, Z., Ding, L., Wang, R., Xie, H., Zheng, Q., Lin, Y., Zhou, Z., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26611484
Wu, M.-F., Zhang, G.-D., Liu, T.-T., Shen, J.-H., Cheng, J.-L., Shen, J., Yang, T.-Y., Huang, C., & Zhang, L. (2022) · Figshare · doi:10.6084/m9.figshare.22609763
Luo, W., Xu, Z., Wang, H., Lu, Z., Ding, L., Wang, R., Xie, H., Zheng, Q., Lin, Y., Zhou, Z., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26611490
Greco, F., Panunzio, A., Vescovo, M., Perillo, G., Bernetti, C., Tafuri, A., Carotti, S., Zobel, B. B., & Mallio, C. A. (2026) · ONCOLOGIE · doi:10.1515/oncologie-2025-0443
Nguyen, T. H., Mai, X. L., Nguyen, T. T. M., Nam, H., Park, S., & Lee, J. Y. (2026) · Cell Death and Disease · doi:10.1038/s41419-025-08403-4
Sağcan, G., & Uzun, H. (2026) · Journal of Clinical Medicine · doi:10.3390/jcm15051776
Liu, L., Lu, W., Miao, S., Yu, Y., Zhang, X.-B., Ye, S., Wang, X., & Liu, L. (2026) · Communications Biology · doi:10.1038/s42003-026-09903-5
Deciphering the metabolic bases of Drosophila intestinal tumors
Delamotte, P. (2024) · theses.fr (ABES) · doi:10.70675/c62595f4zbfe2z4ee5zba1az272c10f57e2a
Jiao, G., Baracaldo-Lancheros, L. F., Dhiman, A., Ferreira, C. R., & Dykhuizen, E. C. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.05.02.722429
Wei, R., Meng, Y., Nasajpour, E., Panovska, D., Oft, H., Xing, Y. L., Lee, C. K., Fernandez-Miranda, J. C., Banu, M. A., Zare, R. N., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.05.11.724415
Overview of clear cell renal cell carcinoma: from mechanisms to clinical
Yang, H., Zhang, X., Ji, Q., & Sheng, X. (2026) · Frontiers in Medicine · doi:10.3389/fmed.2026.1822724
Quinlan, L., Yeung, D. T. O., Heatley, S. L., White, D. L., & Page, E. C. (2026) · Leukemia · doi:10.1038/s41375-026-03060-8
Chen, H., Cheng, C.-J., Hsu, T.-H., Tung, S.-Y., Chou, F.-N., Satapathy, M. K., & Juan, S. (2026) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-026-05733-8
Fatty Acid Metabolism Rewires Glioblastoma Progression and Treg-Mediated Immune Resistance
Chowdhury, N. I., Ewida, H. A., Ahmed, M. S., & Villalba, H. (2026) · Cancers · doi:10.3390/cancers18162573
Recent advances in etiology and treatment of von Hippel-Lindau Disease (VHLD)
Pirestani, S., Nicolas, É., Broadrup, R. L., Clapper, M. L., & Golemis, E. A. (2026) · Cancer and Metastasis Reviews · doi:10.1007/s10555-026-10370-x
Renal cell carcinoma: molecular understanding and therapeutic development
Hou, T., Hua, X., Wei Min, N. I., Yan, P., Inuzuka, H., & Wei, W. (2026) · Cell Death and Differentiation · doi:10.1038/s41418-026-01857-9
Wu, L., Xue, H., Wu, Y., Shen, N., Yang, Z., Gao, L., Ma, W., & Wang, C. (2026) · Oncology Reviews · doi:10.3389/or.2026.1887460
Jiang, Y., Pagen, C., Yin, G., Zhang, Z., Wang, M., Poltorack, C. D., Xue, Y., Han, X., Coffey, N. J., Brown, M., et al. (2026) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2612523123
Self-citationLipid metabolism: a potential checkpoint for cGAS-STING regulation in colorectal cancer
Qiu, Q., Cheng, Z., Gu, J., Zhang, T., Cai, M., & Wang, J. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1928380
Sureshkumar, S., Espitia, C. M., Bi, F., Xiong, R., Gamble, M. E., Hakim, N. L., Kelly, K. R., Carew, J. S., & Nawrocki, S. T. (2026) · Cancers · doi:10.3390/cancers18203358
Jackson-Oxley, J., Alibhai, A. A., Nwanji, I., Lothion‐Roy, J. H., de Brot, S., Dunning, M., Jeyapalan, J. N., Mongan, N. P., & Rutland, C. S. (2026) · Veterinary Sciences · doi:10.3390/vetsci13111178
Metadata
- Authors
- Qiu, B., Ackerman, D., Sanchez, D. J., Li, B., Ochocki, J. D., Grazioli, A., Bobrovnikova-Marjon, E., Diehl, J. A., Keith, B., & Simon, M. C.
- Affiliations
- University of Pennsylvania (US)
- Medical University of South Carolina (US)
- Howard Hughes Medical Institute (US)
- Corresponding author
- Simon, M. Celeste
- ORCID
- Venue
- Cancer Discovery
- Published
- 2015-06-01
- Volume
- 5
- Issue
- 6
- Pages
- 652-667
- ISSN
- 2159-8274 (ISSN-L)
- 2159-8290
- PMC
- PMC4456212
- OpenAlex
- W2135546443
- Cited by
- 394
- References
- 51
- Citations by year
- 2026: 27 · 2025: 37 · 2024: 69 · 2023: 32 · 2022: 47 · 2021: 47 · 2020: 38 · 2019: 27 · 2018: 29 · 2017: 22 · 2016: 14 · 2015: 4
- FWCI
- 7.60
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Cancer Discovery (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Howard Hughes Medical Institute
- National Cancer Institute (F30CA177106, 2-P01-CA104838, P01CA104838, 5-F30-CA177106, F32CA192758)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (T32HD083185)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Keywords
- HIF-2α, clear cell renal cell carcinoma, lipid droplets, PLIN2, endoplasmic reticulum homeostasis, endoplasmic reticulum stress, fat deposition, tumor hypoxia, tumor cell survival
- MeSH terms
- Perilipin-2, Endothelial PAS Domain-Containing Protein 1, Animals, Carcinoma, Renal Cell, Cell Survival, Disease Models, Animal, Endoplasmic Reticulum, Homeostasis, Humans, Kidney Neoplasms, Membrane Proteins, Oncogenes, Protein Biosynthesis, Gene Expression, Gene Expression Regulation, Neoplastic, Drug Resistance, Neoplasm, Cell Line, Tumor, Tumor Burden, Lipid Metabolism, Mice, Basic Helix-Loop-Helix Proteins, Unfolded Protein Response, Endoplasmic Reticulum Stress, Heterografts
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
