The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Signaling Mechanisms Regulating Self-Renewal and Differentiation of Pluripotent Embryonic Stem Cells
Abstract
An ability to propagate pluripotent embryonic cells in culture is the foundation both for defined germline modification in experimental rodents and for future possibilities for broad-based cellular transplantation therapies in humans. Yet, the molecular basis of the self-renewing pluripotent phenotype remains ill-defined. The relationship between factors that influence embryonic stem cell propagation in vitro and mechanisms of stem cell regulation operative in the embryo is also uncertain. In this article we discuss the role of intracellular signalling pathways in the maintenance of pluripotency and induction of differentiation in embryonic stem cell cultures and the mammalian embryo.
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Citations
Cites
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Association and Activation of Jak-Tyk Kinases by CNTF-LIF-OSM-IL-6 β Receptor Components
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Enhanced DNA-Binding Activity of a Stat3-Related Protein in Cells Transformed by the Src Oncoprotein
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BackgroundProtein-tyrosine-phosphatase SHPTP2 couples platelet-derived growth factor receptor beta to Ras.
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Cited by
Functional Expression Cloning of Nanog, a Pluripotency Sustaining Factor in Embryonic Stem Cells
Chambers, I., Colby, D., Robertson, M., Nichols, J., Lee, S., Tweedie, S., & Smith, A. (2003) · Cell · doi:10.1016/s0092-8674(03)00392-1 · Cited by 3,255
Self-citationEmbryonic Stem Cells: Prospects for Developmental Biology and Cell Therapy
Wobus, A. M., & Boheler, K. R. (2005) · Physiological Reviews · doi:10.1152/physrev.00054.2003 · Cited by 782
Stem cells and pancreatic differentiation in vitro
Blyszczuk, P., & Wobus, A. M. (2004) · Journal of Biotechnology · doi:10.1016/j.jbiotec.2004.03.023 · Cited by 31
Metadata
- Authors
- Burdon, T., Chambers, I., Stracey, C., Niwa, H., & Smith, A.
- Venue
- Cells Tissues Organs
- Publisher
- S. Karger AG
- Published
- 1999
- Volume
- 165
- Issue
- 3-4
- Pages
- 131-143
- ISSN
- 1422-6405 (ISSN-L)
- 1422-6421
- OpenAlex
- W2075827370
- Cited by
- 192
- References
- 13
- FWCI
- 1.85
- Type
- journal article
- Language
- en
- Open access
- closed
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- Burdon, T., Chambers, I., Stracey, C., Niwa, H., & Smith, A. (1999). Signaling Mechanisms Regulating Self-Renewal and Differentiation of Pluripotent Embryonic Stem Cells. Cells Tissues Organs. https://doi.org/10.1159/000016693
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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